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Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond

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Untitled work

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Assessing the Performance of Prediction Models: A Framework for Traditional and Novel Measures

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ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

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Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers

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Factors of Risk in the Development of Coronary Heart Disease—Six-Year Follow-up Experience: The Framingham Study

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Glycated hemoglobin, diabetes, and cardiovascular risk in nondiabetic adults

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Genomewide Association Studies and Assessment of the Risk of Disease

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Hyponatremia and Mortality among Patients on the Liver-Transplant Waiting List

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Severe hypoglycemia and risks of vascular events and death

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A Predictive Model for Progression of Chronic Kidney Disease to Kidney Failure

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Comments on ‘Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond’ by M. J. Pencina, R. B. D'Agostino Sr, R. B. D'Agostino Jr, R. S. Vasan, Statistics in Medicine (DOI: 10.1002/sim.2929)

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Limitations of the Odds Ratio in Gauging the Performance of a Diagnostic, Prognostic, or Screening Marker

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Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies

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Association of Fibrosis With Mortality and Sudden Cardiac Death in Patients With Nonischemic Dilated Cardiomyopathy

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Criteria for Evaluation of Novel Markers of Cardiovascular Risk

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C-reactive protein, fibrinogen, and cardiovascular disease prediction

The Emerging Risk Factors Collaboration (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107477 · Cited by 1,150 · see citing works

Coronary Artery Calcium Score and Risk Classification for Coronary Heart Disease Prediction

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Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals

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Association of Troponin T Detected With a Highly Sensitive Assay and Cardiac Structure and Mortality Risk in the General Population

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Association Between Postoperative Troponin Levels and 30-Day Mortality Among Patients Undergoing Noncardiac Surgery

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Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study

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Selection Criteria for Lung-Cancer Screening

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Comparison of Risk Prediction Using the CKD-EPI Equation and the MDRD Study Equation for Estimated Glomerular Filtration Rate

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Clinical risk factors, DNA variants, and the development of type 2 diabetes

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A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease

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Use of Multiple Biomarkers to Improve the Prediction of Death from Cardiovascular Causes

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Assessing the calibration of mortality benchmarks in critical care: The Hosmer-Lemeshow test revisited*

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Predicting the 30-Year Risk of Cardiovascular Disease

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European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)

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Anatomical and clinical characteristics to guide decision making between coronary artery bypass surgery and percutaneous coronary intervention for individual patients: development and validation of SYNTAX score II

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Carotid-Wall Intima–Media Thickness and Cardiovascular Events

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Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction: A Meta-analysis

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Genotype score in addition to common risk factors for prediction of type 2 diabetes

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Association of Serial Measures of Cardiac Troponin T Using a Sensitive Assay With Incident Heart Failure and Cardiovascular Mortality in Older Adults

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Polymorphisms Associated with Cholesterol and Risk of Cardiovascular Events

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Diagnosis of DVT

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A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

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C-Reactive Protein as a Risk Factor for Coronary Heart Disease: A Systematic Review and Meta-analyses for the U.S. Preventive Services Task Force

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Two further applications of a model for binary regression

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Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community

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Lipid-Related Markers and Cardiovascular Disease Prediction

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Predictive accuracy of the Framingham coronary risk score in British men:prospective cohort study

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Serial Changes in Highly Sensitive Troponin I Assay and Early Diagnosis of Myocardial Infarction

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Interpreting Incremental Value of Markers Added to Risk Prediction Models

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The effect of including C-reactive protein in cardiovascular risk prediction models for women

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Detection of Chronic Kidney Disease With Creatinine, Cystatin C, and Urine Albumin-to-Creatinine Ratio and Association With Progression to End-Stage Renal Disease and Mortality

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Advances in Measuring the Effect of Individual Predictors of Cardiovascular Risk: The Role of Reclassification Measures

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Performance of Common Genetic Variants in Breast-Cancer Risk Models

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'European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)' The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) * Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). [Eur Heart J 2012;33:1635-1701, doi: 10.1093/eurheartj/ehs092]

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Emerging Risk Factors for Coronary Heart Disease: A Summary of Systematic Reviews Conducted for the U.S. Preventive Services Task Force

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Framingham risk function overestimates risk of coronary heart disease in men and women from Germany—results from the MONICA Augsburg and the PROCAM cohorts

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Association between a literature-based genetic risk score and cardiovascular events in women

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Evaluation of Newer Risk Markers for Coronary Heart Disease Risk Classification: A Cohort Study

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Novel metrics for evaluating improvement in discrimination: net reclassification and integrated discrimination improvement for normal variables and nested models

Pencina, M. J., D’Agostino, R. B., & Demler, O. (2011) · Statistics in Medicine · doi:10.1002/sim.4348 · Cited by 348 · see citing works

Statistical methods for assessment of added usefulness of new biomarkers

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Association Between Familial Atrial Fibrillation and Risk of New-Onset Atrial Fibrillation

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Consensus recommendations for risk stratification in multiple myeloma: report of the International Myeloma Workshop Consensus Panel 2

