Cited by 313Physical Activity and HealthCardiovascular and exercise physiologyAging, Health, and Disability

The DOI matches its Crossref record; 57 of the 58 references it cites were found in a registry or an index.

Reduced Disability and Mortality Among Aging Runners: A 21-Year Longitudinal Study

Open access

Chakravarty, Eliza F.·2008·Archives of Internal Medicine

DOI 10.1001/archinte.168.15.1638PMC PMC3175643

Open this paper in CoChat — free account

Abstract

BACKGROUND: Exercise has been shown to improve many health outcomes and well-being of people of all ages. Long-term studies in older adults are needed to confirm disability and survival benefits of exercise. METHODS: Annual self-administered questionnaires were sent to 538 members of a nationwide running club and 423 healthy controls from northern California who were 50 years and older beginning in 1984. Data included running and exercise frequency, body mass index, and disability assessed by the Health Assessment Questionnaire Disability Index (HAQ-DI; scored from 0 [no difficulty] to 3 [unable to perform]) through 2005. A total of 284 runners and 156 controls completed the 21-year follow-up. Causes of death through 2003 were ascertained using the National Death Index. Multivariate regression techniques compared groups on disability and mortality. RESULTS: At baseline, runners were younger, leaner, and less likely to smoke compared with controls. The mean (SD) HAQ-DI score was higher for controls than for runners at all time points and increased with age in both groups, but to a lesser degree in runners (0.17 [0.34]) than in controls (0.36 [0.55]) (P < .001). Multivariate analyses showed that runners had a significantly lower risk of an HAQ-DI score of 0.5 (hazard ratio, 0.62; 95% confidence interval, 0.46-0.84). At 19 years, 15% of runners had died compared with 34% of controls. After adjustment for covariates, runners demonstrated a survival benefit (hazard ratio, 0.61; 95% confidence interval, 0.45-0.82). Disability and survival curves continued to diverge between groups after the 21-year follow-up as participants approached their ninth decade of life. CONCLUSION: Vigorous exercise (running) at middle and older ages is associated with reduced disability in later life and a notable survival advantage.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1001/archinte.168.15.1638

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Aging, natural death, and the compression of morbidity
Fries, J. F. (1980) · New England Journal of Medicine · doi:10.1056/nejm198007173030304 · Cited by 3,356
The Association of Changes in Physical-Activity Level and Other Lifestyle Characteristics with Mortality among Men
Paffenbarger, R. S., Hyde, R. T., Wing, A. L., Lee, I.-M., Jung, D. L., & Kampert, J. B. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302253280804 · Cited by 1,972
Nonlinear Mixed Effects Models for Repeated Measures Data
Lindstrom, M. J., & Bates, D. M. (1990) · Biometrics · doi:10.2307/2532087 · Cited by 1,793
Exercise Is Associated with Reduced Risk for Incident Dementia among Persons 65 Years of Age and Older
Larson, E. B., Wang, L., Bowen, J. D., McCormick, W. C., Teri, L., Crane, P., & Kukull, W. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-2-200601170-00004 · Cited by 1,463
The dimensions of health outcomes: the health assessment questionnaire, disability and pain scales.
