The DOI matches its Crossref record.
Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
Abstract
1,25-Dihydroxyvitamin D3 (1,25(OH)2D3) can modulate immune responses, but whether it directly affects B cell function is unknown. Patients with systemic lupus erythematosus, especially those with antinuclear Abs and increased disease activity, had decreased 1,25(OH)2D3 levels, suggesting that vitamin D might play a role in regulating autoantibody production. To address this, we examined the effects of 1,25(OH)2D3 on B cell responses and found that it inhibited the ongoing proliferation of activated B cells and induced their apoptosis, whereas initial cell division was unimpeded. The generation of plasma cells and postswitch memory B cells was significantly inhibited by 1,25(OH)2D3, although the up-regulation of genetic programs involved in B cell differentiation was only modestly affected. B cells expressed mRNAs for proteins involved in vitamin D activity, including 1α-hydroxylase, 24-hydroxylase, and the vitamin D receptor, each of which was regulated by 1,25(OH)2D3 and/or activation. Importantly, 1,25(OH)2D3 up-regulated the expression of p27, but not of p18 and p21, which may be important in regulating the proliferation of activated B cells and their subsequent differentiation. These results indicate that 1,25(OH)2D3 may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B cell-mediated autoimmune disorders.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Bouillon, R., Carmeliet, G., Verlinden, L., van Etten, E., Verstuyf, A., Luderer, H. F., Lieben, L., Mathieu, C., & Demay, M. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0004 · Cited by 1,783
Vitamin effects on the immune system: Vitamins A and D take centre stage
Mora, J. R., Iwata, M., & von Andrian, U. H. (2008) · Nature Reviews Immunology · doi:10.1038/nri2378 · Cited by 1,559
Vitamin D and the immune system
Aranow, C. (2011) · Journal of Investigative Medicine · doi:10.2310/jim.0b013e31821b8755 · Cited by 1,436
Sunlight and Vitamin D: A global perspective for health
Wacker, M., & Holick, M. F. (2013) · Dermato-Endocrinology · doi:10.4161/derm.24494 · Cited by 1,156
The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) (2009) · Nature Genetics · doi:10.1038/ng.396 · Cited by 550
Vitamin D3: a helpful immuno-modulator: Vitamin D3 as immuno-modulator
Di Rosa, M., Malaguarnera, M., Nicoletti, F., & Malaguarnera, L. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03482.x · Cited by 447
Role of B cells as antigen presenting cells
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352
The Role of the Immune System in Metabolic Health and Disease
Zmora, N., Bashiardes, S., Levy, M., & Elinav, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.006 · Cited by 323
1,25‐dihydroxyvitamin D 3 promotes IL‐10 production in human B cells
Heine, G., Niesner, U., Chang, H., Steinmeyer, A., Zügel, U., Zuberbier, T., Radbruch, A., & Worm, M. (2008) · European Journal of Immunology · doi:10.1002/eji.200838216 · Cited by 311
Vitamin D and the intracrinology of innate immunity
Hewison, M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.02.013 · Cited by 230
Ritterhouse, L. L., Crowe, S. R., Niewold, T. B., Kamen, D. L., Macwana, S. R., Roberts, V. C., Dedeke, A. B., Harley, J. B., Scofield, R. H., Guthridge, J. M., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.148494 · Cited by 229
MC 1R, Eumelanin and Pheomelanin: Their Role in Determining the Susceptibility to Skin Cancer
Nasti, T. H., & Timares, L. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12335 · Cited by 217
Ota, K., Dambaeva, S., Han, A.-R., Beaman, K., Gilman-Sachs, A., & Kwak-Kim, J. (2014) · Human Reproduction · doi:10.1093/humrep/det424 · Cited by 212
Vilarrasa, N., Vendrell, J., Maravall, J., Elío, I., Solano, E., San José, P., García, I., Virgili, N., Soler, J., & Gómez, J. M. (2010) · Endocrine · doi:10.1007/s12020-010-9379-4 · Cited by 110
Hamilton, S. A., McNeil, R., Hollis, B. W., Davis, D. J., Winkler, J., Cook, C., Warner, G., Bivens, B., McShane, P., & Wagner, C. L. (2010) · International Journal of Endocrinology · doi:10.1155/2010/917428 · Cited by 105
Immunomodulators in SLE: Clinical evidence and immunologic actions
Durcan, L., & Petri, M. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.06.010 · Cited by 92
Dietary Vitamin D3 Supplements Reduce Demyelination in the Cuprizone Model
Wergeland, S., Torkildsen, Ø., Myhr, K.-M., Aksnes, L., Mørk, S. J., & Bø, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026262 · Cited by 88
Vitamin D Endocrine System and the Immune Response in Rheumatic Diseases
Cutolo, M., Plebani, M., Shoenfeld, Y., Adorini, L., & Tincani, A. (2011) · Vitamins & Hormones · doi:10.1016/b978-0-12-386960-9.00014-9 · Cited by 86
Vitamin D and the athlete: emerging insights
Owens, D. J., Fraser, W. D., & Close, G. L. (2015) · European Journal of Sport Science · doi:10.1080/17461391.2014.944223 · Cited by 81
Bhargava, P., Cassard, S., Steele, S. U., Azevedo, C., Pelletier, D., Sugar, E. A., Waubant, E., & Mowry, E. M. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.10.004 · Cited by 69
Vitamins C., D and zinc: Synergistic roles in immune function and infections
Maggini, S., Maldonado, P., Cardim, P., Newball, C. F., & Sota Latino, E. R. (2017) · Vitamins & Minerals · doi:10.4172/2376-1318.1000167 · Cited by 51
Metadata
- Authors
- Chen, S., Sims, G. P., Chen, X. X., Gu, Y. Y., Chen, S., & Lipsky, P. E.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-08-01
- Volume
- 179
- Issue
- 3
- Pages
- 1634-1647
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2135604027
- Cited by
- 1,119
- References
- 0
- FWCI
- 20.30
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
