Stat3 Activation Is Responsible for IL-6-Dependent T Cell Proliferation Through Preventing Apoptosis: Generation and Characterization of T Cell-Specific Stat3-Deficient Mice

STATs and Gene Regulation

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

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Stat3: a STAT Family Member Activated by Tyrosine Phosphorylation in Response to Epidermal Growth Factor and Interleukin-6

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TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

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Impaired immune and acute-phase responses in interleukin-6-deficient mice

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Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

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Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

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Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

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Essential role of Stat6 in IL-4 signalling

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Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

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Compensatory recovery of liver mass by Akt-mediated hepatocellular hypertrophy in liver-specific STAT3-deficient mice

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Evidences of Early Senescence in Multiple Myeloma Bone Marrow Mesenchymal Stromal Cells

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ADAM17 Activity and IL-6 Trans-Signaling in Inflammation and Cancer

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AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis

Ma, C., Li, S., Hu, Y., Ma, Y., Wu, Y., Wu, C., Liu, X., Wang, B., Hu, G., Zhou, J., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201796 · Cited by 101

A murine model of inducible, cardiac-specific deletion of STAT3: Its use to determine the role of STAT3 in the upregulation of cardioprotective proteins by ischemic preconditioning

Bolli, R., Stein, A., Guo, Y., Wang, O., Rokosh, G. D., Dawn, B., Molkentin, J. D., Sanganalmath, S. K., Zhu, Y., & Xuan, Y.-T. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.01.002 · Cited by 102

Role of Cytokine Signaling during Nervous System Development

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IL-6, in Synergy with IL-7 or IL-15, Stimulates TCR-Independent Proliferation and Functional Differentiation of CD8+ T Lymphocytes

Gagnon, J., Ramanathan, S., LeBlanc, C., Cloutier, A., McDonald, P. P., & Ilangumaran, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.7958 · Cited by 103

IL-10 Suppresses Mast Cell IgE Receptor Expression and Signaling In Vitro and In Vivo

Norton, S. K., Barnstein, B. O., Brenzovich, J., Bailey, D. P., Kashyap, M., Speiran, K., Ford, J. W., Conrad, D. H., Watowich, S. S., Moralle, M. R., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2848 · Cited by 101

PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells

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Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells

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Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion

Fuglesteg, B. N., Suleman, N., Tiron, C. E., Kanhema, T., Lacerda, L., Andreasen, T. V., Sack, M. N., Jonassen, A. K., Mjøs, O. D., Opie, L. H., et al. (2008) · Basic Research in Cardiology · doi:10.1007/s00395-008-0728-x · Cited by 100

The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A

Fu, J., Huang, Y., Bao, T., Liu, C., Liu, X., & Chen, X. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02446-6 · Cited by 103

STAT3‐Mediated astrogliosis protects myelin development in neonatal brain injury

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Vascular Signal Transducer and Activator of Transcription-3 Promotes Angiogenesis and Neuroplasticity Long-Term After Stroke

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STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

Uckun, F. M., Qazi, S., Ma, H., Tuel-ahlgren, L., & Özer, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909086107 · Cited by 96

JunB is essential for IL-23-dependent pathogenicity of Th17 cells

Hasan, Z., Koizumi, S.-I., Sasaki, D., Yamada, H., Arakaki, N., Fujihara, Y., Okitsu, S., Shirahata, H., & Ishikawa, H. (2017) · Nature Communications · doi:10.1038/ncomms15628 · Cited by 98

The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation

Chang, D., Xing, Q., Su, Y., Zhao, X., Xu, W., Wang, X., & Dong, C. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.012 · Cited by 91

A new minimally-invasive method for microinjection into the mouse spinal dorsal horn

Kohro, Y., Sakaguchi, E., Tashima, R., Tozaki‐Saitoh, H., Okano, H., Inoue, K., & Tsuda, M. (2015) · Scientific Reports · doi:10.1038/srep14306 · Cited by 95

Novel IL27p28/IL12p40 Cytokine Suppressed Experimental Autoimmune Uveitis by Inhibiting Autoreactive Th1/Th17 Cells and Promoting Expansion of Regulatory T Cells

Wang, R., Yu, C., Mahdi, R. M., & Egwuagu, C. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.390625 · Cited by 95

Mitochondrial Ca2+ and membrane potential, an alternative pathway for interleukin 6 to regulate CD4 cell effector function