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Comparisons of established risk prediction models for cardiovascular disease: systematic review

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American Society of Clinical Oncology Clinical Practice Guideline Update on the Use of Pharmacologic Interventions Including Tamoxifen, Raloxifene, and Aromatase Inhibition for Breast Cancer Risk Reduction

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Prevalence and Prognosis of Unrecognized Myocardial Infarction Determined by Cardiac Magnetic Resonance in Older Adults

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Assessment of Claims of Improved Prediction Beyond the Framingham Risk Score

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Comparison of the Framingham and Reynolds Risk Scores for Global Cardiovascular Risk Prediction in the Multiethnic Women's Health Initiative

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Sudden Death After Myocardial Infarction

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How to Develop, Validate, and Compare Clinical Prediction Models Involving Radiological Parameters: Study Design and Statistical Methods

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Polygenic risk scores in cardiovascular risk prediction: A cohort study and modelling analyses

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Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes

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Accurate prediction of responses to transarterial chemoembolization for patients with hepatocellular carcinoma by using artificial intelligence in contrast-enhanced ultrasound

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Combination of 68 Ga-PSMA PET/CT and Multiparametric MRI Improves the Detection of Clinically Significant Prostate Cancer: A Lesion-by-Lesion Analysis

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Validation of a Machine Learning Algorithm to Predict 180-Day Mortality for Outpatients With Cancer

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Assessing Risk for Adverse Outcomes in Older Adults: The Need to Include Both Physical Frailty and Cognition

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Comparison of Atherosclerotic Calcification in Major Vessel Beds on the Risk of All-Cause and Cause-Specific Mortality

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Machine Learning–Based Models Incorporating Social Determinants of Health vs Traditional Models for Predicting In-Hospital Mortality in Patients With Heart Failure

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Evaluation of performance measures in predictive artificial intelligence models to support medical decisions: overview and guidance

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Evaluation of the Usefulness of Consensus Definitions of Sarcopenia in Older Men: Results from the Observational Osteoporotic Fractures in Men Cohort Study

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Endothelial Glycocalyx as Biomarker for Cardiovascular Diseases: Mechanistic and Clinical Implications

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Recurrence of Pancreatic Neuroendocrine Tumors and Survival Predicted by Ki67

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Addition of tumor multiplicity improves the prognostic performance of the hepatoma arterial‐embolization prognostic score

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Beyond discrimination: A comparison of calibration methods and clinical usefulness of predictive models of readmission risk

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C 2 HEST Score and Prediction of Incident Atrial Fibrillation in Poststroke Patients: A French Nationwide Study

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Development and Validation of a Pediatric Comorbidity Index

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Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study

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Serum Acylcarnitines and Risk of Cardiovascular Death and Acute Myocardial Infarction in Patients With Stable Angina Pectoris

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Key steps and common pitfalls in developing and validating risk models

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Prediction of Incident Major Osteoporotic and Hip Fractures by Trabecular Bone Score (TBS) and Prevalent Radiographic Vertebral Fracture in Older Men

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Development and Validation of the Summary Elixhauser Comorbidity Score for Use With ICD-10-CM–Coded Data Among Older Adults

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Prospective Associations of Systemic and Urinary Choline Metabolites with Incident Type 2 Diabetes

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Net reclassification index at event rate: properties and relationships

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Independent Associations Between Metabolic Syndrome Severity and Future Coronary Heart Disease by Sex and Race

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Multidimensional Prognostic Index Predicts Mortality and Length of Stay During Hospitalization in the Older Patients: A Multicenter Prospective Study

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Comparison of the CHA 2 DS 2 -VASc, CHADS 2 , HAS-BLED, ORBIT, and ATRIA Risk Scores in Predicting Non–Vitamin K Antagonist Oral Anticoagulants-Associated Bleeding in Patients With Atrial Fibrillation

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Determining Risk of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on Epidemiologic Factors and Genetic Variants

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Association between self-reported functional capacity and major adverse cardiac events in patients at elevated risk undergoing noncardiac surgery: a prospective diagnostic cohort study

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Prediction of type 2 diabetes using genome-wide polygenic risk score and metabolic profiles: A machine learning analysis of population-based 10-year prospective cohort study

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Vital signs and their cross-correlation in sepsis and NEC: a study of 1,065 very-low-birth-weight infants in two NICUs

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Cohen’s Kappa Coefficient as a Measure to Assess Classification Improvement following the Addition of a New Marker to a Regression Model

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Including mRECIST in the Metroticket 2.0 criteria improves prediction of hepatocellular carcinoma-related death after liver transplant

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Clinical Utility of Using Lumbar Spine Trabecular Bone Score to Adjust Fracture Probability: The Manitoba BMD Cohort

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Predicting all‐cause readmissions using electronic health record data from the entire hospitalization: Model development and comparison

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A deep learning-based electrocardiogram risk score for long term cardiovascular death and disease

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Beyond Coronary Calcification, Family History, and C-Reactive Protein

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Do air pollution and neighborhood greenness exposures improve the predicted cardiovascular risk?

