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Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis
Open accessAbstract
CONTEXT: Antidepressant medications represent the best established treatment for major depressive disorder, but there is little evidence that they have a specific pharmacological effect relative to pill placebo for patients with less severe depression. OBJECTIVE: To estimate the relative benefit of medication vs placebo across a wide range of initial symptom severity in patients diagnosed with depression. DATA SOURCES: PubMed, PsycINFO, and the Cochrane Library databases were searched from January 1980 through March 2009, along with references from meta-analyses and reviews. STUDY SELECTION: Randomized placebo-controlled trials of antidepressants approved by the Food and Drug Administration in the treatment of major or minor depressive disorder were selected. Studies were included if their authors provided the requisite original data, they comprised adult outpatients, they included a medication vs placebo comparison for at least 6 weeks, they did not exclude patients on the basis of a placebo washout period, and they used the Hamilton Depression Rating Scale (HDRS). Data from 6 studies (718 patients) were included. DATA EXTRACTION: Individual patient-level data were obtained from study authors. RESULTS: Medication vs placebo differences varied substantially as a function of baseline severity. Among patients with HDRS scores below 23, Cohen d effect sizes for the difference between medication and placebo were estimated to be less than 0.20 (a standard definition of a small effect). Estimates of the magnitude of the superiority of medication over placebo increased with increases in baseline depression severity and crossed the threshold defined by the National Institute for Clinical Excellence for a clinically significant difference at a baseline HDRS score of 25. CONCLUSIONS: The magnitude of benefit of antidepressant medication compared with placebo increases with severity of depression symptoms and may be minimal or nonexistent, on average, in patients with mild or moderate symptoms. For patients with very severe depression, the benefit of medications over placebo is substantial.
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“antidepressants have been demonstrated efficient in treating MDD”
From SSRI Treatment Response Prediction in Depression Based on Brain Activation by Emotional Stimuli (2020) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Fournier and colleagues meta-analysed trials of selective serotonin reuptake inhibitors and estimated the effect size.45 For mild to severe depression the effect estimates ranged from -0.17 to -0.11; this is lower than the effect size for smoking cessation.”
From Change in mental health after smoking cessation: systematic review and meta-analysis (2014) · cites this paper as [45]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“For SSRIs, researchers have argued that a substantial portion of the perceived therapeutic benefit in double-blind randomized clinical trials (RCTs) may stem from placebo responses rather than the drug itself (Sugarman et al., 2014; Fournier et al., 2010; Kirsch, 2014; Moncrieff and Kirsch, 2015).”
From Revisiting the SSRI vs. placebo debate in the treatment of social anxiety disorder: the role of expectancy effects, neural responsivity, and monoamine transporters (2025) · cites this paper as Fournier et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The introduction and widespread use of selective serotonine uptake inhibitors (SSRI) [22, 23] and psychological therapy including cognitive behavioral therapy (CBT) [24, 25] meant that well tolerated and effective treatments for depression and anxiety disorders became available in primary care, widening the group of individuals eligible for treatment.”
From Trends in psychiatric diagnoses, medications and psychological therapies in a large Swedish region: A population-based study (2020) · cites this paper as [23]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“there are differences in individual response”
From SSRI Treatment Response Prediction in Depression Based on Brain Activation by Emotional Stimuli (2020) · cites this paper as [1]
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In the citing paper
“In addition, the effect sizes are generally higher than those obtained for pharmacological treatment of mild-to-moderate depression [34]”
From One-Day Acceptance and Commitment Therapy Compared to Support for Depressed Migraine Patients: a Randomized Clinical Trial. (2020) · cites this paper as [34]
In the citing paper
“Two individual participant data meta-analysis (26, 27) indicated that patients with lower baseline severity would achieve smaller improvement compared to placebo.”
