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Detecting Alcoholism: The CAGE Questionnaire
Abstract
Four clinical interview questions, the CAGE questions, have proved useful in helping to make a diagnosis of alcoholism. The questions focus on Cutting down, Annoyance by criticism, Guilty feeling, and Eye-openers. The acronym "CAGE" helps the physician to recall the questions. How these questions were identified and their use in clinical and research studies are described. (JAMA1984;252:1905-1907)
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“Για την ποσοτική αξιολόγηση της τρέχουσας καταθλιπτικής και αγχώδους συμπτωματολογίας, καθώς και της προβληματικής κατανάλωσης αλκοόλ, χρησιμοποιήθηκαν, αντίστοιχα, οι κλίμακες Patient Health Questionnaire (PHQ-9 27,28 ), Beck Anxiety Inventory (BAI 29,30 ) και CAGE. 31,32”
From Clinical presentation and requests for support of people with HIV/AIDS seeking counselling and psychotherapy in Greece (2019) · cites this paper as [31]
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Cuffel, B. J., Bloom, J. R., Wallace, N., et al. (2002) · Health Services Research · doi:10.1111/1475-6773.026 · Cited by 44
“The CAGE was used to assess alcohol problems (Ewing 1984).”
MethodSpies, C., Emadi, A., Neumann, T., Hannemann, L., Rieger, A., Schaffartzik, W., Rahmanzadeh, R., Berger, G., Funk, T., Blum, S., et al. (1995) · doi:10.1097/00005373-199510000-00025 · Cited by 40
Emotional Distress During Interferon-α-2B and Ribavirin Treatment of Chronic Hepatitis C
Fontana, R. J., Schwartz, S. M., Gebremariam, A., Lok, A. S.-F., & Moyer, C. A. (2002) · Psychosomatics · doi:10.1176/appi.psy.43.5.378 · Cited by 44
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Wellbeing and burnout in medical students in India; a large scale survey
Farrell, S., Kar, A., Valsraj, K. M., Mukherjee, S., Kunheri, B., Molodynski, A., & George, S. (2019) · International Review of Psychiatry · doi:10.1080/09540261.2019.1688047 · Cited by 38
“…(GHQ-12) (Saunders, Aasland, Babor, de la Fuente, & Grant, 1993) was included to identify minor psychiatric disorder, CAGE questionnaire (Ewing, 1984) to identify alcohol abuse, and the Oldenburg Burnout Inventory (Demerouti, Demerouti, Bakker, Vardakou, & Kantas, 2003) to quantify…”
MethodBehavioral Economics and Addictive Disorders
Jarmolowicz, D. P., & Schneider, T. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.005 · Cited by 42
Prevention and Treatment of Compulsive Buying Disorder
Galimov, A., & Black, D. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.027 · Cited by 42
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42
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Rastogi, A., Manthey, J., Wiemker, V., & Probst, C. (2021) · Addiction · doi:10.1111/add.15777 · Cited by 42
Alcohol Consumption and Depression Among University Students and Their Perception of Alcohol Use
Chow, M. S. C., Poon, S. H. L., Lui, K. L., Chan, C. C. Y., & Lam, W. (2021) · East Asian Archives of Psychiatry · doi:10.12809/eaap20108 · Cited by 37
Østbye, T., Taylor, D. H., Krause, K. M., & Scoyoc, L. V. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50164.x · Cited by 42
Perlis, M., Grandner, M., Zee, J., Bremer, E., Whinnery, J., Barilla, H., Andalia, P. A., Gehrman, P., Morales, K., Thase, M., et al. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2015.06.015 · Cited by 40
“The validated measures included seven questionnaires measuring insomnia severity (ISI) [19]; sleepiness (ESS) [20,21]; anxiety (STAI) [22,23], depression (QIDS) [24]; menstrual cycle regularity, menses-related symptoms, and contraception practices (MCQ) [25]; and alcohol use and abuse (AUDIT-CAGE) [26,27].”
MethodRognmo, K., Torvik, F. A., Ask, H., Røysamb, E., & Tambs, K. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-448 · Cited by 43
“Alcohol related problems were measured by the CAGE Alcohol Screening Questionnaire [27].”
