Pathophysiology of diabetes: An overview

Diagnosis and Classification of Diabetes Mellitus

American Diabetes Association (2011) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 13,988

International Diabetes Federation 2017

Carracher, A. M., Marathe, P. H., & Close, K. L. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12644 · Cited by 13,418

Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., et al. (2019) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2019.107843 · Cited by 10,792

Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer

Reck, M., Rodríguez-Abreu, D., Robinson, A. G., Hui, R., Csőszi, T., Fülöp, A., Gottfried, M., Peled, N., Tafreshi, A., Cuffe, S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1606774 · Cited by 10,089

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442

Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer

Borghaei, H., Paz-Ares, L., Horn, L., Spigel, D. R., Steins, M., Ready, N. E., Chow, L. Q., Vokes, E. E., Felip, E., Holgado, E., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1507643 · Cited by 9,335

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J. J., Cowey, C. L., Lao, C. D., Schadendorf, D., Dummer, R., Smylie, M., Rutkowski, P., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504030 · Cited by 8,157

Cancer immunotherapy using checkpoint blockade

Ribas, A., & Wolchok, J. D. (2018) · Science · doi:10.1126/science.aar4060 · Cited by 6,791

Diagnosis and classification of diabetes mellitus

American Diabetes Association (2014) · Diabetes Care · doi:10.2337/dc14-s081 · Cited by 5,974

Mechanisms linking obesity to insulin resistance and type 2 diabetes

Kahn, S. E., Hull, R. L., & Utzschneider, K. M. (2006) · Nature · doi:10.1038/nature05482 · Cited by 5,448

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

Ferris, R. L., Blumenschein, G., Fayette, J., Guigay, J., Colevas, A. D., Licitra, L., Harrington, K., Kasper, S., Vokes, E. E., Even, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602252 · Cited by 5,101

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M. E., Ferguson, P. J., Whitesell, L., Kelly, T. E., Saulsbury, F. T., Chance, P. F., & Ochs, H. D. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,402

Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma

Bellmunt, J., de Wit, R., Vaughn, D. J., Fradet, Y., Lee, J.-L., Fong, L., Vogelzang, N. J., Climent, M. A., Petrylak, D. P., Choueiri, T. K., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1613683 · Cited by 3,395

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2018

American Diabetes Association (2018) · Diabetes Care · doi:10.2337/dc18-s002 · Cited by 3,159

Gestational Diabetes and the Incidence of Type 2 Diabetes

Kim, C., Newton, K. M., & Knopp, R. H. (2002) · Diabetes Care · doi:10.2337/diacare.25.10.1862 · Cited by 2,276

Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications

Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947

Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes

Wellcome Trust Case Control Consortium, Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I., Abecasis, G. R., Almgren, P., et al. (2008) · Nature Genetics · doi:10.1038/ng.120 · Cited by 1,864

Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)

Yamagata, K., Oda, N., Kaisaki, P. J., Menzel, S., Furuta, H., Vaxillaire, M., Southam, L., Cox, R. D., Lathrop, G. M., Boriraj, V. V., et al. (1996) · Nature · doi:10.1038/384455a0 · Cited by 1,614

Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

Finland, G. O. T. 1. D. I., Todd, J. A., the Wellcome Trust Case Control Consortium, Walker, N. M., Cooper, J. D., Smyth, D. J., Downes, K., Plagnol, V., Bailey, R., Nejentsev, S., et al. (2007) · Nature Genetics · doi:10.1038/ng2068 · Cited by 1,456

Mortality and cardiovascular disease in type 1 and type 2 diabetes

Rawshani, A., Rawshani, A., Franzén, S., Eliasson, B., Svensson, A.-M., Miftaraj, M., McGuire, D. K., Sattar, N., Rosengren, A., & Gudbjörnsdottir, S. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1608664 · Cited by 1,389

Pathogenesis of type 2 diabetes mellitus

DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342

Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

Muoio, D. M., & Newgard, C. B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2327 · Cited by 1,177

The Syndromes of Insulin Resistance and Acanthosis Nigricans: Insulin-Receptor Disorders in Man

Kahn, C. R., Flier, J. S., Bar, R. S., Archer, J. A., Gorden, P., Martin, M. M., & Roth, J. (1976) · New England Journal of Medicine · doi:10.1056/nejm197604012941401 · Cited by 1,106

Acquired and Inherited Lipodystrophies

Garg, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra025261 · Cited by 941

