Targeting inflammation through a physical active lifestyle and pharmaceuticals for the treatment of type 2 diabetes

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

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Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

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Inflammation and insulin resistance

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Adipokines in inflammation and metabolic disease

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C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus

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Resveratrol improves health and survival of mice on a high-calorie diet

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

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Type 2 diabetes as an inflammatory disease

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Rosuvastatin to Prevent Vascular Events in Men and Women With Elevated C-Reactive Protein

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The anti-inflammatory effect of exercise

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Muscles, exercise and obesity: skeletal muscle as a secretory organ

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

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IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

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Statins and risk of incident diabetes: A collaborative meta-analysis of randomised statin trials

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Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

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Protection from obesity-induced insulin resistance in mice lacking TNF-α function

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General and abdominal adiposity and risk of death in Europe

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Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of <i>Ikkβ</i>

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

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Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes

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Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein

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Evidence for prescribing exercise as therapy in chronic disease

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Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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Macrophage-mediated inflammation in metabolic disease

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NIDDM as a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X

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Interleukin-6-deficient mice develop mature-onset obesity

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IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans

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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

Maedler, K., Sergeev, P., Ris, F., Oberholzer, J., Joller‐Jemelka, H. I., Spinas, G. A., Kaiser, N., Halban, P. A., & Donath, M. Y. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92172 · Cited by 1,114 · see citing works

The role of exercise and PGC1α in inflammation and chronic disease

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Correlations and interactions in the production of interleukin-6 (IL-6), IL-1, and tumor necrosis factor (TNF) in human blood mononuclear cells: IL-6 suppresses IL-1 and TNF

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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

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Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

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Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

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Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy

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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

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Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

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Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans

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Increased Number of Islet-Associated Macrophages in Type 2 Diabetes

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Interleukin‐6 myokine signaling in skeletal muscle: a double‐edged sword?

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Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

Lee, H., Kim, J.-J., Kim, H. J., Shong, M., Ku, B. J., & Jo, E. (2012) · Diabetes · doi:10.2337/db12-0420 · Cited by 730 · see citing works

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

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Targeting inflammation in the treatment of type 2 diabetes: time to start

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The diseasome of physical inactivity – and the role of myokines in muscle–fat cross talk

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Tumor Necrosis Factor-α Induces Skeletal Muscle Insulin Resistance in Healthy Human Subjects via Inhibition of Akt Substrate 160 Phosphorylation

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T cell activation-associated hepatic injury: mediation by tumor necrosis factors and protection by interleukin 6

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Muscle as a secretory organ

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Effects of an Engineered Human Anti–TNF-α Antibody (CDP571) on Insulin Sensitivity and Glycemic Control in Patients With NIDDM

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Metformin Inhibits Proinflammatory Responses and Nuclear Factor-κB in Human Vascular Wall Cells

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Exercise as an anti-inflammatory therapy for rheumatic diseases—Myokine regulation

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High-Dose Resveratrol Supplementation in Obese Men

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Inflammatory mediators and islet ?-cell failure: a link between type 1 and type 2 diabetes

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Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes

Larsen, C. M., Faulenbach, M., Vaag, A., Ehses, J. A., Donath, M. Y., & Mandrup-Poulsen, T. (2009) · Diabetes Care · doi:10.2337/dc09-0533 · Cited by 401 · see citing works

One-year supplementation with a grape extract containing resveratrol modulates inflammatory-related microRNAs and cytokines expression in peripheral blood mononuclear cells of type 2 diabetes and hypertensive patients with coronary artery disease

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Glucose-induced β cell production of IL-1β contributes to glucotoxicity in human pancreatic islets

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Salsalate Improves Glycemia and Inflammatory Parameters in Obese Young Adults

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Circulating levels of TNF-alpha and IL-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes

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Dose-Dependent Effects of Recombinant Human Interleukin-6 on Glucose Regulation

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TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

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Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

Böni‐Schnetzler, M., Thorne, J. T., Parnaud, G., Marselli, L., Ehses, J. A., Kerr-Conte, J. A., Pattou, F. N., Halban, P. A., Weir, G. C., & Donath, M. Y. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0396 · Cited by 319 · see citing works

Metabolic Responses to Reduced Daily Steps in Healthy Nonexercising Men

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Effects of Gevokizumab on Glycemia and Inflammatory Markers in Type 2 Diabetes

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Why blockade of the renin–angiotensin system reduces the incidence of new-onset diabetes

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Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes

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Metabolic and Vascular Effects of Tumor Necrosis Factor-α Blockade with Etanercept in Obese Patients with Type 2 Diabetes

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Exenatide Exerts a Potent Antiinflammatory Effect

Chaudhuri, A., Ghanim, H., Vora, M., Sia, C. L., Korzeniewski, K., Dhindsa, S., Makdissi, A., & Dandona, P. (2012) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2011-1508 · Cited by 284 · see citing works

Human endotoxemia as a model of systemic inflammation

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Interleukin-6 regulates pancreatic α-cell mass expansion

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Effects of Etanercept in Patients With the Metabolic Syndrome

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Salicylate (Salsalate) in Patients With Type 2 Diabetes: A Randomized Trial

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Endocrinologic and metabolic effects of interleukin-6 in humans

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Sitagliptin Exerts an Antinflammatory Action

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Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men

Gliemann, L., Schmidt, J. F., Olesen, J., Biensø, R. S., Peronard, S. L., Grandjean, S. U., Mortensen, S. P., Nyberg, M., Bangsbo, J., Pilegaard, H., et al. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.258061 · Cited by 244 · see citing works

Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus

Hogan, A. E., Gaoatswe, G., Lynch, L., Corrigan, M. A., Woods, C., O’Connell, J., & O’Shea, D. (2014) · Diabetologia · doi:10.1007/s00125-013-3145-0 · Cited by 239 · see citing works

Muscle-derived interleukin-6—a possible link between skeletal muscle, adipose tissue, liver, and brain

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Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

Westwell-Roper, C. Y., Ehses, J. A., & Verchere, C. B. (2013) · Diabetes · doi:10.2337/db13-0863 · Cited by 225 · see citing works

No Increased Insulin Sensitivity after a Single Intravenous Administration of a Recombinant Human Tumor Necrosis Factor Receptor: Fc Fusion Protein in Obese Insulin-Resistant Patients

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Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes

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Double-Blind, Randomized Study Evaluating the Glycemic and Anti-inflammatory Effects of Subcutaneous LY2189102, a Neutralizing IL-1β Antibody, in Patients With Type 2 Diabetes

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