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Alpha‐ketoglutarate: physiological functions and applications
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“Alpha‐Ketoglutarate is also implicated in resisting muscle loss by improving hypertrophy via preventing protien degradation in muscles. 18”
From Three Tiers to biological escape velocity: The quest to outwit aging (2022) · cites this paper as [18]
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Cites
AMPK: a nutrient and energy sensor that maintains energy homeostasis
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“…inhibition of TOR activity can delay the aging process, as evidenced by increased life span in yeast (Kaeberlein et al., 2007), worms (Vellai et al., 2003; Hansen et al., 2007), flies (Kapahi et al., 2004; Luong et al., 2006), and mice (Selman et al., 2009) with mutations in TOR pathway components.”
BackgroundInfluence of TOR kinase on lifespan in C. elegans
Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity
Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969
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Gianotti, L., Alexander, J. W., Gennari, R., Pyles, T., & Babcock, G. F. (1995) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719501900169 · Cited by 194
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“…1 in the adrenal gland (OXGR 1 AG ) is required for the stimulatory effects of AKG on adipose tissue thermogenesis and lipolysis As an endogenous intermediate metabolite in the TCA cycle, AKG is traditionally known as an energy donor or a precursor in amino acid biosynthesis (Wu et al , 2016).”
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Metadata
- Authors
- Wu, N., Yang, M., Gaur, U., Xu, H., Yao, Y., & Li, D.
- Affiliations
- Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, P.R. China
- Venue
- Biomolecules & Therapeutics
- Published
- 2016-01-01
- Volume
- 24
- Issue
- 1
- Pages
- 1-8
- ISSN
- 2005-4483
- 1976-9148
- PMC
- PMC4703346
- Cited by
- 316
- References
- 6
- Language
- en
- Funders
- Sichuan University of Science and Engineering(SUSE) (2920400)
- National Natural Science Foundation of China(NSFC) (31402063)
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