Most cited biochemistry, genetics and molecular biology papers
- Verified
Robust deep learning–based protein sequence design using ProteinMPNN
Dauparas, J., Anishchenko, I., Bennett, N., Bai, H., Ragotte, R. J., Milles, L. F., Wicky, B. I. M., Courbet, A., de Haas, R. J., Bethel, N., et al. (2022) · Science
Protein Structure and DynamicsMachine Learning in Bioinformatics
Cited by 2,210
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Increased Insulin Sensitivity and Obesity Resistance in Mice Lacking the Protein Tyrosine Phosphatase-1B Gene
Elchebly, M., Payette, P., Michaliszyn, E., Cromlish, W., Collins, S., Loy, A. L., Normandin, D., Cheng, A., Himms-Hagen, J., Chan, C.-C., et al. (1999) · Science
Protein Tyrosine PhosphatasesAdipokines, Inflammation, and Metabolic Diseases
Cited by 2,210
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Listening to silence and understanding nonsense: exonic mutations that affect splicing
Cartegni, L., Chew, S. L., & Krainer, A. R. (2002) · Nature Reviews Genetics
RNA Research and SplicingRNA regulation and disease
Cited by 2,209
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Computational systems biology.
Kitano, H. (2002) · Nature
Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction
Cited by 2,209
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Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
Dawson, S.-J., Tsui, D. W. Y., Murtaza, M., Biggs, H., Rueda, O. M., Chin, S.-F., Dunning, M. J., Gale, D., Forshew, T., Mahler-Araujo, B., et al. (2013) · New England Journal of Medicine
Cancer Genomics and DiagnosticsBRCA gene mutations in cancer
Cited by 2,207
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Hippo pathway in organ size control, tissue homeostasis, and cancer
Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell
Hippo pathway signaling and YAP/TAZMicrotubule and mitosis dynamics
Cited by 2,206
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Butyrate improves insulin sensitivity and increases energy expenditure in mice
Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes
Gut microbiota and healthAdipose Tissue and Metabolism
Cited by 2,204
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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine
Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases
Cited by 2,204
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The Polycomb group protein EZH2 directly controls DNA methylation
Viré, E., Brenner, C., Deplus, R., Blanchon, L., Fraga, M., Didelot, C., Morey, L., Van Eynde, A., Bernard, D., Vanderwinden, J.-M., et al. (2006) · Nature
Epigenetics and DNA MethylationGenomics and Chromatin Dynamics
Cited by 2,204
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Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell
Cancer, Hypoxia, and MetabolismT-cell and B-cell Immunology
Cited by 2,204
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Extracellular DNA Required for Bacterial Biofilm Formation
Whitchurch, C. B., Tolker-Nielsen, T., Ragas, P. C., & Mattick, J. S. (2002) · Science
Bacterial biofilms and quorum sensingBacterial Genetics and Biotechnology
Cited by 2,203
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Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
Hooper, L. V., Wong, M. H., Thelin, A., Hansson, L., Falk, P. G., & Gordon, J. I. (2001) · Science
Gut microbiota and healthGastrointestinal motility and disorders
Cited by 2,202
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Shotgun metagenomics, from sampling to analysis
Quince, C., Walker, A. W., Simpson, J. T., Loman, N. J., & Segata, N. (2017) · Nature Biotechnology
Genomics and Phylogenetic StudiesMicrobial Community Ecology and Physiology
Cited by 2,202
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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences
Gut microbiota and healthGlycosylation and Glycoproteins Research
Cited by 2,200
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Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell
Gut microbiota and healthGastrointestinal motility and disorders
Cited by 2,200
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Telomere length predicts replicative capacity of human fibroblasts.
Allsopp, R. C., Vaziri, H., Patterson, C., Goldstein, S., Younglai, E. V., Futcher, A. B., Greider, C. W., & Harley, C. B. (1992) · Proceedings of the National Academy of Sciences
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 2,200
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Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
Yu, T., Guo, F., Yu, Y., Sun, T., Ma, D., Han, J., Qian, Y., Kryczek, I., Sun, D., Nagarsheth, N., et al. (2017) · Cell
Gut microbiota and healthOral microbiology and periodontitis research
Cited by 2,198
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Tackling the widespread and critical impact of batch effects in high-throughput data
Leek, J. T., Scharpf, R. B., Bravo, H. C., Simcha, D., Langmead, B., Johnson, W. E., Geman, D., Baggerly, K., & Irizarry, R. A. (2010) · Nature Reviews Genetics
Gene expression and cancer classificationBioinformatics and Genomic Networks
Cited by 2,196
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Hybridization as an invasion of the genome
Mallet, J. (2005) · Trends in Ecology & Evolution
Chromosomal and Genetic VariationsGenetic diversity and population structure
Cited by 2,196
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Disease-Specific Induced Pluripotent Stem Cells.
Park, I.-H., Arora, N., Huo, H., Maherali, N., Ahfeldt, T., Shimamura, A., Lensch, M. W., Cowan, C., Hochedlinger, K., & Daley, G. Q. (2008) · Cell
Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering
Cited by 2,196
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Oxidative stress and autophagy: The clash between damage and metabolic needs
Filomeni, G., De Zio, D., & Cecconi, F. (2015) · Cell Death & Differentiation
Autophagy in Disease and TherapyRedox biology and oxidative stress
Cited by 2,195
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Hybridization and speciation
Abbott, R., Albach, D., Ansell, S., Arntzen, J. W., Baird, S. J. E., Bierne, N., Boughman, J., Brelsford, A., Buerkle, C. A., Buggs, R., et al. (2013) · Journal of Evolutionary Biology
Chromosomal and Genetic VariationsEvolution and Genetic Dynamics
Cited by 2,194
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Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
Zeggini, E., Weedon, M. N., Lindgren, C. M., Frayling, T. M., Elliott, K. S., Lango, H., Timpson, N. J., Perry, J. R. B., Rayner, N. W., Freathy, R. M., et al. (2007) · Science
Genetic Associations and EpidemiologyDiabetes and associated disorders
Cited by 2,194
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NicheNet: Modeling intercellular communication by linking ligands to target genes
Browaeys, R., Saelens, W., & Saeys, Y. (2020) · Nature Methods
Gene Regulatory Network AnalysisBioinformatics and Genomic Networks
Cited by 2,192
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