Cited by 251Diabetes Treatment and ManagementDiabetes Management and ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record, with a small difference in title or year; 55 of the 55 references it cites were found in a registry or an index.

Salicylate (Salsalate) in Patients With Type 2 Diabetes: A Randomized Trial

Open access

Goldfine, Allison B., Fonseca, Vivian, Jablonski, Kathleen A., Chen, Yii-Der Ida, Tipton, Laura, Staten, Myrlene A., Shoelson, Steven E.·2013·Annals of Internal Medicine

DOI 10.7326/0003-4819-159-1-201307020-00003PMC PMC4128629

Open this paper in CoChat — free account

Abstract

BACKGROUND: Short-duration studies show that salsalate improves glycemia in type 2 diabetes mellitus (T2DM). OBJECTIVE: To assess 1-year efficacy and safety of salsalate in T2DM. DESIGN: Placebo-controlled, parallel trial; computerized randomization and centralized allocation, with patients, providers, and researchers blinded to assignment. (ClinicalTrials.gov: NCT00799643). SETTING: 3 private practices and 18 academic centers in the United States. PATIENTS: Persons aged 18 to 75 years with fasting glucose levels of 12.5 mmol/L or less (≤225 mg/dL) and hemoglobin A1c (HbA1c) levels of 7.0% to 9.5% who were treated for diabetes. INTERVENTION: 286 participants were randomly assigned (between January 2009 and July 2011) to 48 weeks of placebo (n = 140) or salsalate, 3.5 g/d (n = 146), in addition to current therapies, and 283 participants were analyzed (placebo, n = 137; salsalate, n = 146). MEASUREMENTS: Change in hemoglobin A1c level (primary outcome) and safety and efficacy measures. RESULTS: The mean HbA1c level over 48 weeks was 0.37% lower in the salsalate group than in the placebo group (95% CI, -0.53% to -0.21%; P < 0.001). Glycemia improved despite more reductions in concomitant diabetes medications in salsalate recipients than in placebo recipients. Lower circulating leukocyte, neutrophil, and lymphocyte counts show the anti-inflammatory effects of salsalate. Adiponectin and hematocrit levels increased more and fasting glucose, uric acid, and triglyceride levels decreased with salsalate, but weight and low-density lipoprotein cholesterol levels also increased. Urinary albumin levels increased but reversed on discontinuation; estimated glomerular filtration rates were unchanged. LIMITATION: Trial duration and number of patients studied were insufficient to determine long-term risk-benefit of salsalate in T2DM. CONCLUSION: Salsalate improves glycemia in patients with T2DM and decreases inflammatory mediators. Continued evaluation of mixed cardiorenal signals is warranted.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.7326/0003-4819-159-1-201307020-00003

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769
Self-citation
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Type 2 diabetes as an inflammatory disease
Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737
Self-citation
Uric Acid and Cardiovascular Risk
Feig, D. I., Kang, D., & Johnson, R. J. (2008) · New England Journal of Medicine · doi:10.1056/nejmra0800885 · Cited by 2,467
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
Self-citation
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
Larsen, C. M., Faulenbach, M., Vaag, A., Vølund, A., Ehses, J. A., Seifert, B., Mandrup-Poulsen, T., & Donath, M. Y. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa065213 · Cited by 1,798
Inhibition of NF-κB by Sodium Salicylate and Aspirin
Kopp, E. B., & Ghosh, S. (1994) · Science · doi:10.1126/science.8052854 · Cited by 1,744
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
Yin, M.-J., Yamamoto, Y., & Gaynor, R. B. (1998) · Nature · doi:10.1038/23948 · Cited by 1,596
IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Cai, D., Frantz, J. D., Tawa, N. E., Melendez, P. A., Oh, B.-C., Lidov, H. G. W., Hasselgren, P.-O., Frontera, W. R., Lee, J., Glass, D. J., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.027 · Cited by 1,367
Self-citation
Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study
Schmidt, M. I., Duncan, B. B., Sharrett, A. R., Lindberg, G., Savage, P. J., Offenbacher, S., Azambuja, M. I. R., Tracy, R. P., & HEISS, G. M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01046-6 · Cited by 1,080