β-Cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes

Ahlgren, U., Jonsson, J., Jonsson, L., Simu, K., & Edlund, H. (1998) · Genes & Development · doi:10.1101/gad.12.12.1763 · Cited by 918

Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1

Staffers, D. A., Ferrer, J., Clarke, W. L., & Habener, J. F. (1997) · Nature Genetics · doi:10.1038/ng1097-138 · Cited by 882

Mutation in hepatocyte nuclear factor–1β gene (TCF2) associated with MODY

Horikawa, Y., Iwasaki, N., Hara, M., Furuta, H., Hinokio, Y., Cockburn, B. N., Lindner, T., Yamagata, K., Ogata, M., Tomonaga, O., et al. (1997) · Nature Genetics · doi:10.1038/ng1297-384 · Cited by 880

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

Delépine, M., Nicolino, M., Barrett, T., Golamaully, M., Mark Lathrop, G., & Julier, C. (2000) · Nature Genetics · doi:10.1038/78085 · Cited by 813

Identification of the gene altered in Berardinelli–Seip congenital lipodystrophy on chromosome 11q13

Magré, J., Delépine, M., Khallouf, E., Gedde-Dahl, T., Van Maldergem, L., Sobel, E., Papp, J., Meier, M., Mégarbané, A., BSCL Working Group, et al. (2001) · Nature Genetics · doi:10.1038/ng585 · Cited by 756

Maturity-onset diabetes of the young (MODY): how many cases are we missing?

Shields, B. M., Hicks, S., Shepherd, M. H., Colclough, K., Hattersley, A. T., & Ellard, S. (2010) · Diabetologia · doi:10.1007/s00125-010-1799-4 · Cited by 725

Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression

Hui, J. M., Sud, A., Farrell, G. C., Bandara, P., Byth, K., Kench, J. G., McCaughan, G. W., & George, J. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.08.032 · Cited by 718

Prevalence of Type 2 Diabetes Mellitus among Persons with Hepatitis C Virus Infection in the United States

Mehta, S. H., Brancati, F. L., Sulkowski, M. S., Strathdee, S. A., Szklo, M., & Thomas, D. L. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-8-200010170-00009 · Cited by 676

Trends in the prevalence of preexisting diabetes and gestational diabetes mellitus among a racially/ethnically diverse population of pregnant women, 1999–2005

Lawrence, J. M., Contreras, R., Chen, W., & Sacks, D. A. (2008) · Diabetes Care · doi:10.2337/dc07-2345 · Cited by 658

A Novel Subtype of Type 1 Diabetes Mellitus Characterized by a Rapid Onset and an Absence of Diabetes-Related Antibodies

Imagawa, A., Hanafusa, T., Miyagawa, J.-I., & Matsuzawa, Y. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002033420501 · Cited by 652

Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

Malecki, M. T., Jhala, U. S., Antonellis, A., Fields, L., Doria, A., Orban, T., Saad, M., Warram, J. H., Montminy, M., & Krolewski, A. S. (1999) · Nature Genetics · doi:10.1038/15500 · Cited by 619

Genetic cause of hyperglycaemia and response to treatment in diabetes

Pearson, E. R., Starkey, B. J., Powell, R. J., Gribble, F. M., Clark, P. M., & Hattersley, A. T. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14571-0 · Cited by 607

Genome–wide association studies provide new insights into type 2 diabetes aetiology

Frayling, T. M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2178 · Cited by 594

Familial Hyperinsulinism Caused by an Activating Glucokinase Mutation

Glaser, B., Kesavan, P., Heyman, M., Davis, E., Cuesta, A., Buchs, A., Stanley, C. A., Thornton, P. S., Permutt, M. A., Matschinsky, F. M., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801223380404 · Cited by 564

Diabetic emergencies - ketoacidosis, hyperglycaemic hyperosmolar state and hypoglycaemia

Umpierrez, G., & Korytkowski, M. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.15 · Cited by 563 · cited 1×

A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA.