MethodDrug Use Among Prisoners: By Any Definition, It's a Big Problem
Lintonen, T., Vartiainen, H., Aarnio, J., Hakamäki, S., Viitanen, P., Wuolijoki, T., & Joukamaa, M. I. (2011) · Substance Use & Misuse · doi:10.3109/10826081003682271 · Cited by 43
“Questionnaires such as cut-annoyed-guilty-eye (CAGE; Ewing, 1984), drug use screening test (DAST; Gavin, Ross, & Skinner, 1989) and severity of dependence scale (SDS; Gossop, Best, Marsden, & Strang, 1997) have also been used to assess alcohol and drug dependence in the prison population (e.g.,…”
MethodGrant, T. M., Huggins, J. E., Sampson, P. D., Ernst, C. C., Barr, H. M., & Streissguth, A. P. (2008) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2008.09.871 · Cited by 43
Substance-related disorders: A review of prevalence and correlates among patients with chronic pain
Martel, M. O., Shir, Y., & Ware, M. A. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.06.032 · Cited by 41
Business Travel and Behavioral and Mental Health
Rundle, A., Revenson, T. A., & Friedman, M. A. (2017) · Journal of Occupational and Environmental Medicine · doi:10.1097/jom.0000000000001262 · Cited by 44
Loneliness Among Persons With Severe Mental Illness
Prince, J. D., Oyo, A., Mora, O., Wyka, K., & Schonebaum, A. D. (2017) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0000000000000768 · Cited by 47
Reid-Varley, W.-B., Martinez, C. C. P., & Khurshid, K. A. (2020) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2020.116713 · Cited by 42
Pain and Use of Alcohol in Later Life
Brennan, P. L., & SooHoo, S. (2013) · Journal of Aging and Health · doi:10.1177/0898264313484058 · Cited by 43
“Drinking problems were assessed only at participants’ initial HRS interview, using the CAGE instrument (Ewing, 1984; Mayfield, McLeod, & Hall, 1974).”
MethodGender Differences in Delinquent Behavior among Korean Adolescents
Kim, H., & Kim, H. (2005) · Child Psychiatry & Human Development · doi:10.1007/s10578-005-2691-1 · Cited by 43
Job Satisfaction, Job Reward Characteristics, and Employees' Problem Drinking Behaviors
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Martín, J. V., Galán, I., & Rodríguez‐Artalejo, F. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00826.x · Cited by 43
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Item bias in the CAGE screening test for alcohol use disorders
Volk, R. J., Cantor, S. B., Steinbauer, J. R., et al. (1997) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1997.07162.x · Cited by 43
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Narendorf, S. C., Brydon, D. M., Maria, D. S., Bender, K., Ferguson, K. M., Hsu, H.-T., Barman‐Adhikari, A., Shelton, J., & Petering, R. (2019) · Children and Youth Services Review · doi:10.1016/j.childyouth.2019.104609 · Cited by 42
“…use was assessed with the CAGE screener that asked four questions about whether participants ever felt guilty about using sub-stances, felt they should cut down, had people tell them they were concerned about their substance use, or used substances first thing in the morning (Ewing, 1984).”
MethodMcKay, K. A., Tremlett, H. L., Fisk, J. D., Patten, S. B., Fiest, K. M., Berrigan, L. I., Marrie, R. A., & for the CIHR Team in the Epidemiology and Impact of Comorbidity on Multiple Sclerosis (ECoMS) (2015) · Multiple Sclerosis Journal · doi:10.1177/1352458515599073 · Cited by 42
Validation of the Finnish version of the SCOFF questionnaire among young adults aged 20 to 35 years
Lähteenmäki, S., Aalto‐Setälä, T., Suokas, J. T., Saarni, S. E., Perälä, J., Saarni, S. I., Aro, H. M., Lönnqvist, J. K., & Suvisaari, J. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-5 · Cited by 42
“The CAGE questionnaire.”
MethodTam, C. W. M., Zwar, N. A., & Markham, R. (2013) · BMC Family Practice · doi:10.1186/1471-2296-14-121 · Cited by 38
“Most GPs knew of the CAGE questionnaire [25], and a few were aware of the AUDIT and AUDIT-C.”