In the citing paper
“Individual-level meta-analyses have found a direct relationship between the magnitude of depressive symptoms and the effectiveness of antidepressants.8–10”
In the citing paper
“Thus, the benefits of antidepressants in non-severe depression have been argued to be minimal.8 11”
In the citing paper
“One small individual patient data meta-analysis found support for increasing benefit with increasing severity of depression,20 but three larger individual patient data meta-analyses did not find any such effect of antidepressants compared with placebo on depression severity .44–46”
From Should antidepressants be used for major depressive disorder? (2020) · cites this paper as [20]
In the citing paper
“For example, meta-analysis has demonstrated that antidepressants, though widely prescribed as a treatment for MDD, may be no more effective than placebo for mild to moderate levels of symptom severity; clinically significant benefits are only observed at “very severe” levels of impairment (18).”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [18]
In the citing paper
“For example, meta-analysis has demonstrated that antidepressants, though widely prescribed as a treatment for MDD, may be no more effective than placebo for mild to moderate levels of symptom severity; clinically significant benefits are only observed at “very severe” levels of impairment (18).”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [18]
In the citing paper
“Although antidepressants are unlikely to be effective in most presentations of distress (18), physical activity, psychotherapeutic approaches, and discussions with diabetes team members can be effective.”
From Depression in diabetes: have we been missing something important? (2011) · cites this paper as [18]
In the citing paper
“The strength of the pooled standardised mean difference in change was clinically important - the association between smoking cessation and change in depression and anxiety was equal to or larger than the estimate from trials of antidepressants versus placebo.”
From An application of the stress-diathesis model: A review about the association between smoking tobacco, smoking cessation, and mental health (2023) · cites this paper as Fournier et al., 2010
In the citing paper
“A meta-analysis of individual-level data from randomised controlled trials (RCTs) of antidepressants for”
From An application of the stress-diathesis model: A review about the association between smoking tobacco, smoking cessation, and mental health (2023) · cites this paper as Fournier et al., 2010
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Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Statistical Power Analysis for the Behavioral Sciences (2nd ed.).
Lachenbruch, P. A., & Cohen, J. (1989) · Journal of the American Statistical Association · doi:10.2307/2290095 · Cited by 37,421
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050045 · Cited by 2,442
Selective publication of antidepressant trials and its influence on apparent efficacy
Turner, E. H., Matthews, A. M., Linardatos, E., Tell, R. A., & Rosenthal, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmsa065779 · Cited by 2,435
Elkin, I. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110013002 · Cited by 2,300
Dimidjian, S., Hollon, S. D., Dobson, K. S., Schmaling, K. B., Kohlenberg, R. J., Addis, M. E., Gallop, R., McGlinchey, J. B., Markley, D. K., Gollan, J. K., et al. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.4.658 · Cited by 1,607
Self-citationOstwald, P. F. (1960) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.1960.14.4.817 · Cited by 1,422
The Hamilton Depression Rating Scale: Has the Gold Standard Become a Lead Weight?
Bagby, R. M., Ryder, A. G., Schuller, D. R., & Marshall, M. B. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.12.2163 · Cited by 1,148
Research works printed but not linked: 1
- [3]Depression Guideline Panel Depression in primary care: Vol. 2. Treatment of major depression Clinical Practice Guideline No. 5. AHCPR Publication No. 93-0551 Rockville, MD U.S. Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research 1993
Cited by
Sorted by citations
Items 201–300 of 1,006
Ghosal, S., Bang, E., Yue, W., Hare, B. D., Lepack, A. E., Girgenti, M. J., & Duman, R. S. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.06.017 · Cited by 111
McGirr, A., Van den Eynde, F., Tovar-Perdomo, S., Fleck, M. P. A., & Berlim, M. T. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.10.068 · Cited by 117
Mao, J. J. J., Xie, S. X., Zee, J., Soeller, I., Li, Q. S., Rockwell, K. A., & Amsterdam, J. D. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.01.010 · Cited by 111
Self-citationDepression, Frailty, and All-Cause Mortality: A Cohort Study of Men Older than 75 Years
Almeida, O. P., Hankey, G. J., Yeap, B. B., Golledge, J., Norman, P. E., & Flicker, L. A. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.10.023 · Cited by 111
Effects of transference work in the context of therapeutic alliance and quality of object relations.
