Chemical Lesion of the Bed Nucleus of the Stria Terminalis Blocks the Behavioral Consequences of Uncontrollable Stress.

Hammack, Sayamwong E.; Richey, Kristen J.; Watkins, Linda R.; Maier, Steven F.

doi:10.1037/0735-7044.118.2.443

Cited by 130Memory and Neural MechanismsStress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

Chemical Lesion of the Bed Nucleus of the Stria Terminalis Blocks the Behavioral Consequences of Uncontrollable Stress.

Hammack, Sayamwong E., Richey, Kristen J., Watkins, Linda R., Maier, Steven F.·2004·Behavioral Neuroscience

DOI 10.1037/0735-7044.118.2.443

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Abstract

Uncontrollable or inescapable shock (IS) produces behavioral changes that are characterized by a sensitized fear system and a deficit in fight-flight responding. These behavioral changes have been argued to represent an anxiety-like state produced by the uncontrollability of the stressor. The bed nucleus of the stria terminalis (BNST) has been implicated in the mediation of long-duration responses to unpredictable stressors, which have also been argued to represent anxiety. In the present study, the effects of BNST chemical lesion on the IS-induced sensitization of freezing to an environment previously paired with shock and the IS-induced impairment of escape responding were investigated. BNST chemical lesion blocked the potentiation of freezing and the increases in escape latency that normally follow IS.

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Authors: Hammack, S. E., Richey, K. J., Watkins, L. R., & Maier, S. F.
Affiliations: Emory University (US)
ORCID: Hammack, Sayamwong E.
Watkins, Linda R.
Maier, Steven F.
Venue: Behavioral Neuroscience
Publisher: American Psychological Association (APA)
Published: 2004
Volume: 118
Issue: 2
Pages: 443-448
ISSN: 0735-7044 (ISSN-L)
1939-0084
DOI: 10.1037/0735-7044.118.2.443
OpenAlex: W2010638458
Cited by: 130
References: 78
Citations by year: 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 14 · 2012: 8
FWCI: 3.21
Type: journal article
Language: en
Open access: closed
Locations: Behavioral Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH 50479)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: bed nucleus of the stria terminalis, uncontrollable stress, inescapable shock, freezing behavior, escape latency, anxiety, fight-or-flight response, chemical lesions
MeSH terms: Animals, Behavior, Animal, Male, Septal Nuclei, Stress, Psychological, N-Methylaspartate, Rats, Sprague-Dawley, Rats

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Chemical Lesion of the Bed Nucleus of the Stria Terminalis Blocks the Behavioral Consequences of Uncontrollable Stress.

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