Fries, J. F., Spitz, P. W., & Young, D. Y. (1982) · PubMed · Cited by 1,312
Human Metapneumovirus and Lower Respiratory Tract Disease in Otherwise Healthy Infants and Children
Williams, J. V., Harris, P. A., Tollefson, S. J., Halburnt, L. L., Pingsterhaus, J. M., Edwards, K. M., Wright, P. F., & Crowe, J. E. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa025472 · Cited by 987
Association of Long-Distance Corridor Walk Performance With Mortality, Cardiovascular Disease, Mobility Limitation, and Disability
Newman, A. B., Simonsick, E. M., Naydeck, B. L., Boudreau, R. M., Kritchevsky, S. B., Nevitt, M. C., Pahor, M., Satterfield, S., Brach, J. S., Studenski, S. A., et al. (2006) · JAMA · doi:10.1001/jama.295.17.2018 · Cited by 934
Health assessment questionnaire (HAQ)
Rovenský, J., & Payer, J. (2009) · Dictionary of Rheumatology · doi:10.1007/978-3-211-79280-3_429 · Cited by 696
Associations of Light, Moderate, and Vigorous Intensity Physical Activity with Longevity: The Harvard Alumni Health Study
Lee, I.-M. M., & Paffenbarger, R. S. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010205 · Cited by 647
Human Metapneumovirus Infections in Young and Elderly Adults
Falsey, A. R., Erdman, D. D., Anderson, L. J., & Walsh, E. E. (2003) · The Journal of Infectious Diseases · doi:10.1086/367901 · Cited by 594

Show all 58 references

Sorted by citations

Leisure Time Physical Activity and Mortality: A Detailed Pooled Analysis of the Dose-Response Relationship
Arem, H., Moore, S. C., Patel, A., Hartge, P., Berrington de Gonzalez, A., Visvanathan, K., Campbell, P. T., Freedman, M., Weiderpass, E., Adami, H. O., et al. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.0533 · Cited by 1,498
The mitochondrial basis of aging
Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.028 · Cited by 1,441
From discoveries in ageing research to therapeutics for healthy ageing
Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature · doi:10.1038/s41586-019-1365-2 · Cited by 1,389
Physical activity and functional limitations in older adults: a systematic review related to Canada's Physical Activity Guidelines
Paterson, D. H., & Warburton, D. E. (2010) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-7-38 · Cited by 953
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease
Sartori, R., Romanello, V., & Sandri, M. (2021) · Nature Communications · doi:10.1038/s41467-020-20123-1 · Cited by 940
Leisure-time running reduces all-cause and cardiovascular mortality risk.
Lee, D.-C., Pate, R. R., Lavie, C. J., Sui, X., Church, T. S., & Blair, S. N. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.04.058 · Cited by 819
“from the Runners Association database compared with 423 matched nonrunners from the Lipid Research Clinics database after adjustment for baseline age, sex, and functional ability (12).”
BackgroundMethod
Epigenetic regulation of aging: implications for interventions of aging and diseases
Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 732
Health benefits of physical activity in older patients: a review
Vogel, T., Bréchat, P.-H., Leprêtre, P., Kaltenbach, G., Berthel, M., & Lonsdorfer, J. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2008.01957.x · Cited by 575
Potential Adverse Cardiovascular Effects From Excessive Endurance Exercise
O’Keefe, J. H., Patil, H., Lavie, C. J., Magalski, A., Vogel, R. A., & McCullough, P. A. (2012) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2012.04.005 · Cited by 490
The potential of endurance exercise-derived exosomes to treat metabolic diseases
Safdar, A., Saleem, A., & Tarnopolsky, M. A. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.76 · Cited by 463
Dose of Jogging and Long-Term Mortality