Yang, R., Lirussi, D., Thornton, T. M., Jelley-Gibbs, D. M., Diehl, S. A., Case, L. K., Madesh, M., Taatjes, D. J., Teuscher, C., Haynes, L., et al. (2015) · eLife · doi:10.7554/elife.06376 · Cited by 91

Elevated Inflammatory Response in Caveolin-1-deficient Mice with Pseudomonas aeruginosa Infection Is Mediated by STAT3 Protein and Nuclear Factor κB (NF-κB)

Yuan, K., Huang, C., Fox, J., Gaid, M., Weaver, A., Li, G., Singh, B. B., Gao, H., & Wu, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.237628 · Cited by 90

STAT3 Activation in Th17 and Th22 Cells Controls IL-22–Mediated Epithelial Host Defense during Infectious Colitis

Backert, I., Koralov, S. B., Wirtz, S. J., Kitowski, V., Billmeier, U., Martini, E., Hofmann, K., Hildner, K., Wittkopf, N., Brecht, K., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303076 · Cited by 89

Leptin system in embryo development and implantation: a protein in search of a function

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Distinct Roles for STAT1, STAT3, and STAT5 in Differentiation Gene Induction and Apoptosis Inhibition by Interleukin-9

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Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade

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STAT3 in immune responses and inflammatory bowel diseases

Fu, X. Y. (2006) · Cell Research · doi:10.1038/sj.cr.7310029 · Cited by 90

Intracellular role of IL-6 in mesenchymal stromal cell immunosuppression and proliferation

Dorronsoro, A., Lang, V., Ferrin, I., Fernández‐Rueda, J., Zabaleta, L., Pérez-Ruiz, E., Sepúlveda, P., & Trigueros, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-78864-4 · Cited by 89

Neurogenesis in the Dentate Gyrus Depends on Ciliary Neurotrophic Factor and Signal Transducer and Activator of Transcription 3 Signaling

Müller, S., Chakrapani, P. S. B., Schwegler, H., Hofmann, H., & Kirsch, M. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0234 · Cited by 88

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity

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IL-6 Prevents T Cell-Mediated Hepatitis via Inhibition of NKT Cells in CD4+ T Cell- and STAT3-Dependent Manners

Sun, R., Tian, Z., Kulkarni, S., & Gao, B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.9.5648 · Cited by 86

STAT3 Signaling in CD4+ T Cells Is Critical for the Pathogenesis of Chronic Sclerodermatous Graft-Versus-Host Disease in a Murine Model

Radojčić, V., Pletneva, M., Yen, H., Ivčević, S., Panoskaltsis‐Mortari, A., Gilliam, A. C., Drake, C. G., Blazar, B. R., & Luznik, L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0903006 · Cited by 88

STAT3: An Important Regulator of Multiple Cytokine Functions

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Interleukin-11 and Interleukin-6 Protect Cultured Human Endothelial Cells from H2O2-Induced Cell Death

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Hepatocyte-specific mutation of both NF-κB RelA and STAT3 abrogates the acute phase response in mice

Quinton, L. J., Blahna, M. T., Jones, M. R., Allen, E., Ferrari, J. D., Hilliard, K. L., Zhang, X., Sabharwal, V., Algül, H., Akira, S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59408 · Cited by 84

The Complex Role of STAT3 in Viral Infections

Kuchipudi, S. V. (2015) · Journal of Immunology Research · doi:10.1155/2015/272359 · Cited by 88

STAT Signaling in Glioma Cells

Swiatek-Machado, K., & Kaminska, B. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-30651-9_10 · Cited by 86

A mitochondrial STAT3-methionine metabolism axis promotes ILC2-driven allergic lung inflammation

Fu, L., Zhao, J., Huang, J., Li, N., Dong, X. Z., He, Y., Wang, W., Wang, Y., Qiu, J., & Guo, X. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.12.783 · Cited by 83

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis

Jenkins, B. J., Roberts, A. W., Najdovska, M., Grail, D., & Ernst, M. (2005) · Blood · doi:10.1182/blood-2004-09-3751 · Cited by 85

Postnatally induced inactivation of Osterix in osteoblasts results in the reduction of bone formation and maintenance

Baek, W., Crombrugghe, B. D., & Kim, J. (2009) · Bone · doi:10.1016/j.bone.2009.12.007 · Cited by 83

Leptin Enhances TH2 and ILC2 Responses in Allergic Airway Disease

Zheng, H., Zhang, X., Castillo, E. F., Luo, Y., Liu, M., & Yang, X. O. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.743187 · Cited by 83

Defective Thymocyte Development and Perturbed Homeostasis of T cells in STAT-Induced STAT Inhibitor-1/Suppressors of Cytokine Signaling-1 Transgenic Mice

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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types

Tomasello, E., Pollet, É., Manh, T. V., Uzé, G., & Dalod, M. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00526 · Cited by 91

STAT3 isoforms: Alternative fates in cancer?

