Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

Botstein, D., & Risch, N. (2003) · Nature Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 1,503

The Way Things Move: Looking Under the Hood of Molecular Motor Proteins

Vale, R. D., & Milligan, R. A. (2000) · Science

Microtubule and mitosis dynamicsProtein Structure and Dynamics

Cited by 1,503

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

Luisi, B. F., Xu, W. X., Otwinowski, Z., Freedman, L. P., Yamamoto, K. R., & Sigler, P. B. (1991) · Nature

Protein Structure and DynamicsEstrogen and related hormone effects

Cited by 1,503

Computationally efficient whole-genome regression for quantitative and binary traits

Mbatchou, J., Barnard, L., Backman, J., Marcketta, A., Kosmicki, J. A., Ziyatdinov, A., Benner, C., O’Dushlaine, C., Barber, M., Boutkov, B., et al. (2021) · Nature Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 1,502

Metformin: from mechanisms of action to therapies

Foretz, M., Guigas, B., Bertrand, L., Pollak, M., & Viollet, B. (2014) · Cell Metabolism

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 1,501

The Mononuclear Molybdenum Enzymes

Hille, R. (1996) · Chemical Reviews

Metalloenzymes and iron-sulfur proteinsMetal-Catalyzed Oxygenation Mechanisms

Cited by 1,501

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

Bellot, G., Garcia-Medina, R., Gounon, P., Chiche, J., Roux, D., Pouysségur, J., & Mazure, N. M. (2009) · Molecular and Cellular Biology

Autophagy in Disease and TherapyCell death mechanisms and regulation

Cited by 1,501

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

Liu, R., Hong, J., Xu, X., Feng, Q., Zhang, D., Gu, Y., Shi, J., Zhao, S., Liu, W., Wang, X., et al. (2017) · Nature Medicine

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,501

Deep profiling of mouse splenic architecture with CODEX multiplexed imaging

Goltsev, Y., Samusik, N., Kennedy-Darling, J., Bhate, S., Hale, M., Vazquez, G., Black, S., & Nolan, G. P. (2018) · Cell

Single-cell and spatial transcriptomicsCell Image Analysis Techniques

Cited by 1,501

Design and synthesis of a minimal bacterial genome

Hutchison, C. A., Chuang, R.-Y., Noskov, V. N., Assad-Garcia, N., Deerinck, T. J., Ellisman, M. H., Gill, J., Kannan, K., Karas, B. J., Ma, L., et al. (2016) · Science

Microbial Metabolic Engineering and BioproductionRNA and protein synthesis mechanisms

Cited by 1,500

Extrachromosomal rDNA circles—a cause of aging in yeast

Sinclair, D. A., & Guarente, L. (1997) · Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 1,500

SC3: consensus clustering of single-cell RNA-seq data

Kiselev, V. Y., Kirschner, K., Schaub, M. T., Andrews, T., Yiu, A., Chandra, T., Natarajan, K. N., Reik, W., Barahona, M., Green, A. R., et al. (2017) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 1,500

DNA damage-induced cell death by apoptosis

Roos, W. P., & Kaina, B. (2006) · Trends in Molecular Medicine

DNA Repair MechanismsCell death mechanisms and regulation

Cited by 1,500

Repair Pathway Choices and Consequences at the Double-Strand Break

Ceccaldi, R., Rondinelli, B., & D’Andrea, A. D. (2016) · Trends in Cell Biology

DNA Repair MechanismsCRISPR and Genetic Engineering

Cited by 1,499

Induction of tumors in mice by genomic hypomethylation

Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 1,499

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

Naldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 1,499

Ubiquitin ligases: structure, function, and regulation

Zheng, N., & Shabek, N. (2017) · Annual Review of Biochemistry

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 1,499

The control and consequences of bacterial fermentation in the human colon

Cummings, J. H., & Macfarlane, G. T. (1991) · Journal of Applied Bacteriology

Gut microbiota and healthMicrobial Metabolites in Food Biotechnology

Cited by 1,499

Instability of a 550-Base Pair DNA Segment and Abnormal Methylation in Fragile X Syndrome

Oberlé, I., Rousseau, F., Heitz, D., Kretz, C., Devys, D., Hanauer, A., Boué, J., Bertheas, M. F., & Mandel, J. L. (1991) · Science

Genetics and Neurodevelopmental DisordersEpigenetics and DNA Methylation

Cited by 1,499

Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review

Di Vincenzo, F., Del Gaudio, A., Petito, V., Lopetuso, L. R., & Scaldaferri, F. (2024) · Internal and Emergency Medicine

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 1,498

Mechanisms and regulation of endothelial VEGF receptor signalling

Simons, M., Gordon, E., & Claesson-Welsh, L. (2016) · Nature Reviews Molecular Cell Biology

Angiogenesis and VEGF in CancerLymphatic System and Diseases

Cited by 1,498

MycoCosm portal: gearing up for 1000 fungal genomes

Grigoriev, I. V., Nikitin, R., Haridas, S., Kuo, A., Ohm, R., Otillar, R., Riley, R., Salamov, A., Zhao, X., Korzeniewski, F., et al. (2014) · Nucleic Acids Research

Genomics and Phylogenetic StudiesFungal and yeast genetics research

Cited by 1,498

The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell

Mitochondrial Function and PathologyNeuroscience and Neuropharmacology Research

Cited by 1,498

Pancreatic cancers require autophagy for tumor growth

Yang, S., Wang, X., Contino, G., Liesa, M., Sahin, E., Ying, H., Bause, A., Li, Y., Stommel, J. M., Dell'Antonio, G., et al. (2011) · Genes & Development

Autophagy in Disease and TherapyPancreatic and Hepatic Oncology Research

Cited by 1,498