Watkins, Linda R.

The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress**This research was supported by NIMH Grant MH-50479 and the Undergraduate Research Opportunities Program at the University of Colorado at Boulder.

Deak, T., Nguyen, K. T., Ehrlich, A. L., Watkins, L. R., Spencer, R. L., Maier, S. F., Licinio, J., Wong, M.-L., Chrousos, G. P., Webster, E., et al. (1999) · Endocrinology

Stress Responses and CortisolNeuropeptides and Animal Physiology

Cited by 242

Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming

Frank, M. G., Weber, M. D., Watkins, L. R., & Maier, S. F. (2015) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation

Cited by 237

Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

Barrientos, R. M., Hein, A. M., Frank, M. G., Watkins, L. R., & Maier, S. F. (2012) · The Journal of Neuroscience

Anesthesia and Neurotoxicity ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 235

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

Barrientos, R. M., Frank, M. G., Hein, A. M., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2009) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Cited by 226

Stress Induces the Danger-Associated Molecular Pattern HMGB-1 in the Hippocampus of Male Sprague Dawley Rats: A Priming Stimulus of Microglia and the NLRP3 Inflammasome

Weber, M. D., Frank, M. G., Tracey, K. J., Watkins, L. R., & Maier, S. F. (2015) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disorders

Cited by 215

Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin

Maier, S. F., Wiertelak, E. P., Martin, D., & Watkins, L. R. (1993) · Brain Research

Pain Mechanisms and TreatmentsTryptophan and brain disorders

Cited by 210

5-Hydroxytryptamine 2C Receptors in the Basolateral Amygdala Are Involved in the Expression of Anxiety After Uncontrollable Traumatic Stress

Christianson, J. P., Ragole, T., Amat, J., Greenwood, B. N., Strong, P. V., Paul, E. D., Fleshner, M., Watkins, L. R., & Maier, S. F. (2010) · Biological Psychiatry

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 204

Central Proinflammatory Cytokines and Pain Enhancement

Wieseler-Frank, J., Maier, S. F., & Watkins, L. R. (2005) · Neurosignals

Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 198

BDNF mRNA expression in rat hippocampus following contextual learning is blocked by intrahippocampal IL-1β administration

Barrientos, R. M., Sprunger, D. B., Campeau, S., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2004) · Journal of Neuroimmunology

Memory and Neural MechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 192

“Listening” and “talking” to neurons: implications of immune activation for pain control and increasing the efficacy of opioids

Watkins, L. R., Hutchinson, M. R., Milligan, E. D., & Maier, S. F. (2007) · Brain Research Reviews

Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 185

Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock

Maier, S. F., & Watkins, L. R. (1995) · Brain Research

Stress Responses and CortisolMemory and Neural Mechanisms

Cited by 178

The contribution of the vagus nerve in interleukin-1β-induced fever is dependent on dose

Hansen, M. K., O'Connor, K. A., Goehler, L. E., Watkins, L. R., & Maier, S. F. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Vagus Nerve Stimulation ResearchThermal Regulation in Medicine

Cited by 169

8-OH-DPAT microinjected in the region of the dorsal raphe nucleus blocks and reverses the enhancement of fear conditioning and interference with escape produced by exposure to inescapable shock.

Maier, S. F., Grahn, R. E., & Watkins, L. R. (1995) · Behavioral Neuroscience

Neurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Cited by 167

Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger

Frank, M. G., Watkins, L. R., & Maier, S. F. (2013) · Brain, Behavior, and Immunity

Stress Responses and CortisolNeuroinflammation and Neurodegeneration Mechanisms

Cited by 160

Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear

Baratta, M. V., Christianson, J. P., Gomez, D. M., Zarza, C. M., Amat, J., Masini, C. V., Watkins, L. R., & Maier, S. F. (2007) · Neuroscience

Memory and Neural MechanismsStress Responses and Cortisol

Cited by 156

Stressor Controllability Modulates Stress-Induced Dopamine and Serotonin Efflux and Morphine-Induced Serotonin Efflux in the Medial Prefrontal Cortex

Bland, S. T., Hargrave, D., Pepin, J. L., Amat, J., Watkins, L. R., & Maier, S. F. (2003) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 155

Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control

Amat, J., Paul, E., Watkins, L. R., & Maier, S. F. (2008) · Neuroscience

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Cited by 153

Immune-to-brain communication dynamically modulates pain: physiological and pathological consequences

Wieseler-Frank, J., Maier, S. F., & Watkins, L. R. (2005) · Brain, Behavior, and Immunity

Pain Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 151

Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying Processes

Barrientos, R. M., Frank, M. G., Crysdale, N. Y., Chapman, T. R., Ahrendsen, J. T., Day, H. E. W., Campeau, S., Watkins, L. R., Patterson, S. L., & Maier, S. F. (2011) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 148

Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1β protein response to acute stress

Nguyen, K. T., Deak, T., Will, M. J., Hansen, M. K., Hunsaker, B. N., Fleshner, M., Watkins, L. R., & Maier, S. F. (2000) · Brain Research

Stress Responses and CortisolTryptophan and brain disorders

Cited by 143

The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming

Fonken, L. K., Frank, M. G., Kitt, M. M., D'Angelo, H. M., Norden, D. M., Weber, M. D., Barrientos, R. M., Godbout, J. P., Watkins, L. R., & Maier, S. F. (2016) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAdvanced Glycation End Products research

Cited by 139

Effects of prior stress on LPS-induced cytokine and sickness responses

Johnson, J. D., O'Connor, K. A., Hansen, M. K., Watkins, L. R., & Maier, S. F. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Stress Responses and CortisolTryptophan and brain disorders

Cited by 138

The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome

Frank, M. G., Weber, M. D., Fonken, L. K., Hershman, S. A., Watkins, L. R., & Maier, S. F. (2016) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsAdvanced Glycation End Products research

Cited by 133

Chemical Lesion of the Bed Nucleus of the Stria Terminalis Blocks the Behavioral Consequences of Uncontrollable Stress.

Hammack, S. E., Richey, K. J., Watkins, L. R., & Maier, S. F. (2004) · Behavioral Neuroscience

Memory and Neural MechanismsStress Responses and Cortisol

Cited by 130