Aigner, P., Just, V., & Stoiber, D. (2018) · Cytokine · doi:10.1016/j.cyto.2018.07.014 · Cited by 81

Cytokine signalling in embryonic stem cells

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Interleukin‐6 is responsible for drug resistance and anti‐apoptotic effects in prostatic cancer cells

Pu, Y., Hour, T., Chuang, S., Cheng, A., Lai, M., & Kuo, M. (2004) · The Prostate · doi:10.1002/pros.20057 · Cited by 84

The Expression of Human Cytomegalovirus MicroRNA MiR-UL148D during Latent Infection in Primary Myeloid Cells Inhibits Activin A-triggered Secretion of IL-6

Lau, B., Poole, E. L., Krishna, B. A., Montanuy, I., Wills, M. R., Murphy, E. A., & Sinclair, J. H. (2016) · Scientific Reports · doi:10.1038/srep31205 · Cited by 80

The Vagus Nerve and Nicotinic Receptors Involve Inhibition of HMGB1 Release and Early Pro-inflammatory Cytokines Function in Collagen-Induced Arthritis

Li, T., Zuo, X., Zhou, Y., Wang, Y., Zhuang, H., Zhang, L., Zhang, H., & Xiao, X. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9346-0 · Cited by 79

The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1

Markiewski, M. M., Vadrevu, S. K., Sharma, S., Chintala, N. K., Ghouse, S. M., Cho, J., Fairlie, D. P., Paterson, Y. Y. W., Astrinidis, A., & Karbowniczek, M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1602057 · Cited by 78

STAT3 Is Indispensable to IL-27-Mediated Cell Proliferation but Not to IL-27-Induced Th1 Differentiation and Suppression of Proinflammatory Cytokine Production

Owaki, T., Asakawa, M., Morishima, N., Mizoguchi, I., Fukai, F., Takeda, K., Mizuguchi, J., & Yoshimoto, T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.2903 · Cited by 80

Identification of the Cytoplasmic Domains of CXCR4 Involved in Jak2 and STAT3 Phosphorylation

Ahr, B., Denizot, M., Robert-Hebmann, V., Brelot, A., & Biard‐Piechaczyk, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408481200 · Cited by 81

The role of protein kinase C δ activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation

Gartsbein, M., Alt, A., Hashimoto, K., Nakajima, K., Kuroki, T., & Tennenbaum, T. (2006) · Journal of Cell Science · doi:10.1242/jcs.02744 · Cited by 81

Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD

Terui, K., Enosawa, S., Haga, S., Zhang, H. Q., Kuroda, H., Kouchi, K., Matsunaga, T., Yoshida, H., Engelhardt, J. F., Irani, K., et al. (2004) · Journal of Hepatology · doi:10.1016/j.jhep.2004.08.019 · Cited by 76

Traumatically injured astrocytes release a proteomic signature modulated by STAT 3‐dependent cell survival

Levine, J., Kwon, E., Paez, P., Yan, W., Czerwieniec, G., Loo, J. A., Sofroniew, M. V., & Wanner, I. (2016) · Glia · doi:10.1002/glia.22953 · Cited by 76

Insights into the Role of Follicular Helper T Cells in Autoimmunity

Park, H.-J., Kim, D.-H., Lim, S., Kim, W., Youn, J., Choi, Y.-S., & Choi, J. (2014) · Immune Network · doi:10.4110/in.2014.14.1.21 · Cited by 77

STAT3 but Not STAT1 Is Required for Astrocyte Differentiation

Hong, S., & Song, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086851 · Cited by 77

Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors

Mankan, A. K., & Greten, F. R. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.601739 · Cited by 77

Stat3 as a potential therapeutic target for rheumatoid arthritis

Oike, T., Sato, Y., Kobayashi, T., Miyamoto, K., Nakamura, S., Kaneko, Y., Kobayashi, S., Harato, K., Saya, H., Matsumoto, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-11233-w · Cited by 75