BackgroundSpouse Abuse and Alcohol Problems Among White, African American, and Hispanic U.S. Army Soldiers
Bell, N. S., Harford, T. C., Fuchs, C. H., McCarroll, J. E., & Schwartz, C. E. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00214.x · Cited by 42
Protein biomarkers of alcohol abuse
Torrente, M. P., Freeman, W. M., & Vrana, K. E. (2012) · Expert Review of Proteomics · doi:10.1586/epr.12.38 · Cited by 42
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Sociodemographic and clinical factors associated with depression in epilepsy
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Reliabilities of Short Substance Abuse Screening Tests Among Adolescent Medical Patients
Knight, J. R., Goodman, E., Pulerwitz, T., & DuRant, R. H. (2000) · PEDIATRICS · doi:10.1542/peds.105.s3.948 · Cited by 40
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McLeod, D. R., Foster, G. V., Hoehn‐Saric, R., Svikis, D. S., & Hipsley, P. A. (1994) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1994.tb00928.x · Cited by 41
Detection of bulimia in a primary care setting
Freund, K. M., Graham, S. M., Lesky, L. G., et al. (1993) · Journal of General Internal Medicine · doi:10.1007/bf02600088 · Cited by 42
Heeren, G. A., Jemmott, J. B., Ngwane, Z., Mandeya, A., & Tyler, J. C. (2012) · AIDS and Behavior · doi:10.1007/s10461-011-0129-2 · Cited by 40
“The CAGE [29] was used to assess lifetime alcohol dependence and alcohol problems were denoted by CAGE scores greater than or equal to 2.”
InfluentialReisner, S. L., Mimiaga, M. J., Mayer, K. H., Tinsley, J. P., & Safren, S. A. (2008) · Journal of LGBT Health Research · doi:10.1080/15574090903114739 · Cited by 41
“69), was used to assess problematic alcohol use ( Ewing, 1984 ; Knowlton, McCusker, Stoddard, Zapka, & Mayer, 1994 ; Mayfield, McLeod, & Hall, 1974 ).”
Nilsén, P., Wåhlin, S., & Heather, N. (2011) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph8093609 · Cited by 41
“AUDIT was also selected because of its focus on identifying non-dependent drinkers in contrast to tools such as CAGE (acronym for Cutting down, Annoyance, Guilt and “Eye-opener”) [11] developed to detect more severe alcohol problems.”
MethodRecognized spontaneous abortion in mid-pregnancy and patterns of pregnancy alcohol use
Chiodo, L. M., Bailey, B. A., Sokol, R. J., Janisse, J. J., Delaney‐Black, V., & Hannigan, J. H. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.11.006 · Cited by 41
“…since the cohort was restricted to low-SES urban African-American women, and oversampled drinkers, and the reliability of assessments of maternal alcohol use or abuse can differ across populations (Bradley et al., 1998; Chan et al., 1993; Ewing, 1984; Nardini et al., 2005; Sokol et al., 1989).”
BackgroundMcCrory, C., Finucane, C., O’Hare, C., Frewen, J., Nolan, H., Layte, R., Kearney, P. M., & Kenny, R. A. (2014) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbu163 · Cited by 40
“The CAGE alcohol screening test (Ewing, 1984) was used to index hazardous drinking.”
Methodvan Loon, L. M. A., van de Ven, M. O. M., van Doesum, K. T. M., Hosman, C. M. H., & Witteman, C. L. M. (2015) · Child & Youth Care Forum · doi:10.1007/s10566-015-9304-3 · Cited by 41
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“Moreover, some tools, for example the CAGE [11] and the Michigan Alcoholism Screening Test [12], tend to identify those patients who are at risk for a severe substance use problem more accurately, than those drinking at lower but hazardous levels [13].”
Ait‐Daoud, N., Blevins, D., Khanna, S., Sharma, S., & Holstege, C. P. (2017) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2017.01.005 · Cited by 42
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Perioperative Management of Alcohol Withdrawal Syndrome
Ungur, A. L., Neumann, T., Borchers, F., & Spies, C. (2020) · Visceral Medicine · doi:10.1159/000507595 · Cited by 41
Lee, D., Hong, Y., Seo, H. Y., Yun, J., Nam, S., & Lee, N. (2021) · Safety and Health at Work · doi:10.1016/j.shaw.2021.05.002 · Cited by 44
“Those who answered “yes” for at least one question of the CAGE questionnaire were classified into the risk group of alcohol use disorder [35].”
Gossop, M., Neto, D., Radovanovic, M., Batra, A., Toteva, S., Musalek, M., Skutle, A., & Goos, C. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00066.x · Cited by 41
“Brief screening instruments such as the CAGE (Ewing 1984), the short Alcohol Use Disorders Identification Test (Piccinelli et al. 1997), or the SDS-A (Gossop et al. 1995), may be of use in this context.”
