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Cited by 92Muscle metabolism and nutritionDiet, Metabolism, and DiseaseCardiovascular and exercise physiology

Fructose and glucose co-ingestion during prolonged exercise increases lactate and glucose fluxes and oxidation compared with an equimolar intake of glucose

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Lecoultre, Virgile, Benoit, Rachel, Carrel, Guillaume, Schutz, Yves, Millet, Grégoire P, Tappy, Luc, Schneiter, Philippe·2010·The American Journal of Clinical Nutrition
DOI 10.3945/ajcn.2010.29566
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Abstract

Background When fructose is ingested together with glucose (GLUFRU) during exercise, plasma lactate and exogenous carbohydrate oxidation rates are higher than with glucose alone. Objective The objective was to investigate to what extent GLUFRU increased lactate kinetics and oxidation rate and gluconeogenesis from lactate (GNG(L)) and from fructose (GNG(F)). Design Seven endurance-trained men performed 120 min of exercise at ≈60% VO₂max (maximal oxygen consumption) while ingesting 1.2 g glucose/min + 0.8 g of either glucose or fructose/min (GLUFRU). In 2 trials, the effects of glucose and GLUFRU on lactate and glucose kinetics were investigated with glucose and lactate tracers. In a third trial, labeled fructose was added to GLUFRU to assess fructose disposal. Results In GLUFRU, lactate appearance (120 ± 6 μmol · kg⁻¹ · min⁻¹), lactate disappearance (121 ± 7 μmol · kg⁻¹ · min⁻¹), and oxidation (127 ± 12 μmol · kg⁻¹ · min⁻¹) rates increased significantly (P Conclusions Fructose increased total carbohydrate oxidation, lactate production and oxidation, and GNG(F). Fructose oxidation was explained equally by fructose-derived lactate and glucose oxidation, most likely in skeletal and cardiac muscle. This trial was registered at clinicaltrials.gov as NCT01128647.

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  • Following fructose ingestion, plasma fructose concentrations remain relatively low (<0.5 mmol/l) as fructose is rapidly converted in the intestine and liver to glucose and lactate.

    “Therefore, following fructose ingestion, plasma fructose concentrations remain relatively low (<0.5 mmol/l) (Lecoultre et al. 2010; Rosset et al. 2017b) as fructose is rapidly converted in the intestine and liver to glucose and lactate (Fig. 1), which then enter the systemic circulation and are delivered to peripheral tissues (Lecoultre et al. 2010) and/or contribute to liver glycogen synthesis (G”

    From Fructose co‐ingestion to increase carbohydrate availability in athletes (2019) · cites this paper as Lecoultre et al. 2010

  • When fructose is co-ingested with glucose in large amounts (0.8 g/min and 1.2 g/min, respectively) during exercise, the systemic appearance of fructose-derived glucose and lactate is approximately 0.5 g/min, equally split between glucose and lactate.

    “When fructose is co‐ingested with glucose in large amounts (0.8 g/min and 1.2 g/min, respectively) during exercise, the systemic appearance of fructose‐derived glucose and lactate is ∼0.5 g/min (of which the contribution of glucose and lactate is equally split) (Lecoultre et al. 2010).”

    From Fructose co‐ingestion to increase carbohydrate availability in athletes (2019) · cites this paper as Lecoultre et al. 2010

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Authors
Lecoultre, V., Benoit, R., Carrel, G., Schutz, Y., Millet, G. P., Tappy, L., & Schneiter, P.
Affiliations
University of Lausanne (CH)
ORCID
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2010-11
Volume
92
Issue
5
Pages
1071-1079
ISSN
0002-9165 (ISSN-L)
DOI
10.3945/ajcn.2010.29566
OpenAlex
W2140286192
Cited by
92
References
7
Citations by year
2026: 6 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 11 · 2015: 6 · 2014: 9 · 2013: 8 · 2012: 6
FWCI
2.10
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
fructose, glucose, prolonged exercise, lactate kinetics, lactate oxidation, gluconeogenesis, fructose oxidation, carbohydrate oxidation, endurance-trained men, skeletal muscle, myocardium, glucose tracer, energy substrate utilization
MeSH terms
Adult, Blood Glucose, Fructose, Gluconeogenesis, Glucose, Humans, Male, Oxidation-Reduction, Oxygen Consumption, Exercise, Single-Blind Method, Cross-Over Studies, Lactic Acid

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