Show all 55 references

Research works printed but not linked: 6

Faghihimani E, 2011, Acta Diabetol
Vis M, 2005, J Rheumatol, 32, 252
Ryan J, 1986, Arthritis Rheum, 29, S103
Sweeney JD, 1988, Blood, 72, 311A
Roth S, 1990, Semin Arthritis Rheum, 19, 11
Lanza F, 1989, J Rheumatol, 16, 1570

Sorted by citations

Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Inflammation, metaflammation and immunometabolic disorders
Hotamisligil, G. S. (2017) · Nature · doi:10.1038/nature21363 · Cited by 2,570
Inflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743
The Role of Inflammation in Diabetes: Current Concepts and Future Perspectives
Tsalamandris, S., Antonopoulos, A. S., Oikonomou, E., Papamikroulis, G.-A., Vogiatzi, G., Papaioannou, S., Deftereos, S., & Tousoulis, D. (2019) · European Cardiology Review · doi:10.15420/ecr.2018.33.1 · Cited by 1,381
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732
Targeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678
Targeting inflammation in the treatment of type 2 diabetes: time to start
Donath, M. Y. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4275 · Cited by 690
Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus
Yaribeygi, H., Sathyapalan, T., Atkin, S. L., & Sahebkar, A. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/8609213 · Cited by 749
The link between depression and diabetes: the search for shared mechanisms
Moulton, C. D., Pickup, J. C., & Ismail, K. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(15)00134-5 · Cited by 670
Exercises for mechanical neck disorders
Gross, A., Kay, T. M., Paquin, J.-P., Blanchette, S., Lalonde, P., Christie, T., Dupont, G., Graham, N., Burnie, S. J., Gelley, G., et al. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004250.pub5 · Cited by 613
Anti-inflammatory therapies for cardiovascular disease
Ridker, P. M., & Lüscher, T. F. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu203 · Cited by 568
Treatment of nonalcoholic fatty liver disease: role of AMPK
Smith, B. K., Marcinko, K., Desjardins, E. M., Lally, J., Ford, R. J., & Steinberg, G. R. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00225.2016 · Cited by 509
The role of infiltrating immune cells in dysfunctional adipose tissue
Guzik, T. J., Skiba, D. S., Touyz, R. M., & Harrison, D. G. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx108 · Cited by 462
Obesity as a multisystem disease: Trends in obesity rates and obesity‐related complications
Sarma, S., Sockalingam, S., & Dash, S. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14290 · Cited by 485
A Test in Context
Ridker, P. M. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.11.037 · Cited by 414
The role of macrophages in obesity-associated islet inflammation and β-cell abnormalities
Ying, W., Fu, W., Lee, Y. S., & Olefsky, J. M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0286-3 · Cited by 410
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
Burhans, M. S., Hagman, D. K., Kuzma, J. N., Schmidt, K. A., & Kratz, M. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170040 · Cited by 461
Obesity and Cancer: The Oil that Feeds the Flame
Font-Burgada, J., Sun, B., & Karin, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.015 · Cited by 364
Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes
Everett, B. M., Donath, M. Y., Pradhan, A. D., Thuren, T. Y., Pais, P. S., Nicolau, J. C., Glynn, R. J., Libby, P., & Ridker, P. M. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.03.002 · Cited by 345
LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes
Li, P., Oh, D. Y., Bandyopadhyay, G. K., Lagakos, W., Talukdar, S., Osborn, O., Johnson, A., Chung, H., Mayoral, R., Maris, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3800 · Cited by 327
TLR4 at the Crossroads of Nutrients, Gut Microbiota, and Metabolic Inflammation
Velloso, L. A., Folli, F. B., & Saad, M. J. A. (2015) · Endocrine Reviews · doi:10.1210/er.2014-1100 · Cited by 323
Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?
Blüher, M. (2016) · Clinical Science · doi:10.1042/cs20160005 · Cited by 273
Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis
Ridker, P. M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313129 · Cited by 260
