Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons
Open accessAbstract
It is well known that Rett Syndrome, a severe postnatal childhood neurological disorder, is mostly caused by mutations in the MECP2 gene. However, how deficiencies in MeCP2 contribute to the neurological dysfunction of Rett Syndrome is not clear. We aimed to resolve the role of MeCP2 epigenetic regulation in postnatal brain development in an Mecp2-deficient mouse model. We found that, while Mecp2 was not critical for the production of immature neurons in the dentate gyrus (DG) of the hippocampus, the newly generated neurons exhibited pronounced deficits in neuronal maturation, including delayed transition into a more mature stage, altered expression of presynaptic proteins and reduced dendritic spine density. Furthermore, analysis of gene expression profiles of isolated DG granule neurons revealed abnormal expression levels of a number of genes previously shown to be important for synaptogenesis. Our studies suggest that MeCP2 plays a central role in neuronal maturation, which might be mediated through epigenetic control of expression pathways that are instrumental in both dendritic development and synaptogenesis.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These changes are apparently due to a delay in development and synapse formation in neurons resulting from Mecp2 haploinsufficiency, abnormalities that do not recover with age.
“These changes are apparently due to a delay in development and synapse formation in neurons resulting from Mecp2 haploinsufficiency [115, 330], which are abnormalities in development that do not recover with age.”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [330]
Cites
1 retracted
Stancheva, I., Collins, A. L., den Veyver, I. B. V., Zoghbi, H. Y., & Meehan, R. R. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00276-4 · Cited by 134 · see citing works
RetractedIn silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785 · see citing works
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568 · see citing works
Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124 · see citing works
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
Amir, R. E., Van den Veyver, I. B., Wan, M., Tran, C. Q., Francke, U., & Zoghbi, H. Y. (1999) · Nature Genetics · doi:10.1038/13810 · Cited by 4,990 · see citing works
Summaries of Affymetrix GeneChip probe level data
Irizarry, R. A. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng015 · Cited by 4,906 · see citing works
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
Hartl, F. U., & Hayer-Hartl, M. K. (2002) · Science · doi:10.1126/science.1068408 · Cited by 3,335 · see citing works
Model-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133 · see citing works
GUNDERSEN, H. J. G., BENDTSEN, T. F., KORBO, L., MARCUSSEN, N., MØLLER, A., NIELSEN, K., NYENGAARD, J. R., PAKKENBERG, B., SØRENSEN, F. B., VESTERBY, A., et al. (1988) · APMIS · doi:10.1111/j.1699-0463.1988.tb05320.x · Cited by 2,929 · see citing works
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works
Self-citationCellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected
Santos, S. E. D., Porfírio, J., Cunha, F., Manger, P. R., Tavares, W. C., Pessôa, L. M., Raghanti, M. A., Sherwood, C. C., & Herculano‐Houzel, S. (2017) · Brain Behavior and Evolution · doi:10.1159/000452856 · Cited by 2,651 · see citing works
NeuN, a neuronal specific nuclear protein in vertebratesxs
Mullen, R. J., Buck, C. R., & Smith, A. M. (1992) · Development · doi:10.1242/dev.116.1.201 · Cited by 2,351 · see citing works
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
Guy, J., Hendrich, B., Holmes, M., Martin, J. E., & Bird, A. (2001) · Nature Genetics · doi:10.1038/85899 · Cited by 1,558 · see citing works
Hagberg, B. A., Aicardi, J. F., Dias, K., & Ramos, O. (1983) · Annals of Neurology · doi:10.1002/ana.410140412 · Cited by 1,515 · see citing works
Wnt signalling regulates adult hippocampal neurogenesis
Lie, D. C., Colamarino, S. A., Song, H., Désiré, L., Mira, H., Consiglio, A., Lein, E. S., Jessberger, S., Lansford, H., Dearie, A. R., et al. (2005) · Nature · doi:10.1038/nature04108 · Cited by 1,510 · see citing works
Self-citationTransient expression of doublecortin during adult neurogenesis
Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,494 · see citing works
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent <i>Bdnf</i> Gene Regulation
Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G., & Sun, Y. E. (2003) · Science · doi:10.1126/science.1090842 · Cited by 1,405 · see citing works
Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons
Gleeson, J. G., Lin, P. T., Flanagan, L. A., & Walsh, C. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80778-3 · Cited by 1,341 · see citing works
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
Chen, R. Z., Akbarian, S., Tudor, M., & Jaenisch, R. (2001) · Nature Genetics · doi:10.1038/85906 · Cited by 1,275 · see citing works