Schnohr, P., O’Keefe, J. H., Marott, J. L., Lange, P., & Jensen, G. B. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.11.023 · Cited by 416
Health Span Approximates Life Span Among Many Supercentenarians: Compression of Morbidity at the Approximate Limit of Life Span
Andersen, S. L., Sebastiani, P., Dworkis, D. A., Feldman, L., & Perls, T. T. (2012) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr223 · Cited by 331
Health benefits of different sport disciplines for adults: systematic review of observational and intervention studies with meta-analysis
Oja, P., Titze, S., Kokko, S. P., Kujala, U. M., Heinonen, A. O., Kelly, P., Koski, P., & Foster, C. E. (2015) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-093885 · Cited by 370
Physical activity: Health outcomes and importance for public health policy
Haskell, W. L., Blair, S. N., & Hill, J. O. (2009) · Preventive Medicine · doi:10.1016/j.ypmed.2009.05.002 · Cited by 365
RETRACTED: Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice
Safdar, A., Bourgeois, J. M., Ogborn, D. I., Little, J. P., Hettinga, B. P., Akhtar, M., Thompson, J. E., Melov, S., Mocellin, N. J., Kujoth, G. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019581108 · Cited by 320
Retracted
Running as a Key Lifestyle Medicine for Longevity
Lee, D.-C., Brellenthin, A. G., Thompson, P. D., Sui, X., Lee, I.-M. M., & Lavie, C. J. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.03.005 · Cited by 364
Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity
Seals, D. R., Justice, J. N., & LaRocca, T. J. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.282665 · Cited by 334
Compression of morbidity 1980–2011: a focused review of paradigms and progress
Fries, J. F., Bruce, B., & Chakravarty, E. (2011) · Journal of Aging Research · doi:10.4061/2011/261702 · Cited by 312
Self-citation
Late-life rapamycin treatment reverses age-related heart dysfunction
Flynn, J. M., O’Leary, M. N., Zambataro, C. A., Academia, E. C., Presley, M. P., Garrett, B., Zykovich, A., Mooney, S. D., Strong, R., Rosen, C. J., et al. (2013) · Aging Cell · doi:10.1111/acel.12109 · Cited by 314
Meta-Analyses of the Effects of Habitual Running on Indices of Health in Physically Inactive Adults
Hespanhol Junior, L. C., Pillay, J. D., van Mechelen, W., & Verhagen, E. (2015) · Sports Medicine · doi:10.1007/s40279-015-0359-y · Cited by 265
Exercise sustains the hallmarks of health
Qiu, Y., Fernández-García, B., Lehmann, H. I., Li, G., Kroemer, G., López-Otín, C., & Xiao, J. (2023) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.10.003 · Cited by 270
Aging Hallmarks: The Benefits of Physical Exercise
Rebelo-Marques, A., De Sousa Lages, A., Andrade, R., Ribeiro, C. F., Mota-Pinto, A., Carrilho, F., & Espregueira-Mendes, J. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00258 · Cited by 246
Is running associated with a lower risk of all-cause, cardiovascular and cancer mortality, and is the more the better? A systematic review and meta-analysis
Pedišić, Ž., Shrestha, N., Kovalchik, S. A., Stamatakis, E., Liangruenrom, N., Grgić, J., Titze, S., Biddle, S., Bauman, A. E., & Oja, P. (2019) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-100493 · Cited by 272
miRNA in the Regulation of Skeletal Muscle Adaptation to Acute Endurance Exercise in C57Bl/6J Male Mice
Safdar, A., Abadi, A., Akhtar, M., Hettinga, B. P., & Tarnopolsky, M. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005610 · Cited by 248
Associations of specific types of sports and exercise with all-cause and cardiovascular-disease mortality: a cohort study of 80 306 British adults
Oja, P., Kelly, P., Pedisic, Z., Titze, S., Bauman, A., Foster, C., Hamer, M., Hillsdon, M., & Stamatakis, E. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-096822 · Cited by 212
