NIR-II Fluorescence Imaging Reveals Bone Marrow Retention of Small Polymer Nanoparticles
Abstract
The concept that systemically administered nanoparticles are highly accumulated into the liver, spleen and kidney is a central paradigm in the field of nanomedicine. Here, we report that bone is an important organ for retention of small polymer nanoparticles using in vivo fluorescence imaging in the second near-infrared (NIR-II) window. We prepared different sized polymer nanoparticles with both visible and NIR-II fluorescence. NIR-II imaging reveals that the behavior of nanoparticle distribution in bone was largely dependent on the particle size. Small polymer nanoparticles of ∼15 nm diameter showed fast accumulation and long-term retention in bone, while the nanoparticles larger than ∼25 nm were dominantly distributed in liver. Confocal microscopy of bone sections indicated that the nanoparticles were largely distributed in the endothelial cells of sinusoidal vessels in bone marrow. The study provides promising opportunities for bone imaging and treatment of bone-related disease.
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A recent study demonstrated that bone could also be an important organ for the retention of small nanoparticles.
“However, a recent study demonstrated that bone could also be an important organ for the retention of small nanoparticles.218”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [218]
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- Authors
- Chen, D., Liu, Y., Zhang, Z., Liu, Z., Fang, X., He, S., & Wu, C.
- Affiliations
- Southern University of Science and Technology (CN)
- Corresponding author
- Wu, Changfeng
- Venue
- Nano Letters
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-12-21
- Volume
- 21
- Issue
- 1
- Pages
- 798-805
- ISSN
- 1530-6984 (ISSN-L)
- 1530-6992
- OpenAlex
- W3116178343
- Cited by
- 80
- References
- 49
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 17 · 2023: 15 · 2022: 19 · 2021: 11
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nano Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology of the People's Republic of China (2018YFB0407200, 2020YFA0909000)
- Science, Technology and Innovation Commission of Shenzhen Municipality (KQTD20170810111314625)
- National Natural Science Foundation of China (81771930)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- NIR-II fluorescence imaging, polymeric nanoparticles, nanoparticle biodistribution, particle size dependence, liver accumulation, bone imaging, bone marrow endothelial cells
- MeSH terms
- Bone Marrow, Polymers, Endothelial Cells, Nanoparticles, Optical Imaging
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