GABA regulates synaptic integration of newly generated neurons in the adult brain
Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,261 · see citing works
Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
Zhao, C., Teng, E. M., Summers, R. G., Ming, G.-L., & Gage, F. H. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3648-05.2006 · Cited by 1,257 · see citing works
Self-citationDerepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
Chen, W. G., Chang, Q., Lin, Y., Meissner, A., West, A. E., Griffith, E. C., Jaenisch, R., & Greenberg, M. E. (2003) · Science · doi:10.1126/science.1086446 · Cited by 1,232 · see citing works
Induction of neurogenesis in the neocortex of adult mice
Magavi, S. S. P., Leavitt, B. R., & Macklis, J. D. (2000) · Nature · doi:10.1038/35016083 · Cited by 1,217 · see citing works
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811 · see citing works
Neurogenesis in the Adult Brain
Gage, F. H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-03-00612.2002 · Cited by 796 · see citing works
Self-citationShahbazian, M. D., Young, J. I., Yuva‐Paylor, L. A., Spencer, C. M., Antalffy, B. A., Noebels, J. L., Armstrong, D. L., Paylor, R. E., & Zoghbi, H. Y. (2002) · Neuron · doi:10.1016/s0896-6273(02)00768-7 · Cited by 760 · see citing works
Dendritic Anomalies in Disorders Associated with Mental Retardation
Kaufmann, W. E. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.981 · Cited by 733 · see citing works
Postnatal neurodevelopmental disorders: meeting at the synapse?
Zoghbi, H. Y. (2003) · Science · doi:10.1126/science.1089071 · Cited by 691 · see citing works
Neuronal differentiation in the adult hippocampus recapitulates embryonic development
Espósito, M. S., Piatti, V. C., Laplagne, D. A., Morgenstern, N. A., Ferrari, C. C., Pitossi, F. J., & Schinder, A. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3114-05.2005 · Cited by 679 · see citing works
Rao, M. S. R., & Shetty, A. K. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2003.03123.x · Cited by 654 · see citing works
Synaptic plasticity at hippocampal mossy fibre synapses
Nicoll, R. A., & Schmitz, D. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1786 · Cited by 653 · see citing works
Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome
Horike, S., Cai, S., Miyano, M., Cheng, J., & Kohwi-shigematsu, T. (2004) · Nature Genetics · doi:10.1038/ng1491 · Cited by 585 · see citing works
Learning and Memory and Synaptic Plasticity Are Impaired in a Mouse Model of Rett Syndrome
Moretti, P., Levenson, J. M., Battaglia, F., Atkinson, R., Teague, R., Antalffy, B., Armstrong, D., Arancio, O., Sweatt, J. D., & Zoghbi, H. Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2623-05.2006 · Cited by 545 · see citing works
Kishi, N., & Macklis, J. D. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.07.006 · Cited by 445 · see citing works
The multifarious hippocampal mossy fiber pathway: a review
Henze, D. A., Urban, N. N., & Barrionuevo, G. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00146-9 · Cited by 389 · see citing works
Hagberg, B. A., Witt‐Engerström, I., Opitz, J. M., & Reynolds, J. F. (1986) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320250506 · Cited by 383 · see citing works
Zhao, X., Ueba, T., Christie, B. R., Barkho, B. Z., McConnell, M. J., Nakashima, K., Lein, E. S., Eadie, B. D., Willhoite, A. R., Muotri, A. R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1131928100 · Cited by 376 · see citing works
Self-citationHippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome
Asaka, Y., Jugloff, D. G. M., Zhang, L., Eubanks, J. H., & Fitzsimonds, R. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.07.005 · Cited by 341 · see citing works
EphB/syndecan-2 signaling in dendritic spine morphogenesis
Ethell, I. M., Irie, F., Kalo, M. S., Couchman, J. R., Pasquale, E. B., & Yamaguchi, Y. (2001) · Neuron · doi:10.1016/s0896-6273(01)00440-8 · Cited by 309 · see citing works
Cellular and molecular mechanisms of presynaptic assembly
Ziv, N. E., & Garner, C. C. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1370 · Cited by 306 · see citing works
Barkho, B. Z., Song, H., Aimone, J. B., Smrt, R. D., Kuwabara, T., Nakashima, K., Gage, F. H., & Zhao, X. (2006) · Stem Cells and Development · doi:10.1089/scd.2006.15.407 · Cited by 303 · see citing works
Self-citationSynaptic structural abnormalities in the Ts65Dn mouse model of down syndrome
Belichenko, P. V., Masliah, E., Kleschevnikov, A. M., Villar, A. J., Epstein, C. J., Salehi, A., & Mobley, W. C. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20337 · Cited by 297 · see citing works
Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized
Bienvenu, T., & Chelly, J. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1878 · Cited by 289 · see citing works
Phillips, J. M., & Eberwine, J. H. (1996) · Methods · doi:10.1006/meth.1996.0104 · Cited by 245 · see citing works