Inflammation as a Therapeutic Target for Diabetic Neuropathies
Pop‐Busui, R., Ang, L. P., Holmes, C., Gallagher, K. A., & Feldman, E. L. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0727-5 · Cited by 278
Anti-inflammatory Agents in the Treatment of Diabetes and Its Vascular Complications
Pollack, R. M., Donath, M. Y., LeRoith, D., & Leibowitz, G. (2016) · Diabetes Care · doi:10.2337/dcs15-3015 · Cited by 266
Macrophage function in adipose tissue homeostasis and metabolic inflammation
Chavakis, T., Alexaki, V. I., & Ferrante, A. W. (2023) · Nature Immunology · doi:10.1038/s41590-023-01479-0 · Cited by 279
Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease
Esser, N., Paquot, N., & Scheen, A. J. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2015.974804 · Cited by 255
Inflammation and resolution in obesity
Soták, M., Clark, M., Suur, B. E., & Börgeson, E. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01047-y · Cited by 260
C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria
Menne, J., Eulberg, D., Beyer, D., Baumann, M., Saudek, F., Valkusz, Z., Więcek, A., Haller, H. G., & for the Emapticap Study Group (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfv459 · Cited by 207
Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review)
Varra, F., Varras, M. N., Varra, V., & Theodosis‐Nobelos, P. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13219 · Cited by 232
Regulation of energy balance by inflammation: Common theme in physiology and pathology
Wang, H., & Ye, J. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9306-8 · Cited by 179
Targeting Residual Inflammatory Risk: A Shifting Paradigm for Atherosclerotic Disease
Aday, A. W., & Ridker, P. M. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00016 · Cited by 178
Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk
Goldfine, A. B., & Shoelson, S. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88884 · Cited by 176
Self-citation
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Lagou, V., Mägi, R., Hottenga, J., Grallert, H., Perry, J. R. B., Bouatia‐Naji, N., Marullo, L., Rybin, D. V., Jansen, R., Min, J. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-19366-9 · Cited by 157
Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes
Kohlgruber, A. C., & Lynch, L. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0670-x · Cited by 163
Type‐2 diabetes: Current understanding and future perspectives
Pandey, A., Chawla, S., & Guchhait, P. (2015) · IUBMB Life · doi:10.1002/iub.1396 · Cited by 162
Lactoferrin in aseptic and septic inflammation
Lepanto, M. S., Rosa, L., Paesano, R., Valenti, P., & Cutone, A. (2019) · Molecules · doi:10.3390/molecules24071323 · Cited by 147
Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation
Dragano, N. R. V., Solon, C., Ramalho, A. F. S., de Moura, R. F., Razolli, D. S., Christiansen, E., Azevedo, C., Ulven, T., & Velloso, L. A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0869-7 · Cited by 146
Strategies and Challenges in Clinical Trials Targeting Human Aging
Newman, J. C., Milman, S., Hashmi, S. K., Austad, S. N., Kirkland, J. L., Halter, J. B., & Barzilai, N. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw149 · Cited by 141
Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities
Calvo, S. S.-C., Bharath, L. P., Pugh, G. H., SantaCruz-Calvo, L., Lenin, R. R., Lutshumba, J., Liu, R., Bachstetter, A. D., Zhu, B., & Nikolajczyk, B. S. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00575-1 · Cited by 149
Diabetes and Sepsis: Risk, Recurrence, and Ruination
Frydrych, L. M., Fattahi, F., He, K., Ward, P. A., & Delano, M. J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00271 · Cited by 141
Curcumin and other dietary polyphenols: potential mechanisms of metabolic actions and therapy for diabetes and obesity
Jin, T., Song, Z., Weng, J., & Fantus, I. G. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00285.2017 · Cited by 132
Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions
Zhao, L., Hu, H., Zhang, L., Liu, Z., Huang, Y., Liu, Q., Jin, L., Zhu, M., & Zhang, L. (2024) · MedComm · doi:10.1002/mco2.516 · Cited by 141
Novel Protein Glycan Side-Chain Biomarker and Risk of Incident Type 2 Diabetes Mellitus
