Sleep duration and area-level deprivation in twins
Open accessAbstract
STUDY OBJECTIVES: We used quantitative genetic models to assess whether area-level deprivation as indicated by the Singh Index predicts shorter sleep duration and modifies its underlying genetic and environmental contributions. METHODS: Participants were 4,218 adult twin pairs (2,377 monozygotic and 1,841 dizygotic) from the University of Washington Twin Registry. Participants self-reported habitual sleep duration. The Singh Index was determined by linking geocoding addresses to 17 indicators at the census-tract level using data from Census of Washington State and Census Tract Cartographic Boundary Files from 2000 and 2010. Data were analyzed using univariate and bivariate genetic decomposition and quantitative genetic interaction models that assessed A (additive genetics), C (common environment), and E (unique environment) main effects of the Singh Index on sleep duration and allowed the magnitude of residual ACE variance components in sleep duration to vary with the Index. RESULTS: The sample had a mean age of 38.2 y (standard deviation [SD] = 18), and was predominantly female (62%) and Caucasian (91%). Mean sleep duration was 7.38 h (SD = 1.20) and the mean Singh Index score was 0.00 (SD = 0.89). The heritability of sleep duration was 39% and the Singh Index was 12%. The uncontrolled phenotypic regression of sleep duration on the Singh Index showed a significant negative relationship between area-level deprivation and sleep length (b = -0.080, P < 0.001). Every 1 SD in Singh Index was associated with a ∼4.5 min change in sleep duration. For the quasi-causal bivariate model, there was a significant main effect of E (b(0E) = -0.063; standard error [SE] = 0.30; P < 0.05). Residual variance components unique to sleep duration were significant for both A (b(0Au) = 0.734; SE = 0.020; P < 0.001) and E (b(0Eu) = 0.934; SE = 0.013; P < 0.001). CONCLUSIONS: Area-level deprivation has a quasi-causal association with sleep duration, with greater deprivation being related to shorter sleep. As area-level deprivation increases, unique genetic and nonshared environmental residual variance in sleep duration increases.
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Watson and colleagues combined geospatial neighborhood analyses with sleep genetic information to characterize a social-environmental influence on sleep duration.
“An example of one study that brought these methodologies together is cited by Watson and colleagues,268 who combined geospatial neighborhood analyses with sleep genetic information to characterize a social-environmental influence on sleep duration.”
From Sleep, Health, and Society (2017) · cites this paper as [268]
Cites
Tononi, G., & Cirelli, C. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.025 · Cited by 2,356 · see citing works
Cappuccio, F. P., Cooper, D., D'Elia, L., Strazzullo, P., & Miller, M. A. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr007 · Cited by 2,146 · see citing works
Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults
Cappuccio, F. P., Taggart, F. M., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., & Miller, M. A. (2008) · Sleep · doi:10.1093/sleep/31.5.619 · Cited by 2,076 · see citing works
Self-Reported and Measured Sleep Duration: How Similar Are They?
Lauderdale, D. S., Knutson, K. L., Yan, L. L., Liu, K., & Rathouz, P. J. (2008) · Epidemiology · doi:10.1097/ede.0b013e318187a7b0 · Cited by 1,565 · see citing works
Area Deprivation and Widening Inequalities in US Mortality, 1969–1998
Singh, G. K. (2003) · American Journal of Public Health · doi:10.2105/ajph.93.7.1137 · Cited by 1,431 · see citing works
Neighborhood Disadvantage, Disorder, and Health
Ross, C. E., & Mirowsky, J. (2001) · Journal of Health and Social Behavior · doi:10.2307/3090214 · Cited by 1,396 · see citing works
A Prospective Study of Sleep Duration and Coronary Heart Disease in Women
Ayas, N. T., White, D. P., Manson, J. E., Stampfer, M. J., Speizer, F. E., Malhotra, A., & Hu, F. B. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.2.205 · Cited by 1,155 · see citing works
Sleep duration and mortality: a systematic review and meta-analysis
GALLICCHIO, L., & KALESAN, B. (2009) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2008.00732.x · Cited by 979 · see citing works
Association of usual sleep duration with hypertension: the Sleep Heart Health Study
Gottlieb, D. J., Redline, S., Nieto, F. J., Baldwin, C. M., Newman, A. B., Resnick, H. E., & Punjabi, N. M. (2006) · Sleep · doi:10.1093/sleep/29.8.1009 · Cited by 947 · see citing works
Association of sleep time with diabetes mellitus and impaired glucose tolerance
Gottlieb, D. J., Punjabi, N. M., Newman, A. B., Resnick, H. E., Redline, S., Baldwin, C. M., & Nieto, F. J. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.8.863 · Cited by 927 · see citing works
Variance Components Models for Gene–Environment Interaction in Twin Analysis
Purcell, S. (2002) · Twin Research · doi:10.1375/136905202762342026 · Cited by 924 · see citing works
A prospective study of self-reported sleep duration and incident diabetes in women
