Bear, Mark F.

Effects of STX209 (Arbaclofen) on Neurobehavioral Function in Children and Adults with Fragile X Syndrome: A Randomized, Controlled, Phase 2 Trial

Berry-Kravis, E. M., Hessl, D., Rathmell, B., Zarevics, P., Cherubini, M., Walton-Bowen, K., Mu, Y., Nguyen, D. V., Gonzalez-Heydrich, J., Wang, P. P., et al. (2012) · Science Translational Medicine

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 328

Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine

Kirkwood, A., Rozas, C., Kirkwood, J., Perez, F., & Bear, M. F. (1999) · The Journal of Neuroscience

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 315

Involvement of a Postsynaptic Protein Kinase A Substrate in the Expression of Homosynaptic Long-Term Depression

Kameyama, K., Lee, H.-K., Bear, M. F., & Huganir, R. L. (1998) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 283

Bidirectional synaptic plasticity: from theory to reality

Bear, M. F. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 260

Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome

Krueger, D. D., & Bear, M. F. (2011) · Annual Review of Medicine

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 259

Reversal of Disease-Related Pathologies in the Fragile X Mouse Model by Selective Activation of GABA B Receptors with Arbaclofen

Henderson, C., Wijetunge, L., Kinoshita, M. N., Shumway, M., Hammond, R. S., Postma, F. R., Brynczka, C., Rush, R., Thomas, A., Paylor, R., et al. (2012) · Science Translational Medicine

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 249

Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome

Osterweil, E. K., Chuang, S.-C., Chubykin, A. A., Sidorov, M., Bianchi, R., Wong, R. K. S., & Bear, M. F. (2013) · Neuron

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 230

Learned spatiotemporal sequence recognition and prediction in primary visual cortex

Gavornik, J. P., & Bear, M. F. (2014) · Nature Neuroscience

Visual perception and processing mechanismsNeural dynamics and brain function

Cited by 227

Obligatory Role of NR2A for Metaplasticity in Visual Cortex

Philpot, B. D., Cho, K. K. A., & Bear, M. F. (2007) · Neuron

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 207

Arbaclofen in fragile X syndrome: results of phase 3 trials

Berry-Kravis, E., Hagerman, R., Visootsak, J., Budimirovic, D., Kaufmann, W. E., Cherubini, M., Zarevics, P., Walton-Bowen, K., Wang, P., Bear, M. F., et al. (2017) · Journal of Neurodevelopmental Disorders

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 183

Translating Glutamate: From Pathophysiology to Treatment

Javitt, D. C., Schoepp, D., Kalivas, P. W., Volkow, N. D., Zarate, C., Merchant, K., Bear, M. F., Umbricht, D., Hajos, M., Potter, W. Z., et al. (2011) · Science Translational Medicine

Neuroscience and Neuropharmacology ResearchTreatment of Major Depression

Cited by 168

Arbaclofen in Children and Adolescents with Autism Spectrum Disorder: A Randomized, Controlled, Phase 2 Trial

Veenstra-VanderWeele, J., Cook, E. H., King, B. H., Zarevics, P., Cherubini, M., Walton-Bowen, K., Bear, M. F., Wang, P. P., & Carpenter, R. L. (2017) · Neuropsychopharmacology

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 168

Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation

McCurry, C. L., Shepherd, J. D., Tropea, D., Wang, K. H., Bear, M. F., & Sur, M. (2010) · Nature Neuroscience

Visual perception and processing mechanismsNeuroscience and Neuropharmacology Research

Cited by 159

Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain

Venturino, A., Schulz, R., De Jesús-Cortés, H., Maes, M. E., Nagy, B., Reilly-Andújar, F., Colombo, G., Cubero, R. J. A., Schoot Uiterkamp, F. E., Bear, M. F., et al. (2021) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research

Cited by 140

Therapeutic implications of the mGluR theory of fragile X mental retardation

Bear, M. F. (2005) · Genes, Brain and Behavior

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 137

Role for A Kinase-anchoring Proteins (AKAPS) in Glutamate Receptor Trafficking and Long Term Synaptic Depression

Snyder, E. M., Colledge, M., Crozier, R. A., Chen, W. S., Scott, J. D., & Bear, M. F. (2005) · Journal of Biological Chemistry

Neuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms

Cited by 119

Conserved Hippocampal Cellular Pathophysiology but Distinct Behavioural Deficits in a New Rat Model of FXS

Till, S. M., Asiminas, A., Jackson, A. D., Katsanevaki, D., Barnes, S. A., Osterweil, E. K., Bear, M. F., Chattarji, S., Wood, E. R., Wyllie, D. J. A., et al. (2015) · Human Molecular Genetics

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 109

Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion

Tian, D., Stoppel, L. J., Heynen, A. J., Lindemann, L., Jaeschke, G., Mills, A. A., & Bear, M. F. (2015) · Nature Neuroscience

Genetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities

Cited by 109

Fragile X: translation in action

Bear, M. F., Dölen, G., Osterweil, E., & Nagarajan, N. (2008) · Neuropsychopharmacology

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 94

R-Baclofen reverses cognitive deficits and improves social interactions in two lines of 16p11.2 deletion mice

Stoppel, L. J., Kazdoba, T. M., Schaffler, M. D., Preza, A. R., Heynen, A., Crawley, J. N., & Bear, M. F. (2018) · Neuropsychopharmacology

Genetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities

Cited by 92

Convergence of Hippocampal Pathophysiology in Syngap +/− and Fmr1 −/ y Mice

Barnes, S. A., Wijetunge, L. S., Jackson, A. D., Katsanevaki, D., Osterweil, E. K., Komiyama, N. H., Grant, S. G. N., Bear, M. F., Nägerl, U. V., Kind, P. C., et al. (2015) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 84

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

Asiminas, A., Jackson, A. D., Louros, S. R., Till, S. M., Spano, T., Dando, O., Bear, M. F., Chattarji, S., Hardingham, G. E., Osterweil, E. K., et al. (2019) · Science Translational Medicine

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 78

Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

Kaplan, E. S., Cooke, S. F., Komorowski, R. W., Chubykin, A. A., Thomazeau, A., Khibnik, L. A., Gavornik, J. P., & Bear, M. F. (2016) · eLife

Neuroscience and Neuropharmacology ResearchVisual perception and processing mechanisms

Cited by 77

Divergent dysregulation of gene expression in murine models of fragile X syndrome and tuberous sclerosis

Kong, S. W., Sahin, M., Collins, C. D., Wertz, M. H., Campbell, M. G., Leech, J. D., Krueger, D., Bear, M. F., Kunkel, L. M., & Kohane, I. S. (2014) · Molecular Autism

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 19