Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452

Autophagy: Renovation of Cells and Tissues

Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,418

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894

Neurotrophins: Roles in Neuronal Development and Function

Huang, E. J., & Reichardt, L. F. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.677 · Cited by 4,394

The Nerve Growth Factor 35 Years Later

Levi-Montalcini, R. (1987) · Science · doi:10.1126/science.3306916 · Cited by 3,125

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

Schwarze, S. R., Ho, A., Vocero-Akbani, A., & Dowdy, S. F. (1999) · Science · doi:10.1126/science.285.5433.1569 · Cited by 2,416

Neurotrophins and their receptors: A convergence point for many signalling pathways

Chao, M. V. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1078 · Cited by 2,298

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

Ravikumar, B., Sarkar, S., Davies, J. E., Futter, M., Garcia-Arencibia, M., Green-Thompson, Z. W., Jimenez-Sanchez, M., Korolchuk, V. I., Lichtenberg, M., Luo, S., et al. (2010) · Physiological Reviews · doi:10.1152/physrev.00030.2009 · Cited by 1,727

Extensive Involvement of Autophagy in Alzheimer Disease: An Immuno-Electron Microscopy Study

Nixon, R. A., Wegiel, J., Kumar, A., Yu, W. H., Peterhoff, C., Cataldo, A., & Cuervo, A. M. (2005) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/64.2.113 · Cited by 1,588

Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy

Matsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., & Sadoshima, J. (2007) · Circulation Research · doi:10.1161/01.res.0000261924.76669.36 · Cited by 1,505

The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor

Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., & Parada, L. F. (1991) · Science · doi:10.1126/science.1850549 · Cited by 1,379

The origin and development of glial cells in peripheral nerves

Jessen, K. R., & Mirsky, R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1746 · Cited by 1,354

Nerve Growth Factor Signaling, Neuroprotection, and Neural Repair

Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

Hempstead, B. L., Martin-Zanca, D., Kaplan, D. R., Parada, L. F., & Chao, M. V. (1991) · Nature · doi:10.1038/350678a0 · Cited by 1,229

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

Mehlem, A., Hagberg, C. E., Muhl, L., Eriksson, U., & Falkevall, A. (2013) · Nature Protocols · doi:10.1038/nprot.2013.055 · Cited by 889

Functional Interactions of Neurotrophins and Neurotrophin Receptors

Bothwell, M. (1995) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.18.030195.001255 · Cited by 833

Schwann Cells: Development and Role in Nerve Repair

Jessen, K. R., Mirsky, R., & Lloyd, A. C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020487 · Cited by 751

Neurotrophin Signaling Through the P75 Neurotrophin Receptor

Roux, P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00016-3 · Cited by 717

Nerve growth factor: from neurotrophin to neurokine

Levi-Montalcini, R., Skaper, S. D., Dal Toso, R., Petrelli, L., & Leon, A. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10058-8 · Cited by 686

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Komatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701311104 · Cited by 614

Preparing the ground for tissue regeneration: from mechanism to therapy

Forbes, S. J., & Rosenthal, N. (2014) · Nature Medicine · doi:10.1038/nm.3653 · Cited by 585

Wallerian degeneration in the peripheral nervous system: participation of both Schwann cells and macrophages in myelin degradation

Stoll, G., Griffin, J. W., Li, C. Y., & Trapp, B. D. (1989) · Journal of Neurocytology · doi:10.1007/bf01187086 · Cited by 556

LC3- and p62-based biochemical methods for the analysis of autophagy progression in mammalian cells

Jiang, P., & Mizushima, N. (2015) · Methods · doi:10.1016/j.ymeth.2014.11.021 · Cited by 529

Autophagy as a Stress-Response and Quality-Control Mechanism: Implications for Cell Injury and Human Disease

Murrow, L., & Debnath, J. (2013) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-163918 · Cited by 527

The p75 neurotrophin receptor

Chao, M. V. (1994) · Journal of Neurobiology · doi:10.1002/neu.480251106 · Cited by 479

The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI

Yamashita, T., & Tohyama, M. (2003) · Nature Neuroscience · doi:10.1038/nn1045 · Cited by 460

The nerve growth factor: its mode of action on sensory and sympathetic nerve cells.