Exosomes as Mediators of the Systemic Adaptations to Endurance Exercise
Safdar, A., & Tarnopolsky, M. A. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029827 · Cited by 203
Weight management and physical activity throughout the cancer care continuum
Demark‐Wahnefried, W., Schmitz, K. H., Alfano, C. M., Bail, J. R., Goodwin, P. J., Thomson, C. A., Bradley, D. W., Courneya, K. S., Befort, C. A., Denlinger, C. S., et al. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21441 · Cited by 172
Assessing impacts of objective features and subjective perceptions of street environment on running amount: A case study of Boston
Dong, L., Jiang, H., Li, W., Qiu, B., Wang, H., & Qiu, W. (2023) · Landscape and Urban Planning · doi:10.1016/j.landurbplan.2023.104756 · Cited by 186
Exercise‐stimulated interleukin‐15 is controlled by AMPK and regulates skin metabolism and aging
Crane, J. D., MacNeil, L. G., Lally, J. S., Ford, R. J., Bujak, A. L., Brar, I. K., Kemp, B. E., Raha, S., Steinberg, G. R., & Tarnopolsky, M. A. (2015) · Aging Cell · doi:10.1111/acel.12341 · Cited by 179
Active Aging: A Global Goal
Ballesteros, R. F., Robine, J., Walker, A., & Kalache, A. (2013) · Current Gerontology and Geriatrics Research · doi:10.1155/2013/298012 · Cited by 207
Dysfunctional Nrf2–Keap1 redox signaling in skeletal muscle of the sedentary old
Safdar, A., DeBeer, J., & Tarnopolsky, M. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.08.010 · Cited by 159
Effects of Running on Chronic Diseases and Cardiovascular and All-Cause Mortality
Lavie, C. J., Lee, D.-C., Sui, X., Arena, R. A., O’Keefe, J. H., Church, T. S., Milani, R. V., & Blair, S. N. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.08.001 · Cited by 162
Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue
Couppé, C., Svensson, R. B., Grosset, J.-F., Kovanen, V., Nielsen, R. H., Olsen, M. R., Larsen, J. O., Praet, S., Skovgaard, D. C., Hansen, M., et al. (2014) · AGE · doi:10.1007/s11357-014-9665-9 · Cited by 131
Disability Status, Mortality, and Leading Causes of Death in the United States Community Population
Forman‐Hoffman, V. L., Ault, K. L., Anderson, W. L., Weiner, J. M., Stevens, A. C., Campbell, V. A., & Armour, B. S. (2015) · Medical Care · doi:10.1097/mlr.0000000000000321 · Cited by 129
Exercise Guidelines in Pregnancy
Zavorsky, G. S., & Longo, L. D. (2011) · Sports Medicine · doi:10.2165/11583930-000000000-00000 · Cited by 130
Midlife Fitness and the Development of Chronic Conditions in Later Life
Willis, B. L., Gao, A., Leonard, D. S., DeFina, L. F., & Berry, J. D. (2012) · Archives of Internal Medicine · doi:10.1001/archinternmed.2012.3400 · Cited by 127
Lifestyle Risk Factors Predict Disability and Death in Healthy Aging Adults
Chakravarty, E. F., Hubert, H. B., Krishnan, E., Bruce, B., Lingala, V. B., & Fries, J. F. (2012) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.08.006 · Cited by 109
Self-citation
Effects of exercise on cellular and tissue aging
Carapeto, P. V., & Aguayo-Mazzucato, C. (2021) · Aging · doi:10.18632/aging.203051 · Cited by 107
“Longevity and healthspan • Decreased risk of death [21, 22]”
Background
Running Forward
Rowe, G. C., Safdar, A., & Arany, Z. P. (2014) · Circulation · doi:10.1161/circulationaha.113.001590 · Cited by 107
The effect of exercise, resveratrol or their combination on Sarcopenia in aged rats via regulation of AMPK/Sirt1 pathway
Liao, Z.-Y., Chen, J.-L., Xiao, M.-H., Sun, Y., Zhao, Y.-X., Pu, D., Lv, A.-K., Wang, M.-L., Zhou, J., Zhu, S.-Y., et al. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.08.032 · Cited by 102
Physical activity intervention in older adults: does a participating partner make a difference?