Rao, M. S. R., Hattiangady, B., Abdel‐Rahman, A., Stanley, D. P., & Shetty, A. K. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03853.x · Cited by 220 · see citing works
MeCP2-Dependent Transcriptional Repression Regulates Excitatory Neurotransmission
Nelson, E. D., Kavalali, E. T., & Monteggia, L. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.02.062 · Cited by 218 · see citing works
Ethell, I. M., & Yamaguchi, Y. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.144.3.575 · Cited by 209 · see citing works
Pelka, G. J., Watson, C. M., Radziewic, T., Hayward, M., Lahooti, H., Christodoulou, J., & Tam, P. (2006) · Brain · doi:10.1093/brain/awl022 · Cited by 207 · see citing works
Rett Syndrome and MeCP2: Linking Epigenetics and Neuronal Function
Shahbazian, M. D., & Zoghbi, H. Y. (2002) · The American Journal of Human Genetics · doi:10.1086/345360 · Cited by 201 · see citing works
Transcriptional profiling reveals strict boundaries between hippocampal subregions
Zhao, X., Lein, E. S., He, A., Smith, S. C., Aston, C., & Gage, F. H. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1406 · Cited by 196 · see citing works
Self-citationJung, B. P., Jugloff, D. G. M., Zhang, G., Logan, R., Brown, S., & Eubanks, J. H. (2003) · Journal of Neurobiology · doi:10.1002/neu.10201 · Cited by 177 · see citing works
Cell formation in the human hippocampal formation from mid-gestation to the late postnatal period
Seress, L., Ábrahám, H., Tornóczky, T., & Kosztolányi, G. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00156-7 · Cited by 157 · see citing works
Stancheva, I., Collins, A. L., den Veyver, I. B. V., Zoghbi, H. Y., & Meehan, R. R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.06.007 · Cited by 144 · see citing works
Morphological study of neocortical areas in Rett syndrome
Belichenko, P. V., Hagberg, B. A., & Dahlström, A. B. (1997) · Acta Neuropathologica · doi:10.1007/s004010050582 · Cited by 130 · see citing works
Cheng, L.-C., Tavazoie, M. F., & Doetsch, F. K. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.027 · Cited by 129 · see citing works
DNA methylation and Rett syndrome
Kriaučionis, S., & Bird, A. P. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg286 · Cited by 125 · see citing works
Neuropathology of Rett syndrome
Armstrong, D. D. (2002) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/mrdd.10027 · Cited by 122 · see citing works
Expression Pattern of the Rett Syndrome Gene MeCP2 in Primate Prefrontal Cortex
Akbarian, S., Chen, R. Z., Gribnau, J. H., Rasmussen, T. P., Fong, H., Jaenisch, R., & Jones, E. G. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0420 · Cited by 119 · see citing works
Spatial and temporal gene expression profiling of the contused rat spinal cord
Aimone, J. B., Leasure, J. L., Perreau, V. M., Thallmair, M., & THECHRISTOPHERREEVEPARALYSISFOUNDA (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.042 · Cited by 110 · see citing works
Self-citationNamihira, M., Nakashima, K., & Taga, T. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.029 · Cited by 105 · see citing works
Postnatal development of mossy cells in the human dentate gyrus: A light microscopic Golgi study
Seress, L., & Mrzljak, L. (1992) · Hippocampus · doi:10.1002/hipo.450020205 · Cited by 100 · see citing works
Peddada, S., Yasui, D. H., & LaSalle, J. M. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl124 · Cited by 99 · see citing works
New Neurons in the Adult Mammalian Brain: Synaptogenesis and Functional Integration
Song, H., Kempermann, G., Overstreet‐Wadiche, L., Zhao, C., Schinder, A. F., & Bischofberger, J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3452-05.2005 · Cited by 91 · see citing works
Self-citationThe transcriptional repressor Mecp2 regulates terminal neuronal differentiation
Matarazzo, V. A., Cohen, D. R. S., Palmer, A. M., Simpson, P. J., Khokhar, B., Pan, S., & Ronnett, G. V. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.05.005 · Cited by 82 · see citing works
Jugloff, D. G. M., Jung, B., Purushotham, D., Logan, R., & Eubanks, J. H. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.11.002 · Cited by 78 · see citing works
Li, S., Reinprecht, I., Fahnestock, M. L., & Racine, R. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00485-2 · Cited by 76 · see citing works
Nolasco, S., Bellido, J., Gonçalves, J., Zabala, J. C., & Soares, H. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.022 · Cited by 61 · see citing works
siRNA Induced Transcriptional Gene Silencing in Mammalian Cells
Kawasaki, H., Taira, K., & Morris, K. V. (2005) · Cell Cycle · doi:10.4161/cc.4.3.1520 · Cited by 58 · see citing works
Kindling induces the mRNA expression of methyl DNA-binding factors in the adult rat hippocampus
Francis, J., Jung, B., Zhang, G., Cheng, J., Ho, W., Burnham, W. M., & Eubanks, J. H. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00150-1 · Cited by 18 · see citing works
Unbiased characterization of high-density oligonucleotide microarrays using probe-level statistics