Akinkuolie, A. O., Pradhan, A. D., Buring, J. E., Ridker, P. M., & Mora, S. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.115.305635 · Cited by 126
Inflammation in the Pathophysiology and Therapy of Cardiometabolic Disease
Donath, M. Y., Meier, D. T., & Böni‐Schnetzler, M. (2019) · Endocrine Reviews · doi:10.1210/er.2019-00002 · Cited by 135
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
Martínez-Colón, G. J., Ratnasiri, K., Chen, R., Jiang, S., ZANLEY, E. J., Rustagi, A., Verma, R., Chen, H. M., Andrews, J. R., Mertz, K. D., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abm9151 · Cited by 140
The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing
Cavadas, C., Aveleira, C. A., Souza, G. F. P., & Velloso, L. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.107 · Cited by 105
Macrophages, fat, and the emergence of immunometabolism
Ferrante, A. W. (2013) · Journal of Clinical Investigation · doi:10.1172/jci73658 · Cited by 102
Multiple benefits of targeting inflammation in the treatment of type 2 diabetes
Donath, M. Y. (2016) · Diabetologia · doi:10.1007/s00125-016-3873-z · Cited by 101
Anti-Inflammatory Strategies Targeting Metaflammation in Type 2 Diabetes
Kuryłowicz, A., & Koźniewski, K. (2020) · Molecules · doi:10.3390/molecules25092224 · Cited by 104
A favorable effect of hydroxychloroquine on glucose and lipid metabolism beyond its anti-inflammatory role
Hage, M. P., Al-Badri, M. R., & Azar, S. T. (2014) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018814547204 · Cited by 98
Interleukin-1 in obesity-related low-grade inflammation: From molecular mechanisms to therapeutic strategies
Ghanbari, M., Maragheh, S. M., Aghazadeh, A., Mehrjuyan, S. R., Hussen, B. M., Shadbad, M. A., Dastmalchi, N., & Safaralizadeh, R. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107765 · Cited by 101
The Role of Mitochondria in Diabetic Kidney Disease
Hallan, S. I., & Sharma, K. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0748-0 · Cited by 93
Inflammatory Trajectory of Type 2 Diabetes: Novel Opportunities for Early and Late Treatment
Pellegrini, V., Grotta, R. L., Carreras, F., Giuliani, A., Sabbatinelli, J., Olivieri, F., Berra, C., Ceriello, A., & Prattichizzo, F. (2024) · Cells · doi:10.3390/cells13191662 · Cited by 105
Interventions for age-related diseases: Shifting the paradigm
Figueira, I., Fernandes, A. M. A., Mladenović, A., Lopez-Contreras, A. J., Henriques, C. M., Selman, C., Ferreiro, E. B., Gonos, E. S., Trejo, J. L., Misra, J., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.09.009 · Cited by 92
DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases
Handelsman, Y., Anderson, J. E., Bakris, G. L., Ballantyne, C. M., Bhatt, D. L., Bloomgarden, Z. T., Bozkurt, B., Budoff, M. J., Butler, J., Cherney, D. Z. I., et al. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155931 · Cited by 99
Self-citation
Imbalanced insulin action in chronic over nutrition: Clinical harm, molecular mechanisms, and a way forward
Williams, K. J., & Wu, X. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.004 · Cited by 83
Salsalate and adiponectin ameliorate hepatic steatosis by inhibition of the hepatokine fetuin-A
Jung, T. W., Youn, B., Choi, H. Y., Lee, S. Y., Hong, H. C., Yang, S. J., Yoo, H. J., Kim, B., Baik, S. H., & Choi, K. M. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.07.034 · Cited by 82
Mechanisms underlying the metabolic actions of testosterone in humans: A narrative review
Dandona, P., Dhindsa, S., Ghanim, H., & Saad, F. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14206 · Cited by 90
Prevention of age-related endothelial dysfunction by habitual aerobic exercise in healthy humans: possible role of nuclear factor κB
Walker, A. E., Kaplon, R. E., Pierce, G. L., Nowlan, M. J., & Seals, D. R. (2014) · Clinical Science · doi:10.1042/cs20140030 · Cited by 80
Translating the Science of Aging into Therapeutic Interventions
Kirkland, J. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025908 · Cited by 78
Repositioning of diabetes treatments for depressive symptoms: A systematic review and meta-analysis of clinical trials
Moulton, C. D., Hopkins, C. W. P., Ismail, K., & Stahl, D. R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.010 · Cited by 81