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Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus

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Dynamic α-Fetoprotein Response and Outcomes After Liver Transplant for Hepatocellular Carcinoma

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Older Adults, “Malignant” Left Ventricular Hypertrophy, and Associated Cardiac-Specific Biomarker Phenotypes to Identify the Differential Risk of New-Onset Reduced Versus Preserved Ejection Fraction Heart Failure

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Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies

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SemSeq4FD: Integrating global semantic relationship and local sequential order to enhance text representation for fake news detection

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The Choice of Normative Pediatric Reference Database Changes Spine Bone Mineral Density Z-Scores But Not the Relationship Between Bone Mineral Density and Prevalent Vertebral Fractures

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Acute kidney injury as an independent risk factor for unplanned 90-day hospital readmissions

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Radiomics approach for preoperative identification of stages I−II and III−IV of esophageal cancer

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A Comparison of the Updated Diamond-Forrester, CAD Consortium, and CONFIRM History-Based Risk Scores for Predicting Obstructive Coronary Artery Disease in Patients With Stable Chest Pain

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Validation and comparison of imaging-based scores for prediction of early stroke risk after transient ischaemic attack: a pooled analysis of individual-patient data from cohort studies

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Sequential organ failure assessment score is an excellent operationalization of disease severity of adult patients with hospitalized community acquired pneumonia – results from the prospective observational PROGRESS study

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Trabecular bone score may improve FRAX® prediction accuracy for major osteoporotic fractures in elderly Japanese men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Cohort Study

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Challenges of developing a cardiovascular risk calculator for patients with rheumatoid arthritis

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A multicentre validation study of the deep learning-based early warning score for predicting in-hospital cardiac arrest in patients admitted to general wards

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ACC/AHA guidelines superior to ESC/EAS guidelines for primary prevention with statins in non-diabetic Europeans: the Copenhagen General Population Study

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Sentinel node biopsy in patients with melanoma improves the accuracy of staging when added to clinicopathological features of the primary tumor

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Plasma Leucine-Rich α-2-Glycoprotein 1 Predicts Rapid eGFR Decline and Albuminuria Progression in Type 2 Diabetes Mellitus

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Key Concepts and Limitations of Statistical Methods for Evaluating Biomarkers of Kidney Disease

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In which patients does lumbar spine trabecular bone score (TBS) have the largest effect?

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Assessing the impact of social determinants of health on predictive models for potentially avoidable 30-day readmission or death

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Net reclassification improvement and integrated discrimination improvement require calibrated models: relevance from a marker and model perspective

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Peripheral blood RNA biomarkers for cardiovascular disease from bench to bedside: a position paper from the EU-CardioRNA COST action CA17129

Vanhaverbeke, M., Attard, R., Barteková, M., Ben‐Aicha, S., Brandenburger, T., de Gonzalo‐Calvo, D., Emanueli, C., Farrugia, R. C., Grillari, J., Hackl, M., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab327 · Cited by 54 · see citing works

Application of net reclassification index to non-nested and point-based risk prediction models: a review

Thomas, L. E., O'Brien, E. C., Piccini, J. P., D’Agostino, R. B., & Pencina, M. J. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy345 · Cited by 54 · see citing works

Prediction modeling—part 1: regression modeling

Au, E. H. K., Francis, A., Bernier-Jean, A., & Teixeira-Pinto, A. M. (2020) · Kidney International · doi:10.1016/j.kint.2020.02.007 · Cited by 54 · see citing works

A CT-based radiomics nomogram for distinguishing between benign and malignant bone tumours

Sun, W., Liu, S., Guo, J., Liu, S., Hao, D., Hou, F., Wang, H., & Xu, W. (2021) · Cancer Imaging · doi:10.1186/s40644-021-00387-6 · Cited by 53 · see citing works

Net Reclassification Improvement: Computation, Interpretation, and Controversies A Literature Review and Clinician’s Guide

Leening, M. J. G., Moniek, M., Vedder, M., Jacqueline, M., Witteman, C. M., Michael, P., Pencina, J., & Steyerberg, E. W. (2015)

Commentary: Reporting standards are needed for evaluations of risk reclassification

Pepe, M. S., & Janes, H. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr083 · Cited by 26 · see citing works

The Net Reclassification Index (NRI): a Misleading Measure of Prediction Improvement with Miscalibrated or Overfit Models

PEPE, M. S., Fang, J., Feng, Z., Gerds, T. A., & Hilden, J. (2013) · Collection of Biostatistics Research Archive · Cited by 13 · see citing works

Net reclassification improvement and integrated discrimination improvement require calibrated models: relevance from a marker and model perspective

Leening, M. J. G., Steyerberg, E. W., CALSTER, B. V., D’Agostino, R. B., & Pencina, M. J. (2014) · Statistics in Medicine · doi:10.1002/sim.6133 · Cited by 55 · see citing works

Performance of the Net Reclassification Improvement for Nonnested Models and a Novel Percentile-Based Alternative

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