Aimone, J. B., & Gage, F. H. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.11.016 · Cited by 8 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · see citing works
The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works
Self-citationPartial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
Tropea, D., Giacometti, E., Wilson, N. R., Beard, C., McCurry, C., Fu, D. D., Flannery, R., Jaenisch, R., & Sur, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812394106 · Cited by 593 · see citing works
Autism spectrum disorder: neuropathology and animal models
Varghese, M., Keshav, N., Jacot-Descombes, S., Warda, T., Wicinski, B., Dickstein, D. L., Harony-Nicolas, H., De Rubeis, S., Drapeau, E., Buxbaum, J. D., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1736-4 · Cited by 536 · see citing works
Cross talk between microRNA and epigenetic regulation in adult neurogenesis
Szulwach, K. E., Li, X., Smrt, R. D., Li, Y., Luo, Y., Lin, L., Santistevan, N. J., Li, W., Zhao, X., & Jin, P. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200908151 · Cited by 493 · see citing works
Self-citationThe Role of MeCP2 in the Brain
Guy, J., Cheval, H., Selfridge, J., & Bird, A. P. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154121 · Cited by 414 · see citing works
MicroRNA miR-137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb-1
Smrt, R. D., Szulwach, K. E., Pfeiffer, R. L., Li, X., Guo, W., Pathania, M., Teng, Z.-Q., Luo, Y., Peng, J., Bordey, A., et al. (2010) · Stem Cells · doi:10.1002/stem.431 · Cited by 404 · see citing works
Self-citationEpigenetic mechanisms in neurogenesis
Yao, B., Christian, K. M., He, C., Jin, P., Ming, G., & Song, H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.70 · Cited by 391 · see citing works
Epigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works
Signaling in Adult Neurogenesis
Suh, H., Deng, W., & Gage, F. H. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113256 · Cited by 373 · see citing works
Self-citationSignaling mechanisms regulating adult neural stem cells and neurogenesis
Faigle, R., & Song, H. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.002 · Cited by 335 · see citing works
Epigenetic choreographers of neurogenesis in the adult mammalian brain
Dengke, K., Marchetto, M. C., Guo, J. U., Ming, G., Gage, F. H., & Song, H. (2010) · Nature Neuroscience · doi:10.1038/nn.2672 · Cited by 332 · see citing works
Self-citationEpigenetic Regulation of miR-184 by MBD1 Governs Neural Stem Cell Proliferation and Differentiation
Liu, C., Teng, Z., Santistevan, N. J., Szulwach, K. E., Guo, W., Jin, P., & Zhao, X. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.02.017 · Cited by 304 · see citing works
Self-citationBelichenko, P. V., Wright, E. E., Belichenko, N. P., Masliah, E., Li, H. H., Mobley, W. C., & Francke, U. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.22009 · Cited by 272 · see citing works
Review: adult neurogenesis contributes to hippocampal plasticity
Toda, T., & Gage, F. H. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2735-4 · Cited by 262 · see citing works
Self-citationChapleau, C. A., Calfa, G. D., Lane, M. C., Albertson, A. J., Larimore, J. L., Kudo, S., Armstrong, D. L., Percy, A. K., & Pozzo‐Miller, L. D. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.05.001 · Cited by 253 · see citing works
Rett syndrome: insights into genetic, molecular and circuit mechanisms
Ip, J. P. K., Mellios, N., & Sur, M. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0006-3 · Cited by 247 · see citing works
Luo, Y., Shan, G., Guo, W., Smrt, R. D., Johnson, E. B., Li, X., Pfeiffer, R. L., Szulwach, K. E., Duan, R., Barkho, B. Z., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000898 · Cited by 238 · see citing works
Self-citationAutism Spectrum Disorders and Epigenetics
Grafodatskaya, D., Chung, B., Szatmari, P., & Weksberg, R. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.05.005 · Cited by 235 · see citing works
Plasticity and injury in the developing brain
Johnston, M. V., Ishida, A., Nakajima, W., Matsushita, H., Nishimura, A., & Tsuji, M. (2008) · Brain and Development · doi:10.1016/j.braindev.2008.03.014 · Cited by 230 · see citing works
Transgenic miR132 Alters Neuronal Spine Density and Impairs Novel Object Recognition Memory
Hansen, K. F., Sakamoto, K., Wayman, G. A., Impey, S., & Obrietan, K. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015497 · Cited by 225 · see citing works
Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning
Guo, W., Allan, A. M., Zong, R.-T., Zhang, L., Johnson, E. B., Schaller, E., Murthy, A. C., Goggin, S. L., Eisch, A. J., Oostra, B. A., et al. (2011) · Nature Medicine · doi:10.1038/nm.2336 · Cited by 221 · see citing works
Self-citationSignaling in adult neurogenesis
Mu, Y., Lee, S. W., & Gage, F. H. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.04.010 · Cited by 217 · see citing works
Self-citationMicroRNA Regulation of Neural Stem Cells and Neurogenesis: Figure 1.