Høglend, P. A., Hersoug, A. G., Bøgwald, K., Amlo, S., Marble, A., Sørbye, Ø., Røssberg, J. I., Ulberg, R., Gabbard, G. O., & Crits-Christoph, P. F. (2011) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0024863 · Cited by 110
Antidepressants can induce mutation and enhance persistence toward multiple antibiotics
Wang, Y., Yu, Z., Ding, P., Lu, J., Mao, L., Ngiam, L., Yuan, Z., Engelstädter, J., Schembri, M. A., & Guo, J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208344120 · Cited by 115
Mechanisms of antidepressant resistance
El-Hage, W., Leman, S., Camus, V., & Belzung, C. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00146 · Cited by 111
ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression
Singh, A., Bousman, C., Ng, C. H., Byron, K., & Berk, M. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.115 · Cited by 110
Hoen, P. W., Whooley, M. A., Martens, E. J., Na, B., van Melle, J. P., & de Jonge, P. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.03.080 · Cited by 113
Correll, C. U., Solmi, M., Cortese, S., D, M. F. M., Højlund, M., KRAEMER, H. C., McIntyre, R. S., Pine, D. S., Schneider, L. S. S., & Kane, J. M. (2023) · World Psychiatry · doi:10.1002/wps.21056 · Cited by 115
Cameron, I. M., Cardy, A., Crawford, J. R., du Toit, S. W., Hay, S., Lawton, K., Mitchell, K., Sharma, S., Shivaprasad, S., Winning, S., et al. (2011) · British Journal of General Practice · doi:10.3399/bjgp11x583209 · Cited by 109
Toward personalizing treatment for depression: predicting diagnosis and severity
Huang, S. H., LePendu, P., Iyer, S. V., Tai‐Seale, M., Carrell, D., & Shah, N. H. (2014) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2014-002733 · Cited by 109
Khan, A., Mar, K. F., Faucett, J., Schilling, S., & Brown, W. A. (2017) · World Psychiatry · doi:10.1002/wps.20421 · Cited by 112
An Overview of the Beneficial Effects of Exercise on Health and Performance
Krämer, A. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1792-1_1 · Cited by 137
Andrews, P. W., Kornstein, S. G., Halberstadt, L. J., Gardner, C. O., & Neale, M. C. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00159 · Cited by 107
Coupland, C. A. C., Hill, T., Morriss, R. K., Moore, M. V., Arthur, A. J., & Hippisley‐Cox, J. (2018) · BMC Medicine · doi:10.1186/s12916-018-1022-x · Cited by 105
A Scientometrics Analysis and Visualization of Depressive Disorder
Xu, D. W., Wang, Y., Wang, K.-T., Wang, Y., Dong, X., Tang, J., & Cui, Y. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200905151333 · Cited by 108
Double-blind fluoxetine trial in comorbid MDD-CUD youth and young adults.
Cornelius, J. R., Bukstein, O. G., Douaihy, A. B., Clark, D. B., Chung, T. A., Daley, D. C., Wood, D. S., & Brown, S. J. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.05.010 · Cited by 105
Clinical Utility of the Inventory of Depression and Anxiety Symptoms (IDAS)
Stasik-O’Brien, S. M., Brock, R. L., Chmielewski, M., Naragon-Gainey, K., Koffel, E., McDade-Montez, E., O’Hara, M. W., & Watson, D. (2019) · Assessment · doi:10.1177/1073191118790036 · Cited by 106
Vigod, S. N., Wilson, C. A., & Howard, L. M. (2016) · BMJ · doi:10.1136/bmj.i1547 · Cited by 148
Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease
Simpson, J. M., Gil‐Mohapel, J., Pouladi, M. A., Ghilan, M., Xie, Y., Hayden, M. R., & Christie, B. R. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.012 · Cited by 114
Belzung, C. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2013.342 · Cited by 106
Turner, E. H., Knoepflmacher, D., & Shapley, L. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001189 · Cited by 112
