Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns
Open accessAbstract
Major nonprimate-primate differences in cortico-genesis include the dimensions, precursor lineages, and developmental timing of the germinal zones (GZs). microRNAs (miRNAs) of laser-dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP and the GZ including ventricular zone (VZ) and outer and inner subcompartments of the outer subventricular zone (OSVZ) in area 17 displayed unique miRNA profiles. miRNAs present in primate, but absent in rodent, contributed disproportionately to the differential expression between GZ subregions. Prominent among the validated targets of these miRNAs were cell-cycle and neurogenesis regulators. Coevolution between the emergent miRNAs and their targets suggested that novel miRNAs became integrated into ancient gene circuitry to exert additional control over proliferation. We conclude that multiple cell-cycle regulatory events contribute to the emergence of primate-specific cortical features, including the OSVZ, generated enlarged supragranular layers, largely responsible for the increased primate cortex computational abilities.
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Primate-specific co-evolution of microRNAs and their targets in the germinal zones may have contributed to neocortical expansion in primates.
“Primate-specific co-evolution of microRNAs and their targets in the germinal zones may have contributed to neocortical expansion in primates (Arcila et al., 2014).”
From Genetic Changes Shaping the Human Brain (2015) · cites this paper as Arcila et al., 2014
Primate-specific microRNAs target cell-cycle and neurogenesis regulators, thereby increasing proliferation of neocortical progenitors.
“The primate-specific microRNAs target cell-cycle and neurogenesis regulators, thereby increasing proliferation of neocortical progenitors.”
From Genetic Changes Shaping the Human Brain (2015) · cites this paper as Arcila et al., 2014
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- Authors
- Arcila, M. L., Betizeau, M., Cambronne, X. A., Guzman, E., Doerflinger, N., Bouhallier, F., Zhou, H., Wu, B., Rani, N., Bassett, D. S., Borello, U., Huissoud, C., Goodman, R. H., Dehay, C., & Kosik, K. S.
- Affiliations
- University of California, Santa Barbara (US)
- Lyon 1 Université (FR)
- Oregon Health & Science University (US)
- Corresponding author
- Dehay, Colette
- Kosik, Kenneth S.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 81
- Issue
- 6
- Pages
- 1255-1262
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4020629
- OpenAlex
- W2047794859
- Cited by
- 80
- References
- 51
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 2
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Agenția Națională pentru Cercetare și Dezvoltare
- Agence Nationale de la Recherche (ANR-11-IDEX-0007, ANR-11-LABX-0042, ANR-10-LABX-0061)
- National Institute of Mental Health (R01MH093661)
- National Institute of Neurological Disorders and Stroke (F32NS076094, R21NS079317)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- microRNA, germinal zone, cortical development, macaque visual cortex, outer subventricular zone, ventricular zone, cortical plate, cell cycle regulation, neurogenesis, supragranular layers
- MeSH terms
- Animals, Cell Cycle, Female, Gene Expression Regulation, Macaca, Neurons, Visual Cortex, Evolution, Molecular, MicroRNAs, Neurogenesis
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