Shi, Y., Zhao, X., Hsieh, J., Wichterle, H., Impey, S., Banerjee, S., Neveu, P. A., & Kosik, K. S. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4280-10.2010 · Cited by 198 · see citing works
Self-citationBDNF deregulation in Rett syndrome
Li, W., & Pozzo‐Miller, L. D. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.024 · Cited by 175 · see citing works
Liyanage, V. R. B., & Rastegar, M. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8295-9 · Cited by 171 · see citing works
Epigenetic dysregulation in cognitive disorders
Gräff, J., & Mansuy, I. M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06787.x · Cited by 163 · see citing works
Guo, W., Murthy, A. C., Zhang, L., Johnson, E. B., Schaller, E., Allan, A. M., & Zhao, X. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr501 · Cited by 159 · see citing works
Self-citationEzh2 Regulates Adult Hippocampal Neurogenesis and Memory
Zhang, J., Ji, F., Liu, Y., Lei, X., Li, H., Ji, G., Yuan, Z., & Jiao, J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4129-13.2014 · Cited by 158 · see citing works
Wnt7a Regulates Multiple Steps of Neurogenesis
Qu, Q., Sun, G., Murai, K., Ye, P., Li, W., Asuelime, G. E., Cheung, Y.-T., & Shi, Y. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00325-13 · Cited by 150 · see citing works
Epilepsy in Rett syndrome, and CDKL5‐ and FOXG1‐gene–related encephalopathies
Guerrini, R., & Parrini, E. (2012) · Epilepsia · doi:10.1111/j.1528-1167.2012.03656.x · Cited by 146 · see citing works
Hsieh, J., & Eisch, A. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.01.008 · Cited by 144 · see citing works
Regulation of Adult Neurogenesis in Mammalian Brain
Niklison-Chirou, M. V., Agostini, M., Amelio, I., & Melino, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144869 · Cited by 143 · see citing works
Fuchs, C., Trazzi, S., Torricella, R., Viggiano, R., De Franceschi, M., Amendola, E., Gross, C., Calzà, L., Bartesaghi, R., & Ciani, E. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.06.006 · Cited by 138 · see citing works
Neurogenesis in the adult hippocampus: history, regulation, and prospective roles
Fares, J., Diab, Z. B., Nabha, S. M., & Fares, Y. (2018) · International Journal of Neuroscience · doi:10.1080/00207454.2018.1545771 · Cited by 139 · see citing works
Epigenetic regulation of nervous system development by DNA methylation and histone deacetylation
MacDonald, J. L., & Roskams, A. J. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.002 · Cited by 136 · see citing works
Experimental models of Rett syndrome based on Mecp2 dysfunction
Calfa, G. D., Percy, A. K., & Pozzo‐Miller, L. D. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.010261 · Cited by 132 · see citing works
From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms
Kabir, Z. D., Martínez-Rivera, A., & Rajadhyaksha, A. M. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0532-0 · Cited by 125 · see citing works
Crosstalk among Epigenetic Pathways Regulates Neurogenesis
Jobe, E. M., McQuate, A. L., & Zhao, X. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00059 · Cited by 124 · see citing works
Self-citationSpooren, W., Lindemann, L., Ghosh, A., & Santarelli, L. (2012) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2012.09.004 · Cited by 119 · see citing works
Modeling psychiatric disorders at the cellular and network levels
Brennand, K. J., Simone, A., Tran, N., & Gage, F. H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.20 · Cited by 119 · see citing works
Self-citationNeural stem cells: developmental mechanisms and disease modeling
Zhao, X., & Moore, D. L. (2017) · Cell and Tissue Research · doi:10.1007/s00441-017-2738-1 · Cited by 117 · see citing works
Self-citationKathuria, A., Nowosiad, P., Jagasia, R., Aigner, S., Taylor, R. D., Andreae, L. C., Gatford, N. J. F., Lucchesi, W., Srivastava, D. P., & Price, J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.185 · Cited by 114 · see citing works
Complexities of Rett Syndrome and MeCP2: Figure 1.
