Aging and the human gut microbiota—from correlation to causality

Structure, function and diversity of the healthy human microbiome

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Enterotypes of the human gut microbiome

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Changes of Intestinal Functions in Liver Cirrhosis

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Linking long-term dietary patterns with gut microbial enterotypes

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Gut microbiota in health and disease

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Gut microbiota composition correlates with diet and health in the elderly

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The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age

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Composition, variability, and temporal stability of the intestinal microbiota of the elderly

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Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

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The Application of Ecological Theory Toward an Understanding of the Human Microbiome

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Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

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Bacteria–host communication: the language of hormones

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Characterization of Bacterial Communities in Feces from Healthy Elderly Volunteers and Hospitalized Elderly Patients by Using Real-Time PCR and Effects of Antibiotic Treatment on the Fecal Microbiota

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Intestinal Integrity and <i>Akkermansia muciniphila</i> , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

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A Core Human Microbiome as Viewed through 16S rRNA Sequence Clusters

Huse, S. M., Ye, Y., Zhou, Y., & Fodor, A. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034242 · Cited by 572 · see citing works

The function of our microbiota: who is out there and what do they do?

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Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults

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Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection

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Intestinal bacteria and ageing

Woodmansey, E. J. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03400.x · Cited by 446 · see citing works

Quorum sensing: the many languages of bacteria

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Going viral: next-generation sequencing applied to phage populations in the human gut

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Comparison of Compositions and Metabolic Activities of Fecal Microbiotas in Young Adults and in Antibiotic-Treated and Non-Antibiotic-Treated Elderly Subjects

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Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors

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Functional metagenomic profiling of intestinal microbiome in extreme ageing

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Human intestinal microbiota and healthy ageing

Tiihonen, K., Ouwehand, A. C., & Rautonen, N. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.10.004 · Cited by 346 · see citing works

Fecal Microbiota Composition and Frailty

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Gut microbiota: Changes throughout the lifespan from infancy to elderly

O’Toole, P. W., & Claesson, M. J. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.11.010 · Cited by 279 · see citing works

A Pseudomonas aeruginosa Type VI Secretion Phospholipase D Effector Targets Both Prokaryotic and Eukaryotic Cells

Jiang, F., Waterfield, N. R., Yang, J., Yang, G., & Jin, Q. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.04.010 · Cited by 271 · see citing works

Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism

Collino, S., Montoliu, I., Martin, F.-P. J., Scherer, M., Mari, D., Salvioli, S., Bucci, L., Ostan, R., Monti, D., Biagi, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056564 · Cited by 270 · see citing works

The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition

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Clostridium difficile Carriage in Elderly Subjects and Associated Changes in the Intestinal Microbiota

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How a neutral evolutionary ratchet can build cellular complexity

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Combined PCR-DGGE fingerprinting and quantitative-PCR indicates shifts in fecal population sizes and diversity of Bacteroides, bifidobacteria and Clostridium cluster IV in institutionalized elderly

Zwielehner, J., Liszt, K. I., Handschur, M., Laßl, C., Lapin, A., & Haslberger, A. G. (2009) · Experimental Gerontology · doi:10.1016/j.exger.2009.04.002 · Cited by 196 · see citing works

Fecal transplant: A safe and sustainable clinical therapy for restoring intestinal microbial balance in human disease?

Vrieze, A., de Groot, P. F., Kootte, R. S., Knaapen, M., van Nood, E., & Nieuwdorp, M. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.003 · Cited by 99 · see citing works

Phage-Mediated Selection on Microbiota of a Long-Lived Host

Koskella, B. (2013) · Current Biology · doi:10.1016/j.cub.2013.05.038 · Cited by 98 · see citing works

Autoinducer-2 Plays a Crucial Role in Gut Colonization and Probiotic Functionality of Bifidobacterium breve UCC2003

Christiaen, S. E. A., Motherway, M. O., Bottacini, F., Lanigan, N., Casey, P. G., Huys, G. R. B., Nelis, H. J. C. F., van Sinderen, D., & Coenye, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098111 · Cited by 88 · see citing works

The effect of ageing with and without non-steroidal anti-inflammatory drugs on gastrointestinal microbiology and immunology