Levi‐Montalcini, R. (1966) · PubMed · Cited by 455

Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves

Gomez-Sanchez, J. A., Carty, L., Iruarrizaga-Lejarreta, M., Palomo-Irigoyen, M., Varela-Rey, M., Griffith, M., Hantke, J., Macias-Camara, N., Azkargorta, M., Aurrekoetxea, I., et al. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201503019 · Cited by 453

Specificity of peripheral nerve regeneration: Interactions at the axon level

Allodi, I., Udina, E., & Navarro, X. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.005 · Cited by 420

Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence

Tai, H., Wang, Z., Gong, H., Han, X., Zhou, J., Wang, X., Wei, X., Ding, Y., Huang, N., Qin, J., et al. (2017) · Autophagy · doi:10.1080/15548627.2016.1247143 · Cited by 334

Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

McCullough, L. D., Zeng, Z., Li, H., Landree, L. E., McFadden, J., & Ronnett, G. V. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m409985200 · Cited by 333

Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease

Martini, R., Fischer, S., López‐Vales, R., & David, S. (2008) · Glia · doi:10.1002/glia.20766 · Cited by 319

Peripheral Nerve Repair and Reconstruction

Griffin, J. W., Hogan, M. V., Chhabra, A. B., & Deal, D. N. (2013) · The Journal of Bone & Joint Surgery · doi:10.2106/jbjs.l.00704 · Cited by 310

The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves

Beirowski, B., Adalbert, R., Wagner, D., Grumme, D. S., Addicks, K., Ribchester, R. R., & Coleman, M. P. (2005) · BMC Neuroscience · doi:10.1186/1471-2202-6-6 · Cited by 293

Inhibition of p75 Neurotrophin Receptor Attenuates Isoflurane-mediated Neuronal Apoptosis in the Neonatal Central Nervous System

Head, B. P., Patel, H. H., Niesman, I. R., Drummond, J. C., Roth, D. M., & Patel, P. M. (2009) · Anesthesiology · doi:10.1097/aln.0b013e31819b602b · Cited by 251

NEUROTROPHINS AND THEIR RECEPTORS IN NERVE INJURY AND REPAIR

EBADI, M., BASHIR, R. M., HEIDRICK, M. L., HAMADA, F. M., EL REFAEY, E., HAMED, A., HELAL, G., BAXI, M. D., CERUTIS, D. R., & LASSI, N. K. (1997) · Neurochemistry International · doi:10.1016/s0197-0186(96)00071-x · Cited by 246

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

Gage, F. H., Batchelor, P., Chen, K. S., Chin, D., Higgins, G. A., Koh, S., Deputy, S., Rosenberg, M. B., Fischer, W., & Bjorklund, A. (1989) · Neuron · doi:10.1016/0896-6273(89)90184-0 · Cited by 241

Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre‐activation of AMPK‐dependent autophagy

Jiang, T., Yu, J., Zhu, X., Wang, H., Tan, M., Cao, L., Zhang, Q., Gao, L., Shi, J., Zhang, Y., et al. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12655 · Cited by 238

Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury

Brosius Lutz, A., Chung, W.-S., Sloan, S. A., Carson, G. A., Zhou, L., Lovelett, E., Posada, S., Zuchero, J. B., & Barres, B. A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710566114 · Cited by 225

Activation of Rac GTPase by p75 Is Necessary for c-jun N-Terminal Kinase-Mediated Apoptosis

Harrington, A. W., Kim, J. Y., & Yoon, S. O. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-01-00156.2002 · Cited by 208

Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration

Hirata, K., & Kawabuchi, M. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10108 · Cited by 203

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

Shang, L., & Wang, X. (2011) · Autophagy · doi:10.4161/auto.7.8.15860 · Cited by 201

A Critical Role for Macrophages Near Axotomized Neuronal Cell Bodies in Stimulating Nerve Regeneration

Niemi, J. P., DeFrancesco-Lisowitz, A., Roldán-Hernández, L., Lindborg, J. A., Mandell, D., & Zigmond, R. E. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3319-12.2013 · Cited by 192

Autophagy induction stabilizes microtubules and promotes axon regeneration after spinal cord injury

He, M., Ding, Y., Chu, C., Tang, J., Xiao, Q., & Luo, Z.-G. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1611282113 · Cited by 177

Inhibition by Multifunctional Magnetic Nanoparticles Loaded with Alpha-Synuclein RNAi Plasmid in a Parkinson's Disease Model