Adjunctive minocycline treatment for major depressive disorder: A proof of concept trial
Dean, O. M., Kanchanatawan, B., Ashton, M. M., Mohebbi, M., Ng, C. H., Maes, M. H. J., Berk, L., Sughondhabirom, A., Tangwongchai, S., Singh, A., et al. (2017) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867417709357 · Cited by 106
Evolutionary theories of depression: a critical review
Hagen, E. H. (2011) · The Canadian Journal of Psychiatry · doi:10.1177/070674371105601203 · Cited by 105
Lessons learned from placebo groups in antidepressant trials
Mora, M. C. S., Nestoriuc, Y., & Rief, W. (2011) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2010.0394 · Cited by 111
Depression and cardiovascular disease: an update on how course of illness may influence risk
Fiedorowicz, J. G. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0492-6 · Cited by 103
Guidelines for Rehabilitation in Patients With Cardiovascular Disease (JCS 2012):– Digest Version –
JCSJointWorkingGroup (2014) · Circulation · Cited by 105
Roest, A. M., de Jonge, P., Williams, C. D., de Vries, Y. A., Schoevers, R. A., & Turner, E. H. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.15 · Cited by 101
Valiengo, L. D. C. L., Goulart, A. C., de Oliveira, J. F., Benseñor, I. M., Lotufo, P. A., & Brunoni, A. R. (2016) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2016-314075 · Cited by 104
Karanges, E. A., Stephenson, C. P., & McGregor, I. S. (2014) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867414538675 · Cited by 102
Branchi, I., Santarelli, S., Capoccia, S., Poggini, S., D’Andrea, I., Cirulli, F., & Alleva, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062226 · Cited by 108
Kambeitz, J. P., & Howes, O. D. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.07.034 · Cited by 96
Gonzalez, M., Pascoe, M. C., Yang, G., de Manincor, M., Grant, S., Lacey, J., Firth, J., & Sarris, J. (2021) · Psycho-Oncology · doi:10.1002/pon.5671 · Cited by 102
Comparison of psychotherapies for adult depression to pill placebo control groups: a meta-analysis
Cuijpers, P. J., Turner, E. H., Mohr, D. C., Hofmann, S. G., Andersson, G., Berking, M., & Coyne, J. C. (2013) · Psychological Medicine · doi:10.1017/s0033291713000457 · Cited by 104
Thombs, B. D., Ziegelstein, R. C., Roseman, M., Kloda, L. A., & Ioannidis, J. P. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-13 · Cited by 100
Agomelatine versus other antidepressive agents for major depression
Guaiana, G., Gupta, S., Chiodo, D., Davies, S., Haederle, K., & Koesters, M. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008851.pub2 · Cited by 107
Prins, J., Olivier, B., & Korte, S. M. (2011) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2011.594039 · Cited by 106
Dynamic Learning of Patient Response Types: An Application to Treating Chronic Diseases
Negoescu, D. M., Bimpikis, K., Brandeau, M. L., & Iancu, D. A. (2017) · Management Science · doi:10.1287/mnsc.2017.2793 · Cited by 99
Kreider, K. E. (2017) · Diabetes Therapy · doi:10.1007/s13300-017-0231-1 · Cited by 107
A Systematic Approach to Pharmacotherapy for Geriatric Major Depression
Mulsant, B. H., Blumberger, D. M., Ismail, Z., Rabheru, K., & Rapoport, M. J. (2014) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2014.05.002 · Cited by 105
Baumeister, H. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.05.025 · Cited by 97
Management of Depression in Patients With Cancer: A Clinical Practice Guideline
Li, M., Kennedy, E. B., Byrne, N., Gérin-Lajoie, C., Katz, M. R., Keshavarz, H., Sellick, S., & Green, E. (2016) · Journal of Oncology Practice · doi:10.1200/jop.2016.011072 · Cited by 96
Conflicts of interest and the quality of recommendations in clinical guidelines