Gellert, P. R., Ziegelmann, J. P., Warner, L. M., & Schwarzer, R. (2011) · European Journal of Ageing · doi:10.1007/s10433-011-0193-5 · Cited by 103
Endothelium-dependent control of cerebrovascular functions through age: exercise for healthy cerebrovascular aging
Bolduc, V., Thorin‐Trescases, N., & Thorin, É. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00624.2012 · Cited by 105
Mortality Among Marathon Runners in the United States, 2000-2009
Mathews, S. C., Narotsky, D. L., Bernholt, D. L., Vogt, M. N. P., Hsieh, Y., Pronovost, P. J., & Pham, J. C. (2012) · The American Journal of Sports Medicine · doi:10.1177/0363546512444555 · Cited by 103
Health and economic burden of running‐related injuries in runners training for an event: A prospective cohort study
Hespanhol, L., van Mechelen, W., Postuma, E., & Verhagen, E. A. L. M. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12541 · Cited by 97
Lifelong aerobic exercise protects against inflammaging and cancer
Nilsson, M. I., Bourgeois, J. M., Nederveen, J. P., Leite, M. R., Hettinga, B. P., Bujak, A. L., May, L. L., Lin, E., Crozier, M., Rusiecki, D. R., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0210863 · Cited by 98
Marathon run: cardiovascular adaptation and cardiovascular risk
Predel, H. (2014) · European Heart Journal · doi:10.1093/eurheartj/eht502 · Cited by 105
Lifelong Exercise Patterns and Cardiovascular Health
Maessen, M. F. H., Verbeek, A. L. M., Bakker, E. A., Thompson, P. D., Hopman, M. T. E., & Eijsvogels, T. M. H. (2016) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.02.028 · Cited by 92
Run for your life … at a comfortable speed and not too far
O’Keefe, J. H., & Lavie, C. J. (2012) · Heart · doi:10.1136/heartjnl-2012-302886 · Cited by 98
Vascular endothelial ageing, heartbeat after heartbeat
Thorin, É., & Thorin‐Trescases, N. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp236 · Cited by 91
Translational Geroscience: Emphasizing function to achieve optimal longevity
Seals, D. R., & Melov, S. (2014) · Aging · doi:10.18632/aging.100694 · Cited by 90
Effects of physical exercise programme on happiness among older people
Khazaee-Pool, M., Sadeghi, R., Majlessi, F., & Foroushani, A. R. (2014) · Journal of Psychiatric and Mental Health Nursing · doi:10.1111/jpm.12168 · Cited by 89
Health and Economic Burden of Running-Related Injuries in Dutch Trailrunners: A Prospective Cohort Study
Hespanhol, L., van Mechelen, W., & Verhagen, E. A. L. M. (2016) · Sports Medicine · doi:10.1007/s40279-016-0551-8 · Cited by 85
The Active Aging Agenda, Old Folk Devils and a New Moral Panic
Pike, E. C. J. (2011) · Sociology of Sport Journal · doi:10.1123/ssj.28.2.209 · Cited by 87
Can Intensive Exercise Harm the Heart?
Levine, B. D. (2014) · Circulation · doi:10.1161/circulationaha.114.008142 · Cited by 85
Acute kidney injury associated with endurance events—is it a cause for concern? A systematic review
Hodgson, L. E., Walter, E. J., Venn, R. M., Galloway, R., Pitsiladis, Y. P., Sardat, F., & Forni, L. G. (2017) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2015-000093 · Cited by 81
Foot Core Training to Prevent Running-Related Injuries: A Survival Analysis of a Single-Blind, Randomized Controlled Trial
Taddei, U. T., Matias, A. B., Duarte, M., & Sacco, I. D. C. N. (2020) · The American Journal of Sports Medicine · doi:10.1177/0363546520969205 · Cited by 86
Health Benefits of Different Sports: a Systematic Review and Meta-Analysis of Longitudinal and Intervention Studies Including 2.6 Million Adult Participants
Oja, P., Memon, A. R., Titze, S., Jurakić, D., Chen, S., Shrestha, N., Em, S., Matolić, T., Vasankari, T. J., Heinonen, A. O., et al. (2024) · Sports Medicine - Open · doi:10.1186/s40798-024-00692-x · Cited by 92
Cardiovascular damage resulting from chronic excessive endurance exercise.