Samaco, R. C., & Neul, J. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0169-11.2011 · Cited by 112 · see citing works
Induced pluripotent stem cells: a new revolution for clinical neurology?
Mattis, V. B., & Svendsen, C. N. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70022-9 · Cited by 112 · see citing works
Shen, M., Wang, F., Li, M., Sah, N., Stockton, M. E., Tidei, J. J., Gao, Y., Korabelnikov, T., Kannan, S., Vevea, J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0338-y · Cited by 112 · see citing works
Self-citationTen-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
Li, X., Yao, B., Chen, L., Kang, Y., Li, Y., Cheng, Y., Li, L., Li, L., Wang, Z., Wang, M., et al. (2017) · Nature Communications · doi:10.1038/ncomms15903 · Cited by 104 · see citing works
Epigenetic regulation in neurodevelopment and neurodegenerative diseases
Gapp, K., Woldemichael, B. T., Bohacek, J., & Mansuy, I. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.11.040 · Cited by 106 · see citing works
Chapleau, C. A., Larimore, J. L., Theibert, A. B., & Pozzo‐Miller, L. D. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9027-6 · Cited by 104 · see citing works
Epigenetic regulation of neurogenesis in the adult mammalian brain
Sun, J., Sun, J., Ming, G., & Song, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07607.x · Cited by 102 · see citing works
Dendritic spine dysgenesis in Rett syndrome
Xu, X., Miller, E. C., & Pozzo‐Miller, L. D. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00097 · Cited by 94 · see citing works
RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression
Guo, W., Zhang, L., Christopher, D. M., Teng, Z., Fausett, S. R., Liu, C.-M., George, O. L., Klingensmith, J., Jin, P., & Zhao, X. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.027 · Cited by 96 · see citing works
Self-citationBaj, G., Patrizio, A., Montalbano, A., Sciancalepore, M., & Tongiorgi, E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00018 · Cited by 93 · see citing works
Unlocking epigenetic codes in neurogenesisPreprint
Yao, B., & Jin, P. (2014) · Genes & Development · doi:10.1101/gad.241547.114 · Cited by 92 · see citing works
An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions
Lossi, L., Castagna, C., & Merighi, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073881 · Cited by 99 · see citing works
Kishi, N., & Macklis, J. D. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.12.007 · Cited by 90 · see citing works
Steps towards standardized quantification of adult neurogenesis
Zhao, X., & van Praag, H. (2020) · Nature Communications · doi:10.1038/s41467-020-18046-y · Cited by 89 · see citing works
Self-citationBedogni, F., Cobolli Gigli, C., Pozzi, D., Rossi, R. L., Scaramuzza, L., Rossetti, G., Pagani, M., Kilstrup-Nielsen, C., Matteoli, M., & Landsberger, N. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv078 · Cited by 84 · see citing works
Copf, T. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.008 · Cited by 85 · see citing works
Hippocampal deficits in neurodevelopmental disorders
Li, Y., Shen, M., Stockton, M. E., & Zhao, X. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.10.001 · Cited by 84 · see citing works
Self-citationEpigenetic Regulation of Mammalian Stem Cells
Li, X., & Zhao, X. (2008) · Stem Cells and Development · doi:10.1089/scd.2008.0036 · Cited by 83 · see citing works
Self-citationMECP2 Isoform-Specific Vectors with Regulated Expression for Rett Syndrome Gene Therapy
Rastegar, M., Hotta, A., Pasceri, P., Makarem, M., Cheung, A. Y. L., Elliott, S., Park, K. J., Adachi, M., Jones, F. S., Clarke, I. D., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006810 · Cited by 79 · see citing works
Developmental Dynamics of Rett Syndrome
Feldman, D., Banerjee, A., & Sur, M. (2016) · Neural Plasticity · doi:10.1155/2016/6154080 · Cited by 79 · see citing works
Lu, Y., Wang, F., Li, Y., Ferris, J., Lee, J., & Gao, F. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn373 · Cited by 75 · see citing works
Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links
Hulbert, S. W., & Jiang, Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.040 · Cited by 72 · see citing works
Shepherd, G. M., & Katz, D. M. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.06.006 · Cited by 75 · see citing works