Ayas, N. T., White, D. P., Al-Delaimy, W. K., Manson, J. E., Stampfer, M. J., Speizer, F. E., Patel, S., & Hu, F. B. (2003) · Diabetes Care · doi:10.2337/diacare.26.2.380 · Cited by 883 · see citing works
Sleep Deprivation and Activation of Morning Levels of Cellular and Genomic Markers of Inflammation
Irwin, M. R. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.16.1756 · Cited by 850 · see citing works
Comparison between subjective and actigraphic measurement of sleep and sleep rhythms
Lockley, S. W., Skene, D. J., & Arendt, J. (1999) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1999.00155.x · Cited by 622 · see citing works
Grandner, M. A., Hale, L., Moore, M., & Patel, N. P. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.07.006 · Cited by 602 · see citing works
Sleep Duration as a Risk Factor for Diabetes Incidence in a Large US Sample
Gangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., & Malaspina, D. (2007) · Sleep · doi:10.1093/sleep/30.12.1667 · Cited by 573 · see citing works
Racial differences in self-reports of sleep duration in a population-based study
Hale, L., & Do, D. P. (2007) · SLEEP · doi:10.1093/sleep/30.9.1096 · Cited by 523 · see citing works
Neighborhood Disorder, Psychophysiological Distress, and Health
Hill, T. D., Ross, C. E., & Angel, R. J. (2005) · Journal of Health and Social Behavior · doi:10.1177/002214650504600204 · Cited by 510 · see citing works
Positive affect, psychological well-being, and good sleep
Steptoe, A., O’Donnell, K., Marmot, M. G., & Wardle, J. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.11.008 · Cited by 483 · see citing works
Whinnery, J., Jackson, N., Rattanaumpawan, P., & Grandner, M. A. (2014) · SLEEP · doi:10.5665/sleep.3508 · Cited by 423 · see citing works
Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery
Faraut, B., Boudjeltia, K. Z., Vanhamme, L., & Kerkhofs, M. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2011.05.001 · Cited by 418 · see citing works
Siegel, J. M. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.001 · Cited by 404 · see citing works
Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
AlDabal, L. M. J. A., & BaHammam, A. S. (2011) · The Open Respiratory Medicine Journal · doi:10.2174/1874306401105010031 · Cited by 357 · see citing works
Sleep Deprivation in the Rat: An Update of the 1989 Paper
Rechtschaffen, A., & Bergmann, B. M. (2002) · SLEEP · doi:10.1093/sleep/25.1.18 · Cited by 351 · see citing works
Hauri, P., & Wisbey, J. A. (1992) · SLEEP · doi:10.1093/sleep/15.4.293 · Cited by 334 · see citing works
Determining zygosity in the Vietnam Era Twin Registry: an approach using questionnaires
Eisen, S. A., Neuman, R. J., Goldberg, J. H., Rice, J. P., & True, W. (1989) · Clinical Genetics · doi:10.1111/j.1399-0004.1989.tb02967.x · Cited by 273 · see citing works
Associations of executive function with sleepiness and sleep duration in adolescents
Anderson, B., Storfer-Isser, A., Taylor, H. G., Rosen, C. L., & Redline, S. (2009) · Pediatrics · doi:10.1542/peds.2008-1182 · Cited by 233 · see citing works
Hill, T. D., Burdette, A. M., & Hale, L. (2009) · Health & Place · doi:10.1016/j.healthplace.2009.04.001 · Cited by 218 · see citing works
Moore, M., Kirchner, H. L., Drotar, D., Johnson, N., Rosen, C., & Redline, S. (2011) · Sleep Medicine · doi:10.1016/j.sleep.2010.07.020 · Cited by 211 · see citing works
Mendelsohn, A. R., & Larrick, J. W. (2013) · Rejuvenation Research · doi:10.1089/rej.2013.1530 · Cited by 206 · see citing works
Impairment of Attentional Networks after 1 Night of Sleep Deprivation
Tomasi, D. G., Wang, R. L., Telang, F., Boronikolas, V., Jayne, M. C., Wang, G., Fowler, J. S., & Volkow, N. D. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn073 · Cited by 201 · see citing works
The Determination of Twin Zygosity by Means of a Mailed Questionnaire
Torgersen, S. (1979) · Acta geneticae medicae et gemellologiae · doi:10.1017/s0001566000009077 · Cited by 199 · see citing works
Spitz, É., Moutier, R., Reed, T., Busnel, M. C., Marchaland, C., Roubertoux, P. L., & Carlier, M. (1996) · Behavior Genetics · doi:10.1007/bf02361159 · Cited by 175 · see citing works
Age-Related Increase in Awakenings: Impaired Consolidation of NonREM Sleep at All Circadian Phases
Dijk, D., Duffy, J. F., & Czeisler, C. A. (2001) · SLEEP · doi:10.1093/sleep/24.5.565 · Cited by 159 · see citing works
A Note on False Positives and Power in G × E Modelling of Twin Data
van der Sluis, S., Posthuma, D., & Dolan, C. (2011) · Behavior Genetics · doi:10.1007/s10519-011-9480-3 · Cited by 149 · see citing works
Hale, L., Hill, T. D., & Burdette, A. M. (2010) · Preventive Medicine · doi:10.1016/j.ypmed.2010.06.017 · Cited by 140 · see citing works
Frei, P., Mohler, E., & Röösli, M. (2013) · International Journal of Hygiene and Environmental Health · doi:10.1016/j.ijheh.2013.04.003 · Cited by 139 · see citing works
Association of Sleep Duration and Hypertension Among US Adults Varies by Age and Sex
Fang, J., Wheaton, A. G., Keenan, N. L., Greenlund, K. J., Perry, G., & Croft, J. B. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.201 · Cited by 135 · see citing works
Marital conflict and children's sleep: Reciprocal relations and socioeconomic effects.