Cosgrove, L., Bursztajn, H. J., Erlich, D. R., Wheeler, E. E., & Shaughnessy, A. F. (2012) · Journal of Evaluation in Clinical Practice · doi:10.1111/jep.12016 · Cited by 98
Biased emotional recognition in depression: Perception of emotions in music by depressed patients
Punkanen, M., Eerola, T., & Erkkilä, J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.10.034 · Cited by 101
Rational Use of Antidepressant Drugs
Fava, G. A. (2014) · Psychotherapy and Psychosomatics · doi:10.1159/000362803 · Cited by 95
Development of Clinical Practice Guidelines
Hollon, S. D., Areán, P. A., Craske, M. G., Crawford, K. A., Kivlahan, D. R., Magnavita, J. J., Ollendick, T. H., Sexton, T. L., Spring, B. J., Bufka, L. F., et al. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050212-185529 · Cited by 103
Self-citationEuesden, J., Danese, A., Lewis, C. M., & Maughan, B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173015 · Cited by 105
Ghosal, S., Duman, C. H., Liu, R.-J., Wu, M., Terwilliger, R., Girgenti, M. J., Wohleb, E., Fogaca, M. V., Teichman, E. M., Hare, B., et al. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104669 · Cited by 89
Okumura, Y., & Ichikura, K. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.04.023 · Cited by 86
Mechanic, D. (2014) · Health Affairs · doi:10.1377/hlthaff.2014.0504 · Cited by 104
Lorenzo‐Luaces, L., DeRubeis, R. J., van Straten, A., & Tiemens, B. G. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.010 · Cited by 96
Self-citationMaust, D. T., Blow, F. C., Wiechers, I. R., Kales, H. C., & Marcus, S. C. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m10713 · Cited by 93
Corticotropin-releasing factor-related peptides, serotonergic systems, and emotional behavior
Fox, J. H., & Lowry, C. A. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00169 · Cited by 93
Nelms, J. A., & Castel, L. D. (2016) · EXPLORE · doi:10.1016/j.explore.2016.08.001 · Cited by 93
Chronic Low Back Pain and Psychosocial Issues
Moore, J. E. (2010) · Physical Medicine and Rehabilitation Clinics of North America · doi:10.1016/j.pmr.2010.06.005 · Cited by 97
Reid, S., & Barbui, C. (2010) · BMJ · doi:10.1136/bmj.c1468 · Cited by 93
Serotonin transporter gene, stress and raphe–raphe interactions: a molecular mechanism of depression
Jasinska, A. J., Lowry, C. A., & Burmeister, M. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.001 · Cited by 95
Rolle, C. E., Fonzo, G. A., Wu, W., Toll, R. T., Jha, M. K., Cooper, C. M., Fatt, C. C., Pizzagalli, D. A., Trombello, J. M., Deckersbach, T., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.3867 · Cited by 90
Berk, M., Woods, R. L., Nelson, M. R., Shah, R. C., Reid, C. M., Storey, E., Fitzgerald, S., Lockery, J. E., Wolfe, R., Mohebbi, M., et al. (2020) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2020.1214 · Cited by 89
Behavioural activation for depression: Efficacy, effectiveness and dissemination
Soucy Chartier, I., & Provencher, M. D. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.07.023 · Cited by 90
Lifestyle medicine for depression: A meta-analysis of randomized controlled trials
Wong, V. W.-H., Ho, F. Y., Shi, N.-K., Sarris, J. J., Chung, K., & Yeung, W. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.012 · Cited by 89
Antidepressants in elderly: Metaregression of double-blind, randomized clinical trials
Calati, R., Signorelli, M. S., Balestri, M., Marsano, A., Ronchi, D. D., Aguglia, E., & Serretti, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.053 · Cited by 95
The efficacy and effectiveness of psychological treatments for mood, anxiety, and related disorders.