Patil, H., O’Keefe, J. H., Lavie, C. J., Magalski, A., Vogel, R. A., & McCullough, P. A. (2012) · Europe PMC (PubMed Central) · Cited by 78
The Relationships between Age and Running Biomechanics
DeVita, P., Fellin, R. E., Seay, J. F., Ip, E. H., Stavro, N., & Messier, S. P. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000744 · Cited by 74
Examining the influence of neighborhood and street-level built environment on fitness jogging in Chengdu, China: A massive GPS trajectory data analysis
Yang, W., Hu, J., Liu, Y., & Guo, W. (2023) · Journal of Transport Geography · doi:10.1016/j.jtrangeo.2023.103575 · Cited by 72
Effects of physical activity, body mass index, waist-to-hip ratio and waist circumference on total mortality risk in the Swedish National March Cohort
Bellocco, R., Jia, C., Ye, W., & Lagerros, Y. T. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9497-6 · Cited by 72
RETRACTED ARTICLE:Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice
Safdar, A., Khrapko, K., Flynn, J. M., Saleem, A., Lisio, M. D., Johnston, A. P. W., Kratysberg, Y., Samjoo, I. A., Kitaoka, Y., Ogborn, D. I., et al. (2015) · Skeletal Muscle · doi:10.1186/s13395-016-0075-9 · Cited by 68
Retracted
Exerkines and cardiometabolic benefits of exercise: from bench to clinic
Jin, L., Díaz-Cañestro, C., Wang, Y., Tse, M. A., & Xu, A. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00027-z · Cited by 76
Myocardial Function in Older Male Amateur Marathon Runners: Assessment by Tissue Doppler Echocardiography, Speckle Tracking, and Cardiac Biomarkers
Knebel, F., Schimke, I., Schroeckh, S., Peters, H., Eddicks, S., Schattke, S., Brechtel, L. M., Lock, J., Wernecke, K. D., Dreger, H., et al. (2009) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2009.04.009 · Cited by 68
Aging Skeletal Muscles: What Are the Mechanisms of Age-Related Loss of Strength and Muscle Mass, and Can We Impede Its Development and Progression?
Gustafsson, T. P., & Ulfhake, B. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252010932 · Cited by 78
The Theory and Practice of Active Aging
Fries, J. F. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/420637 · Cited by 78
Differential satellite cell density of type I and II fibres with lifelong endurance running in old men
Mackey, A. L., Karlsen, A., Couppé, C., Mikkelsen, U. R., Nielsen, R. H., Magnusson, S. P., & Kjær, M. (2013) · Acta Physiologica · doi:10.1111/apha.12195 · Cited by 63
Looking Ahead Perspective: Where Will the Future of Exercise Biology Take Us?
Zierath, J. R., & Wallberg‐Henriksson, H. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.015 · Cited by 59
Exercise and vascular function: how much is too much?
Durand, M. J., & Gutterman, D. D. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0486 · Cited by 58
Effectiveness of online tailored advice to prevent running-related injuries and promote preventive behaviour in Dutch trail runners: a pragmatic randomised controlled trial
Hespanhol, L., van Mechelen, W., & Verhagen, E. A. L. M. (2017) · British Journal of Sports Medicine · doi:10.1136/bjsports-2016-097025 · Cited by 58
Prevalence, incidence and course of lower extremity injuries in runners during a 12‐month follow‐up period
van Poppel, D., Scholten-Peeters, G. G. M., van Middelkoop, M., & Verhagen, A. P. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12110 · Cited by 56
Strenuous endurance exercise improves life expectancy: it's in our genes: Table 1
Ruiz, J. R., Morán, M., Arenas, J., & Lucía, A. (2010) · British Journal of Sports Medicine · doi:10.1136/bjsm.2010.075085 · Cited by 59
Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women
Hebert, S. L., Marquet, P., Lanza, I. R., MCCRADY-SPITZER, S. K., Levine, J. A., Middha, S., Carter, R. E., Klaus, K. A., Therneau, T. M., Highsmith, E. W., et al. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv086 · Cited by 55
Mitochondrial biogenesis related endurance genotype score and sports performance in athletes
Eynon, N., Ruiz, J. R., Meckel, Y., Morán, M., & Lucía, A. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.07.004 · Cited by 53
Environmental Preferences and Concerns of Recreational Road Runners
Schuurman, N., Rosenkrantz, L., & Lear, S. A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18126268 · Cited by 49
Increased Average Longevity among the “Tour de France” Cyclists
Nieman, D. C. (2012) · Yearbook of Sports Medicine · doi:10.1016/j.yspm.2011.12.013 · Cited by 49
Leisure-time physical activity, cardiovascular risk factors and mortality during a 34-year follow-up in men
Savela, S., Koistinen, P., Tilvis, R. S., Strandberg, A. Y., Pitkälä, K. H., Salomaa, V. V., Miettinen, T. A., & Strandberg, T. E. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9483-z · Cited by 49
Strenuous Exercise and Cardiovascular Disease Outcomes
Kim, J. H., & Baggish, A. L. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0636-3 · Cited by 49
Endurance Exercise and the Heart: Friend or Foe?
