Cited by 584Cytokine Signaling Pathways and InteractionsT-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

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Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

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Takeda, Kiyoshi, Kaisho, Tsuneyasu, Yoshida, Nobuaki, Takeda, Junji, Kishimoto, Tadamitsu, Akira, Shizuo·1998·The Journal of Immunology

DOI 10.4049/jimmunol.161.9.4652

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Abstract

Stat3, a member of STAT, is activated by a variety of cytokines such as IL-6 family of cytokines, granulocyte CSF, epidermal growth factor, and leptin. A recent study with mice genetically deficient in the Stat3 gene has revealed its important role in the early embryogenesis. To assess the function of Stat3 in adult tissues, we disrupted the Stat3 gene specifically in T cells by conditional gene targeting using Cre-loxP system. In Stat3-deficient T cells, IL-6-induced proliferation was severely impaired. IL-6 did not enhance cell cycle progression, but prevented apoptosis of normal T cells. In contrast, IL-6 did not prevent apoptosis of Stat3-deficient T cells. Antiapoptotic protein, Bcl-2, was normally up-regulated in response to IL-6 even in Stat3-deficient T cells. These results demonstrate that Stat3 activation is involved in IL-6-dependent T cell proliferation through prevention of apoptosis independently of Bcl-2.

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Authors: Takeda, K., Kaisho, T., Yoshida, N., Takeda, J., Kishimoto, T., & Akira, S.
Affiliations: Hyogo Medical University (JP)
Research Institute, Osaka Maternal and Child Health Center , Izumi, Osaka ,
The University of Osaka (JP)
ORCID: Takeda, Kiyoshi
Kaisho, Tsuneyasu
Yoshida, Nobuaki
Takeda, Junji
Kishimoto, Tadamitsu
Akira, Shizuo
Venue: The Journal of Immunology
Publisher: Oxford University Press (OUP)
Published: 1998-11-01
Volume: 161
Issue: 9
Pages: 4652-4660
ISSN: 0022-1767 (ISSN-L)
1550-6606
DOI: 10.4049/jimmunol.161.9.4652
OpenAlex: W4313347835
Cited by: 584
References: 52
Citations by year: 2026: 3 · 2025: 7 · 2024: 13 · 2023: 11 · 2022: 14 · 2021: 19 · 2020: 19 · 2019: 19 · 2018: 21 · 2017: 20 · 2016: 34 · 2015: 28 · 2014: 27 · 2013: 34 · 2012: 25
FWCI: 10.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: The Journal of Immunology (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords: STAT3, interleukin-6, T cell proliferation, apoptosis, Bcl-2, conditional gene targeting, Cre-loxP system, STAT family, cell cycle progression, anti-apoptotic signaling

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Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

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