Gage, Fred H.

Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS

Jovičić, A., Mertens, J., Boeynaems, S., Bogaert, E., Chai, N., Yamada, S. B., Paul, J. W., Sun, S., Herdy, J. R., Bieri, G., et al. (2015) · Nature Neuroscience

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 598

Synapse formation on neurons born in the adult hippocampus

Toni, N., Teng, E. M., Bushong, E. A., Aimone, J. B., Zhao, C., Consiglio, A., van Praag, H., Martone, M. E., Ellisman, M. H., & Gage, F. H. (2007) · Nature Neuroscience

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 579

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells

Yeo, G. W., Coufal, N. G., Liang, T. Y., Peng, G. E., Fu, X.-D., & Gage, F. H. (2009) · Nature Structural & Molecular Biology

RNA Research and SplicingRNA regulation and disease

Cited by 572

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

Study, T. P. O. B. D., Mertens, J., Wang, Q.-W., Kim, Y., Yu, D. X., Pham, S., Yang, B., Zheng, Y., Diffenderfer, K. E., Zhang, J., et al. (2015) · Nature

Bipolar Disorder and TreatmentPluripotent Stem Cells Research

Cited by 562

Mosaic Copy Number Variation in Human Neurons

McConnell, M. J., Lindberg, M. R., Brennand, K. J., Piper, J. C., Voet, T., Cowing-Zitron, C., Shumilina, S., Lasken, R. S., Vermeesch, J. R., Hall, I. M., et al. (2013) · Science

Genomic variations and chromosomal abnormalitiesCancer Genomics and Diagnostics

Cited by 551

A regenerative approach to the treatment of multiple sclerosis

Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., et al. (2013) · Nature

Multiple Sclerosis Research StudiesNeurogenesis and neuroplasticity mechanisms

Cited by 531

Local generation of glia is a major astrocyte source in postnatal cortex

Ge, W.-P., Miyawaki, A., Gage, F. H., Jan, Y. N., & Jan, L. Y. (2012) · Nature

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 507

Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain

Deng, W., Saxe, M. D., Gallina, I. S., & Gage, F. H. (2009) · The Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Cited by 493

Signaling through BMPR-IA regulates quiescence and long-term activity of neural stem cells in the adult hippocampus

Mira, H., Andreu, Z., Suh, H., Lie, D. C., Jessberger, S., Consiglio, A., San Emeterio, J., Hortigüela, R., Marqués-Torrejón, M. Á., Nakashima, K., et al. (2010) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 480

Non-Cell-Autonomous Effect of Human SOD1G37R Astrocytes on Motor Neurons Derived from Human Embryonic Stem Cells

Marchetto, M. C. N., Muotri, A. R., Mu, Y., Smith, A. M., Cezar, G. G., & Gage, F. H. (2008) · Cell Stem Cell

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 475

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

Marchetto, M. C., Belinson, H., Tian, Y., Freitas, B. C., Fu, C., Vadodaria, K. C., Beltrao-Braga, P. C., Trujillo, C. A., Mendes, A. P. D., Padmanabhan, K., et al. (2017) · Molecular Psychiatry

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 466

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer’s Disease

Eftekharzadeh, B., Daigle, J. G., Kapinos, L. E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S. J., Dujardin, S., Amaral, A. S., et al. (2018) · Neuron

Alzheimer's disease research and treatmentsNuclear Structure and Function

Cited by 460

Neocortical neurogenesis in humans is restricted to development

Bhardwaj, R. D., Curtis, M. A., Spalding, K. L., Buchholz, B. A., Fink, D., Björk-Eriksson, T., Nordborg, C., Gage, F. H., Druid, H., Eriksson, P. S., et al. (2006) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 448

A small modulatory dsRNA specifies the fate of adult neural stem cells

Kuwabara, T., Hsieh, J., Nakashima, K., Taira, K., & Gage, F. H. (2004) · Cell

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 447

The role of retrotransposable elements in ageing and age-associated diseases

Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J. D., Linker, S. B., Gage, F. H., Kreiling, J. A., Petrashen, A. P., et al. (2021) · Nature

Chromosomal and Genetic VariationsGenetics, Aging, and Longevity in Model Organisms

Cited by 446

Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

Krishnaswami, S. R., Grindberg, R. V., Novotny, M., Venepally, P., Lacar, B., Bhutani, K., Linker, S. B., Pham, S., Erwin, J. A., Miller, J. A., et al. (2016) · Nature Protocols

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 445

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro

Bardy, C., van den Hurk, M., Eames, T., Marchand, C., Hernandez, R. V., Kellogg, M., Gorris, M., Galet, B., Palomares, V., Brown, J., et al. (2015) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchNeural dynamics and brain function

Cited by 429

RNA-sequencing from single nuclei

Grindberg, R. V., Yee-Greenbaum, J. L., McConnell, M. J., Novotny, M., O’Shaughnessy, A. L., Lambert, G. M., Araúzo-Bravo, M. J., Lee, J., Fishman, M., Robbins, G. E., et al. (2013) · Proceedings of the National Academy of Sciences

Single-cell and spatial transcriptomicsGenomics and Phylogenetic Studies

Cited by 422

Nuclear RNA-seq of single neurons reveals molecular signatures of activation

Lacar, B., Linker, S. B., Jaeger, B. N., Krishnaswami, S. R., Barron, J. J., Kelder, M. J. E., Parylak, S. L., Paquola, A. C. M., Venepally, P., Novotny, M., et al. (2016) · Nature Communications

Single-cell and spatial transcriptomicsMemory and Neural Mechanisms

Cited by 405

Neurodegenerative disease and adult neurogenesis

Winner, B., Kohl, Z., & Gage, F. H. (2011) · European Journal of Neuroscience

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 405

Genomic anatomy of the hippocampus

Thompson, C. L., Pathak, S. D., Jeromin, A., Ng, L. L., MacPherson, C. R., Mortrud, M. T., Cusick, A., Riley, Z. L., Sunkin, S. M., Bernard, A., et al. (2008) · Neuron

Memory and Neural MechanismsNeuroscience and Neuropharmacology Research

Cited by 403

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

Vilchez, D., Boyer, L., Morantte, I., Lutz, M., Merkwirth, C., Joyce, D., Spencer, B., Page, L., Masliah, E., Berggren, W. T., et al. (2012) · Nature

Ubiquitin and proteasome pathwaysAutophagy in Disease and Therapy

Cited by 388

2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size

Otani, T., Marchetto, M. C., Gage, F. H., Simons, B. D., & Livesey, F. J. (2016) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsPluripotent Stem Cells Research

Cited by 353

High-resolution comparative analysis of great ape genomes

Kronenberg, Z. N., Fiddes, I. T., Gordon, D., Murali, S., Cantsilieris, S., Meyerson, O. S., Underwood, J. G., Nelson, B. J., Chaisson, M. J. P., Dougherty, M. L., et al. (2018) · Science

Genomics and Phylogenetic StudiesGenomic variations and chromosomal abnormalities

Cited by 350