Cited by 437Nanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsPhotodynamic Therapy Research Studies

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An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

Zhang, Zhijun, Xu, Wenhan, Kang, Miaomiao, Wen, Haifei, Guo, Heng, Zhang, Pengfei, Xi, Lei, Li, Kai, Wang, Lei, Wang, Dong, Tang, Ben Zhong·2020·Advanced Materials

DOI 10.1002/adma.202003210

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Abstract

Aiming to achieve versatile phototheranostics with the integrated functionalities of multiple diagnostic imaging and synergistic therapy, the optimum use of dissipated energy through both radiative and nonradiative pathways is definitely appealing, yet a significantly challenging task. To the best of the knowledge, there have been no previous reports on a single molecular species effective at affording all phototheranostic modalities including fluorescence imaging (FLI), photoacoustic imaging (PAI), photothermal imaging (PTI), photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, a simple and highly powerful one‐for‐all phototheranostics based on aggregation‐induced emission (AIE)‐active fluorophores is tactfully designed and constructed. Thanks to its strong electron donor–acceptor interaction and finely modulated intramolecular motion, the AIE fluorophore‐based nanoparticles simultaneously exhibit bright near‐infrared II (NIR‐II) fluorescence emission, efficient reactive oxygen species generation, and high photothermal conversion efficiency upon NIR irradiation, indicating the actualization of a balance between radiative and nonradiative energy dissipations. Furthermore, the unprecedented performance on NIR‐II FLI‐PAI‐PTI trimodal‐imaging‐guided PDT–PTT synergistic therapy is demonstrated by the precise tumor diagnosis and complete tumor elimination outcomes. This study thus brings a new insight into the development of superior versatile phototheranostics for practical cancer theranostics.

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Luo, J., Xie, Z., Lam, J. W. Y., Cheng, L., Tang, B. Z., Chen, H., Qiu, C., Kwok, H. S., Zhan, X., Liu, Y., et al. (2001) · Chemical Communications · doi:10.1039/b105159h · Cited by 8,358
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New Strategies for Fluorescent Probe Design in Medical Diagnostic Imaging
Kobayashi, H., Ogawa, M., Alford, R. E., Choyke, P. L., & Urano, Y. (2009) · Chemical Reviews · doi:10.1021/cr900263j · Cited by 2,205
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Fan, W., Yung, B. C., Huang, P., & Chen, X. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00258 · Cited by 1,813
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Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778
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Zhang, Z., Xu, W., Xiao, P., Kang, M., Yan, D., Wen, H., Song, N., Wang, D., & Tang, B. Z. (2021) · ACS Nano · doi:10.1021/acsnano.1c03700 · Cited by 80
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Yu, Y., Wang, H., Zhuang, Z., Ji, C., Zhang, L., Li, Y., Zhao, Z., Ding, D., Feng, G., & Tang, B. Z. (2024) · ACS Nano · doi:10.1021/acsnano.4c01600 · Cited by 78
Self-citation
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Zhen, S., Xu, Z., Suo, M., Zhang, T., Lyu, M., Li, T., Zhang, T., Li, M., Zhao, Z., & Tang, B. Z. (2024) · Advanced Materials · doi:10.1002/adma.202411133 · Cited by 77
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Cheng, Z., Zhang, T., Wang, W., Shen, Q., Hong, Y., Shao, J., Xie, X., Fei, Z., & Dong, X. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.02.017 · Cited by 76
Supramolecular J-aggregates of aza-BODIPY by steric and π–π nteractions for NIR-II phototheranostics
Tian, Y., Yin, D., Cheng, Q., Dang, H., Teng, C., & Yan, L. (2022) · Journal of Materials Chemistry B · doi:10.1039/d1tb02820k · Cited by 75
Single-molecule photosensitizers for NIR-II fluorescence and photoacoustic imaging guided precise anticancer phototherapy
Gu, H., Liu, W., Sun, W. C., Du, J., Fan, J., & Peng, X. (2022) · Chemical Science · doi:10.1039/d2sc02879d · Cited by 76
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Xiong, J., Wang, P., Son, S., Zhong, C., Zhang, F., Mao, Z., Liu, Z., & Kim, J. S. (2022) · Matter · doi:10.1016/j.matt.2022.02.019 · Cited by 75
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Wang, M., Yan, D., Wang, M., Wu, Q., Song, R., Huang, Y., Rao, J., Wang, D., Zhou, F., & Tang, B. Z. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202205371 · Cited by 74
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Zhu, Y., Lai, H., Guo, H., Peng, D., Han, L., Gu, Y., Wei, Z., Zhao, D., Zheng, N., Hu, D., et al. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202117433 · Cited by 74
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Yu, Y., Jia, H., Liu, Y., Zhang, L., Feng, G., & Tang, B. Z. (2022) · Molecules · doi:10.3390/molecules28010332 · Cited by 71
“Recently, Tang and coworkers reported three compounds (TI, TSI, and TSSI) for efficient multimodal imaging-guided tumor therapy (Figure 4d) [50].”
BackgroundSelf-citation
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Li, J., Zhang, Z., Jiang, S., Kang, M., Wang, D., Li, X., Huang, P., Gao, X., Wang, D., & Tang, B. Z. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401627 · Cited by 72
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Liu, Y., Ran, X., Zhou, D., Zhang, H., Chen, Y., Xu, J., Chen, S., Kong, Q., Yu, X., & Li, K. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202311365 · Cited by 69
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Liu, X., Duan, Y., & Liu, B. (2021) · Aggregate · doi:10.1002/agt2.26 · Cited by 68
Aggregation‐Induced Emission Nanoprobes Working in the NIR‐II Region: From Material Design to Fluorescence Imaging and Phototherapy
Xu, Z., Jiang, Y., Fan, M., Tang, S., Liu, M., Law, W., Yang, C., Ying, M., Ma, M., Dong, B., et al. (2021) · Advanced Optical Materials · doi:10.1002/adom.202100859 · Cited by 67
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Shi, Y., Zhu, D., DongJuan, W., Liu, B., Du, X., Wei, G., & Zhou, X. M. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214725 · Cited by 68
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Self-citation
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Self-citation
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Yan, D., Wang, D., & Tang, B. Z. (2025) · Nature Reviews Bioengineering · doi:10.1038/s44222-025-00342-1 · Cited by 68
“Owing to those superiorities, substantial progress has been made in the domain of biomedicine, marked by a series of key landmarks 15,20,23,27–39 (Fig.”
Self-citation
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Self-citation
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Fang, L., Meng, Q., Zhang, Y., Su, R. J., Xing, F., Yang, H., Hou, Y., Ma, P., Huang, K., & Feng, S. (2023) · ACS Nano · doi:10.1021/acsnano.3c06542 · Cited by 61
Nanobody modified high-performance AIE photosensitizer nanoparticles for precise photodynamic oral cancer therapy of patient-derived tumor xenograft
Wu, W., Shi, L., Duan, Y., Xu, S., Shen, L., Zhu, T., Hou, L., Meng, X., & Liu, B. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120870 · Cited by 60
Type I Photosensitization with Strong Hydroxyl Radical Generation in NIR Dye Boosted by Vigorous Intramolecular Motions for Synergistic Therapy
Lin, R., Liu, J., Xu, W., Liu, Z., He, X., Zheng, C., Kang, M., Li, X., Zhang, Z., Feng, H., et al. (2023) · Advanced Materials · doi:10.1002/adma.202303212 · Cited by 59
Self-citation
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Li, H., Jin, B., Wang, Y., Deng, B., Wang, D., & Tang, B. Z. (2022) · Advanced Materials · doi:10.1002/adma.202210085 · Cited by 60
Self-citation
Hydrogen peroxide-responsive AIE probe for imaging-guided organelle targeting and photodynamic cancer cell ablation
Wu, Q., Li, Y., Li, Y., Wang, D., & Tang, B. Z. (2021) · Materials Chemistry Frontiers · doi:10.1039/d1qm00328c · Cited by 56
Self-citation
Dual‐acceptor engineering of donor‐acceptor type molecules for all‐round boosting anti‐tumor phototherapy
Gu, H., Sun, W. C., Du, J., Fan, J., & Peng, X. (2023) · Smart Molecules · doi:10.1002/smo.20230014 · Cited by 58