Kelly, R. J., & El‐Sheikh, M. (2011) · Journal of Family Psychology · doi:10.1037/a0023789 · Cited by 131 · see citing works
Eguchi, K., Pickering, T. G., Schwartz, J. E., Hoshide, S., Ishikawa, J., Ishikawa, S., Shimada, K., & Kario, K. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.20.2225 · Cited by 127 · see citing works
Bed Sharing, Sleep Habits, and Sleep Problems Among Chinese School-Aged Children
Liu, X., Liu, L., & Wang, R. (2003) · SLEEP · doi:10.1093/sleep/26.7.839 · Cited by 123 · see citing works
Violence Exposure, Sleep Disturbance, and Poor Academic Performance in Middle School
Lepore, S. J., & Kliewer, W. L. (2013) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-013-9709-0 · Cited by 114 · see citing works
Behavior Genetic Research Methods: Testing Quasi-Causal Hypotheses Using Multivariate Twin Data
Turkheimer, E., & Harden, K. P. (2014) · Handbook of Research Methods in Social and Personality Psychology · doi:10.1017/cbo9780511996481.012 · Cited by 111 · see citing works
Self-citationTiming of REM and Stages 3 + 4 Sleep During Temporal Isolation in Man
Elliot, D. W., Charles, A. C., Janet, C. Z., & Joseph, M. R. (1980) · SLEEP · doi:10.1093/sleep/2.4.391 · Cited by 102 · see citing works
Role of sleep in the regulation of the immune system and the pituitary hormones
Gómez‐González, B., Domı́nguez-Salazar, E., Hurtado‐Alvarado, G., Esqueda-León, E., Santana-Miranda, R., Rojas-Zamorano, J. A., & Velázquez‐Moctezuma, J. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06616.x · Cited by 97 · see citing works
Sleep Duration and Depressive Symptoms: A Gene-Environment Interaction
Watson, N. F., Harden, K. P., Buchwald, D., Vitiello, M. V., Pack, A. I., Strachan, E. D., & Goldberg, J. H. (2014) · SLEEP · doi:10.5665/sleep.3412 · Cited by 97 · see citing works
Self-citationShort sleep duration and its association with energy metabolism
Klingenberg, L., Sjödin, A., Holmbäck, U., Astrup, A., & Chaput, J. ‐. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.00991.x · Cited by 94 · see citing works
Update on Energy Homeostasis and Insufficient Sleep
Penev, P. D. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1067 · Cited by 86 · see citing works
Nocturnal sleep duration and cognitive impairment in a population‐based study of older adults
Loerbroks, A., Debling, D., Amelang, M., & Stürmer, T. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2305 · Cited by 86 · see citing works
Association of perceived stress with sleep duration and sleep quality in police officers.
