Most cited biochemistry, genetics and molecular biology papers
- Verified
Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease
Imhann, F., Vich Vila, A., Bonder, M. J., Fu, J., Gevers, D., Visschedijk, M. C., Spekhorst, L. M., Alberts, R., Franke, L., van Dullemen, H. M., et al. (2018) · Gut
Gut microbiota and healthInflammatory Bowel Disease
Cited by 788
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Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse
Sohal, R. S., Ku, H.-H., Agarwal, S., Forster, M. J., & Lal, H. (1994) · Mechanisms of Ageing and Development
Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology
Cited by 788
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Immune Responses to Viral Gene Therapy Vectors
Shirley, J. L., de Jong, Y. P., Terhorst, C., & Herzog, R. W. (2020) · Molecular Therapy
Virus-based gene therapy researchImmunotherapy and Immune Responses
Cited by 788
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mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 788
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Mixed model association for biobank-scale data sets
Loh, P.-R., Kichaev, G., Gazal, S., Schoech, A. P., & Price, A. L. (2017) · Nature Genetics
Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals
Cited by 788
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Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation
Zhang, D.-W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., & Hobbs, H. H. (2007) · Journal of Biological Chemistry
Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health
Cited by 788
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Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
Cummins, E. P., Berra, E., Comerford, K. M., Ginouves, A., Fitzgerald, K. T., Seeballuck, F., Godson, C., Nielsen, J. E., Moynagh, P., Pouyssegur, J., et al. (2006) · Proceedings of the National Academy of Sciences
NF-κB Signaling PathwaysSignaling Pathways in Disease
Cited by 788
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Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery
Kao, J., Salari, K., Bocanegra, M., Choi, Y.-L., Girard, L., Gandhi, J., Kwei, K. A., Hernandez-Boussard, T., Wang, P., Gazdar, A. F., et al. (2009) · PLoS ONE
Breast Cancer Treatment StudiesCancer Genomics and Diagnostics
Cited by 788
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Autophagy in the Cellular Energetic Balance
Singh, R., & Cuervo, A. M. (2011) · Cell Metabolism
Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism
Cited by 788
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Antisense oligonucleotides: the next frontier for treatment of neurological disorders
Rinaldi, C., & Wood, M. J. A. (2018) · Nature Reviews Neurology
RNA Interference and Gene DeliveryNeurogenetic and Muscular Disorders Research
Cited by 788
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Mitonuclear communication in homeostasis and stress
Quirós, P. M., Mottis, A., & Auwerx, J. (2016) · Nature Reviews Molecular Cell Biology
Mitochondrial Function and PathologyAutophagy in Disease and Therapy
Cited by 787
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NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis
Alvarez, S. W., Sviderskiy, V. O., Terzi, E. M., Papagiannakopoulos, T., Moreira, A. L., Adams, S., Sabatini, D. M., Birsoy, K., & Possemato, R. (2017) · Nature
Ferroptosis and cancer prognosisCancer, Hypoxia, and Metabolism
Cited by 787
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Biological interpretation of genome-wide association studies using predicted gene functions
Pers, T. H., Karjalainen, J. M., Chan, Y., Westra, H.-J., Wood, A. R., Yang, J., Lui, J. C., Vedantam, S., Gustafsson, S., Esko, T., et al. (2015) · Nature Communications
Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology
Cited by 787
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Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles
Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature
Cellular transport and secretionNeuroscience and Neuropharmacology Research
Cited by 787
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Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism
Peng, M., Yin, N., Chhangawala, S., Xu, K., Leslie, C. S., & Li, M. O. (2016) · Science
Cancer, Hypoxia, and MetabolismT-cell and B-cell Immunology
Cited by 787
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An aboriginal Australian genome reveals separate human dispersals into Asia
Rasmussen, M., Guo, X., Wang, Y., Lohmueller, K. E., Rasmussen, S., Albrechtsen, A., Skotte, L., Lindgreen, S., Metspalu, M., Jombart, T., et al. (2011) · Science
Forensic and Genetic ResearchPleistocene-Era Hominins and Archaeology
Cited by 787
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Reduced levels of hsp90 compromise steroid receptor action in vivo
Picard, D., Khursheed, B., Garabedian, M. J., Fortin, M. G., Lindquist, S., & Yamamoto, K. R. (1990) · Nature
Heat shock proteins researchEstrogen and related hormone effects
Cited by 787
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A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
Kobayashi, T., Stang, E., Fang, K. S., de Moerloose, P., Parton, R. G., & Gruenberg, J. (1998) · Nature
Cellular transport and secretionSystemic Lupus Erythematosus Research
Cited by 787
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NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
Serra, V., Markman, B., Scaltriti, M., Eichhorn, P. J. A., Valero, V., Guzman, M., Botero, M. L., Llonch, E., Atzori, F., Di Cosimo, S., et al. (2008) · Cancer Research
PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer
Cited by 787
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MAM: more than just a housekeeper
Hayashi, T., Rizzuto, R., Hajnoczky, G., & Su, T.-P. (2009) · Trends in Cell Biology
Mitochondrial Function and PathologyIon Channels and Receptors
Cited by 787
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Array tomography: a new tool for imaging the molecular architecture and ultrastructure of neural circuits
Micheva, K. D., & Smith, S. J. (2007) · Neuron
Advanced Fluorescence Microscopy TechniquesCell Image Analysis Techniques
Cited by 787
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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews
Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism
Cited by 787
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Rapid Destruction of Human Cdc25A in Response to DNA Damage
Mailand, N., Falck, J., Lukas, C., Syljuåsen, R. G., Welcker, M., Bartek, J., & Lukas, J. (2000) · Science
DNA Repair MechanismsCancer-related Molecular Pathways
Cited by 787
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Siderophore-Mediated Iron Transport: Crystal Structure of FhuA with Bound Lipopolysaccharide
Ferguson, A. D., Hofmann, E., Coulton, J. W., Diederichs, K., & Welte, W. (1998) · Science
Bacterial Genetics and BiotechnologyEnzyme Structure and Function
Cited by 787
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