Targeting inflammatory pathways for the treatment of cardiovascular disease
Ridker, P. M. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht398 · Cited by 78
Differential white cell count and incident type 2 diabetes: the Insulin Resistance Atherosclerosis Study
Lorenzo, C., Hanley, A. J., & Haffner, S. M. (2013) · Diabetologia · doi:10.1007/s00125-013-3080-0 · Cited by 72
Novel agents for the treatment of type 2 diabetes
DeFronzo, R. A., Triplitt, C. L., Abdul-Ghani, M., & Cersosimo, E. (2014) · Diabetes Spectrum · doi:10.2337/diaspect.27.2.100 · Cited by 83
Controlling diabetes by chromium complexes: The role of the ligands
Peng, M., & Yang, X. (2015) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2015.01.002 · Cited by 70
Risk of Rheumatoid Arthritis in Patients with Type 2 Diabetes: A Nationwide Population-Based Case-Control Study
Lu, M., Yan, S.-T., Yin, W., Koo, M., & Lai, N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101528 · Cited by 73
Inhibitory effects of berberine on proinflammatory M1 macrophage polarization through interfering with the interaction between TLR4 and MyD88
Gong, J., Li, J., Dong, H., Chen, G., Qin, X., Hu, M., Yuan, F., Fang, K., Wang, D., Jiang, S., et al. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2710-6 · Cited by 68
Nuclear factor κB–inducing kinase activation as a mechanism of pancreatic β cell failure in obesity
Malle, E. K., Zammit, N. W., Walters, S. N., Koay, Y. C., Wu, J., Tan, B. M., Villanueva, J. E., Brink, R. A., Loudovaris, T., Cantley, J., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20150218 · Cited by 65
Cafeteria diet-induced obesity causes oxidative damage in white adipose
Johnson, A. R., Wilkerson, M. D., Sampey, B. P., Troester, M. A., Hayes, D. N., & Makowski, L. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.113 · Cited by 63
Effect of Targeting Inflammation With Salsalate
Hauser, T. H., Salastekar, N. V., Schaefer, E. J., Desai, T., Goldfine, H. L., Fowler, K. M., Weber, G. M., Welty, F. K., Clouse, M. E., Shoelson, S. E., et al. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.0605 · Cited by 63
Self-citation
Combating Inflammation in Cardiovascular Disease
Sethwala, A., Goh, I. Y., & Amerena, J. V. (2020) · Heart Lung and Circulation · doi:10.1016/j.hlc.2020.09.003 · Cited by 68
Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance
Brénachot, X., Ramadori, G., Ioris, R. M., Veyrat‐Durebex, C., Altirriba, J., Aras, E., Ljubicic, S., Kohno, D., Fabbiano, S., Clément, S., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02074-2 · Cited by 62
Targeting Inflammation to Reduce Residual Cardiovascular Risk
Ajala, O. N., & Everett, B. M. (2020) · Current Atherosclerosis Reports · doi:10.1007/s11883-020-00883-3 · Cited by 65
LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding
Lee, H. H., Sanada, S., An, S. M., Ye, B. J., Lee, J. H., Seo, Y., Lee, C., Lee‐Kwon, W., Küper, C., Neuhofer, W., et al. (2016) · Scientific Reports · doi:10.1038/srep24921 · Cited by 58
Protective Role of St. John’s Wort and Its Components Hyperforin and Hypericin against Diabetes through Inhibition of Inflammatory Signaling: Evidence from In Vitro and In Vivo Studies
Novelli, M., Masiello, P., Beffy, P., & Menegazzi, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218108 · Cited by 63
Latent Inflammation and Insulin Resistance in Adipose Tissue
Stafeev, I., Vorotnikov, A. V., Ratner, E. I., Menshikov, M. Y., & Parfyonova, Y. V. (2017) · International Journal of Endocrinology · doi:10.1155/2017/5076732 · Cited by 61
Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes
Kimple, M. E., Neuman, J. C., Linnemann, A. K., & Casey, P. J. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.40 · Cited by 54
Repurposing Drugs to Target the Diabetes Epidemic
Turner, N. A., Zeng, X., Osborne, B., Rogers, S., & Ye, J.-M. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.01.007 · Cited by 59
Plant Hormones: Key Players in Gut Microbiota and Human Diseases?
Chanclud, E., & Lacombe, B. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2017.07.003 · Cited by 54
Targeting Inflammation Using Salsalate in Patients With Type 2 Diabetes: Effects on Flow-Mediated Dilation (TINSAL-FMD)