Sanchis‐Gomar, F., Pérez, L. M., Joyner, M. J., Löllgen, H., & Lucía, A. (2015) · Sports Medicine · doi:10.1007/s40279-015-0434-4 · Cited by 45
A profile of health, lifestyle and training habits of 4720 Australian recreational runners—The case for promoting running for health benefits
Kozlovskaia, M., Vlahovich, N., Rathbone, E. N., Manzanero, S., Keogh, J., & Hughes, D. C. (2017) · Health Promotion Journal of Australia · doi:10.1002/hpja.30 · Cited by 45
Exercise as a Therapeutic Strategy for Primary Mitochondrial Cytopathies
Tarnopolsky, M. A. (2014) · Journal of Child Neurology · doi:10.1177/0883073814538512 · Cited by 45
Plasma irisin in runners and nonrunners: no favorable metabolic associations in humans
Hew‐Butler, T., Landis‐Piwowar, K. R., Byrd, G. F., Seimer, M., Seigneurie, N., Byrd, B., & Muzik, O. (2015) · Physiological Reports · doi:10.14814/phy2.12262 · Cited by 43
Decreased physical activity is a predictor for a complicated recovery post cardiac surgery
van Laar, C., Timman, S. T., & Noyez, L. (2017) · Health and Quality of Life Outcomes · doi:10.1186/s12955-016-0576-6 · Cited by 40
Connected Community and Household Food-Based Strategy (CCH-FBS): Its Importance for Health, Food Safety, Sustainability and Security in Diverse Localities
Wahlqvist, M. L. (2009) · Ecology of Food and Nutrition · doi:10.1080/03670240903308596 · Cited by 38
Risikoreduktion kardiovaskulärer Erkrankungen durch körperliche Aktivität
Löllgen, H., & Löllgen, D. (2011) · Der Internist · doi:10.1007/s00108-011-2889-1 · Cited by 40
The nature of running: On embedded landscape ideals in leisure planning
Qviström, M. (2016) · Urban forestry & urban greening · doi:10.1016/j.ufug.2016.04.012 · Cited by 39
Effects of running fatigue on lower extremity symmetry among amateur runners: From a biomechanical perspective
Gao, Z., Fekete, G., Baker, J. S., Liang, M., Xuan, R., & Gu, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.899818 · Cited by 38
Associations between cardiorespiratory fitness and lifestyle‐related factors with DNA methylation‐based ageing clocks in older men: WASEDA 'S Health Study
Kawamura, T., Radak, Z. O., Tabata, H., Akiyama, H., Nakamura, N., Kawakami, R., Ito, T., Usui, C., Jókai, M., Torma, F., et al. (2023) · Aging Cell · doi:10.1111/acel.13960 · Cited by 38
The role of perceived barriers and objectively measured physical activity in adults aged 65–100
Gellert, P. R., Witham, M. D., Crombie, I. K., Donnan, P. T., McMurdo, M. E. T., & Sniehotta, F. F. (2015) · Age and Ageing · doi:10.1093/ageing/afv001 · Cited by 38
Cardiac Risks Associated With Marathon Running
Day, S. M., & Thompson, P. D. (2010) · Sports Health A Multidisciplinary Approach · doi:10.1177/1941738110373066 · Cited by 41
Disability and Incident Coronary Heart Disease in Older Community‐Dwelling Adults: The Three‐City Study
Plichart, M., Barberger‐Gateau, P., Tzourio, C., Amouyel, P., Pérès, K., Ritchie, K. A., Jouven, X., Ducimetière, P., & Empana, J. P. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02758.x · Cited by 36
Disability in Systemic Sclerosis — A Longitudinal Observational Study
Schnitzer, M. E., Hudson, M., Baron, M. G., & Steele, R. J. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100635 · Cited by 36