Hunsley, J. D., Elliott, K., & Therrien, Z. (2014) · Canadian Psychology/Psychologie canadienne · doi:10.1037/a0036933 · Cited by 108
Batstra, L., & FRANCES, A. J. (2012) · The Journal of Nervous and Mental Disease · doi:10.1097/nmd.0b013e318257c4a2 · Cited by 99
Prevalence of depressive symptoms and predictors of treatment among U.S. adults from 2005 to 2010
Wittayanukorn, S., Qian, J., & Hansen, R. A. (2014) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.12.009 · Cited by 86
Almeida, O. P., Ford, A. H., Hirani, V., Singh, V., VANBOCKXMEER, F., McCaul, K. A., & Flicker, L. A. (2014) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.114.145177 · Cited by 87
Multimodal Detection of Depression in Clinical Interviews
Dibeklioğlu, H., Hammal, Z., Yang, Y., & Cohn, J. F. (2015) · INTERNATIONAL CONFERENCE ON MULTIMODAL INTERACTION · doi:10.1145/2818346.2820776 · Cited by 87
Heuschkel, K., & Kuypers, K. P. C. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00224 · Cited by 86
Interpretation of Depression Detection Models via Feature Selection Methods
Alghowinem, S., Gedeon, T., Goecke, R., Cohn, J. F., & Parker, G. B. (2020) · IEEE Transactions on Affective Computing · doi:10.1109/taffc.2020.3035535 · Cited by 89
Mula, M., Brodie, M. J., de Toffol, B., Guekht, A. B., Hečimović, H., Kanemoto, K., Kanner, A. M., Teixeira, A. L., & Wilson, S. J. (2021) · Epilepsia · doi:10.1111/epi.17140 · Cited by 86
Bloom, H. S., & Michalopoulos, C. (2013) · Prevention Science · doi:10.1007/s11121-010-0198-x · Cited by 83
Friedman, E. S., Davis, L. L., Zisook, S., Wisniewski, S. R., Trivedi, M. H., Fava, M., & Rush, A. J. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.010 · Cited by 81
“A more recent meta-analysis (Fournier et al., 2010) found that the magnitude of benefit from ADM treatment compared with placebo increases with the severity of initial depressive symptoms and, on average, may be minimal or nonexistent in patients with mild-to-moderate depression.”
MethodMariani, J. J., Pavlicova, M., Bisaga, A., Nunes, E. V., Brooks, D. J., & Levin, F. R. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.05.032 · Cited by 85
DeRubeis, R. J., Gelfand, L. A., German, R. E., Fournier, J. C. J., & Forand, N. R. (2013) · Psychotherapy Research · doi:10.1080/10503307.2013.838654 · Cited by 85
Self-citationAntidepressants for preventing postnatal depression
Molyneaux, E., Telesia, L., Henshaw, C. A., Boath, E., Bradley, E., & Howard, L. M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004363.pub3 · Cited by 84
Minimum clinically important differences identified for commonly used depression rating scales
Masson, S. C., & Tejani, A. M. (2013) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2013.01.010 · Cited by 85
Treating to target in major depressive disorder: response to remission to functional recovery
McIntyre, R. S., Lee, Y. L., & Mansur, R. B. (2015) · CNS Spectrums · doi:10.1017/s1092852915000826 · Cited by 85
Mind matters: placebo enhances reward learning in Parkinson's disease
Schmidt, L., Braun, E. K., Wager, T. D., & Shohamy, D. (2014) · Nature Neuroscience · doi:10.1038/nn.3842 · Cited by 84
Agomelatine: A narrative review
Demyttenaere, K. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.004 · Cited by 83
Furukawa, T. A., Horikoshi, M., Kawakami, N., Kadota, M., Sasaki, M., Sekiya, Y., Hosogoshi, H., Kashimura, M., Asano, K., Terashima, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035330 · Cited by 88
Group sequential enrichment design incorporating subgroup selection
Magnusson, B., & Turnbull, B. W. (2013) · Statistics in Medicine · doi:10.1002/sim.5738 · Cited by 86
Benzodiazepines as a monotherapy in depressive disorders: a systematic review
Benasi, G., Guidi, J., Offidani, E., Balon, R., Rickels, K., & Fava, G. A. (2018) · Psychotherapy and Psychosomatics · doi:10.1159/000486696 · Cited by 79
Tran, P., Skolnick, P., Czobor, P., Huang, N. Y., Bradshaw, M., McKinney, A., & Fava, M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.09.003 · Cited by 81
Research Design in Clinical Psychology
Kazdin, A. E. (2021) · doi:10.1017/9781108993647 · Cited by 240
Fann, J. R., Bombardier, C. H., Temkin, N., Esselman, P., Warms, C., Barber, J., & Dikmen, S. (2017) · Journal of Head Trauma Rehabilitation · doi:10.1097/htr.0000000000000322 · Cited by 82
Blumenthal, J. A., Smith, P. J., & Hoffman, B. M. (2012) · ACSMʼs Health & Fitness Journal · doi:10.1249/01.fit.0000416000.09526.eb · Cited by 81
Talking sensibly about depression
Patel, V. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002257 · Cited by 80
Moderators of Outcome in Late-Life Depression: A Patient-Level Meta-Analysis
Nelson, J. C., Delucchi, K. L., & Schneider, L. S. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12070927 · Cited by 80
Cognitive behavioural therapy halves the risk of repeated suicide attempts: systematic review.