Goldfine, A. B., Buck, J. S., Desouza, C. V., Fonseca, V. A., Chen, Y.-D. I., Shoelson, S. E., Jablonski, K. A., Creager, M. A., & for the TINSAL-FMD (Targeting Inflammation Using Salsalate in Type 2 Diabetes–Flow-Mediated Dilation) Ancillary Study Team (2013) · Diabetes Care · doi:10.2337/dc13-0859 · Cited by 51
Self-citation
Influence of Elicitors and Eustressors on the Production of Plant Secondary Metabolites
Alvarado, A. M., Aguirre-Becerra, H., Vázquez-Hernández, C., Magaña-López, E., Parola-Contreras, I., Caicedo-López, L. H., Contreras-Medina, L. M., García‐Trejo, J. F., Guevara-González, R. G., & Feregrino‐Pérez, A. A. (2019) · Springer eBooks · doi:10.1007/978-981-13-7154-7_11 · Cited by 51
Can aging be 'drugged'?
Riera, C. E., & Dillin, A. G. (2015) · Nature Medicine · doi:10.1038/nm.4005 · Cited by 48
Involvements of long noncoding RNAs in obesity‐associated inflammatory diseases
Wijesinghe, S. N., Nicholson, T. A., Tsintzas, K., & Jones, S. W. (2020) · Obesity Reviews · doi:10.1111/obr.13156 · Cited by 48
Treatment of type 2 diabetes by targeting interleukin-1: a meta-analysis of 2921 patients
Kataria, Y., Ellervik, C., & Mandrup-Poulsen, T. R. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00743-6 · Cited by 50
Effect of Periodontal Treatment on HbA1c among Patients with Prediabetes
Kocher, T., Holtfreter, B., Petersmann, A., Eickholz, P., Hoffmann, T. K., Kaner, D., Kim, T., Meyle, J., Schlagenhauf, U., Doering, S., et al. (2018) · Journal of Dental Research · doi:10.1177/0022034518804185 · Cited by 47
Targeting P-selectin glycoprotein ligand-1/P-selectin interactions as a novel therapy for metabolic syndrome
Patel, M. S., Miranda-Nieves, D., Chen, J., Haller, C. A., & Chaikof, E. L. (2016) · Translational research · doi:10.1016/j.trsl.2016.11.007 · Cited by 46
Effects of anti-inflammatory therapies on glycemic control in type 2 diabetes mellitus
Li, D., Zhong, J., Zhang, Q., & Zhang, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1125116 · Cited by 54
Salsalate Activates Brown Adipose Tissue in Mice
van Dam, A. D., Nahon, K. J., Kooijman, S., van den Berg, S. M., Kanhai, A. A., Kikuchi, T., Heemskerk, M. M., van Harmelen, V., Lombès, M., van den Hoek, A. M., et al. (2014) · Diabetes · doi:10.2337/db14-1125 · Cited by 41
Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice
Wang, N., Tian, X., Chen, Y., Tan, H.-Q., Xie, P.-J., Shao-jun, C., Fu, Y., Chen, Y., Xu, W., & Wei, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-14408-7 · Cited by 41
Self-citation
Targeting inflammation through a physical active lifestyle and pharmaceuticals for the treatment of type 2 diabetes
Knudsen, S. H., & Pedersen, B. K. (2015) · Current Diabetes Reports · doi:10.1007/s11892-015-0642-1 · Cited by 41
Salicylic acid-mediated plant defense: Recent developments, missing links, and future outlook
Palmer, I. A., Shang, Z., & Fu, Z. Q. (2017) · Frontiers in Biology · doi:10.1007/s11515-017-1460-4 · Cited by 41
Role of obesity-induced inflammation in the development of insulin resistance and type 2 diabetes: history of the research and remaining questions
Kim, J., & Lee, J. (2021) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2040188.094 · Cited by 47
Ultrasonic-assisted efficient synthesis of inclusion complexes of salsalate drug and β-cyclodextrin derivatives for potent biomedical applications
Mohandoss, S., Edison, T. N. J. I., Atchudan, R., Palanisamy, S., Prabhu, N. M., Napoleon, A. A., You, S., & Lee, Y. R. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114358 · Cited by 39
Skeletal muscle non-shivering thermogenesis as an attractive strategy to combat obesity
Li, H., Wang, C., Li, L., & Li, L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119024 · Cited by 38
Efficacy and Safety of Diacerein in Patients With Inadequately Controlled Type 2 Diabetes: A Randomized Controlled Trial
Cardoso, C. R. L., Leite, N. C., Carlos, F., Loureiro, A. A., Viegas, B. B., & Salles, G. F. (2017) · Diabetes Care · doi:10.2337/dc17-0374 · Cited by 38
Contributions of innate type 2 inflammation to adipose function
Bolus, W. R., & Hasty, A. H. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r085993 · Cited by 42
The Potential Role of Fatty Acids in Treating Diabetic Neuropathy
Yorek, M. A. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1046-9 · Cited by 38

