Kosik, Kenneth S.

Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development

Nowakowski, T. J., Rani, N., Golkaram, M., Zhou, H. R., Alvarado, B., Huch, K., West, J. A., Leyrat, A., Pollen, A. A., Kriegstein, A. R., et al. (2018) · Nature Neuroscience

MicroRNA in disease regulationNeurogenesis and neuroplasticity mechanisms

Cited by 166

A molecular signature for anastasis, recovery from the brink of apoptotic cell death

Sun, G., Guzman, E., Balasanyan, V., Conner, C. M., Wong, K., Zhou, H. R., Kosik, K. S., & Montell, D. J. (2017) · Journal of Cell Biology

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 151

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

Sohn, P. D., Huang, C. T.-L., Yan, R., Fan, L., Tracy, T. E., Camargo, C. M., Montgomery, K. M., Arhar, T., Mok, S.-A., Freilich, R., et al. (2019) · Neuron

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 148

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

Giraldo, M., Lopera, F., Siniard, A. L., Corneveaux, J. J., Schrauwen, I., Carvajal, J., Muñoz, C., Ramirez-Restrepo, M., Gaiteri, C., Myers, A. J., et al. (2013) · Neurobiology of Aging

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 147

Distinct Roles of Synapsin I and Synapsin II during Neuronal Development

Ferreira, A., Chin, L.-S., Li, L., Lanier, L. M., Kosik, K. S., & Greengard, P. (1998) · Molecular Medicine

Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 131

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

Moguilner, S., Baez, S., Hernandez, H., Migeot, J., Legaz, A., Gonzalez-Gomez, R., Farina, F. R., Prado, P., Cuadros, J., Tagliazucchi, E., et al. (2024) · Nature Medicine

Dementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies

Cited by 128

Cofactors are essential constituents of stable and seeding-active tau fibrils

Fichou, Y., Lin, Y., Rauch, J. N., Vigers, M., Zeng, Z., Srivastava, M., Keller, T. J., Freed, J. H., Kosik, K. S., & Han, S. (2018) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 128

Activation of the neuronal c-Abl tyrosine kinase by amyloid-β-peptide and reactive oxygen species

Alvarez, A. R., Sandoval, P. C., Leal, N. R., Castro, P. U., & Kosik, K. S. (2004) · Neurobiology of Disease

Alzheimer's disease research and treatmentsCell death mechanisms and regulation

Cited by 125

Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells

Fong, H., Wang, C., Knoferle, J., Walker, D., Balestra, M. E., Tong, L. M., Leung, L., Ring, K. L., Seeley, W. W., Karydas, A., et al. (2013) · Stem Cell Reports

Alzheimer's disease research and treatmentsPluripotent Stem Cells Research

Cited by 122

Microglial microRNAs mediate sex-specific responses to tau pathology

Kodama, L., Guzman, E., Etchegaray, J. I., Li, Y., Sayed, F. A., Zhou, L., Zhou, Y., Zhan, L., Le, D., Udeochu, J. C., et al. (2020) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 115

Neuropsychological Profile of a Large Kindred with Familial Alzheimer's Disease Caused by the E280A Single Presenilin-1 Mutation

Ardila, A., Lopera, F., Rosselli, M., Moreno, S., Madrigal, L., Arango-Lasprilla, J. C., Arcos, M., Murcia, C., Arango-Viana, J. C., Ossa, J., et al. (2000) · Archives of Clinical Neuropsychology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 113

Calcineurin is associated with the cytoskeleton of cultured neurons and has a role in the acquisition of polarity.

Ferreira, A., Kincaid, R., & Kosik, K. S. (1993) · Molecular Biology of the Cell

Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanisms

Cited by 110

Human iPSC-derived neuronal model of Tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability

Silva, M. C., Cheng, C., Mair, W., Almeida, S., Fong, H., Biswas, M. H. U., Zhang, Z., Huang, Y., Temple, S., Coppola, G., et al. (2016) · Stem Cell Reports

Alzheimer's disease research and treatmentsAmyotrophic Lateral Sclerosis Research

Cited by 103

Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer’s dementia

Sepulveda-Falla, D., Sanchez, J. S., Almeida, M. C., Boassa, D., Acosta-Uribe, J., Vila-Castelar, C., Ramirez-Gomez, L., Baena, A., Aguillon, D., Villalba-Moreno, N. D., et al. (2022) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 92

MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

Bettcher, B. M., Fitch, R., Wynn, M. J., Lalli, M. A., Elofson, J., Jastrzab, L., Mitic, L., Miller, Z. A., Rabinovici, G. D., Miller, B. L., et al. (2016) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 89

Microtubule-associated Protein 2c Reorganizes Both Microtubules and Microfilaments into Distinct Cytological Structures in an Actin-binding Protein-280–deficient Melanoma Cell Line

Cunningham, C. C., Leclerc, N., Flanagan, L. A., Lu, M., Janmey, P. A., & Kosik, K. S. (1997) · The Journal of Cell Biology

Microtubule and mitosis dynamicsCellular Mechanics and Interactions

Cited by 88

Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns

Arcila, M. L., Betizeau, M., Cambronne, X. A., Guzman, E., Doerflinger, N., Bouhallier, F., Zhou, H., Wu, B., Rani, N., Bassett, D. S., et al. (2014) · Neuron

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 80

Whole-genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease

Lalli, M. A., Bettcher, B. M., Arcila, M. L., Garcia, G., Guzman, C., Madrigal, L., Ramirez, L., Acosta-Uribe, J., Baena, A., Wojta, K. J., et al. (2015) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 73

APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease

Quiroz, Y. T., Aguillon, D., Aguirre-Acevedo, D. C., Vasquez, D., Zuluaga, Y., Baena, A. Y., Madrigal, L., Hincapié, L., Sanchez, J. S., Langella, S., et al. (2024) · New England Journal of Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 63

Origin of the PSEN1 E280A mutation causing early‐onset Alzheimer's disease

Lalli, M. A., Cox, H. C., Arcila, M. L., Cadavid, L., Moreno, S., Garcia, G., Madrigal, L., Reiman, E. M., Arcos‐Burgos, M., Bedoya, G., et al. (2014) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsForensic and Genetic Research

Cited by 60

Pooling/bootstrap-based GWAS (pbGWAS) identifies new loci modifying the age of onset in PSEN1 p.Glu280Ala Alzheimer's disease

Vélez, J. I., Chandrasekharappa, S. C., Henao, E., Martinez, A. F., Harper, U., Jones, M., Solomon, B. D., Lopez, L., Garcia, G., Aguirre-Acevedo, D. C., et al. (2013) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 44

Evolution of new miRNAs and cerebro-cortical development

Kosik, K. S., & Nowakowski, T. (2018) · Annual Review of Neuroscience

Neurogenesis and neuroplasticity mechanismsMicroRNA in disease regulation

Cited by 34

Testing the Conjecture That Quantum Processes Create Conscious Experience

Neven, H., Read, P., Kosik, K. S., Van der Molen, T., Bouwmeester, D., Bodnia, E., Turin, L., & Koch, C. (2024) · Entropy

Philosophy and Theoretical ScienceQuantum Mechanics and Applications

Cited by 33

Along the way to a neurofibrillary tangle: a look at the structure of tau

Kosik, K. S., Kowall, N. W., & McKee, A. (1989) · Annals of Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 31