Tiihonen, K., Tynkkynen, S., Ouwehand, A. C., Ahlroos, T., & Rautonen, N. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450888871x · Cited by 86 · see citing works

A Metaproteomic Approach to Study Human-Microbial Ecosystems at the Mucosal Luminal Interface

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Alterations in intestinal microbiota of elderly Irish subjects post-antibiotic therapy

O’Sullivan, Ó., Coakley, M., Lakshminarayanan, B., Conde, S., Claesson, M. J., Cusack, S., Fitzgerald, A. J., O’Toole, P. W., Stanton, C., & Ross, R. P. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks348 · Cited by 76 · see citing works

Towards an Evolutionary Model of Animal-Associated Microbiomes

Yeoman, C. J., Chia, N., Yıldırım, S., Miller, M. E. B., Kent, A. D., Stumpf, R. M., Leigh, S. R., Nelson, K. E., White, B. A., & Wilson, B. A. (2011) · Entropy · doi:10.3390/e13030570 · Cited by 56 · see citing works

Human Intestinal Cells Modulate Conjugational Transfer of Multidrug Resistance Plasmids between Clinical Escherichia coli Isolates

Machado, A. M. D., & Sommer, M. O. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100739 · Cited by 27 · see citing works

The intelligent clock and the Rube Goldberg clock

Sancar, A. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb0108-23 · Cited by 20 · see citing works

Intestinal Microbiota Is Influenced by Gender and Body Mass Index

Haro, C., Rangel-Zúñiga, O. A., Alcalá-Díaz, J. F., Gómez-Delgado, F., Pérez-Martínez, P., Delgado-Lista, J., Quintana-Navarro, G. M., Landa, B. B., Navas-Cortés, J. A., Tena-Sempere, M., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154090 · Cited by 671 · see citing works

Human genetic variation and the gut microbiome in disease

Hall, A. B., Tolonen, A. C., & Xavier, R. J. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.63 · Cited by 517 · see citing works

Gut microbiota: A player in aging and a target for anti-aging intervention

Vaiserman, A. M., Koliada, A. K., & Marotta, F. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.001 · Cited by 465 · see citing works

The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists

Thomas, S., Izard, J., Walsh, E. K., Batich, K. A., Chongsathidkiet, P., Clarke, G. A., Sela, D. A., Muller, A. J., Mullin, J. M., Albert, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2929 · Cited by 369 · see citing works

Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

Liberale, L., Montecucco, F., Tardif, J., Libby, P., & Camici, G. G. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz961 · Cited by 347 · see citing works

Trimethylamine‐<i>N</i>‐oxide promotes brain aging and cognitive impairment in mice

Li, D., Ke, Y., Zhan, R., Liu, C., Zhao, M., Zeng, A., Shi, X., Ji, L., Cheng, S., Pan, B., et al. (2018) · Aging Cell · doi:10.1111/acel.12768 · Cited by 304 · see citing works

Dysfunction of the neurovascular unit in ischemic stroke and neurodegenerative diseases: An aging effect

Cai, W., Zhang, K., Li, P., Zhu, L., Xu, J., Yang, B., Hu, X., Lu, Z., & Chen, J. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.006 · Cited by 288 · see citing works

<i>Lactobacillus</i> and <i>Bifidobacterium</i> Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota

Ni, Y., Yang, X., Zheng, L., Wang, Z., Wu, L., Jiang, J., Yang, T., Ma, L., & Fu, Z. (2019) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201900603 · Cited by 255 · see citing works

Gut microbiota changes in the extreme decades of human life: a focus on centenarians

Santoro, A., Ostan, R., Candela, M., Biagi, E., Brigidi, P., Capri, M., & Franceschi, C. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2674-y · Cited by 250 · see citing works

Characteristics of gut microbiota in people with obesity

Duan, M., Wang, Y., Zhang, Q., Zou, R., Guo, M., & Zheng, H. (2021) · PLoS ONE · doi:10.1371/journal.pone.0255446 · Cited by 233 · see citing works

Supplementation of Diet With Galacto-oligosaccharides Increases Bifidobacteria, but Not Insulin Sensitivity, in Obese Prediabetic Individuals

Canfora, E. E., van der Beek, C. M., Hermes, G. D. A., Goossens, G. H., Jocken, J. W. E., Holst, J. J., van Eijk, H. M. H., Venema, K., Smidt, H., Zoetendal, E. G., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.051 · Cited by 227 · see citing works