Ogier, M., & Katz, D. M. (2008) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2008.04.005 · Cited by 73 · see citing works
Simvastatin Promotes Adult Hippocampal Neurogenesis by Enhancing Wnt/β-Catenin Signaling
Robin, N. C., Agoston, Z., Biechele, T. L., James, R. G., Berndt, J. D., & Moon, R. T. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.11.002 · Cited by 73 · see citing works
DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution
Song, C., Feodorova, Y. N., Guy, J., Peichl, L., Jost, K. L., Kimurâ, H., Cardoso, M. C., Bird, A. P., Leonhardt, H., Joffe, B. I., et al. (2014) · Epigenetics & Chromatin · doi:10.1186/1756-8935-7-17 · Cited by 71 · see citing works
Rett Syndrome: From the Gene to the Disease
Glavan, T. M., Knežević, J., Slavica, M., & Pavelić, J. (2008) · European Neurology · doi:10.1159/000165342 · Cited by 71 · see citing works
Genetics and Epigenetics in Adult NeurogenesisPreprint
Hsieh, J., & Zhao, X. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018911 · Cited by 71 · see citing works
Self-citationStuss, D. P., Boyd, J. D., Levin, D. B., & Delaney, K. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031896 · Cited by 70 · see citing works
Li, H., Zhong, X., Chau, K. F., Santistevan, N. J., Guo, W., Kong, G., Li, X., Kadakia, M. B., Masliah, J., Chi, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6601 · Cited by 66 · see citing works
Self-citationDNA-Methylation: Master or Slave of Neural Fate Decisions?
Stricker, S. H., & Götz, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00005 · Cited by 64 · see citing works
Gao, Y., Su, J., Guo, W., Polich, E. D., Magyar, D. P., Xing, Y., Li, H., Smrt, R. D., Chang, Q., & Zhao, X. (2015) · Stem Cells · doi:10.1002/stem.1950 · Cited by 65 · see citing works
Self-citationThe role of MeCP2 in CNS development and function
Na, E. S., & Monteggia, L. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.05.014 · Cited by 67 · see citing works
Liu, C.-M., Teng, Z., McQuate, A. L., Jobe, E. M., Christ, C. C., von Hoyningen-Huene, S. J., Reyes, M. D., Polich, E. D., Xing, Y., Li, Y., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0051436 · Cited by 63 · see citing works
Self-citationIntrinsic membrane properties of locus coeruleus neurons in Mecp2-null mice
Zhang, X., Cui, N., Wu, Z., Su, J., Tadepalli, J. S., Sekizar, S., & Jiang, C. L. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00442.2009 · Cited by 64 · see citing works
Lang, M., Wither, R. G., Colic, S., Wu, C., Monnier, P. P., Bardakjian, B. L., Zhang, L., & Eubanks, J. H. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt421 · Cited by 63 · see citing works
Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease
Fitzsimons, C. P., van Bodegraven, E. J., Schouten, M., Lardenoije, R., Kompotis, K., Kenis, G., van den Hurk, M., Boks, M. P., Biojone, C., Joca, S. R. L., et al. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-25 · Cited by 63 · see citing works
Buchthal, B., Lau, D., Weiss, U. K., Weislogel, J.-M., & Bading, H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.382507 · Cited by 60 · see citing works
Rett Syndrome: From Bed to Bench
Weng, S.-M., Bailey, M. E. S., & Cobb, S. (2011) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2011.08.002 · Cited by 61 · see citing works
MeCP2 Deficiency in Neuroglia: New Progress in the Pathogenesis of Rett Syndrome
Jin, X.-R., Chen, X.-S., & Xiao, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00316 · Cited by 55 · see citing works
Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome
Carstens, K. E., Lustberg, D. J., Shaughnessy, E. K., McCann, K. E., Alexander, G. M., & Dudek, S. M. (2021) · Journal of Clinical Investigation · doi:10.1172/jci137221 · Cited by 57 · see citing works
MECP2 genomic structure and function: insights from ENCODE
Singh, J., Saxena, A., Christodoulou, J., & Ravine, D. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn591 · Cited by 58 · see citing works
Synaptic determinants of Rett syndrome
Boggio (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00028 · Cited by 56 · see citing works
Wang, F., Tidei, J. J., Polich, E. D., Gao, Y., Zhao, H., Perrone‐Bizzozero, N. I., Guo, W., & Zhao, X. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513780112 · Cited by 57 · see citing works
