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Cited by 213D Printing in Biomedical ResearchNeuroscience and Neural EngineeringBarrier Structure and Function Studies

In Situ Detection of Neuroinflammation Using Multicellular 3D Neurovascular‐Unit‐on‐a‐Chip

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Choi, Jin‐Ha, Choi, Hye Kyu, Lee, Ki‐Bum·2023·Advanced Functional Materials
DOI 10.1002/adfm.202304382PMC PMC11412436
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Abstract

The human neurovascular system is a complex network of blood vessels and brain cells that is essential to the proper functioning of the brain. Researchers have become increasingly interested in the system for developing drugs to treat neuroinflammation. Currently, creating neurovascular models begins with animal models, followed by testing on humans in clinical trials. However, the high number of medication failures that pass through animal testing indicates that animal models do not always reflect the outcome of human clinical trials. To overcome the challenges of the issues with animal models, a neurovascular‐unit‐on‐a‐chip system is developed to accurately replicate the in vivo human neurovascular microenvironment. By replicating the human neurovascular unit, a more accurate representation of human physiology can be achieved compared to animal models. The ability to detect proinflammatory cytokines in situ and monitor physiological changes can provide an invaluable tool for evaluating the efficacy and safety of drugs. Using nanosized graphene oxide for in situ detection of inflammatory responses is an innovative approach that can advance the field of neuroinflammation research. Overall, the developed neuroinflammation‐on‐a‐chip system has the potential to provide a more efficient and effective method for developing drugs for treating neurodegenerative diseases and other central nervous system diseases.

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  • Nano-sized patterned platforms have successfully detected markers for CNS diseases, showing remarkable efficacy in early disease marker detection.

    “By employing nano-sized patterned platforms, researchers have successfully detected markers that serve as indicators for CNS diseases. This platform has shown remarkable efficacy in early disease marker detection, marking a significant step toward early intervention and treatment [35, 36].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [35]

    The Results and Discussion section (page not supplied) reports that an rGO-and-aptamer sensor on a neurovascular chip detected the inflammatory cytokines IL-6 and TNF-α in an experimental model of early neuroinflammation. It does not demonstrate early detection of CNS diseases or efficacy for early intervention and treatment; those are broader claims than the reported experiment supports. (LLM, conf=0.86)

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Authors
Choi, J., Choi, H. K., & Lee, K.
Affiliations
Rutgers, The State University of New Jersey (US)
Corresponding author
Lee, Ki‐Bum
ORCID
Venue
Advanced Functional Materials
Publisher
Wiley
Published
2023-09
Volume
33
Issue
46
ISSN
  • 1616-301X (ISSN-L)
  • 1616-3028
DOI
10.1002/adfm.202304382
PMC
PMC11412436
OpenAlex
W4386391647
Cited by
21
References
85
Citations by year
2026: 8 · 2025: 8 · 2024: 5
FWCI
1.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Functional Materials (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation (CBET‐1803517)
  • New Jersey Commission on Spinal Cord Research (CSCR17IRG010, CSCR16ERG019)
  • Alzheimer's Association (CSCR22ERG023)
  • National Heart, Lung, and Blood Institute (U01HL150852)
  • National Research Foundation of Korea (NRF‐2022R1C1C1008797)
  • National Institutes of Health (R21AR071101, 1R01DC016612, 3R01DC016612‐01S1, 5R01DC016612‐02S1, T32EB005583)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
neuroinflammation, neurovascular unit, in situ detection, graphene oxide, inflammatory cytokines, alternative to animal models, drug screening, neurodegenerative diseases, blood-brain barrier

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