Authors: Goldfine, A. B., Fonseca, V., Jablonski, K. A., Chen, Y.-D. I., Tipton, L., Staten, M. A., & Shoelson, S. E.
Affiliations: Tulane University (US)
Corresponding author: Shoelson, Steven E.
ORCID: Goldfine, Allison B.
Fonseca, Vivian
Chen, Yii-Der Ida
Tipton, Laura
Venue: Annals of Internal Medicine
Publisher: American College of Physicians
Published: 2013-07-02
Volume: 159
Issue: 1
Pages: 1-12
ISSN: 0003-4819 (ISSN-L)
1539-3704
DOI: 10.7326/0003-4819-159-1-201307020-00003
PMC: PMC4128629
OpenAlex: W2031980199
Cited by: 251
References: 55
Citations by year: 2026: 6 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 10 · 2021: 16 · 2020: 19 · 2019: 19 · 2018: 12 · 2017: 20 · 2016: 38 · 2015: 31 · 2014: 28 · 2013: 15
FWCI: 29.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations: Annals of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000124, UL1TR000454, 5p50hl083813-05)
National Heart, Lung, and Blood Institute (P50 HL83813, P50-HL083813)
National Institute of General Medical Sciences (U54GM104940)
National Institute of Diabetes and Digestive and Kidney Diseases (RC4DK090792, U01DK074556, P30 DK03836, P30DK036836, P30DK063491)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: salsalate, type 2 diabetes, glycemic control, HbA1c, nonsteroidal anti-inflammatory drugs, anti-inflammatory activity, white blood cell count, adiponectin, uric acid, triglycerides, urinary albumin, estimated glomerular filtration rate, drug safety, long-term efficacy, weight gain
MeSH terms: Adolescent, Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glycated Hemoglobin, Humans, Kidney, Male, Middle Aged, Salicylates, Single-Blind Method, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Salicylate (Salsalate) in Patients With Type 2 Diabetes: A Randomized Trial

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks