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Cannabis Abuse and the Course of Recent-Onset Schizophrenic Disorders
Abstract
OBJECTIVE: We sought to examine the relation between cannabis abuse and the symptomatic course of recent-onset schizophrenia and related disorders. DESIGN: A prospective cohort study over a year using monthly Brief Psychiatric Rating Scale assessments. PARTICIPANTS: Cannabis-abusing patients (n = 24) were compared with nonabusers (n = 69). Eleven patients were mild and 13 were heavy cannabis-abusing patients. RESULTS: Significantly more and earlier psychotic relapses occurred in the cannabis-abusing group (P = .03). This association became stronger when mild and heavy cannabis abuse were distinguished (P = .002). No confounding effect of other variables, eg, other street drugs, was found. In all but one patient, cannabis abuse preceded the onset of the first psychotic symptoms for at least 1 year. CONCLUSIONS: Cannabis abuse and particularly heavy abuse can be considered a stressor eliciting relapse in patients with schizophrenia and related disorders and possibly a premorbid precipitant.
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Metadata
- Authors
- Linszen, D. H.
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 1994-04-01
- Volume
- 51
- Issue
- 4
- Pages
- 273
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W1995314680
- Cited by
- 656
- References
- 2
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- closed
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