Gøtzsche, P. C., & Gøtzsche, P. K. (2017) · Journal of the Royal Society of Medicine · doi:10.1177/0141076817731904 · Cited by 79
Decisional conflict among women considering antidepressant medication use in pregnancy
Walton, G. D., Ross, L. E., Stewart, D. E., Grigoriadis, S., Dennis, C.-L., & Vigod, S. (2014) · Archives of Women's Mental Health · doi:10.1007/s00737-014-0448-1 · Cited by 78
Grunebaum, M. F., Ellis, S. P., Duan, N., Burke, A. K., Oquendo, M. A., & John Mann, J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.247 · Cited by 79
Aughterson, H., Baxter, L., & Fancourt, D. E. (2020) · BMC Family Practice · doi:10.1186/s12875-020-01264-0 · Cited by 81
Fumeaux, C. J. F., Harari, M. M., Weisskopf, E., Eap, C. B., Epiney, M., Vial, Y., Csajka, C., Graz, M. B., & Panchaud, A. (2019) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2019.1658740 · Cited by 82
Yeung, A. S., Jing, Y., Brenneman, S. K., Chang, T. E., Baer, L., Hebden, T., Kalsekar, I., McQuade, R. D., Kurlander, J., Siebenaler, J., et al. (2012) · Depression and Anxiety · doi:10.1002/da.21983 · Cited by 74
Mintzes, B. J. (2012) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031811-124540 · Cited by 80
Morgan, A. J., Jorm, A. F., & Mackinnon, A. J. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.101394 · Cited by 79
Zagorscak, P., Heinrich, M., Sommer, D., Wagner, B., & Knaevelsrud, C. (2018) · Psychotherapy and Psychosomatics · doi:10.1159/000481515 · Cited by 85
Romero-Sanchiz, P., Nogueira-Arjona, R., García-Ruiz, A., Luciano, J. V., García Campayo, J., Gili, M., Botella, C., Baños, R., Castro, A., López-Del-Hoyo, Y., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0172741 · Cited by 78
Does GP training in depression care affect patient outcome? - A systematic review and meta-analysis
Sikorski, C., Luppa, M., König, H., van den Bussche, H., & Riedel-Heller, S. G. (2012) · BMC Health Services Research · doi:10.1186/1472-6963-12-10 · Cited by 77
Metadata
- Authors
- Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Dimidjian, S., Amsterdam, J. D., Shelton, R. C., & Fawcett, J.
- Affiliations
- University of Pennsylvania (US)
- University of New Mexico (US)
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2010-01-06
- Volume
- 303
- Issue
- 1
- Pages
- 47
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- PMC
- PMC3712503
- OpenAlex
- W2004762037
- Cited by
- 2,009
- References
- 56
- Citations by year
- 2026: 54 · 2025: 72 · 2024: 89 · 2023: 70 · 2022: 81 · 2021: 134 · 2020: 81 · 2019: 111 · 2018: 143 · 2017: 128 · 2016: 112 · 2015: 149 · 2014: 154 · 2013: 170 · 2012: 172
- FWCI
- 144.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Sanofi
- National Alliance for Research on Schizophrenia and Depression
- Universiteit Maastricht
- National Institute of Mental Health (K24MH001741, R10 MH50129, R01MH060998, K02MH001697, R10MH055875, R10MH055877)
- Janssen Pharmaceuticals
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- antidepressants, major depressive disorder, depression severity, placebo response, Hamilton Depression Rating Scale, treatment effect heterogeneity, mild depression, antidepressant efficacy
- MeSH terms
- Adult, Antidepressive Agents, Depression, Major Depressive Disorder, Humans, Placebo Effect, Randomized Controlled Trials as Topic, Treatment Outcome
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