Inhibition of Signal Transducer and Activator of Transcription 3 ( STAT 3) reduces neonatal hypoxic‐ischaemic brain damage

Hristova, M., Rocha‐Ferreira, E., Fontana, X., Thei, L., Buckle, R., Christou, M., Hompoonsup, S., Gostelow, N., Raivich, G., & Peebles, D. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13490 · Cited by 74

GP130-STAT3 Regulates Epithelial Cell Migration and Is Required for Repair of the Bronchiolar Epithelium

Kida, H., Mucenski, M. L., Thitoff, A. R., Cras, T. D. L., Park, K.-S., Ikegami, M., Müller, W., & Whitsett, J. A. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.071052 · Cited by 74

Recombinant human lactoferrin expressed in glycoengineered Pichia pastoris: effect of terminal N-acetylneuraminic acid on in vitro secondary humoral immune response

Choi, B., Actor, J. K., Rios, S. E., d′Anjou, M., Stadheim, T. A., Warburton, S., Giaccone, E. M., Cukan, M. C., Li, H., Kull, A. R., et al. (2008) · Glycoconjugate Journal · doi:10.1007/s10719-008-9123-y · Cited by 74

Uncovering the pathogenesis of large granular lymphocytic leukemia—novel STAT3 and STAT5b mutations

Rajala, H. L. M., Porkka, K., Maciejewski, J. P., Loughran, T. P., & Mustjoki, S. M. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.882105 · Cited by 74

STAT Signaling in Glioma Cells

Swiatek-Machado, K., & Kaminska, B. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-4719-7_10 · Cited by 74

IL-6 Amplifier, NF-κB–Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses

Lee, J., Nakagiri, T., Oto, T., Harada, M., Morii, E., Shintani, Y., Inoue, M., Iwakura, Y., Miyoshi, S., Okumura, M., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103613 · Cited by 72

Insulin secretory defects and impaired islet architecture in pancreatic β-cell-specific STAT3 knockout mice

Gorogawa, S.-I., Fujitani, Y., Kaneto, H., Hazama, Y., Watada, H., Miyamoto, Y., Takeda, K., Akira, S., Magnuson, M. A., Yamasaki, Y., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.05.095 · Cited by 71

ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3

Bong, Y., Lee, H., Carim‐Todd, L., Mood, K., Nishanian, T. G., Tessarollo, L., & Daar, I. O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702337104 · Cited by 73

Growth Hormone Inhibits Signal Transducer and Activator of Transcription 3 Activation and Reduces Disease Activity in Murine Colitis

Han, X., Sosnowska, D., Bonkowski, E. L., & Denson, L. A. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.05.018 · Cited by 71

Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice

Sakamori, R., Takehara, T., Ohnishi, C., Tatsumi, T., Ohkawa, K., Takeda, K., Akira, S., & Hayashi, N. (2007) · Hepatology · doi:10.1002/hep.21837 · Cited by 71

Cell Signals Influencing Hepatic Fibrosis

Cong, M., Iwaisako, K., Jiang, C., & Kisseleva, T. (2012) · International Journal of Hepatology · doi:10.1155/2012/158547 · Cited by 74

IL-10 Indirectly Regulates Corneal Lymphangiogenesis and Resolution of Inflammation via Macrophages

Hos, D., Bucher, F., Regenfuß, B., Dreisow, M.-L., Bock, F., Heindl, L. M., Eming, S. A., & Cursiefen, C. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.012 · Cited by 70

A functional role of Stat3 in in vivo megakaryopoiesis

Kirito, K., Osawa, M., Morita, H., Shimizu, R., Yamamoto, M. P., Oda, A., Fujita, H., Tanaka, M., Nakajima, K., Miura, Y., et al. (2002) · Blood · doi:10.1182/blood.v99.9.3220 · Cited by 68

Involvement of IL-6, apart from its role in immunity, in mediating a chronic response during experimental arthritis.

de Hooge, A. D., van de Loo, F. V. D., Arntz, O., & van den Berg, W. (2000) · American Journal of Pathology · doi:10.1016/s0002-9440(10)64846-8 · Cited by 78

STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation

Hiraoka, T., Hirota, Y., Saito‐Fujita, T., Matsuo, M., Egashira, M., Matsumoto, L., Haraguchi, H., Dey, S. K., Furukawa, K. S., Fujii, T., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.87591 · Cited by 68

