Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

Short-chain fatty acids in control of body weight and insulin sensitivity

Canfora, E. E., Jocken, J. W., & Blaak, E. E. (2015) · Nature Reviews Endocrinology

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,298

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications

Cellular Mechanics and InteractionsProtease and Inhibitor Mechanisms

Cited by 2,296

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Samuel, V. T., & Shulman, G. I. (2012) · Cell

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,294

From Levinthal to pathways to funnels

Dill, K. A., & Chan, H. S. (1997) · Nature Structural & Molecular Biology

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 2,293

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

Boldin, M. P., Goncharov, T. M., Goltseve, Y. V., & Wallach, D. (1996) · Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 2,292

Development of a second-generation antiandrogen for treatment of advanced prostate cancer.

Tran, C., Ouk, S., Clegg, N. J., Chen, Y., Watson, P. A., Arora, V., Wongvipat, J., Smith-Jones, P. M., Yoo, D., Kwon, A., et al. (2009) · Science

Prostate Cancer Treatment and ResearchHeterocyclic Compound Synthesis and Bioactivity

Cited by 2,292

Aptamers as therapeutics

Keefe, A. D., Pai, S., & Ellington, A. (2010) · Nature Reviews Drug Discovery

Advanced biosensing and bioanalysis techniquesRNA Interference and Gene Delivery

Cited by 2,289

HHblits: lightning-fast iterative protein sequence searching by HMM-HMM alignment

Remmert, M., Biegert, A., Hauser, A., & Söding, J. (2012) · Nature Methods

Genomics and Phylogenetic StudiesMachine Learning in Bioinformatics

Cited by 2,288

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,287

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature

Genetics, Aging, and Longevity in Model OrganismsMesenchymal stem cell research

Cited by 2,287

The amazing osteocyte

Bonewald, L. F. (2011) · Journal of Bone and Mineral Research

Bone Metabolism and DiseasesBone health and osteoporosis research

Cited by 2,287

The mechanisms of action of metformin

Rena, G., Hardie, D. G., & Pearson, E. R. (2017) · Diabetologia

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 2,287

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

Grant, S. F. A., Thorleifsson, G., Reynisdottir, I., Benediktsson, R., Manolescu, A., Sainz, J., Helgason, A., Stefansson, H., Emilsson, V., Helgadottir, A., et al. (2006) · Nature Genetics

Genetic Associations and EpidemiologyDiabetes and associated disorders

Cited by 2,287

Toxicity of cationic lipids and cationic polymers in gene delivery

Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J. (2006) · Journal of Controlled Release

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 2,286

Codon-substitution models for heterogeneous selection pressure at amino acid sites

Yang, Z., Nielsen, R., Goldman, N., & Pedersen, A.-M. K. (2000) · Genetics

Evolution and Genetic DynamicsGenomics and Phylogenetic Studies

Cited by 2,286

Inflammatory caspases are innate immune receptors for intracellular LPS

Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., Hu, L., & Shao, F. (2014) · Nature

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,285

Genome editing with engineered zinc finger nucleases

Urnov, F. D., Rebar, E. J., Holmes, M. C., Zhang, H. S., & Gregory, P. D. (2010) · Nature Reviews Genetics

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,285

Regulation of microRNA function in animals

Gebert, L. F. R., & MacRae, I. J. (2019) · Nature Reviews Molecular Cell Biology

MicroRNA in disease regulationPlant Molecular Biology Research

Cited by 2,284

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity

Inflammasome and immune disordersImmune Response and Inflammation

Cited by 2,282

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews

Cellular Mechanics and InteractionsAtherosclerosis and Cardiovascular Diseases

Cited by 2,280

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., Brunskill, E. W., Sayen, M. R., Gottlieb, R. A., Dorn, G. W., et al. (2005) · Nature

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 2,280

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

Murphy, C. T., McCarroll, S. A., Bargmann, C. I., Fraser, A., Kamath, R. S., Ahringer, J., Li, H., & Kenyon, C. (2003) · Nature

Genetics, Aging, and Longevity in Model OrganismsFOXO transcription factor regulation

Cited by 2,280

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science

Single-cell and spatial transcriptomicsMetabolomics and Mass Spectrometry Studies

Cited by 2,279

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine

Cancer, Lipids, and MetabolismOvarian cancer diagnosis and treatment

Cited by 2,279