Niu, S., Zhang, L.-K., Zhang, L., Zhuang, S., Zhan, X., Chen, W.-Y., Du, S., Yin, L., You, R., Li, C.-H., et al. (2017) · Theranostics · doi:10.7150/thno.16562 · Cited by 172

Chitosan degradation products facilitate peripheral nerve regeneration by improving macrophage-constructed microenvironments

Zhao, Y., Wang, Y., Gong, J., Yang, L., Niu, C., Ni, X., Wang, Y., Peng, S., Gu, X., Sun, C., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.02.026 · Cited by 164

Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination

Jang, S. Y., Shin, Y. K., Park, S., Park, J. Y., Lee, H., Yoo, Y. H., Kim, J. K., & Park, H. T. (2015) · Glia · doi:10.1002/glia.22957 · Cited by 148

Metformin Improves Functional Recovery After Spinal Cord Injury via Autophagy Flux Stimulation

Zhang, D., Xuan, J., Zheng, B., Zhou, Y., Lin, Y., Wu, Y., Zhou, Y., Huang, Y.-X., Wang, Q., Shen, L., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9895-1 · Cited by 137

The Role of Schwann Cell-Axon Interaction in Peripheral Nerve Regeneration

Namgung, U. (2014) · Cells Tissues Organs · doi:10.1159/000370324 · Cited by 135

Synthesis and screening of 3-MA derivatives for autophagy inhibitors

Wu, Y., Wang, X., Guo, H., Zhang, B., Zhang, X.-B., Shi, Z., & Yu, L. (2013) · Autophagy · doi:10.4161/auto.23641 · Cited by 134

The role of local protein synthesis and degradation in axon regeneration

Gumy, L. F., Tan, C. L., & Fawcett, J. W. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.06.004 · Cited by 134

Radiation‐induced Reductions in Macrophage Recruitment Have Only Slight Effects on Myelin Degeneration in Sectioned Peripheral Nerves of Mice

Perry, V. H., Tsao, J. W., Feam, S., & Brown, M. C. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01063.x · Cited by 133

Regulation of Neuronal Autophagy in Axon: Implication of Autophagy in Axonal Function and Dysfunction/Degeneration

Yue, Z. (2007) · Autophagy · doi:10.4161/auto.3602 · Cited by 130

Dose and duration of nerve growth factor (NGF) administration determine the extent of behavioral recovery following peripheral nerve injury in the rat

Kemp, S. W. P., Webb, A. A., Dhaliwal, S., Syed, S., Walsh, S. K., & Midha, R. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.03.017 · Cited by 129

The small GTP-binding protein Cdc42 is required for nerve growth factor withdrawal-induced neuronal death

Bazenet, C. E., Mota, M. A., & Rubin, L. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3984 · Cited by 128

Nerve growth factor improves functional recovery by inhibiting endoplasmic reticulum stress-induced neuronal apoptosis in rats with spinal cord injury

Zhang, H., Wu, F., Kong, X., Yang, J., Chen, H., Deng, L., Cheng, Y. H., Ye, L., Zhu, S., Zhang, X., et al. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-130 · Cited by 120

Schwann cell autophagy counteracts the onset and chronification of neuropathic pain

Marinelli, S., Nazio, F., Tinari, A., Ciarlo, L., D'Amelio, M., Pieroni, L., Vacca, V., Urbani, A., Cecconi, F., Malorni, W., et al. (2014) · Pain · doi:10.1016/j.pain.2013.09.013 · Cited by 119

IGF-I and IGFBP-2 Stimulate AMPK Activation and Autophagy, Which Are Required for Osteoblast Differentiation

Xi, G., Rosen, C. J., & Clemmons, D. R. (2015) · Endocrinology · doi:10.1210/en.2015-1690 · Cited by 111

NGF steers microglia toward a neuroprotective phenotype

Rizzi, C., Tiberi, A., Giustizieri, M., Marrone, M. C., Gobbo, F., Carucci, N. M., Meli, G., Arisi, I., D’Onofrio, M., Marinelli, S., et al. (2018) · Glia · doi:10.1002/glia.23312 · Cited by 110

Isolation of Myelin

Larocca, J. N., & Norton, W. T. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0325s33 · Cited by 109

