Cited by 560Sleep and Work-Related FatigueWorkplace Health and Well-beingCircadian rhythm and melatonin

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Shift work and cardiovascular disease – pathways from circadian stress to morbidity

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Puttonen, Sampsa, Härmä, Mikko, Hublin, Christer·2010·Scandinavian Journal of Work, Environment & Health

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Abstract

In order to establish a causal relation between shift work and cardiovascular disease (CVD), we need to verify the pathways from the former to the latter. This paper aims to review the current knowledge of the mechanisms between shift work and CVD. Shift work can increase the risk of CVD by several interrelated psychosocial, behavioral, and physiological mechanisms. The psychosocial mechanisms relate to difficulties in controlling working hours, decreased work-life balance, and poor recovery following work. The most probable behavioral changes are weight gain and smoking. The plausible physiological and biological mechanisms are related to the activation of the autonomic nervous system, inflammation, changed lipid and glucose metabolism, and related changes in the risk for atherosclerosis, metabolic syndrome, and type II diabetes. The data provide evidence for possible disease mechanisms between shift work and CVD, but compelling evidence on any specific mechanism is missing.

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Refers to the following texts of the Journal: 2006;32(6):502-514 1999;25(2):85-99 1989;15(3):165-179 2009;35(3):163-179 2009;35(3):157-161 2006;32(6):413-419 2006;32(6):431-442 2001;27(2):97-105 1999;25(4):376-381 1997;23(4):257-265 2009;35(1):48-55 1998;24 suppl 3:141-145 SJWEH Supplements 2008;(5):14-21 2004;30(2):139-148 2004;30(2):149-156 The following articles refer to this text: 2010;36(2):81-84; 2011;37(1):62-69; 2011;37(1):54-61; 2011;37(4):263-275; 2012;38(1):1-3; 2012;38(4):343-348; 2014;40(3):287-294; 2014;40(6):557-568; 2014;40(6):621-630; 2015;41(1):54-64; 2015;41(1):84-93; 2015;41(3):259-267; 2015;41(3):268-279; 2016;42(6):459-468; 2016;42(6):455-457; 2017;43(2):117-126; 2017;43(2):127-135; 2017;43(3):250-259; 2017;43(6):569-577; 2018;44(3):229-238; 2018;44(3):251-257; 2018;44(3):265-273; 2018;44(4):403-413; 2019;45(5):465-474; 2020;46(5):516-524; 2021;47(3):200-207; 2021;47(8):565-581; 2022;48(1):31-40; 2022;48(7):511-519; 2022;48(7):520-529 References
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BackgroundResult
Negative Impacts of Shiftwork and Long Work Hours
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Authors: Puttonen, S., Härmä, M., & Hublin, C.
Affiliations: Finnish Institute of Occupational Health (FI)
ORCID: Puttonen, Sampsa
Härmä, Mikko
Hublin, Christer
Venue: Scandinavian Journal of Work, Environment & Health
Publisher: Scandinavian Journal of Work, Environment and Health
Published: 2010-01-20
Volume: 36
Issue: 2
Pages: 96-108
ISSN: 0355-3140 (ISSN-L)
1795-990X
DOI: 10.5271/sjweh.2894
OpenAlex: W2125679654
Cited by: 560
References: 135
Citations by year: 2026: 20 · 2025: 19 · 2024: 23 · 2023: 28 · 2022: 41 · 2021: 39 · 2020: 41 · 2019: 50 · 2018: 40 · 2017: 35 · 2016: 46 · 2015: 48 · 2014: 37 · 2013: 29 · 2012: 30
FWCI: 3.59
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
Locations: Scandinavian Journal of Work Environment & Health (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Workplace Health and Well-being
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: shift work, cardiovascular disease, work-life balance, weight gain, smoking, autonomic nervous system, inflammation, lipid metabolism, glucose metabolism, atherosclerosis, metabolic syndrome, type 2 diabetes, causal pathways
MeSH terms: Adult, Cardiovascular Diseases, Circadian Rhythm, Europe, Female, Humans, Male, Middle Aged, Work Schedule Tolerance

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Shift work and cardiovascular disease – pathways from circadian stress to morbidity

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