Gage, Fred H.

Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors

Crotti, A., Benner, C., Kerman, B. E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., Cattaneo, E., Gage, F. H., Cleveland, D. W., & Glass, C. K. (2014) · Nature Neuroscience

Neuroinflammation and Neurodegeneration MechanismsGenetic Neurodegenerative Diseases

Cited by 333

Th17 lymphocytes induce neuronal cell death in a human iPSC-based model of Parkinson's disease

Sommer, A., Marxreiter, F., Krach, F., Fadler, T., Grosch, J., Maroni, M., Graef, D., Eberhardt, E., Riemenschneider, M. J., Yeo, G. W., et al. (2018) · Cell Stem Cell

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 332

Neurogenic niche modulation by activated microglia: transforming growth factor β increases neurogenesis in the adult dentate gyrus

Battista, D., Ferrari, C. C., Gage, F. H., & Pitossi, F. J. (2006) · European Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 306

Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice

van Praag, H., Lucero, M. J., Yeo, G. W., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H., Hammerstone, J., et al. (2007) · The Journal of Neuroscience

Phytochemicals and Antioxidant ActivitiesNeurogenesis and neuroplasticity mechanisms

Cited by 303

Adult neurogenesis: integrating theories and separating functions

Aimone, J. B., Deng, W., & Gage, F. H. (2010) · Trends in Cognitive Sciences

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 303

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

Schafer, S. T., Paquola, A. C. M., Stern, S., Gosselin, D., Ku, M., Pena, M., Kuret, T. J. M., Liyanage, M., Mansour, A. A., Jaeger, B. N., et al. (2019) · Nature Neuroscience

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 288

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

McConnell, M. J., Moran, J. V., Abyzov, A., Akbarian, S., Bae, T., Cortes-Ciriano, I., Erwin, J. A., Fasching, L., Flasch, D. A., Freed, D., et al. (2017) · Science

Genomic variations and chromosomal abnormalitiesGenetics and Neurodevelopmental Disorders

Cited by 262

Fate of endogenous stem/progenitor cells following spinal cord injury

Horky, L. L., Galimi, F., Gage, F. H., & Horner, P. J. (2006) · Journal of Comparative Neurology

Neurogenesis and neuroplasticity mechanismsSpinal Cord Injury Research

Cited by 258

Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

Mertens, J., Herdy, J. R., Traxler, L., Schafer, S. T., Schlachetzki, J. C. M., Böhnke, L., Reid, D. A., Lee, H., Zangwill, D., Fernandes, D. P., et al. (2021) · Cell Stem Cell

Pluripotent Stem Cells ResearchAlzheimer's disease research and treatments

Cited by 240

Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons

Smrt, R. D., Eaves-Egenes, J., Barkho, B. Z., Santistevan, N. J., Zhao, C., Aimone, J. B., Gage, F. H., & Zhao, X. (2007) · Neurobiology of Disease

Genetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 239

Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells

Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Marchetto, M. C. N., Muotri, A. R., Mu, Y., Carson, C. T., Macia, A., Moran, J. V., & Gage, F. H. (2011) · Proceedings of the National Academy of Sciences

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 229

Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

Herdy, J. R., Traxler, L., Agarwal, R. K., Karbacher, L., Schlachetzki, J. C. M., Boehnke, L., Zangwill, D., Galasko, D., Glass, C. K., Mertens, J., et al. (2022) · Cell Stem Cell

Telomeres, Telomerase, and SenescenceAlzheimer's disease research and treatments

Cited by 208

A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells

Stein, J. L., de la Torre-Ubieta, L., Tian, Y., Parikshak, N. N., Hernández, I. A., Marchetto, M. C., Baker, D. K., Lu, D., Hinman, C. R., Lowe, J. K., et al. (2014) · Neuron

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 201

L1-associated genomic regions are deleted in somatic cells of the healthy human brain

Erwin, J. A., Paquola, A. C. M., Singer, T., Gallina, I., Novotny, M., Quayle, C., Bedrosian, T. A., Alves, F. I. A., Butcher, C. R., Herdy, J. R., et al. (2016) · Nature Neuroscience

Genomic variations and chromosomal abnormalitiesChromosomal and Genetic Variations

Cited by 195

A human neurodevelopmental model for Williams syndrome

Chailangkarn, T., Trujillo, C. A., Freitas, B. C., Hrvoj-Mihic, B., Herai, R. H., Yu, D. X., Brown, T. T., Marchetto, M. C., Bardy, C., McHenry, L., et al. (2016) · Nature

Williams Syndrome ResearchGenetics and Neurodevelopmental Disorders

Cited by 195

Rapid and efficient generation of functional motor neurons from human pluripotent stem cells using gene delivered transcription factor codes

Hester, M. E., Murtha, M. J., Song, S., Rao, M., Miranda, C. J., Meyer, K., Tian, J., Boulting, G., Schaffer, D. V., Zhu, M. X., et al. (2011) · Molecular Therapy

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 183

Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer’s disease

Traxler, L., Herdy, J. R., Stefanoni, D., Eichhorner, S., Pelucchi, S., Szücs, A., Santagostino, A., Kim, Y., Agarwal, R. K., Schlachetzki, J. C. M., et al. (2022) · Cell Metabolism

Alzheimer's disease research and treatmentsCancer, Hypoxia, and Metabolism

Cited by 179

The Role of Transposable Elements in Health and Diseases of the Central Nervous System

Reilly, M. T., Faulkner, G. J., Dubnau, J., Ponomarev, I., & Gage, F. H. (2013) · The Journal of Neuroscience

Chromosomal and Genetic VariationsGenomic variations and chromosomal abnormalities

Cited by 175

Redefining the boundaries of the hippocampal CA2 subfield in the mouse using gene expression and 3‐dimensional reconstruction

Lein, E. S., Callaway, E. M., Albright, T. D., & Gage, F. H. (2005) · Journal of Comparative Neurology

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 158

Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases

Marchetto, M. C. N., Winner, B., & Gage, F. H. (2010) · Human Molecular Genetics

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 152

Cdk5 Regulates Accurate Maturation of Newborn Granule Cells in the Adult Hippocampus

Jessberger, S., Aigner, S., Clemenson, G. D., Toni, N., Lie, D. C., Karalay, Ö., Overall, R., Kempermann, G., & Gage, F. H. (2008) · PLoS Biology

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 134

Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

Marchetto, M. C., Hrvoj-Mihic, B., Kerman, B. E., Yu, D. X., Vadodaria, K. C., Linker, S. B., Narvaiza, I., Santos, R., Denli, A. M., Mendes, A. P., et al. (2019) · eLife

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 132

Early life experience drives structural variation of neural genomes in mice

Bedrosian, T. A., Quayle, C., Novaresi, N., & Gage, F. H. (2018) · Science

Chromosomal and Genetic VariationsEpigenetics and DNA Methylation

Cited by 131

BDNF in the dentate gyrus is required for consolidation of “pattern-separated” memories.

Bekinschtein, P., Kent, B. A., Oomen, C. A., Clemenson, G. D., Gage, F. H., Saksida, L. M., & Bussey, T. J. (2013) · Cell Reports

Memory and Neural MechanismsNeurogenesis and neuroplasticity mechanisms

Cited by 124