Authors: Zhang, Z., Xu, W., Kang, M., Wen, H., Guo, H., Zhang, P., Xi, L., Li, K., Wang, L., Wang, D., & Tang, B. Z.
Affiliations: Shenzhen University (CN)
Hong Kong University of Science and Technology (HK)
Southern University of Science and Technology (CN)
Chinese Academy of Sciences (CN)
Corresponding author: Wang, Dong
Tang, Ben Zhong
ORCID: Zhang, Zhijun
Xu, Wenhan
Kang, Miaomiao
Wen, Haifei
Guo, Heng
Zhang, Pengfei
Xi, Lei
Li, Kai
Wang, Lei
Wang, Dong
Tang, Ben Zhong
Venue: Advanced Materials
Publisher: Wiley
Published: 2020-07-21
Volume: 32
Issue: 36
Pages: e2003210-e2003210
ISSN: 0935-9648 (ISSN-L)
1521-4095
DOI: 10.1002/adma.202003210
OpenAlex: W3045107785
Cited by: 436
References: 45
Citations by year: 2026: 34 · 2025: 55 · 2024: 94 · 2023: 78 · 2022: 79 · 2021: 86 · 2020: 10
FWCI: 19.88
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Advanced Materials (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
Keywords: phototheranostics, aggregation-induced emission, NIR-II fluorescence imaging, photoacoustic imaging, photothermal imaging, photodynamic therapy, photothermal therapy, synergistic cancer therapy, donor-acceptor interactions, reactive oxygen species generation, tumor diagnosis, multimodal imaging
MeSH terms: Neoplasms, Phototherapy, Optical Imaging, Multimodal Imaging

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An All‐Round Athlete on the Track of Phototheranostics: Subtly Regulating the Balance between Radiative and Nonradiative Decays for Multimodal Imaging‐Guided Synergistic Therapy

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