Most cited biochemistry, genetics and molecular biology papers
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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
Jazayeri, A., Falck, J., Lukas, C., Bartek, J., Smith, G. C. M., Lukas, J., & Jackson, S. P. (2006) · Nature Cell Biology
DNA Repair MechanismsCancer-related Molecular Pathways
Cited by 1,064
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Effect of single and compound knockouts of estrogen receptors α (ERα) and β (ERβ) on mouse reproductive phenotypes
Dupont, S., Krust, A., Gansmuller, A., Dierich, A., Chambon, P., & Mark, M. (2000) · Development
Estrogen and related hormone effectsReproductive Biology and Fertility
Cited by 1,064
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Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
Koike-Yusa, H., Li, Y., Tan, E.-P., Velasco-Herrera, M. D. C., & Yusa, K. (2014) · Nature Biotechnology
CRISPR and Genetic EngineeringVirus-based gene therapy research
Cited by 1,064
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Stressful life events, genetic liability, and onset of an episode of major depression in women
Kendler, K. S., Kessler, R. C., Walters, E. E., MacLean, C. J., Neale, M. C., Heath, A. C., & Eaves, L. J. (1995) · American Journal of Psychiatry
Genetic Associations and EpidemiologyChild and Adolescent Psychosocial and Emotional Development
Cited by 1,063
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Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery
Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research
Cited by 1,063
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The Evolutionary Landscape of Alternative Splicing in Vertebrate Species
Barbosa-Morais, N. L., Irimia, M., Pan, Q., Xiong, H. Y., Gueroussov, S., Lee, L. J., Slobodeniuc, V., Kutter, C., Watt, S., Çolak, R., et al. (2012) · Science
RNA Research and SplicingRNA and protein synthesis mechanisms
Cited by 1,063
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Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., & Vermeire, S. (2011) · Gut
Gut microbiota and healthInflammatory Bowel Disease
Cited by 1,063
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Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling
Brand, M. D. (2016) · Free Radical Biology and Medicine
Mitochondrial Function and PathologyRedox biology and oxidative stress
Cited by 1,063
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Maturation of the infant microbiome community structure and function across multiple body sites and in relation to mode of delivery
Chu, D. M., Ma, J., Prince, A. L., Antony, K. M., Seferovic, M. D., & Aagaard, K. M. (2017) · Nature Medicine
Gut microbiota and healthInfant Nutrition and Health
Cited by 1,063
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Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos
Petropoulos, S., Edsgärd, D., Reinius, B., Deng, Q., Panula, S. P., Codeluppi, S., Plaza Reyes, A., Linnarsson, S., Sandberg, R., & Lanner, F. (2016) · Cell
Developmental Biology and Gene RegulationSingle-cell and spatial transcriptomics
Cited by 1,063
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Streaming fragment assignment for real-time analysis of sequencing experiments
Roberts, A., & Pachter, L. (2013) · Nature Methods
Genomics and Phylogenetic StudiesSingle-cell and spatial transcriptomics
Cited by 1,063
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Pyroptosis versus necroptosis: similarities, differences, and crosstalk
Frank, D., & Vince, J. E. (2019) · Cell Death & Differentiation
Inflammasome and immune disordersCell death mechanisms and regulation
Cited by 1,062
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The role of the Atg1/ULK1 complex in autophagy regulation
Mizushima, N. (2010) · Current Opinion in Cell Biology
Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism
Cited by 1,062
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The -Catenin Destruction Complex
Stamos, J. L., & Weis, W. I. (2013) · Cold Spring Harbor Perspectives in Biology
Wnt/β-catenin signaling in development and cancerUbiquitin and proteasome pathways
Cited by 1,062
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Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
López-Maury, L., Marguerat, S., & Bähler, J. (2008) · Nature Reviews Genetics
Gene Regulatory Network AnalysisEvolution and Genetic Dynamics
Cited by 1,061
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Mitochondrial dysfunction in cell senescence and aging
Miwa, S., Kashyap, S., Chini, E., & von Zglinicki, T. (2022) · Journal of Clinical Investigation
Mitochondrial Function and PathologyTelomeres, Telomerase, and Senescence
Cited by 1,061
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Endothelial Cell Senescence in Human Atherosclerosis: Role of Telomere in Endothelial Dysfunction
Minamino, T., Miyauchi, H., Yoshida, T., Ishida, Y., Yoshida, H., & Komuro, I. (2002) · Circulation
Telomeres, Telomerase, and SenescenceNitric Oxide and Endothelin Effects
Cited by 1,061
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Reanalysis suggests that genomic islands of speciation are due to reduced diversity, not reduced gene flow
Cruickshank, T. E., & Hahn, M. W. (2014) · Molecular Ecology
Genetic diversity and population structureEvolution and Genetic Dynamics
Cited by 1,061
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Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain
Deverman, B. E., Pravdo, P. L., Simpson, B. P., Kumar, S. R., Chan, K. Y., Banerjee, A., Wu, W.-L., Yang, B., Huber, N., Pasca, S. P., et al. (2016) · Nature Biotechnology
Virus-based gene therapy researchRNA Interference and Gene Delivery
Cited by 1,061
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The majority of microRNAs detectable in serum and saliva is concentrated in exosomes
Gallo, A., Tandon, M., Alevizos, I., & Illei, G. G. (2012) · PLoS ONE
Extracellular vesicles in diseaseMicroRNA in disease regulation
Cited by 1,060
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Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer
Singh, A., Misra, V., Thimmulappa, R. K., Lee, H., Ames, S., Hoque, M. O., Herman, J. G., Baylin, S. B., Sidransky, D., Gabrielson, E., et al. (2006) · PLoS Medicine
Genomics, phytochemicals, and oxidative stressLung Cancer Treatments and Mutations
Cited by 1,060
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HIF-1 and tumor progression: pathophysiology and therapeutics
Semenza, G. L. (2002) · Trends in Molecular Medicine
Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer
Cited by 1,060
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Hyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews
Proteoglycans and glycosaminoglycans researchWound Healing and Treatments
Cited by 1,060
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Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
Calon, A., Espinet, E., Palomo-Ponce, S., Tauriello, D. V. F., Iglesias, M., Céspedes, M. V., Sevillano, M., Nadal, C., Jung, P., Zhang, X. H.-F., et al. (2012) · Cancer Cell
TGF-β signaling in diseasesCancer Cells and Metastasis
Cited by 1,060
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