The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men
Abstract
BACKGROUND: The regulatory function of the endothelium is altered in hypercholesterolemia, and the subsequent endothelial dysfunction plays a central role in the development of atherosclerosis. OBJECTIVE: To determine whether endothelial function in hypercholesterolemic patients is affected by replacing a saturated fat-enriched diet with a low-fat, low-saturated fat diet (the U.S. National Cholesterol Education Program stage 1 [NCEP-1] diet) or a diet rich in monounsaturated fat (such as that common in Mediterranean countries). DESIGN: Intervention dietary study with a baseline phase and two randomized crossover dietary periods. SETTING: Hospital Universitario Reina Sofía, Córdoba, Spain. PATIENTS: 22 hypercholesterolemic men. INTERVENTION: Patients followed a diet high in saturated fat, then were assigned in a crossover design to the NCEP-1 diet or a Mediterranean diet. Each dietary period lasted 28 days. MEASUREMENTS: Plasma P-selectin levels, lipid concentrations, and endothelial function. RESULTS: Compared with the saturated fat diet, flow-mediated dilatation increased during the Mediterranean diet but not during the NCEP-1 diet. In addition, levels of plasma cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and P-selectin decreased during the NCEP-1 and Mediterranean diets. CONCLUSION: In hypercholesterolemic men, diets low in fat (especially saturated fat) and diets rich in monounsaturated fats improve endothelial function.
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Cites
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RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
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Metadata
- Authors
- Fuentes, F., López-Miranda, J., Sánchez, E., Sánchez, F., Paez, J., Paz-Rojas, E., Marín, C., Gómez, P., Jimenez-Perepérez, J., Ordovás, J. M., & Pérez-Jiménez, F.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 2001-06-19
- Volume
- 134
- Issue
- 12
- Pages
- 1115-1119
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2161953598
- Cited by
- 260
- References
- 4
- FWCI
- 12.18
- Type
- journal article
- Language
- en
- Open access
- closed
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