Self-citationMicroRNAs and epigenetic regulation in the mammalian inner ear: implications for deafness
Friedman, L. M., & Avraham, K. B. (2009) · Mammalian Genome · doi:10.1007/s00335-009-9230-5 · Cited by 55 · see citing works
Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior
Sun, D., Sun, X.-D., Zhao, L., Lee, D.-H., Hu, J.-X., Tang, F., Pan, J., Mei, L., Zhu, X., & Xiong, W. (2018) · Cell Death and Disease · doi:10.1038/s41419-017-0019-2 · Cited by 56 · see citing works
Degano, A. L., Pasterkamp, R. J., & Ronnett, G. V. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.07.009 · Cited by 55 · see citing works
Liyanage, V. R. B., Zachariah, R. M., & Rastegar, M. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-46 · Cited by 54 · see citing works
Cell Signaling in Neuronal Stem Cells
Quiroz, E. N., Quiroz, R. N., Ahmad, M., Escorcia, L. G., Camacho, J. L. V., Fernandez-Ponce, C. M., & Aroca, G. (2018) · Cells · doi:10.3390/cells7070075 · Cited by 55 · see citing works
Rett syndrome and the urge of novel approaches to study MeCP2 functions and mechanisms of action
Bedogni, F., Rossi, R. L., Galli, F., Cobolli Gigli, C., Gandaglia, A., Kilstrup-Nielsen, C., & Landsberger, N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.01.011 · Cited by 51 · see citing works
De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis
Zocher, S., Overall, R. W., Berdugo‐Vega, G., Rund, N., Karasinsky, A., Adusumilli, V. S., Steinhauer, C., Scheibenstock, S., Händler, K., Schultze, J. L., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020107100 · Cited by 51 · see citing works
The Role of MicroRNAs in Neural Stem Cells and Neurogenesis
Ji, F., Lv, X., & Jiao, J. (2013) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2012.12.008 · Cited by 52 · see citing works
Elevated expression of MeCP2 in cardiac and skeletal tissues is detrimental for normal development
Alvarez-Saavedra, M., Carrasco, L., Sura‐Trueba, S., Aiello, V. D., Walz, K., Neto, J. X., & Young, J. I. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq096 · Cited by 52 · see citing works
Lagali, P. S., Corcoran, C., & Picketts, D. J. (2010) · Clinical Genetics · doi:10.1111/j.1399-0004.2010.01503.x · Cited by 48 · see citing works
KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients
Hinz, L., Barrufet, J. T., & Heine, V. M. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0852-x · Cited by 48 · see citing works
Yıldırım, M., Delepine, C., Feldman, D., Pham, V. A., Chou, S., Ip, J. P. K., Nott, A., Tsai, L., Ming, G., So, P. T. C., et al. (2022) · eLife · doi:10.7554/elife.78079 · Cited by 44 · see citing works
In vitro neurogenesis: development and functional implications of iPSC technology
Compagnucci, C., Nizzardo, M., Corti, S. P., Zanni, G., & Bertini, E. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1511-1 · Cited by 43 · see citing works
- Authors
- Smrt, R. D., Eaves-Egenes, J., Barkho, B. Z., Santistevan, N. J., Zhao, C., Aimone, J. B., Gage, F. H., & Zhao, X.
- Affiliations
- University of New Mexico (US)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Zhao, Xinyu
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2007-07
- Volume
- 27
- Issue
- 1
- Pages
- 77-89
- ISSN
- 0969-9961 (ISSN-L)
- PMC
- PMC2789309
- OpenAlex
- W1985334727
- Cited by
- 239
- References
- 71
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 12 · 2018: 13 · 2017: 22 · 2016: 13 · 2015: 10 · 2014: 19 · 2013: 16 · 2012: 16
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- School of Medicine, University of New Mexico
- National Institute of Mental Health (R01MH080434)
- National Institute of General Medical Sciences (T34GM008751)
- National Center for Research Resources (P20RR015636)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- MeCP2, MeCP2 deficiency, Rett syndrome, hippocampus, dentate gyrus, granule neurons, neuronal maturation, dendritic spine density, synaptogenesis, presynaptic proteins, epigenetic regulation, postnatal brain development, gene expression profiling
- MeSH terms
- Animals, Animals, Newborn, Cell Differentiation, Mice, Inbred ICR, Neurons, Rett Syndrome, Presynaptic Terminals, Mice, Knockout, Gene Expression Regulation, Developmental, Dentate Gyrus, Epigenesis, Genetic, Dendritic Spines, Mice, Methyl-CpG-Binding Protein 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
