Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

RANK is essential for osteoclast and lymph node development.

Dougall, W. C., Glaccum, M., Charrier, K., Rohrbach, K., Brasel, K., De Smedt, T., Daro, E., Smith, J., Tometsko, M. E., Maliszewski, C. R., et al. (1999) · Genes & Development

Bone Metabolism and DiseasesT-cell and B-cell Immunology

Cited by 1,478

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology

Hippo pathway signaling and YAP/TAZCellular Mechanics and Interactions

Cited by 1,478

A unifying model for mTORC1-mediated regulation of mRNA translation

Thoreen, C. C., Chantranupong, L., Keys, H. R., Wang, T., Gray, N. S., & Sabatini, D. M. (2012) · Nature

PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms

Cited by 1,477

Epigenetic inheritance at the agouti locus in the mouse

Morgan, H. D., Sutherland, H. G. E., Martin, D. I. K., & Whitelaw, E. (1999) · Nature Genetics

Epigenetics and DNA MethylationGenetic Syndromes and Imprinting

Cited by 1,476

Genome-wide cell-free DNA fragmentation in patients with cancer

Cristiano, S., Leal, A., Phallen, J., Fiksel, J., Adleff, V., Bruhm, D. C., Jensen, S. Ø., Medina, J. E., Hruban, C., White, J. R., et al. (2019) · Nature

Cancer Genomics and DiagnosticsPrenatal Screening and Diagnostics

Cited by 1,476

Structure of Bcl-x L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

Sattler, M., Liang, H., Nettesheim, D., Meadows, R. P., Harlan, J. E., Eberstadt, M., Yoon, H. S., Shuker, S. B., Chang, B. S., Minn, A. J., et al. (1997) · Science

Cell death mechanisms and regulationProtein Structure and Dynamics

Cited by 1,476

Absence of expression of the FMR-1 gene in fragile X syndrome

Pieretti, M., Zhang, F., Fu, Y.-H., Warren, S. T., Oostra, B. A., Caskey, C. T., & Nelson, D. L. (1991) · Cell

Genetics and Neurodevelopmental DisordersGenetic Neurodegenerative Diseases

Cited by 1,476

Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis

Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., et al. (2014) · Cancer Cell

MicroRNA in disease regulationExtracellular vesicles in disease

Cited by 1,476

Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012

Mayer-Davis, E. J., Lawrence, J. M., Dabelea, D., Divers, J., Isom, S., Dolan, L., Imperatore, G., Linder, B., Marcovina, S., Pettitt, D. J., et al. (2017) · New England Journal of Medicine

Diabetes and associated disordersDiabetes Management and Research

Cited by 1,476

Rare chromosomal deletions and duplications increase risk of schizophrenia

The International Schizophrenia Consortium (2008) · Nature

Genomic variations and chromosomal abnormalitiesSchizophrenia research and treatment

Cited by 1,475

Type 1 diabetes mellitus

Katsarou, A., Gudbjörnsdottir, S., Rawshani, A., Dabelea, D., Bonifacio, E., Anderson, B. J., Jacobsen, L. M., Schatz, D. A., & Lernmark, Å. (2017) · Nature Reviews Disease Primers

Diabetes and associated disordersDiabetes Management and Research

Cited by 1,475

The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family.

Van Wart, H. E., & Birkedal-Hansen, H. (1990) · Proceedings of the National Academy of Sciences

Protease and Inhibitor MechanismsBlood Coagulation and Thrombosis Mechanisms

Cited by 1,475

Facing up to the global challenges of ageing

Partridge, L., Deelen, J., & Slagboom, P. E. (2018) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 1,475

Proteasome inhibitors: valuable new tools for cell biologists.

Lee, D. H., & Goldberg, A. L. (1998) · Trends in Cell Biology

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 1,474

The Influence of Macromolecular Crowding and Macromolecular Confinement on Biochemical Reactions in Physiological Media

Minton, A. P. (2001) · Journal of Biological Chemistry

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 1,474

Gene expression profile of aging and its retardation by caloric restriction

Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science

Genetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

Cited by 1,473

Deep learning for computational biology

Angermueller, C., Pärnamaa, T., Parts, L., & Stegle, O. (2016) · Molecular Systems Biology

Machine Learning in BioinformaticsBioinformatics and Genomic Networks

Cited by 1,473

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

Jain, A., Lamark, T., Sjøttem, E., Bowitz Larsen, K., Atesoh Awuh, J., Øvervatn, A., McMahon, M., Hayes, J. D., & Johansen, T. (2010) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressEndoplasmic Reticulum Stress and Disease

Cited by 1,472

The Biology of Proteostasis in Aging and Disease

Labbadia, J., & Morimoto, R. I. (2015) · Annual Review of Biochemistry

Heat shock proteins researchGenetics, Aging, and Longevity in Model Organisms

Cited by 1,472

Ferroptosis: Mechanisms and links with diseases

Yan, H.-F., Zou, T., Tuo, Q.-Z., Xu, S., Li, H., Belaidi, A. A., & Lei, P. (2021) · Signal Transduction and Targeted Therapy

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 1,471

Assessment of PLSDA Cross Validation

Westerhuis, J. A., Hoefsloot, H. C. J., Smit, S., Vis, D. J., Smilde, A. K., van Velzen, E. J. J., van Duijnhoven, J. P. M., & van Dorsten, F. A. (2008) · Metabolomics

Metabolomics and Mass Spectrometry StudiesSpectroscopy and Chemometric Analyses

Cited by 1,471

Targeting EZH2 in cancer

Kim, K. H., & Roberts, C. W. M. (2016) · Nature Medicine

Epigenetics and DNA MethylationChromatin Remodeling and Cancer

Cited by 1,471

Improved free-energy parameters for predictions of RNA duplex stability.

Freier, S. M., Kierzek, R., Jaeger, J. A., Sugimoto, N., Caruthers, M. H., Neilson, T., & Turner, D. H. (1986) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsDNA and Nucleic Acid Chemistry

Cited by 1,470

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

Seiler, A., Schneider, M., Förster, H., Roth, S., Wirth, E. K., Culmsee, C., Plesnila, N., Kremmer, E., Rådmark, O., Wurst, W., et al. (2008) · Cell Metabolism

Redox biology and oxidative stressCell death mechanisms and regulation

Cited by 1,470