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Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012
Abstract
Importance Severe sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown whether progress has been made in decreasing their mortality rate. Objective To describe changes in mortality for severe sepsis with and without shock in ICU patients. Design, setting, and participants Retrospective, observational study from 2000 to 2012 including 101,064 patients with severe sepsis from 171 ICUs with various patient case mix in Australia and New Zealand. Main outcomes and measures Hospital outcome (mortality and discharge to home, to other hospital, or to rehabilitation). Results Absolute mortality in severe sepsis decreased from 35.0% (95% CI, 33.2%-36.8%; 949/2708) to 18.4% (95% CI, 17.8%-19.0%; 2300/12,512; P Conclusions and relevance In critically ill patients in Australia and New Zealand with severe sepsis with and without shock, there was a decrease in mortality from 2000 to 2012. These findings were accompanied by changes in the patterns of discharge to home, rehabilitation, and other hospitals.
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Māori patients in New Zealand are 2-3 fold more likely to develop sepsis than non‐Māori, and across all age groups are more likely to die of sepsis than non‐Māori patients.
“For example, Māori patients in New Zealand are 2–3 fold more likely to develop sepsis than non‐Māori, and across all age groups are more likely to die of sepsis than non‐Māori patients”
From On race, human variation, and who gets and dies of sepsis (2022) · cites this paper as Kaukonen et al., 2014
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Metadata
- Authors
- Kaukonen, K.-M., Bailey, M., Suzuki, S., Pilcher, D., & Bellomo, R.
- Affiliations
- Australian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia2Critical Care Research Group, Intensive Care Unit, Helsinki University Central Hospital, Hels
- Australian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
- Intensive Care Unit, Austin Health, Heidelberg, Australia
- Australian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia4ANZICS Centre for Outcome and Resource Evaluation CORE, Melbourne, Australia5Department of In
- Australian and New Zealand Intensive Care Research Centre (ANZIC RC), Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia3Intensive Care Unit, Austin Health, Heidelberg, Australia
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 2014-04-02
- Volume
- 311
- Issue
- 13
- Pages
- 1308
- ISSN
- 0098-7484
- Cited by
- 1,459
- References
- 5
- Language
- en
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