Biological aging and the human gut microbiota

Maffei, V. J., Kim, S., Blanchard, E., Luo, M., Jazwinski, S. M., Taylor, C. M., & Welsh, D. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx042 · Cited by 219 · see citing works

On the Importance of the Microbiome and Pathobiome in Coral Health and Disease

Sweet, M. J., & Bulling, M. T. (2017) · Frontiers in Marine Science · doi:10.3389/fmars.2017.00009 · Cited by 216 · see citing works

Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population

Vaiserman, A. M., Romanenko, M., Півень, Л. В., Moseiko, V., Lushchak, O. V., Kryzhanovska, N., Gurianov, V. G., & Koliada, A. K. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01903-7 · Cited by 216 · see citing works

Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia

Picca, A., Fanelli, F., Calvani, R., Mulè, G., Pesce, V., Sisto, A., Pantanelli, C., Bernabei, R., Landi, F., & Marzetti, E. (2018) · Mediators of Inflammation · doi:10.1155/2018/7026198 · Cited by 181 · see citing works

Sex Differences in the Gut Microbiota as Potential Determinants of Gender Predisposition to Disease

Santos-Marcos, J. A., Haro, C., Vega‐Rojas, A., Alcala-Diaz, J. F., Molina‐Abril, H., Leon‐Acuña, A., López-Moreno, J., Landa, B. B., Tena‐Sempere, M., Pérez‐Martínez, P., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800870 · Cited by 164 · see citing works

Consumption of Two Healthy Dietary Patterns Restored Microbiota Dysbiosis in Obese Patients With Metabolic Dysfunction

Haro, C., García‐Carpintero, S., Rangel‐Zúñiga, O. A., Alcalá‐Díaz, J. F., Landa, B. B., Clemente, J. C., Pérez‐Martínez, P., López‐Miranda, J., Pérez‐Jiménez, F., & Camargo, A. (2017) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.201700300 · Cited by 149 · see citing works

Probiotics and gastrointestinal conditions: An overview of evidence from the Cochrane Collaboration

Parker, E. A. D., Roy, T., D’Adamo, C. R., & Wieland, L. S. (2017) · Nutrition · doi:10.1016/j.nut.2017.06.024 · Cited by 148 · see citing works

Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective

Vemuri, R., Gundamaraju, R., Shastri, M. D., Shukla, S. D., Kalpurath, K., Ball, M. A. Z., Tristram, S. G., Shankar, E. M., Ahuja, K., & Eri, R. D. (2018) · BioMed Research International · doi:10.1155/2018/4178607 · Cited by 141 · see citing works

Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

Siddharth, J., Chakrabarti, A., Pannérec, A., Karaz, S., Morin-Rivron, D., Masoodi, M., Feige, J. N., & Parkinson, S. J. (2017) · Aging · doi:10.18632/aging.101262 · Cited by 127 · see citing works

The potential of insects as food sources – a review

de Carvalho, N. M., Madureira, A. R., & Pintado, M. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1703170 · Cited by 126 · see citing works

Gut microbiota and old age: Modulating factors and interventions for healthy longevity

Coman, V., & Vodnar, D. C. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111095 · Cited by 124 · see citing works

Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells

Moorefield, E., Andres, S. F., Blue, R. E., Landeghem, L. V., Mah, A. T., Santoro, M. A., & Ding, S. (2017) · Aging · doi:10.18632/aging.101279 · Cited by 110 · see citing works

The role of the gut microbiota on animal model reproducibility

Turner, P. V. (2018) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12022 · Cited by 111 · see citing works

Fermented Foods and Beverages in Human Diet and Their Influence on Gut Microbiota and Health

de Carvalho, N. M., Costa, E. M., Silva, S., Pimentel, L. L., Fernandes, T. H., & Pintado, M. (2018) · Fermentation · doi:10.3390/fermentation4040090 · Cited by 109 · see citing works

Identification of Cartilage Microbial DNA Signatures and Associations With Knee and Hip Osteoarthritis

Dunn, C. M., Velasco, C., Rivas, A., Andrews, M., Sturdy, C., Jacob, P. B., & Jeffries, M. A. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41210 · Cited by 98 · see citing works

Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers

Hajjo, R., Sabbah, D. A., & Bawab, A. Q. A. (2022) · Diagnostics · doi:10.3390/diagnostics12071742 · Cited by 100 · see citing works

Gut microbiota and allogeneic transplantation

Wang, W., Xu, S., Ren, Z., Jiang, J., & Zheng, S. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0640-8 · Cited by 91 · see citing works

Microbiome Changes during Tuberculosis and Antituberculous Therapy

Hong, B., Maulén, N. P., Adami, A. J., Granados, H., Balcells, M. E., & Cervantes, J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00096-15 · Cited by 88 · see citing works

Changes in the gut microbial communities following addition of walnuts to the diet

Byerley, L. O., Samuelson, D. R., Blanchard, E., Luo, M., Lorenzen, B., Banks, S., Ponder, M. A., Welsh, D. A., & Taylor, C. M. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.07.001 · Cited by 87 · see citing works

A great-ape view of the gut microbiome

Nishida, A. H., & Ochman, H. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0085-z · Cited by 82 · see citing works

MVP: a microbe–phage interaction database

Gao, N., Zhang, C., Zhang, Z., Hu, S., Lercher, M. J., Zhao, X., Peer Bork, B., Liu, Z., & Chen, W.-H. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1124 · Cited by 79 · see citing works

How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives

Ratanapokasatit, Y., Laisuan, W., Rattananukrom, T., Petchlorlian, A., Thaipisuttikul, I., & Sompornrattanaphan, M. (2022) · Life · doi:10.3390/life12070936 · Cited by 84 · see citing works

Gut Microbiota Disorder, Gut Epithelial and Blood–Brain Barrier Dysfunctions in Etiopathogenesis of Dementia: Molecular Mechanisms and Signaling Pathways

Welcome, M. O. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08547-5 · Cited by 76 · see citing works

Primate microbiomes over time: Longitudinal answers to standing questions in microbiome research

Björk, J. R., Dasari, M. R., Grieneisen, L., & Archie, E. A. (2019) · American Journal of Primatology · doi:10.1002/ajp.22970 · Cited by 74 · see citing works

Gut microbiota from high-risk men who have sex with men drive immune activation in gnotobiotic mice and in vitro HIV infection

Li, S. X., Sen, S., Schneider, J. M., Xiong, K.-N., Nusbacher, N. M., Moreno-Huizar, N., Shaffer, M., Armstrong, A. J. S., Severs, E., Kuhn, K. A., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007611 · Cited by 75 · see citing works

Host and microbiota metabolic signals in aging and longevity

Zhou, Y., Hu, G., & Wang, M. C. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00837-z · Cited by 70 · see citing works

Interactions between gut microbiota and skeletal muscle

Gizard, F., Fernandez, A., & Vadder, F. D. (2020) · Nutrition and Metabolic Insights · doi:10.1177/1178638820980490 · Cited by 66 · see citing works

Minimizing confounders and increasing data quality in murine models for studies of the gut microbiome

Miyoshi, J., Leone, V., Nobutani, K., Musch, M. W., Martinez, K., Wang, Y., Miyoshi, S., Bobe, A. M., Eren, A. M., & Chang, E. B. (2018) · PeerJ · doi:10.7717/peerj.5166 · Cited by 65 · see citing works

Genetic Pathways of Aging and Their Relevance in the Dog as a Natural Model of Human Aging

Sándor, S., & Kubinyi, E. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00948 · Cited by 66 · see citing works

Microbiomarkers in inflammatory bowel diseases: caveats come with caviar

Sommer, F., Rühlemann, M. C., Bang, C., Höppner, M. P., Rehman, A., Kaleta, C., Schmitt‐Kopplin, P., Dempfle, A., Weidinger, S., Ellinghaus, E., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313678 · Cited by 62 · see citing works

Letrozole treatment of adult female mice results in a similar reproductive phenotype but distinct changes in metabolism and the gut microbiome compared to pubertal mice

Torres, P. J., Skarra, D. V., Ho, B., Sau, L., Anvar, A. R., Kelley, S. T., & Thackray, V. G. (2019) · BMC Microbiology · doi:10.1186/s12866-019-1425-7 · Cited by 62 · see citing works

Magnesium in joint health and osteoarthritis

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