Effectiveness of Start to Run, a 6-week training program for novice runners, on increasing health-enhancing physical activity: a controlled study
Ooms, L., Veenhof, C., & de Bakker, D. H. (2013) · BMC Public Health · doi:10.1186/1471-2458-13-697 · Cited by 36
Resting VO2, maximal VO2 and metabolic equivalents in free-living healthy elderly women
Sergi, G., Coin, A., Sarti, S., Perissinotto, E., Peloso, M., Mulone, S., Trolese, M., Inelmen, E. M., Enzi, G., & Manzato, E. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.07.010 · Cited by 33
Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease
Horowitz, A. M., & Villeda, S. (2017) · F1000Research · doi:10.12688/f1000research.11437.1 · Cited by 32
Exercise and Health: Dose and Response, Considering Both Ends of the Curve
Simon, H. B. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.05.012 · Cited by 35
Influence of aerobic fitness on age-related lymphocyte DNA damage in humans: relationship with mitochondria respiratory chain and hydrogen peroxide production
Mota, M. P., Peixoto, F., Soares, J., Figueiredo, P., Leitão, J. C., Gaivão, I., & Duarte, J. A. (2010) · AGE · doi:10.1007/s11357-010-9138-8 · Cited by 30
The exercise cytokine interleukin-15 rescues slow wound healing in aged mice
Wong, W., Crane, E. D., Kuo, Y., Kim, A., & Crane, J. D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010740 · Cited by 30
Association Between Combined Lifestyle Factors and Healthy Ageing in Chinese Adults: The Singapore Chinese Health Study
Zhou, Y., Song, X., Pan, X., Feng, L., Luo, N., Yuan, J., Pan, A., & Koh, W. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab033 · Cited by 32
Frequency of exercise-induced ST-T-segment deviations and cardiac arrhythmias in recreational endurance athletes during a marathon race: results of the prospective observational Berlin Beat of Running study
Herm, J., Töpper, A., Wutzler, A., Kunze, C., Krüll, M., Brechtel, L. M., Lock, J., Fiebach, J. B., Heuschmann, P. U., Haverkamp, W., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015798 · Cited by 29

Authors: Chakravarty, E. F.
Affiliations: Stanford Medicine (US)
Corresponding author: Chakravarty, Eliza F.
Venue: Archives of Internal Medicine
Publisher: American Medical Association (AMA)
Published: 2008-08-11
Volume: 168
Issue: 15
Pages: 1638
ISSN: 0003-9926 (ISSN-L)
DOI: 10.1001/archinte.168.15.1638
PMC: PMC3175643
OpenAlex: W2034439760
Cited by: 313
References: 58
Citations by year: 2026: 19 · 2025: 9 · 2024: 16 · 2023: 19 · 2022: 19 · 2021: 18 · 2020: 16 · 2019: 22 · 2018: 13 · 2017: 18 · 2016: 15 · 2015: 30 · 2014: 19 · 2013: 14 · 2012: 18
FWCI: 10.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Archives of Internal Medicine (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR-43584, P01AR043584)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords: running, older adults, disability, mortality, physical activity, HAQ-DI, long-term follow-up, aging, survival
MeSH terms: Age Factors, Aged, Aged, 80 and over, Disability Evaluation, Female, Humans, Longitudinal Studies, Male, Middle Aged, Mortality, Surveys and Questionnaires, Running, Sex Factors, Smoking, United States, Exercise, Body Mass Index, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reduced Disability and Mortality Among Aging Runners: A 21-Year Longitudinal Study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks