Cited by 80Nanoparticle-Based Drug DeliveryOptical Imaging and Spectroscopy TechniquesNanoplatforms for cancer theranostics

NIR-II Fluorescence Imaging Reveals Bone Marrow Retention of Small Polymer Nanoparticles

Chen, Dandan, Liu, Ye, Zhang, Zhe, Liu, Zhihe, Fang, Xiaofeng, He, Shuqing, Wu, Changfeng·2021·Nano Letters

Abstract

The concept that systemically administered nanoparticles are highly accumulated into the liver, spleen and kidney is a central paradigm in the field of nanomedicine. Here, we report that bone is an important organ for retention of small polymer nanoparticles using in vivo fluorescence imaging in the second near-infrared (NIR-II) window. We prepared different sized polymer nanoparticles with both visible and NIR-II fluorescence. NIR-II imaging reveals that the behavior of nanoparticle distribution in bone was largely dependent on the particle size. Small polymer nanoparticles of ∼15 nm diameter showed fast accumulation and long-term retention in bone, while the nanoparticles larger than ∼25 nm were dominantly distributed in liver. Confocal microscopy of bone sections indicated that the nanoparticles were largely distributed in the endothelial cells of sinusoidal vessels in bone marrow. The study provides promising opportunities for bone imaging and treatment of bone-related disease.

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Crossref · 10.1021/acs.nanolett.0c04543

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49 of 49 references verified0 citation errors · 0 not checkable

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Authors
Chen, D., Liu, Y., Zhang, Z., Liu, Z., Fang, X., He, S., & Wu, C.
Affiliations
Southern University of Science and Technology (CN)
Corresponding author
Wu, Changfeng
Venue
Nano Letters
Published
2020-12-21
Volume
21
Issue
1
Pages
798-805
ISSN
  • 1530-6984 (ISSN-L)
  • 1530-6992
OpenAlex
W3116178343
Cited by
80
References
49
Citations by year
2026: 5 · 2025: 13 · 2024: 17 · 2023: 15 · 2022: 19 · 2021: 11
FWCI
2.93
Type
journal article
Language
en
Open access
closed
Locations
  • Nano Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Science and Technology of the People's Republic of China (2018YFB0407200, 2020YFA0909000)
  • Science, Technology and Innovation Commission of Shenzhen Municipality (KQTD20170810111314625)
  • National Natural Science Foundation of China (81771930)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
NIR-II fluorescence imaging, polymeric nanoparticles, nanoparticle biodistribution, particle size dependence, liver accumulation, bone imaging, bone marrow endothelial cells
MeSH terms
Bone Marrow, Polymers, Endothelial Cells, Nanoparticles, Optical Imaging

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