The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Inflammation and cancer
Open accessAbstract
There is evidence supporting the hypothesis that inflammation participates in providing conditions that lead to cancer. An unresolved inflammation due to any failure in the precise control of the immune response can continue to perturb the cellular microenvironment, thereby leading to alterations in cancer-related genes and posttranslational modification in crucial cellular proteins involved in the cell cycle, DNA repair and apoptosis. In addition, there are data indicating that inflammatory cells and immunomodulatory mediators present in the tumor microenvironment influence tumor progression and metastasis. Historically, tumor-infiltrating leukocytes have been considered to be manifestations of an intrinsic defence mechanism against developing tumors. However, increasing evidence indicates that leukocyte infiltration can promote tumor phenotypes, such as angiogenesis, growth and invasion. This may be due to inflammatory cells that probably can influence cancer promotion by secreting cytokines, growth factors, chemokines and proteases, which stimulate proliferation and invasiveness of cancer cells. Consequently, events and molecules implicated in this cross talk between the tumor microenvironment and inflammatory process may emerge as attractive targets in anticancer therapeutic interventions with significant clinical impact.
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Cites
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Cited by
Yang, Y., Kim, S. C., Yu, T., Yi, Y.-S., Rhee, M. H., Sung, G.-H., Yoo, B. C., & Cho, J. Y. (2014) · Mediators of Inflammation · doi:10.1155/2014/352371 · Cited by 406
Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents
Tasneem, S., Liu, B., Li, B., Choudhary, M. I., & Wang, W. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.001 · Cited by 358
Korniluk, A., Koper, O., Kemona, H., & Dymicka-Piekarska, V. (2017) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-016-1464-0 · Cited by 282
TNF-α promotes colon cancer cell migration and invasion by upregulating TROP-2
Zhao, P., & Zhang, Z. (2018) · Oncology Letters · doi:10.3892/ol.2018.7735 · Cited by 87
Belmar-Lopez, C., Mendoza, G., Oberg, D., Burnet, J., Simon, C., Cervello, I., Iglesias, M., Ramirez, J. C., Lopez-Larrubia, P., Quintanilla, M., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-139 · Cited by 71
Metadata
- Authors
- Eiró, N.
- Venue
- World Journal of Gastrointestinal Surgery
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2012
- Volume
- 4
- Issue
- 3
- Pages
- 62
- ISSN
- 1948-9366 (ISSN-L)
- OpenAlex
- W2073516340
- Cited by
- 173
- References
- 11
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
