Mitochondrial reactive oxygen species regulate hypoxic signaling

Hamanaka, Robert B; Chandel, Navdeep S

doi:10.1016/j.ceb.2009.08.005

Cited by 332Redox biology and oxidative stressCancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Mitochondrial reactive oxygen species regulate hypoxic signaling

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Hamanaka, Robert B, Chandel, Navdeep S·2009·Current Opinion in Cell Biology

DOI 10.1016/j.ceb.2009.08.005PMC PMC2787901

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Abstract

Physiological hypoxia results in a host of responses that include increased ventilation, constriction of the pulmonary artery, and a cellular transcriptional program that promotes glycolysis, angiogenesis, and erythropoiesis. Mitochondria are the primary consumers of cellular oxygen and have thus been speculated for years to be the site of cellular oxygen sensing. Many of the cellular responses to hypoxia are now known to be mediated by the production of reactive oxygen species at mitochondrial complex III. While the mechanism by which cytosolic oxidant concentration is increased during hypoxia is unknown, the importance of the maintenance of cellular oxygen supply requires further investigation into the role of ROS as hypoxia signaling molecules. The following is a brief overview of the current understanding of the role of mitochondrial-produced ROS in cellular oxygen signaling.

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HIFs both sense and remodel intracellular ROS levels through effects on mitochondrial activity, antioxidant pathways, and metabolic flux.
“These functions are intimately coupled to redox regulation, as HIFs both sense and remodel intracellular ROS levels through effects on mitochondrial activity, antioxidant pathways, and metabolic flux [252,253].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [252]
The section “Mitochondrial ROS are required for hypoxic activation of HIFs” reports that mitochondrial ROS help stabilize HIF-1α, supporting the ROS-to-HIF direction of the claim. The passages do not establish the reverse claim that HIFs remodel intracellular ROS through mitochondrial activity, antioxidant pathways, or metabolic flux. Page numbers are not provided in our copy. (LLM, conf=0.86)
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Authors: Hamanaka, R. B., & Chandel, N. S.
Affiliations: Northwestern University (US)
Corresponding author: Chandel, Navdeep S
ORCID: Hamanaka, Robert B
Chandel, Navdeep S
Venue: Current Opinion in Cell Biology
Publisher: Elsevier BV
Published: 2009-12
Volume: 21
Issue: 6
Pages: 894-899
ISSN: 0955-0674 (ISSN-L)
DOI: 10.1016/j.ceb.2009.08.005
PMC: PMC2787901
OpenAlex: W2107708548
Cited by: 332
References: 58
Citations by year: 2026: 16 · 2025: 15 · 2024: 24 · 2023: 24 · 2022: 23 · 2021: 25 · 2020: 23 · 2019: 10 · 2018: 18 · 2017: 20 · 2016: 20 · 2015: 14 · 2014: 20 · 2013: 20 · 2012: 27
FWCI: 1.48
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R01CA123067-03, RO1GM60472-10)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords: mitochondrial reactive oxygen species, hypoxia signaling, cellular oxygen sensing, mitochondrial complex III, glycolysis, angiogenesis, erythropoiesis, pulmonary vasoconstriction
MeSH terms: Animals, Hypoxia, Humans, Mitochondria, Models, Biological, Signal Transduction, Reactive Oxygen Species, Basic Helix-Loop-Helix Proteins

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Mitochondrial reactive oxygen species regulate hypoxic signaling

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