Anti-inflammatory effects of luteolin on experimental autoimmune thyroiditis in mice

Xia, N., Chen, G., Liu, M., Ye, X., Pan, Y., Ge, J., Mao, Y., Wang, H., Wang, J., & Xie, S. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3854 · Cited by 72

Fgfr1 regulates development through the combinatorial use of signaling proteinsPreprint

Brewer, J. R., Molotkov, A., Mazot, P., Hoch, R. V., & Soriano, P. M. (2015) · Genes & Development · doi:10.1101/gad.264994.115 · Cited by 70

STAT3 signaling in myeloid cells promotes pathogenic myelin-specific T cell differentiation and autoimmune demyelination

Lu, H. C., Kim, S.-J., Steelman, A. J., Tracy, K., Zhou, B., Michaud, D., Hillhouse, A., Konganti, K., & Li, J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913997117 · Cited by 72

Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch

Takahashi, S., Ochiai, S., Jin, J., Takahashi, N., Toshima, S., Ishigame, H., Kabashima, K., Kubo, M., Nakayama, M., Shiroguchi, K., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113433 · Cited by 68

Activation of oligodendroglial Stat3 is required for efficient remyelination

Steelman, A. J., Zhou, Y., Koito, H., Kim, S., Payne, H. R., Lu, Q. R., & Li, J. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.03.023 · Cited by 69

STAT3 Regulates ABCA3 Expression and Influences Lamellar Body Formation in Alveolar Type II Cells

Matsuzaki, Y., Besnard, V., Clark, J. C., Xu, Y. J., Wert, S. E., Ikegami, M., & Whitsett, J. A. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0311oc · Cited by 67

Cytokines and Their STATs in Cutaneous and Visceral Leishmaniasis

Cummings, H., Tuladhar, R., & Satoskar, A. R. (2010) · BioMed Research International · doi:10.1155/2010/294389 · Cited by 67

Cutting Edge: IL-10–Mediated Tristetraprolin Induction Is Part of a Feedback Loop That Controls Macrophage STAT3 Activation and Cytokine Production

Gaba, A., Grivennikov, S. I., Vu, M., Stumpo, D. J., Blackshear, P. J., & Karin, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201126 · Cited by 67

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28

Jiang, Y., Liu, Y., Li, J., Sun, S., Jin, W., Wang, X., & Dong, C. (2018) · Nature Communications · doi:10.1038/s41467-018-03852-2 · Cited by 71

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27

Brender, C., Tannahill, G. M., Jenkins, B. J., Fletcher, J. G., Columbus, R., Saris, C. J. M., Ernst, M., Nicola, N. A., Hilton, D. J., Alexander, W. S., et al. (2007) · Blood · doi:10.1182/blood-2006-08-041541 · Cited by 65

STAT proteins: Signal tranducers and activators of transcription

Bromberg, J., & Chen, X. (2001) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(01)33052-5 · Cited by 66

IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization

Pennock, N. D., Gapin, L., & Kedl, R. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1407393111 · Cited by 64

NF-κB and STAT3 signaling hubs for lung innate immunity

Quinton, L. J., & Mizgerd, J. P. (2011) · Cell and Tissue Research · doi:10.1007/s00441-010-1044-y · Cited by 65

Natural Occurring IL-17 Producing T Cells Regulate the Initial Phase of Neutrophil Mediated Airway Responses

Tanaka, S., Yoshimoto, T., Naka, T., Nakae, S., Iwakura, Y.-I., Cua, D., & Kubo, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803828 · Cited by 67

Roles of Stat3 and ERK in G‐CSF Signaling

Kamezaki, K., Shimoda, K., Numata, A., Haro, T., Kakumitsu, H., Yoshie, M., Yamamoto, M., Takeda, K., Matsuda, T., Akira, S., et al. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0173a · Cited by 66

Bone Morphogenetic Protein (BMP)-2 Induces Apoptosis in Human Myeloma Cells

Kawamura, C., Kizaki, M., & Ikeda, Y. (2002) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190290012182 · Cited by 65

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis

Hox, V., O'Connell, M. P., Lyons, J. J., Sackstein, P., Dimaggio, T., Jones, N., Nelson, C., Boehm, M., Holland, S. M., Freeman, A. F., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.11.024 · Cited by 64

The Ubiquitin Ligase TRAF6 Negatively Regulates the JAK-STAT Signaling Pathway by Binding to STAT3 and Mediating Its Ubiquitination