Kadowaki, T., Kadowaki, H., Mori, Y., Tobe, K., Sakuta, R., Suzuki, Y., Tanabe, Y., Sakura, H., Awata, T., Goto, Y.-I., et al. (1994) · New England Journal of Medicine · doi:10.1056/nejm199404073301403 · Cited by 551

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

Osbak, K. K., Colclough, K., Saint-Martin, C., Beer, N. L., Bellanné-Chantelot, C., Ellard, S., & Gloyn, A. L. (2009) · Human Mutation · doi:10.1002/humu.21110 · Cited by 485

9. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2018

American Diabetes Association (2018) · Diabetes Care · doi:10.2337/dc18-s009 · Cited by 485

Pathogenesis of Type 2 Diabetes Mellitus

Leahy, J. L. (2005) · Archives of Medical Research · doi:10.1016/j.arcmed.2005.01.003 · Cited by 469

The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up

Aroda, V. R., Christophi, C. A., Edelstein, S. L., Zhang, P., Herman, W. H., Barrett-Connor, E., Delahanty, L. M., Montez, M. G., Ackermann, R. T., Zhuo, X., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3761 · Cited by 467

Thiazide Diuretics, Potassium, and the Development of Diabetes: A Quantitative Review

Zillich, A. J., Garg, J., Basu, S., Bakris, G. L., & Carter, B. L. (2006) · Hypertension · doi:10.1161/01.hyp.0000231552.10054.aa · Cited by 456

Latent Autoimmune Diabetes Mellitus in Adults (LADA): the Role of Antibodies to Glutamic Acid Decarboxylase in Diagnosis and Prediction of Insulin Dependency

Zimmet, P., Tuomi, T., Mackay, I. R., Rowley, M. J., Knowles, W., Cohen, M., & Lang, D. A. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00275.x · Cited by 413

The maturity-onset diabetes of the young (MODY1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism

Stoffel, M., & Duncan, S. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13209 · Cited by 406

Insulin Mutation Screening in 1,044 Patients With Diabetes

Edghill, E. L., Flanagan, S. E., Patch, A.-M., Boustred, C., Parrish, A., Shields, B., Shepherd, M. H., Hussain, K., Kapoor, R. R., Malecki, M., et al. (2008) · Diabetes · doi:10.2337/db07-1405 · Cited by 397

Somatostatinoma Syndrome: Biochemical, Morphologic and Clinical Features

Krejs, G. J., Orci, L., Conlon, J. M., Ravazzola, M., Davis, G. R., Raskin, P., Collins, S. M., McCarthy, D. M., Baetens, D., Rubenstein, A., et al. (1979) · New England Journal of Medicine · doi:10.1056/nejm197908093010601 · Cited by 395

Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction

Ræder, H., Johansson, S., Holm, P. I., Haldorsen, I. S., Mas, E., Sbarra, V., Nermoen, I., Eide, S. Å., Grevle, L., Bjørkhaug, L., et al. (2006) · Nature Genetics · doi:10.1038/ng1708 · Cited by 376

Lipodystrophies

Garg, A. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00414-3 · Cited by 372

Clinical Spectrum Associated with Hepatocyte Nuclear Factor-1β Mutations

Bellanné-Chantelot, C., Chauveau, D., Gautier, J.-F., Dubois-Laforgue, D., Clauin, S., Beaufils, S., Wilhelm, J.-M., Boitard, C., Noël, L.-H., Velho, G., et al. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-140-7-200404060-00009 · Cited by 358

Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

Taylor, S. I. (1992) · Diabetes · doi:10.2337/diab.41.11.1473 · Cited by 344

Mutations in hepatocyte nuclear factor-1β and their related phenotypes

Edghill, E. L., Bingham, C., Ellard, S., & Hattersley, A. T. (2006) · Journal of Medical Genetics · doi:10.1136/jmg.2005.032854 · Cited by 344

Adult-Onset Autoimmune Diabetes in Europe Is Prevalent With a Broad Clinical Phenotype

Hawa, M. I., Kolb, H., Schloot, N., Beyan, H., Paschou, S. A., Buzzetti, R., Mauricio, D., De Leiva, A., Yderstraede, K., Beck-Neilsen, H., et al. (2013) · Diabetes Care · doi:10.2337/dc12-0931 · Cited by 339

ASSOCIATION OF CYTOMEGALOVIRUS INFECTION WITH AUTOIMMUNE TYPE 1 DIABETES

Pak, C., Mcarthur, R., Eun, H.-M., & Yoon, J.-W. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92941-8 · Cited by 321

ISPAD Clinical Practice Consensus Guidelines 2018: The diagnosis and management of monogenic diabetes in children and adolescents

Hattersley, A. T., Greeley, S. A. W., Polak, M., Rubio-Cabezas, O., Njølstad, P. R., Mlynarski, W., Castano, L., Carlsson, A., Raile, K., Chi, D. V., et al. (2018) · Pediatric Diabetes · doi:10.1111/pedi.12772 · Cited by 319

10. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes—2018

American Diabetes Association (2018) · Diabetes Care · doi:10.2337/dc18-s010 · Cited by 302

Variant Hepatocyte Nuclear Factor 1 is required for visceral endoderm specification

Barbacci, E., Reber, M., Ott, M.-O., Breillat, C., Huetz, F., & Cereghini, S. (1999) · Development · doi:10.1242/dev.126.21.4795 · Cited by 293

Mutations in the Hepatocyte Nuclear Factor-1β Gene Are Associated with Familial Hypoplastic Glomerulocystic Kidney Disease

Bingham, C., Bulman, M. P., Ellard, S., Allen, L. I. S., Lipkin, G. W., Hoff, W. G. V., Woolf, A. S., Rizzoni, G., Novelli, G., Nicholls, A. J., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/316945 · Cited by 287

Glucokinase as pancreatic beta cell glucose sensor and diabetes gene.

Matschinsky, F., Liang, Y., Kesavan, P., Wang, L., Froguel, P., Velho, G., Cohen, D., Permutt, M. A., Tanizawa, Y., & Jetton, T. L. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116809 · Cited by 287

GAD antibody negative NIDDM in adult Black subjects with diabetic ketoacidosis and increased frequency of human leukocyte antigen DR3 and DR4. Flatbush diabetes

Banerji, M. A., Chaiken, R. L., Huey, H., Tuomi, T., Norin, A. J., Mackay, I. R., Rowley, M. J., Zimmet, P. Z., & Lebovitz, H. E. (1994) · Diabetes · doi:10.2337/diab.43.6.741 · Cited by 266

Autoimmune mechanisms in type 1 diabetes

Knip, M., & Siljander, H. (2008) · Autoimmunity Reviews · doi:10.1016/j.autrev.2008.04.008 · Cited by 263

The Insulin-Pancreatic Acinar Axis

Williams, J. A., & Goldfine, I. D. (1985) · Diabetes · doi:10.2337/diab.34.10.980 · Cited by 262

Neonatal Diabetes Mellitus

Aguilar-Bryan, L., & Bryan, J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0029 · Cited by 250

Autoantibodies in type 1 diabetes

Taplin, C. E., & Barker, J. M. (2008) · Autoimmunity · doi:10.1080/08916930701619169 · Cited by 250

SGLT2 inhibitors and diabetic ketoacidosis: data from the FDA Adverse Event Reporting System

Fadini, G. P., Bonora, B. M., & Avogaro, A. (2017) · Diabetologia · doi:10.1007/s00125-017-4301-8 · Cited by 242

A genetic diagnosis of HNF1A diabetes alters treatment and improves glycaemic control in the majority of insulin‐treated patients

Shepherd, M., Shields, B., Ellard, S., Rubio‐Cabezas, O., & Hattersley, A. T. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02690.x · Cited by 241

The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion

Gupta, R. K., Vatamaniuk, M. Z., Lee, C. S., Flaschen, R. C., Fulmer, J. T., Matschinsky, F. M., Duncan, S. A., & Kaestner, K. H. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200522365 · Cited by 240

Disparities in the risk of gestational diabetes by race-ethnicity and country of birth: Gestational diabetes and race/ethnicity

Hedderson, M. M., Darbinian, J. A., & Ferrara, A. (2010) · Paediatric and Perinatal Epidemiology · doi:10.1111/j.1365-3016.2010.01140.x · Cited by 240

Long-Term Course of Neonatal Diabetes

von Mühlendah, K. E., & Herkenhoff, H. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509143331105 · Cited by 237

Type 1 diabetes associated autoimmunity

Kahaly, G. J., & Hansen, M. P. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.02.017 · Cited by 227

Mutations in the Genes Encoding the Transcription Factors Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha in Maturity-Onset Diabetes of the Young and Hyperinsulinemic Hypoglycemia

Colclough, K., Bellanne-Chantelot, C., Saint-Martin, C., Flanagan, S. E., & Ellard, S. (2013) · Human Mutation · doi:10.1002/humu.22279 · Cited by 224

Mutations in the Insulin Gene Can Cause MODY and Autoantibody-Negative Type 1 Diabetes

Molven, A., Ringdal, M., Nordbø, A. M., Ræder, H., Støy, J., Lipkind, G. M., Steiner, D. F., Philipson, L. H., Bergmann, I., Aarskog, D., et al. (2008) · Diabetes · doi:10.2337/db07-1467 · Cited by 209