Ecological Momentary Assessment of Smoking Behavior in Persistent Pain Patients
Dhingra, L. K., Homel, P., Grossman, B. R., Chen, J., Scharaga, E. A., Calamita, S., Shin, J. K., & Portenoy, R. K. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e31829821c7 · Cited by 41
Chronic treatment with modafinil may not be beneficial in patients with chronic fatigue syndrome
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“…distribution, metabolism or excretion; a history of alcohol/drug abuse, more than two positive replies on the CAGE alcoholism questionnaire (Ewing, 1984), or a positive illicit urine drug screen at screening; use of psychoactive medication; any major sight, hearing or movement problems;…”
BackgroundMidanik, L. T., Zahnd, E. G., & Klein, D. (1998) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1998.tb03625.x · Cited by 41
Cichowitz, C., Maraba, N., Hamilton, R., Charalambous, S., & Hoffmann, C. J. (2017) · PLOS ONE · doi:10.1371/journal.pone.0189820 · Cited by 38
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“Several reliable and valid self-report questionnaires have been effectively employed in these settings; current examples include the Generalized Anxiety Disorder (GAD)-7 [10,11], the CAGE alcohol screen [12], the Patient Health Questionnaire (PHQ)-2 and PHQ-9 [13,14], the Quick Inventory of Depressive Symptomatology S…”
Strayer, R. J., Friedman, B. W., Haroz, R., Ketcham, E. M., Klein, L. R., LaPietra, A. M., Motov, S. M., Repanshek, Z. D., Taylor, S., Weiner, S. G., et al. (2023) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2023.01.010 · Cited by 40
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The Effect of Alcohol Abuse on the Health Status of Older Adults Seen in the Emergency Department
Friedmann, P. D., Jin, L., Karrison, T. G., Nerney, M. P., Hayley, D. C., Mulliken, R., Walter, J. J., Miller, A., & Chin, M. H. (1999) · The American Journal of Drug and Alcohol Abuse · doi:10.1081/ada-100101877 · Cited by 40
Consumer Satisfaction with Inpatient Psychiatric Treatment Among Persons with Severe Mental Illness
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Diffusion Tensor Imaging of Pedophilia
Cantor, J. M., Lafaille, S. J., Soh, D. W., et al. (2015) · Archives of Sexual Behavior · doi:10.1007/s10508-015-0629-7 · Cited by 40
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“It contains four self-report questions assessing heavy and hazardous alcohol consumption, alcohol abuse, and alcohol dependence, with a score of 2 or greater indicating a clinically significant alcohol problem (Ewing, 1984).”
BackgroundSiefried, K. J., Mao, L., Kerr, S. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174613 · Cited by 40
Lanthier-Labonté, S., Dufour, M., Milot, D.-M., & Loslier, J. (2020) · Addictive Behaviors · doi:10.1016/j.addbeh.2020.106331 · Cited by 39
Self-Rated Health Trajectories in the African American Health Cohort
Ayyagari, P., Ullrich, F. A., Malmstrom, T. K., Andresen, E. M., Schootman, M., Miller, J. P., Miller, D. K., & Wolinsky, F. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053278 · Cited by 40
“Alcohol dependency was measured at the one-year follow-up using the four-item CAGE scale (Cut-down, Annoyed, Guilty, and Eye opener) [39], which ranged from 0 (low) to 4 (high).”
MethodMoline, J. M., Herbert, R., Levin, S. M., Stein, D., Luft, B. J., Udasin, I. G., & Landrigan, P. J. (2008) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20022 · Cited by 41
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“Although frequently used as a dichotomous indicator, the CAGE has also been used as a continuous variable by Ewing (1984).”
MethodWelsh, J. A., Buchsbaum, D. G., & Kaplan, C. (1993) · Quality of Life Research · doi:10.1007/bf00449428 · Cited by 37
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“…48 drinks per month; (ii) greater than 4 or 7 drinks per week for females and greater than 6 or 14 drinks per week for males; (iii) an Alcohol Use Disorder Identification Test (AUDIT;(Saunders et al., 1993)) score of 8 of higher; (iv) a score of 2 or higher on the CAGE questionnaire (Ewing, 1984).”