Wei, J., Yuan, Y., Jin, C., Chen, H., Leng, L., He, F., & Wang, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049567 · Cited by 65

B Cell–Intrinsic MyD88 Signaling Promotes Initial Cell Proliferation and Differentiation To Enhance the Germinal Center Response to a Virus-like Particle

Tian, M., Hua, Z., Hong, S., Zhang, Z., Liu, C., Lin, L., Chen, J., Zhang, W., Zhou, X., Zhang, F., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1701067 · Cited by 63

Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration

Zhou, Y., Medik, Y. B., Patel, B., Zamler, D. B., Chen, S., Chapman, T., Schneider, S. M., Park, E. M., Babcock, R. L., Chrisikos, T. T., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20221333 · Cited by 63

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

Matthews, J. R., Sansom, O. J., & Clarke, A. R. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.77 · Cited by 63

Differential Binding to and Regulation of JAK2 by the SH2 Domain and N-Terminal Region of SH2-Bβ

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Deletion of Intestinal Epithelial Cell STAT3 Promotes T-Lymphocyte STAT3 Activation and Chronic Colitis Following Acute Dextran Sodium Sulfate Injury in Mice

Willson, T. A., Jurickova, I., Collins, M. H., & Denson, L. A. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31828028ad · Cited by 62

STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility

Cenit, M., Alcina, A., Márquez, A., Mendoza, J., Díaz-Rubio, M., Heras, V. D. L., Izquierdo, G., Arroyo, R., Fernández, Ó., de la Concha, E. G., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.10 · Cited by 69

Involvement of JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) in the Thyrotropin Signaling Pathway

Park, E. S., Kim, H., Suh, J. M., Park, S. J., You, S. H., Chung, H. K., Lee, K. W., Kwon, O., Cho, B. Y., Kim, Y. K., et al. (2000) · Molecular Endocrinology · doi:10.1210/me.14.5.662 · Cited by 61

Kruppel-Like Transcription Factor 13 Regulates T Lymphocyte Survival In Vivo

Zhou, M., McPherson, L. A., Feng, D., Song, A., Dong, C., Lyu, S., Zhou, L., Shi, X., Ahn, Y.-T., Wang, D., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.9.5496 · Cited by 60

Cytokine Receptor Signaling

Javed, M. J., Richmond, T. D., & Barber, D. L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00063-2 · Cited by 59

Signaling mechanisms of cytokine receptors and their perturbances in disease

Touw, I. P., de Koning, J. P., Ward, A. C., & Hermans, M. H. A. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00206-3 · Cited by 60

Defective IL-2-mediated IL-2 receptor alpha chain expression in Stat3- deficient T lymphocytes

Akaishi, H. (1998) · International Immunology · doi:10.1093/intimm/10.11.1747 · Cited by 91

Tissue-Specific Autoregulation of the stat3 Gene and Its Role in Interleukin-6-Induced Survival Signals in T Cells

Narimatsu, M., Maeda, H., Itoh, S., Atsumi, T., Ohtani, T., Nishida, K., Itoh, M., Kamimura, D., Park, S., Mizuno, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6615-6625.2001 · Cited by 145

Both Stat3-Activation and Stat3-Independent BCL2 Downregulation Are Important for Interleukin-6–Induced Apoptosis of 1A9-M Cells

Oritani, K., Tomiyama, Y., Kincade, P. W., Aoyama, K., Yokota, T., Matsumura, I., Kanakura, Y., Nakajima, K., Hirano, T., & Matsuzawa, Y. (1999) · Blood · doi:10.1182/blood.v93.4.1346 · Cited by 46

IL-6, but not IFN-γ, triggers apoptosis and inhibits in vivo growth of human malignant T cells on STAT3 silencing

Regis, G., Icardi, L., Conti, L., Chiarle, R., Piva, R., Giovarelli, M., Poli, V, & Novelli, F. (2009) · Leukemia · doi:10.1038/leu.2009.139 · Cited by 47

Interleukin-6–dependent gene expression profiles in multiple myeloma INA-6 cells reveal a Bcl-2 family–independent survival pathway closely associated with Stat3 activation

Brocke-Heidrich, K., Kretzschmar, A. K., Pfeifer, G., Henze, C., Löffler, D., Koczan, D., Thiesen, H., Burger, R., Gramatzki, M., & Horn, F. (2003) · Blood · doi:10.1182/blood-2003-04-1048 · Cited by 151