Autoimmune Forms of Hypoglycemia

Lupsa, B. C., Chong, A. Y., Cochran, E. K., Soos, M. A., Semple, R. K., & Gorden, P. (2009) · Medicine · doi:10.1097/md.0b013e3181a5b42e · Cited by 202

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus

Kim, S. K., Selleri, L., Lee, J. S., Zhang, A. Y., Gu, X., Jacobs, Y., & Cleary, M. L. (2002) · Nature Genetics · doi:10.1038/ng860 · Cited by 202

Neonatal diabetes mellitus: a disease linked to multiple mechanisms

Polak, M., & Cavé, H. (2007) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-2-12 · Cited by 197

Additional Autoimmune Disease Found in 33% of Patients at Type 1 Diabetes Onset

Triolo, T. M., Armstrong, T. K., McFann, K., Yu, L., Rewers, M. J., Klingensmith, G. J., Eisenbarth, G. S., & Barker, J. M. (2011) · Diabetes Care · doi:10.2337/dc10-1756 · Cited by 197

Gestational diabetes: risks, management, and treatment options

Kim, C. (2010) · International Journal of Women's Health · doi:10.2147/ijwh.s13333 · Cited by 192

Mutations at the BLK locus linked to maturity onset diabetes of the young and β-cell dysfunction

Borowiec, M., Liew, C. W., Thompson, R., Boonyasrisawat, W., Hu, J., Mlynarski, W. M., El Khattabi, I., Kim, S.-H., Marselli, L., Rich, S. S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906474106 · Cited by 189

The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus

Fujimoto, W. Y. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00337-5 · Cited by 183

Lamin A/C gene: sex-determined expression of mutations in Dunnigan-type familial partial lipodystrophy and absence of coding mutations in congenital and acquired generalized lipoatrophy.

Vigouroux, C., Magré, J., Vantyghem, M. C., Bourut, C., Lascols, O., Shackleton, S., Lloyd, D. J., Guerci, B., Padova, G., Valensi, P., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1958 · Cited by 180

Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1β1

Bingham, C., Ellard, S., Allen, L., Bulman, M., Shepherd, M., Frayling, T., Berry, P. J., Clark, P. M., Lindner, T., Bell, G. I., et al. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.057003898.x · Cited by 179

Heterozygous ABCC8 mutations are a cause of MODY

Bowman, P., Flanagan, S. E., Edghill, E. L., Damhuis, A., Shepherd, M. H., Paisey, R., Hattersley, A. T., & Ellard, S. (2012) · Diabetologia · doi:10.1007/s00125-011-2319-x · Cited by 177

Gestational diabetes mellitus: Challenges for different ethnic groups

Yuen, L. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i8.1024 · Cited by 176

Agenesis of Human Pancreas due to Decreased Half-Life of Insulin Promoter Factor 1

Schwitzgebel, V. M., Mamin, A., Brun, T., Ritz-Laser, B., Zaiko, M., Maret, A., Jornayvaz, F. R., Theintz, G. E., Michielin, O., Melloul, D., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030046 · Cited by 175

Hepatocyte nuclear factor‐1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF‐1β in human pancreatic development

Edghill, E. L., Bingham, C., Slingerland, A. S., Minton, J. A. L., Noordam, C., Ellard, S., & Hattersley, A. T. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01999.x · Cited by 174

Autoimmune diseases in children and adults with type 1 diabetes from the T1D exchange clinic registry

Hughes, J. W., Riddlesworth, T. D., DiMeglio, L. A., Miller, K. M., Rickels, M. R., McGill, J. B., & for the T1D Exchange Clinic Network (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2478 · Cited by 173

Drug-Induced Hyperglycemia

Luna, B. (2001) · JAMA · doi:10.1001/jama.286.16.1945 · Cited by 173

Monogenic Diabetes in the Young, Pharmacogenetics and Relevance to Multifactorial Forms of Type 2 Diabetes

Vaxillaire, M., & Froguel, P. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0024 · Cited by 167

Accuracy and predictive value of classification schemes for ketosis-prone diabetes

Balasubramanyam, A., Garza, G., Rodriguez, L., Hampe, C. S., Gaur, L., Lernmark, A., & Maldonado, M. R. (2006) · Diabetes Care · doi:10.2337/dc06-0749 · Cited by 166

Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1β gene mutation

Bingham, C., Ellard, S., van't Hoff, W. G., Simmonds, H. A., Marinaki, A. M., Badman, M. K., Winocour, P. H., Stride, A., Lockwood, C. R., Nicholls, A. J., et al. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00903.x · Cited by 161

Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities

Rubio-Cabezas, O., Minton, J. A. L., Kantor, I., Williams, D., Ellard, S., & Hattersley, A. T. (2010) · Diabetes · doi:10.2337/db10-0011 · Cited by 160

Zinc Transporter 8 Antibodies Complement GAD and IA-2 Antibodies in the Identification and Characterization of Adult-Onset Autoimmune Diabetes

Lampasona, V., Petrone, A., Tiberti, C., Capizzi, M., Spoletini, M., di Pietro, S., Songini, M., Bonicchio, S., Giorgino, F., Bonifacio, E., et al. (2010) · Diabetes Care · doi:10.2337/dc08-2305 · Cited by 159

Wolcott-Rallison Syndrome Is the Most Common Genetic Cause of Permanent Neonatal Diabetes in Consanguineous Families

Rubio‐Cabezas, O., Patch, A., Minton, J. A. L., Flanagan, S. E., Edghill, E. L., Hussain, K., Balafrej, A., Deeb, A., Buchanan, C. R., Jefferson, I. G., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1137 · Cited by 154

Clinical features and treatment of maturity onset diabetes of the young (MODY)

Gardner, D. S.-L., & Tai, E. S. (2012) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s23353 · Cited by 152

Loss-of-Function Mutations in APPL1 in Familial Diabetes Mellitus

Prudente, S., Jungtrakoon, P., Marucci, A., Ludovico, O., Buranasupkajorn, P., Mazza, T., Hastings, T., Milano, T., Morini, E., Mercuri, L., et al. (2015) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2015.05.011 · Cited by 148

Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities

Resmini, E., Minuto, F., Colao, A., & Ferone, D. (2009) · Acta Diabetologica · doi:10.1007/s00592-009-0112-9 · Cited by 147

Minimal incidence of neonatal/infancy onset diabetes in Italy is 1:90,000 live births

The Early Diabetes Study Group of ISPED, Iafusco, D., Massa, O., Pasquino, B., Colombo, C., Iughetti, L., Bizzarri, C., Mammì, C., Presti, D. L., Suprani, T., et al. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0331-8 · Cited by 145

Insulin Autoimmune Syndrome (Hirata Disease): Clinical Features and Epidemiology in Japan

Uchigata, Y., Eguchi, Y., Takayama-Hasumi, S., & Omori, Y. (1994) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(94)90040-x · Cited by 127

HLA complex genes in type 1 diabetes and other autoimmune diseases. Which genes are involved?

Undlien, D. E., Lie, B. A., & Thorsby, E. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(00)02180-6 · Cited by 122

Autoimmune stiff person syndrome and related myelopathies: Understanding of electrophysiological and immunological processes

Rakočević, G., & Floeter, M. K. (2011) · Muscle & Nerve · doi:10.1002/mus.23234 · Cited by 120

The C42R Mutation in the Kir6.2 (KCNJ11) Gene as a Cause of Transient Neonatal Diabetes, Childhood Diabetes, or Later-Onset, Apparently Type 2 Diabetes Mellitus

Yorifuji, T., Nagashima, K., Kurokawa, K., Kawai, M., Oishi, M., Akazawa, Y., Hosokawa, M., Yamada, Y., Inagaki, N., & Nakahata, T. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0096 · Cited by 118

Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression.

Stoffers, D., Thomas, M. K., & Habener, J. (1997) · Trends in endocrinology and metabolism · doi:10.1016/s1043-2760(97)00008-8 · Cited by 117

Diabetes-Haufigkeit bei Akromegalie und Cushing-Syndrom

Biering, H., Knappe, G., Gerl, H., & Lochs, H. (2000) · Acta Medica Austriaca · doi:10.1046/j.1563-2571.2000.00106.x · Cited by 113

Molecular Scanning of the Insulin Receptor Gene in Syndromes of Insulin Resistance

Krook, A., Kumar, S., Laing, I., Boulton, A. J. M., Wass, J. A. H., & O’Rahilly, S. (1994) · Diabetes · doi:10.2337/diab.43.3.357 · Cited by 112

Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?

