Latz, Eicke

Inflammasome signalling in brain function and neurodegenerative disease

Heneka, M. T., McManus, R. M., & Latz, E. (2018) · Nature Reviews Neuroscience

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 836

HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2

Yu, M., Wang, H., Ding, A., Golenbock, D. T., Latz, E., Czura, C. J., Fenton, M. J., Tracey, K. J., & Yang, H. (2006) · Shock

Immune Response and InflammationAdvanced Glycation End Products research

Cited by 832

A guiding map for inflammation

Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., et al. (2017) · Nature Immunology

Immune Response and InflammationInflammation biomarkers and pathways

Cited by 831

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Franklin, B. S., Bossaller, L., De Nardo, D., Ratter, J. M., Stutz, A., Engels, G., Brenker, C., Nordhoff, M., Mirandola, S. R., Al-Amoudi, A., et al. (2014) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 773

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Gaidt, M. M., Ebert, T. S., Chauhan, D., Ramshorn, K., Pinci, F., Zuber, S., O’Duill, F., Schmid-Burgk, J. L., Hoss, F., Buhmann, R., et al. (2017) · Cell

Inflammasome and immune disordersinterferon and immune responses

Cited by 638

A Novel Host-Parasite Lipid Cross-talk

van der Kleij, D., Latz, E., Brouwers, J. F. H. M., Kruize, Y. C. M., Schmitz, M., Kurt-Jones, E. A., Espevik, T., de Jong, E. C., Kapsenberg, M. L., Golenbock, D. T., et al. (2002) · Journal of Biological Chemistry

Parasites and Host InteractionsImmune Response and Inflammation

Cited by 587

Immediate and long-term consequences of COVID-19 infections for the development of neurological disease

Heneka, M. T., Golenbock, D., Latz, E., Morgan, D., & Brown, R. (2020) · Alzheimer's Research & Therapy

Long-Term Effects of COVID-19COVID-19 Clinical Research Studies

Cited by 555

Erratum: Targeting the NLRP3 inflammasome in inflammatory diseases

Mangan, M. S. J., Olhava, E. J., Roush, W. R., Seidel, H. M., Glick, G. D., & Latz, E. (2018) · Nature Reviews Drug Discovery

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 465

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

Bertheloot, D., & Latz, E. (2017) · Cellular & Molecular Immunology

Immune Response and InflammationIL-33, ST2, and ILC Pathways

Cited by 455

NLRP3 inflammasomes link inflammation and metabolic disease

De Nardo, D., & Latz, E. (2011) · Trends in Immunology

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 425

The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

Schoenemeyer, A., Barnes, B. J., Mancl, M. E., Latz, E., Goutagny, N., Pitha, P. M., Fitzgerald, K. A., & Golenbock, D. T. (2005) · Journal of Biological Chemistry

interferon and immune responsesImmune Response and Inflammation

Cited by 411

Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes

Scheiblich, H., Dansokho, C., Mercan, D., Schmidt, S. V., Bousset, L., Wischhof, L., Eikens, F., Odainic, A., Spitzer, J., Griep, A., et al. (2021) · Cell

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 360

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

Tejera, D., Mercan, D., Sanchez‐Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & Heneka, M. T. (2019) · The EMBO Journal

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 351

Noncanonical Autophagy Is Required for Type I Interferon Secretion in Response to DNA-Immune Complexes

Henault, J., Martinez, J., Riggs, J. M., Tian, J., Mehta, P., Clarke, L., Sasai, M., Latz, E., Brinkmann, M. M., Iwasaki, A., et al. (2012) · Immunity

Immune Response and InflammationAutophagy in Disease and Therapy

Cited by 348

Innate Immunity and Neurodegeneration

Labzin, L. I., Heneka, M. T., & Latz, E. (2018) · Annual Review of Medicine

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 319

Apolipoprotein C3 induces inflammation and organ damage by alternative inflammasome activation

Zewinger, S., Reiser, J., Jankowski, V., Alansary, D., Hahm, E., Triem, S., Klug, M., Schunk, S. J., Schmit, D., Kramann, R., et al. (2020) · Nature Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 280

Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment

Schneider, K. M., Mohs, A., Gui, W., Galvez, E. J. C., Candels, L. S., Hoenicke, L., Muthukumarasamy, U., Holland, C. H., Elfers, C., Kilic, K., et al. (2022) · Nature Communications

Gut microbiota and healthImmune cells in cancer

Cited by 225

β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia

Friker, L. L., Scheiblich, H., Hochheiser, I. V., Brinkschulte, R., Riedel, D., Latz, E., Geyer, M., & Heneka, M. T. (2020) · Cell Reports

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 191

NLRP3 inflammasome activation in inflammaging

Latz, E., & Duewell, P. (2018) · Seminars in Immunology

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 174

The Inflammasome in Atherosclerosis and Type 2 Diabetes

Masters, S. L., Latz, E., & O’Neill, L. A. J. (2011) · Science Translational Medicine

Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic Diseases

Cited by 169

Activation of the NLRP 3 inflammasome in microglia: the role of ceramide

Scheiblich, H., Schlütter, A., Golenbock, D. T., Latz, E., Martinez‐Martinez, P., & Heneka, M. T. (2017) · Journal of Neurochemistry

Inflammasome and immune disordersNeuroinflammation and Neurodegeneration Mechanisms

Cited by 147

Microglial PD-1 stimulation by astrocytic PD-L1 suppresses neuroinflammation and Alzheimer’s disease pathology

Kummer, M. P., Ising, C., Kummer, C., Sarlus, H., Griep, A., Vieira‐Saecker, A., Schwartz, S., Halle, A., Brückner, M., Händler, K., et al. (2021) · The EMBO Journal

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 127

ATF3 Is a Key Regulator of Macrophage IFN Responses

Labzin, L. I., Schmidt, S. V., Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lütjohann, D., Schultze, J. L., Latz, E., et al. (2015) · The Journal of Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 124

Microglial NLRP3 Inflammasome Activation Upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies

Scheiblich, H., Bousset, L., Schwartz, S., Griep, A., Latz, E., Melki, R., & Heneka, M. T. (2021) · The Journal of Immunology

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 122