Actin Polymerization Is Essential for Myelin Sheath Fragmentation during Wallerian Degeneration

Jung, J., Cai, W., Lee, H. K., Pellegatta, M., Shin, Y. K., Jang, S. Y., Suh, D. J., Wrabetz, L. G., Feltri, M. L., & Park, H. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4537-10.2011 · Cited by 106

Antagonistic control of muscle cell size by AMPK and mTORC1

Mounier, R., Lantier, L., Leclerc, J., Sotiropoulos, A., Foretz, M., & Viollet, B. (2011) · Cell Cycle · doi:10.4161/cc.10.16.17102 · Cited by 105

Role of autophagy in the pathogenesis of multiple sclerosis

Liang, P., & Le, W. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-015-1545-5 · Cited by 103

The neurotrophin receptor p75NTR in Schwann cells is implicated in remyelination and motor recovery after peripheral nerve injury

Tomita, K., Kubo, T., Matsuda, K., 藤原敏宏, Yano, K., Winograd, J. M., Tohyama, M., & Hosokawa, K. (2007) · Glia · doi:10.1002/glia.20533 · Cited by 93

Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons

Dodson, M. B., Wani, W. Y., Redmann, M., Benavides, G. A., Johnson, M. S., Ouyang, X., Cofield, S. S., Mitra, K., Darley-Usmar, V. M., & Zhang, J. (2017) · Autophagy · doi:10.1080/15548627.2017.1356948 · Cited by 93

The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function

Tanaka, Y., Niwa, S., Dong, M., Farkhondeh, A., Wang, L., Zhou, R., & Hirokawa, N. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.002 · Cited by 90

A unified cell biological perspective on axon–myelin injury

Simons, M., Misgeld, T., & Kerschensteiner, M. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201404154 · Cited by 88

Pathways regulating modality-specific axonal regeneration in peripheral nerve

Wood, M. D., & Mackinnon, S. E. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.02.001 · Cited by 86

Endogenous Brain-Derived Neurotrophic Factor in the Nucleus Tractus Solitarius Tonically Regulates Synaptic and Autonomic Function

Clark, C. G., Hasser, E. M., Kunze, D. L., Katz, D. M., & Kline, D. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0746-11.2011 · Cited by 82

Quantitative analysis of autophagic flux by confocal pH-imaging of autophagic intermediates

Maulucci, G., Chiarpotto, M., Papi, M., Samengo, D., Pani, G., & Spirito, M. D. (2015) · Autophagy · doi:10.1080/15548627.2015.1084455 · Cited by 81

Autophagy Promotes Peripheral Nerve Regeneration and Motor Recovery Following Sciatic Nerve Crush Injury in Rats

Huang, H.-C., Chen, L., Zhang, H.-X., Li, S.-F., Liu, P., Zhao, T.-Y., & Li, C.-X. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0672-9 · Cited by 80

mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

Norrmén, C., Figlia, G., Pfistner, P., Pereira, J. A., Bachofner, S., & Suter, U. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3619-17.2018 · Cited by 79

Nerve growth factor regulation and production by macrophages in osteoarthritic synovium

Takano, S., Uchida, K., Inoue, G., Miyagi, M., Aikawa, J., Iwase, D., Iwabuchi, K., Matsumoto, T., Satoh, M., Mukai, M., et al. (2017) · Clinical & Experimental Immunology · doi:10.1111/cei.13007 · Cited by 77

Nerve Growth Factor Regulation by TNF- α and IL-1 β in Synovial Macrophages and Fibroblasts in Osteoarthritic Mice

Takano, S., Uchida, K., Miyagi, M., Inoue, G., Fujimaki, H., Aikawa, J., Iwase, D., Minatani, A., Iwabuchi, K., & Takaso, M. (2016) · Journal of Immunology Research · doi:10.1155/2016/5706359 · Cited by 75

CRISPR-based Activation of Endogenous Neurotrophic Genes in Adipose Stem Cell Sheets to Stimulate Peripheral Nerve Regeneration

Hsu, M., Liao, H.-T., Truong, V. A., Huang, K.-L., Yu, F.-J., Chen, H., Nguyen, T. K. N., Макаревич, П. И., Parfyonova, Y. V., & Hu, Y.-C. (2019) · Theranostics · doi:10.7150/thno.36790 · Cited by 71