Kim, S. (2015) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2015.39.6.468 · Cited by 112

Molecular Genetics of Maturity-onset Diabetes of the Young

Froguel, P., & Velho, G. (1999) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00134-9 · Cited by 110

Latent Autoimmune Diabetes in Adults (LADA)

Naik, R. G., & Palmer, J. P. (2003) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1025148211587 · Cited by 100

Severe Antibody-Mediated Human Insulin Resistance: Successful Treatment With the Insulin Analog Lispro: A case report

Lahtela, J. T., Knip, M., Paul, R., Antonen, J. A., & Salmi, J. (1997) · Diabetes Care · doi:10.2337/diacare.20.1.71 · Cited by 95

Syndromes of Autoimmunity and Hypoglycemia: Autoantibodies Directed Against insulinand Its Receptor

Taylor, S. I., Barbetti, F., Accili, D., Roth, J., & Görden, P. (1989) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30392-x · Cited by 94

Familial Hyperproinsulinemia Due to a Proposed Defect in Conversion of Proinsulin to Insulin

Gruppuso, P. A., Görden, P., Kahn, C. R., Cornblath, M., Zeller, W. P., & Schwartz, R. (1984) · New England Journal of Medicine · doi:10.1056/nejm198409063111003 · Cited by 91

Diabetes in Africans. Part 2: Ketosis-prone atypical diabetes mellitus.

Sobngwi, E., Mauvais‐Jarvis, F., Vexiau, P., Mbanya, J. C., & Gautier, J. F. (2002) · PubMed · Cited by 90

Permanent Neonatal Diabetes due to Paternal Germline Mosaicism for an Activating Mutation of the KCNJ11 Gene Encoding the Kir6.2 Subunit of the β-Cell Potassium Adenosine Triphosphate Channel

Gloyn, A. L., Cummings, E. A., Edghill, E. L., Harries, L. W., Scott, R. R., Costa, T., Temple, I. K., Hattersley, A. T., & Ellard, S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0568 · Cited by 90

Metabolic and immunologic features of Chinese patients with atypical diabetes mellitus.

Tan, K. C. B., Mackay, I. R., Zimmet, P. Z., Hawkins, B. R., & Lam, K. S. L. (2000) · Diabetes Care · doi:10.2337/diacare.23.3.335 · Cited by 85

Maturity onset diabetes of the young: clinical characteristics, diagnosis and management.

Kavvoura, F. K., & Owen, K. R. (2012) · Pediatric endocrinology review · Cited by 73

Diabetes: equity and social determinants.

Whiting, D. R., Unwin, N. C., Roglić, G., Blas, E., & Kurup, A. S. (2010) · Cited by 69

Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity

Biason‐Lauber, A., Boehm, B. O., Lang‐Muritano, M., Gauthier, B. R., Brun, T., Wollheim, C. B., & Schoenle, E. J. (2005) · Diabetologia · doi:10.1007/s00125-005-1723-5 · Cited by 69

Abnormal glucose tolerance post-gestational diabetes mellitus as defined by the International Association of Diabetes and Pregnancy Study Groups criteria

Noctor, E., Crowe, C., Carmody, L. A., Saunders, J. A., Kirwan, B., O’Dea, A., Gillespie, P., Glynn, L. G., McGuire, B. E., O’Neill, C., et al. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-1260 · Cited by 65

Diabetes Mellitus in Pancreatic Cancer and the Need for Diagnosis of Asymptomatic Disease

Bartosch-Härlid, A., & Andersson, R. (2010) · Pancreatology · doi:10.1159/000264676 · Cited by 63

Wolcott-Rallison syndrome due to the same mutation (W522X) in EIF2AK3 in two unrelated families and review of the literature*

Özbek, M. N., Senée, V., Aydemir, S., Kotan, L. D., Mungan, N. Ö., Yüksel, B., Julier, C., & Topaloglu, A. K. (2010) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2009.00591.x · Cited by 50

Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation inNEUROD1

Gonsorčíková, L., Průhová, Š., Cinek, O., Ek, J., Pelikánová, T., Jørgensen, T., Eiberg, H., Pedersen, O. B., Hansen, T. F., & Lebl, J. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2008.00379.x · Cited by 47

Krüppel-like Factor 11 Regulates the Expression of Metabolic Genes via an Evolutionarily Conserved Protein Interaction Domain Functionally Disrupted in Maturity Onset Diabetes of the Young

Lomberk, G. A., Grzenda, A. L., Mathison, A., Escande, C., Zhang, J., Calvo, E. L., Miller, L. J., Iovanna, J., Chini, E. N., Fernández-Zapico, M. E., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.434670 · Cited by 46

The crucial role of IL-2/IL-2RA-mediated immune regulation in the pathogenesis of type 1 diabetes, an evidence coming from genetic and animal model studies

Chistiakov, D. A., Voronova, N. V., & Chistiakov, P. A. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.03.002 · Cited by 45

Relationship between serum insulin autoantibodies, islet cell antibodies and Coxsackie-B4 and mumps virus-specific antibodies at the clinical manifestation of Type 1 (insulin-dependent) diabetes

Karjalainen, J., Knip, M., Hy�ty, H., Leinikki, P., Ilonen, J., K��r, M. L., & �kerblom, H. K. (1988) · Diabetologia · doi:10.1007/bf00276847 · Cited by 44

A case of slowly progressive type 1 diabetes with unstable glycemic control caused by unusual insulin antibody and successfully treated with steroid therapy

Matsuyoshi, A., Shimoda, S., Tsuruzoe, K., Taketa, K., Chirioka, T., Sakamoto, F., Sakakida, M., Miyamura, N., & Araki, E. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.10.018 · Cited by 41

Impaired Fasting Glucose in Cystic Fibrosis

Frohnert, B. I., Ode, K. L., Moran, A., Nathan, B. M., Laguna, T. A., Holme, B., & Thomas, W. T. B. (2010) · Diabetes Care · doi:10.2337/dc10-0613 · Cited by 41

Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

Bacon, S., Kyithar, M. P., Schmid, J., Rizvi, S. R., Bonner, C., Graf, R., Prehn, J. H. M., & Byrne, M. M. (2012) · BMC Endocrine Disorders · doi:10.1186/1472-6823-12-13 · Cited by 41

Autoimmune Diabetes Associated With Pembrolizumab: A Review of Published Case Reports

Cheema, A., Makadia, B., Karwadia, T., Bajwa, R., & Hossain, M. (2018) · World Journal of Oncology · doi:10.14740/wjon1085w · Cited by 41

7 Diabetes and adrenal disease

Nestler, J. E., & McClanahan, M. A. (1992) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(05)80169-7 · Cited by 40

Functional Characterization of MODY2 Mutations Highlights the Importance of the Fine-Tuning of Glucokinase and Its Role in Glucose Sensing

García-Herrero, C.-M., Rubio‐Cabezas, O., Azriel, S., Gutierrez‐Nogués, Á., Aragonés, Á., Vincent, O., Campos‐Barros, Á., Argente, J., & Navas, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030518 · Cited by 29

Functional evaluation of the type 1 diabetes (T1D) susceptibility candidate genes

Park, Y. (2007) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2007.01.043 · Cited by 26

Diagnostic criteria for gestational diabetes mellitus

Cosson, E. (2010) · Diabetes & Metabolism · doi:10.1016/j.diabet.2010.11.007 · Cited by 26

Diabetes due to exocrine pancreatic disease--a review of patients attending a hospital-based diabetes clinic

Price, S., Cole, D. C., & Alcolado, J. C. (2010) · QJM · doi:10.1093/qjmed/hcq127 · Cited by 17

South Asian version of flatbush diabetes mellitus- A case report and review article

Khan, K., & Akram, J. (2009) · International Journal of Medicine and Medical Sciences · doi:10.5897/ijmms.9000224 · Cited by 5

Wearable Electrochemical Glucose Sensors in Diabetes Management: A Comprehensive Review

Saha, T., Del Caño, R., Mahato, K., De la Paz, E., Chen, C., Ding, S., Yin, L., & Wang, J. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00078 · Cited by 442

Annona muricata: Comprehensive Review on the Ethnomedicinal, Phytochemistry, and Pharmacological Aspects Focusing on Antidiabetic Properties

Zubaidi, S. N., Mohd Nani, H., Ahmad Kamal, M. S., Abdul Qayyum, T., Maarof, S., Afzan, A., Mohmad Misnan, N., Hamezah, H. S., Baharum, S. N., & Mediani, A. (2023) · Life · doi:10.3390/life13020353 · Cited by 72

Physical activity during pregnancy and the risk of gestational diabetes mellitus: a systematic review and dose–response meta-analysis

Xie, W., Zhang, L., Cheng, J., Wang, Y., Kang, H., & Gao, Y. (2024) · BMC Public Health · doi:10.1186/s12889-024-18131-7 · Cited by 41

Pharmacological effects and molecular targets of L-theanine in cardiovascular diseases and comorbidities

García-Niño, W. R., Zúñiga-Muñoz, A. M., & Maldonado-Macías, X. P. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178715 · Cited by 1