Charles, L. E., Slaven, J. E., Mnatsakanova, A., Claudia, C., Violanti, J. M., Fekedulegn, D. B., Andrew, M. E., Vila, B. J., & Burchfiel, C. M. (2011) · PubMed · Cited by 85 · see citing works
University of Washington Twin Registry: Poised for the Next Generation of Twin Research
Strachan, E. D., Hunt, C., Afari, N., Duncan, G. E., Noonan, C., Schur, E. A., Watson, N. F., Goldberg, J. H., & Buchwald, D. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.124 · Cited by 80 · see citing works
Self-citationShort sleep duration is an independent predictor of stroke events in elderly hypertensive patients
Eguchi, K., Hoshide, S., Ishikawa, S., Shimada, K., & Kario, K. (2010) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2010.09.001 · Cited by 79 · see citing works
Afari, N., Noonan, C., Goldberg, J. H., Edwards, K. L., Gadepalli, K., Osterman, B., Evanoff, C., & Buchwald, D. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706779462543 · Cited by 78 · see citing works
Self-citationSleep Duration and Body Mass Index in Twins: A Gene-Environment Interaction
Watson, N. F., Harden, K. P., Buchwald, D., Vitiello, M. V., Pack, A. I., Weigle, D. S., & Goldberg, J. H. (2012) · SLEEP · doi:10.5665/sleep.1810 · Cited by 72 · see citing works
Self-citationTraffic-related air pollution and sleep in the Boston Area Community Health Survey
Fang, S. C., Schwartz, J. D., YANG, M. H., Yaggi, H. K., Bliwise, D. L., & de Araújo, A. B. (2014) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/jes.2014.47 · Cited by 72 · see citing works
Low Socioeconomic Status Negatively Affects Sleep in Pregnant Women
Okun, M. L., Tolge, M., & Hall, M. H. (2014) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/1552-6909.12295 · Cited by 70 · see citing works
Afari, N., Noonan, C., Goldberg, J. H., et al. (2006) · Twin Research and Human Genetics · doi:10.1375/twin.9.6.1023 · Cited by 68 · see citing works
The effects of sleep debt and monotonous work on sleepiness and performance during a 12‐h dayshift
Sallinen, M., Härmä, M., Akila, R., Holm, A., Luukkonen, R. A., Mikola, H., Müller, K., & Virkkala, J. (2004) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2004.00425.x · Cited by 67 · see citing works
Sleep patterns and the risk for unipolar depression: a review
Gruber, R., Wiebe, & Cassoff (2012) · Nature and Science of Sleep · doi:10.2147/nss.s23490 · Cited by 46 · see citing works
Jarrin, D. C., McGrath, J. J., Silverstein, J. E., & Drake, C. L. (2012) · Behavioral Sleep Medicine · doi:10.1080/15402002.2011.636112 · Cited by 43 · see citing works
Ethnicity Moderates the Influence of Perceived Social Status on Subjective Sleep Quality
Goodin, B. R., McGuire, L. M., & Smith, M. T. (2010) · Behavioral Sleep Medicine · doi:10.1080/15402002.2010.509193 · Cited by 41 · see citing works
Campbell, C. M., Bounds, S. C., Kuwabara, H., Edwards, R. R., Campbell, J. N., Haythornthwaite, J. A., & Smith, M. T. (2013) · Pain Medicine · doi:10.1111/pme.12231 · Cited by 37 · see citing works
Association of Inflammatory Markers with Cardiovascular Risk and Sleepiness
Miller, M. A. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1356 · Cited by 37 · see citing works
Kim, S., Chai, S. K., Lee, K. W., et al. (2014) · Osong Public Health and Research Perspectives · doi:10.1016/j.phrp.2014.03.004 · Cited by 37 · see citing works
Sleep duration across the lifespan: Implications for health
Grandner, M. A. (2012) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.02.001 · Cited by 35 · see citing works
A link between sleep loss, glucose metabolism and adipokines
Padilha, H. G., Crispim, C. A., Zimberg, I. Z., De-Souza, D. A., Waterhouse, J. M., Tufik, S., & de-Mello, M. T. (2011) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2011007500113 · Cited by 31 · see citing works
Subjective annoyance caused by environmental noise.
Dv, A.-R., Suárez-Varela, M. M. M., Garcia Garcia, A., et al. (1994) · PubMed · Cited by 30 · see citing works
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- Authors
- Watson, N. F., Horn, E., Duncan, G. E., Buchwald, D., Vitiello, M. V., & Turkheimer, E.
- Affiliations
- University of Washington (US)
- University of Virginia (US)
- Corresponding author
- Watson, Nathaniel F.
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-01-01
- Volume
- 39
- Issue
- 1
- Pages
- 67-77
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- PMC
- PMC4678336
- OpenAlex
- W2410357234
- Cited by
- 33
- References
- 67
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 3
- FWCI
- 4.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- SLEEP (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (OD006547)
- National Institute on Aging (R01AG042176)
- National Heart, Lung, and Blood Institute (K23HL083350)
- National Institute of Nursing Research (P30NR011400)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Health › Health disparities and outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- sleep duration, area deprivation, Singh index, heritability, twin studies, unique environmental effects, nonshared environment, additive genetic effects, shared environment, residual variance, socioeconomic deprivation
- MeSH terms
- Adult, Environment, Female, Humans, Male, Models, Genetic, Registries, Sleep, Socioeconomic Factors, Time Factors, Twins, Dizygotic, Twins, Monozygotic, Washington, Censuses, White People, Self Report, Gene-Environment Interaction
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