BackgroundNon‐alcoholic beverage consumption among US adults who consume alcohol
Bowdring, M. A., McCarthy, D. M., Fairbairn, C. E., & Prochaska, J. J. (2024) · Addiction · doi:10.1111/add.16452 · Cited by 46
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Gossage, J. P., Snell, C. L., Parry, C. D. H., Marais, A., Barnard, R., de Vries, M. M., Blankenship, J., Seedat, S., Hasken, J. M., & May, P. A. (2014) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph110707406 · Cited by 50
“Embedded into the questionnaire were two standard problem drinking assessment tools, the World Health Organization’s Alcohol Use Disorders Test (AUDIT) [31] and the CAGE [32].”
BackgroundMethodInfluentialAlcohol use among Latino migrant workers in South Florida
Sánchez, J. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.03.025 · Cited by 40
Drum, M. L., Shiovitz‐Ezra, S., Gaumer, E., & Lindau, S. T. (2009) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbn017 · Cited by 38
Factors Associated with Clinical and Topographical Features of Laryngeal Tuberculosis
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“Patients who had the habit of smoking daily regardless of the amount were considered smokers and those who consumed any alcoholic beverage and gave a positive response to at least two questions in the CAGE questionnaire were considered drinkers [18].”
BackgroundKim, S., Kim, Y., & Park, S. M. (2016) · BMJ Open · doi:10.1136/bmjopen-2015-010494 · Cited by 41
Carlson, M. E., Vigen, C. L. P., Rubayi, S., Blanche, E. I., Blanchard, J., Atkins, M. S., Bates‐Jensen, B. M., Garber, S. L., Pyatak, E. A., Díaz, J., et al. (2017) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2017.1313931 · Cited by 39
Effective Connectivity in Default Mode Network for Alcoholism Diagnosis
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“Generally, the evaluation of AUD is performed using questionnaires such as AUDIT (Alcohol Use Disorder Identification Test) [10], CAGE (Cutting down, Annoyance by criticism, Guilty feeling, and Eye-openers questions) [11] etc.”
MethodHudetz, J. A., Byrne, A. J., Patterson, K. M., Pagel, P. S., & Warltier, D. C. (2009) · Psychological Reports · doi:10.2466/pr0.105.3.921-932 · Cited by 39
“The CAGE questionnaire was used as a screening instrument for detecting alcoholism (Ewing, 1984).”
MethodCapture-recapture methods to size alcohol related problems in a population
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Causes of Macrocytosis in HIV-infected Patients not Treated with Zidovudine
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Nested case‐control analysis of high pesticide exposure events from the Agricultural Health Study
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Positive and negative consequences of alcohol drinking among young university students in Finland
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Alcohol use amongst community‐dwelling elderly people: a review of the literature
Lakhani, N. (1997) · Journal of Advanced Nursing · doi:10.1046/j.1365-2648.1997.19970251227.x · Cited by 39
Treatment of Alcohol Withdrawal in Hospitalized Patients
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Bell, I. R., Bootzin, R. R., Ritenbaugh, C., et al. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00330-4 · Cited by 39
Prevalence of female alcohol dependence and abuse in Sweden
Spak, F., & Hällström, T. (2003) · Addiction · doi:10.1046/j.1360-0443.1995.90810776.x · Cited by 39
Adolescent injury in the emergency department: Opportunity for alcohol interventions?
Maio, R. F., Shope, J. T., Blow, F. C., et al. (2000) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(00)70076-x · Cited by 39
Padrões alimentares de idosos e seus determinantes: estudo de base populacional no sul do Brasil
Gomes, A. P., Bierhals, I. O., Vieira, L. S., et al. (2020) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232020256.20932018 · Cited by 38
Metadata
- Authors
- Ewing, J. A.
- Corresponding author
- Ewing, John A.
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1984-10-12
- Volume
- 252
- Issue
- 14
- Pages
- 1905
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W4254121089
- Cited by
- 3,005
- References
- 0
- Citations by year
- 2026: 40 · 2025: 79 · 2024: 67 · 2023: 80 · 2022: 103 · 2021: 103 · 2020: 186 · 2019: 114 · 2018: 128 · 2017: 130 · 2016: 136 · 2015: 142 · 2014: 144 · 2013: 137 · 2012: 133
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Social Sciences › Psychology › Applied Psychology › Psychological Testing and Assessment
- Keywords
- alcoholism, CAGE questionnaire, screening questions, clinical interview, diagnostic criteria
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