Peripheral Nerve Regeneration and NGF-Dependent Neurite Outgrowth of Adult Sensory Neurons Converge on STAT3 Phosphorylation Downstream of Neuropoietic Cytokine Receptor gp130

Quarta, S., Baeumer, B. E., Scherbakov, N., Andratsch, M., Rose‐John, S., Dechant, G., Bandtlow, C. E., & Kress, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1209-13.2014 · Cited by 65

Autophagy Is Involved in the Reduction of Myelinating Schwann Cell Cytoplasm during Myelin Maturation of the Peripheral Nerve

Jang, S. Y., Shin, Y. K., Park, S. Y., Park, J. Y., Rha, S.-H., Kim, J. K., Lee, H. J., & Park, H. T. (2015) · PLOS ONE · doi:10.1371/journal.pone.0116624 · Cited by 61 · cited 2×

Regulation of Caveolin-1 and Junction Proteins by bFGF Contributes to the Integrity of Blood–Spinal Cord Barrier and Functional Recovery

Ye, L.-B., Yu, X., Xia, Q.-H., Yang, Y., Chen, D., Wu, F., Wei, X., Zhang, X., Zheng, B., Fu, X., et al. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0437-3 · Cited by 61

Differential regulation of macrophage phenotype by mature and pro-nerve growth factor

Williams, K. S., Killebrew, D. A., Clary, G., Seawell, J. A., & Meeker, R. B. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.05.016 · Cited by 55

NGF Attenuates High Glucose-Induced ER Stress, Preventing Schwann Cell Apoptosis by Activating the PI3K/Akt/GSK3β and ERK1/2 Pathways

Li, R., Wu, Y., Zou, S., Wang, X., Li, Y., Xu, K., Gong, F., Liu, Y., Wang, J., Liao, Y., et al. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2333-6 · Cited by 54

Schwann cell dedifferentiation-associated demyelination leads to exocytotic myelin clearance in inflammatory segmental demyelination

Jang, S. Y., Yoon, B.-A., Shin, Y. K., Yun, S. H., Jo, Y. R., Choi, Y. Y., Ahn, M., Shin, T., Park, J. I., Kim, J. K., et al. (2017) · Glia · doi:10.1002/glia.23200 · Cited by 46

The role of autophagy in axonal degeneration of the optic nerve

Koch, J. C., & Lingor, P. (2016) · Experimental Eye Research · doi:10.1016/j.exer.2015.08.016 · Cited by 46

p75NTR expression and nuclear localization of p75NTR intracellular domain in spiral ganglion Schwann cells following deafness correlate with cell proliferation

Provenzano, M. J., Minner, S. A., Zander, K., Clark, J. J., Kane, C. J., Green, S. H., & Hansen, M. R. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.05.010 · Cited by 46

Roles of glial p75NTR in axonal regeneration

Zhou, X., & Li, H. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21220 · Cited by 45

Schwann-Cell Autophagy, Functional Recovery, and Scar Reduction After Peripheral Nerve Repair

Ko, P., Yang, C.-C., Kuo, Y., Su, F., Hsu, T., Tu, Y., & Jou, I. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1056-8 · Cited by 41

Increased autophagy in peripheral nerves may protect Wistar Ottawa Karlsburg W rats against neuropathy

Kosacka, J., Nowicki, M., Blüher, M., Baum, P., Stockinger, M., Toyka, K. V., Klöting, I., Stümvoll, M., Serke, H., Bechmann, I., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.09.017 · Cited by 40

p75NTR is highly expressed in vestibular schwannomas and promotes cell survival by activating nuclear transcription factor κB

Ahmad, I. N., Yue, W. Y., Fernando, A., Clark, J. J., Woodson, E. A., & Hansen, M. R. (2014) · Glia · doi:10.1002/glia.22709 · Cited by 39

Induction of a reactive state in perineuronal satellite glial cells akin to that produced by nerve injury is linked to the level of p75NTR expression in adult sensory neurons: Decrease in Neuronal p75NTR Induces SGC Reactivity

Nadeau, J. R., Wilson-Gerwing, T. D., & Verge, V. M. K. (2014) · Glia · doi:10.1002/glia.22640 · Cited by 35

p75NTR and Sortilin Increase After Facial Nerve Injury

Provenzano, M. J., Xu, N., Meer, M. V., Clark, J. J., & Hansen, M. R. (2008) · The Laryngoscope · doi:10.1097/mlg.0b013e31814b8d9f · Cited by 32

Paradoxical Effect of TrkA Inhibition in Alzheimer's Disease Models

Zhang, Q., Descamps, O., Hart, M. J., Poksay, K. S., Spilman, P. R., Kane, D. J., Gorostiza, O. F., John, V., & Bredesen, D. E. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-130017 · Cited by 26

Comparative Proteomic Analysis of Primary Schwann Cells and a Spontaneously Immortalized Schwann Cell Line RSC 96: A Comprehensive Overview with a Focus on Cell Adhesion and Migration Related Proteins

Ji, Y., Shen, M., Wang, X., Zhang, S., Yu, S., Chen, G., Gu, X., & Ding, F. (2012) · Journal of Proteome Research · doi:10.1021/pr201221u · Cited by 25

The p75 NGF Receptor Exposed

Zampieri, N., & Chao, M. V. (2004) · Science · doi:10.1126/science.1098110 · Cited by 24

Glial cell line-derived neurotrophic factor promotes increased phenotypic marker expression in femoral sensory and motor-derived Schwann cell cultures

Jesuraj, N. J., Marquardt, L. M., Kwasa, J. A. C., & Sakiyama‐Elbert, S. E. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.04.005 · Cited by 24

Redoxins in peripheral neurons after sciatic nerve injury

Valek, L., Kanngießer, M., Häußler, A., Agarwal, N. K., Lillig, C. H., & Tegeder, I. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.09.008 · Cited by 24

IL‑1β and TNF‑α suppress TGF‑β‑promoted NGF expression in periodontal ligament‑derived fibroblasts through inactivation of TGF‑β‑induced Smad2/3‑ and p38 MAPK‑mediated signals

Ohta, M. M., Chosa, N., Kyakumoto, S., Yokota, S., Okubo, N., Nemoto, A., Kamo, M., Joh, S., Satoh, K., & Ishisaki, A. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3714 · Cited by 23

Myelinophagy: Schwann cells dine in

Thumm, M., & Simons, M. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201506039 · Cited by 22

Mechanism for neurotropic action of vorinostat, a pan histone deacetylase inhibitor

Shukla, S., Shariat‐Madar, Z., Walker, L., & Tekwani, B. L. (2016) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2016.09.003 · Cited by 22

Cyclosporin A Affects Axons and Macrophages During Wallerian Degeneration

Taskinen, H., & Röyttä, M. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.431 · Cited by 18

NGF-dependent axon growth and regeneration are altered in sympathetic neurons of dystrophic mdx mice

Lombardi, L., Persiconi, I., Gallo, A., Hoogenraad, C. C., & Stefano, M. E. D. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.01.006 · Cited by 17

Glycyrrhizin improves p75NTR-associated sciatic nerve regeneration in a BALB/c mouse model

Jia, Y., LI, J.-R., Mao, C., Yin, W.-T., & Jiang, R. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1546 · Cited by 15

The role of retinoids in the induction of nerve growth factor: a potential treatment for diabetic neuropathy

Lane, J. T. (2014) · Translational research · doi:10.1016/j.trsl.2014.06.001 · Cited by 14

Effect of Liposome-Mediated Macrophage Depletion on Schwann Cell Proliferation During Wallerian Degeneration

Kubota, A., & Suzuki, K. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.789 · Cited by 12

The nerve growth factor: its widening role and place in neurobiology.

Levi‐Montalcini, R. (1976) · PubMed · Cited by 9

A Novel In Vitro Injury Model Based on Microcontact Printing Demonstrates Negative Effects of Hydrogen Peroxide on Axonal Regeneration both in Absence and Presence of Glia

Yaka, C., Björk, P., Schönberg, T., & Erlandsson, A. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2012.2562 · Cited by 5

Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy

Kraft, C., Boya, P., Codogno, P., Elazar, Z., Eskelinen, E., Farrés, J., Kirkin, V., Jungbluth, H., Martı́nez, A., Pleß, O., et al. (2018) · Autophagy · doi:10.1080/15548627.2018.1515532 · Cited by 4

Neurotrophin biology at NGF 2016: From fundamental science to clinical applications

Plotkin, J. L., & Wu, C. (2016) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2016.11.005 · Cited by 2