Meta-analysis of gene–environment interactions in developmental psychopathology

Taylor, Alan; Kim-Cohen, Julia

doi:10.1017/s095457940700051x

Cited by 227Meta-analysis and systematic reviewsChild and Adolescent Psychosocial and Emotional DevelopmentPsychopathy, Forensic Psychiatry, Sexual Offending

Meta-analysis of gene–environment interactions in developmental psychopathology

Taylor, Alan, Kim-Cohen, Julia·2007·Development and Psychopathology

DOI 10.1017/s095457940700051x

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Abstract

As studies of measured gene–environment interactions (G × E) in developmental psychopathology gain momentum, methods for systematically and quantitatively summarizing effects across multiple studies are urgently needed. Meta-analyses of G × E findings are critical for evaluating the overall statistical and theoretical significance of any given G × E based on cumulative and systematically combined knowledge. Although meta-analytic methods for the combination of study findings based on single effect measures such as odds ratios and mean differences are well established, equivalent methods for the meta-analysis of studies investigating interactions are not well developed. This article describes one simple approach to the meta-analysis of G × E effects using, as a contemporaneous example, the interaction of the monoamine oxidase A ( MAOA ) gene and the impact of childhood maltreatment on risk for developing antisocial behavior.

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Children carrying specific genetic variants are at increased risk for behavioral problems in later life, but only when raised in dysfunctional families.
“children carrying specific genetic variants are at increased risk for behavioral problems in later life, but only when raised in dysfunctional families [33]”
From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [33]

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Authors: Taylor, A., & Kim-Cohen, J.
Affiliations: King's College London (GB)
Yale University
Corresponding author: Taylor, Alan
Venue: Development and Psychopathology
Publisher: Cambridge University Press (CUP)
Published: 2007
Volume: 19
Issue: 4
Pages: 1029-1037
ISSN: 0954-5794 (ISSN-L)
1469-2198
DOI: 10.1017/s095457940700051x
OpenAlex: W2133897913
Cited by: 227
References: 56
Citations by year: 2025: 2 · 2024: 2 · 2023: 6 · 2022: 2 · 2021: 1 · 2020: 29 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 15 · 2014: 21 · 2013: 24 · 2012: 17
FWCI: 3.64
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified, 283 d)
Locations: Development and Psychopathology (publishedVersion)
PubMed (publishedVersion)
Topics: Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
Keywords: gene-environment interaction, developmental psychopathology, monoamine oxidase A, MAOA gene, child abuse, antisocial behavior
MeSH terms: Adolescent, Adult, Antisocial Personality Disorder, Mental Disorders, Child, Child Abuse, Developmental Disabilities, Child, Preschool, Crime, Genotype, Humans, Infant, Longitudinal Studies, Monoamine Oxidase, Social Environment, Meta-Analysis as Topic, Odds Ratio, Conduct Disorder, Genetic Predisposition to Disease

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Meta-analysis of gene–environment interactions in developmental psychopathology

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