Cited by 267Stress Responses and CortisolAdrenal Hormones and DisordersCircadian rhythm and melatonin

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HPA Axis‐Rhythms

Spiga, Francesca, Walker, Jamie J., Terry, John R., Lightman, Stafford L.·2014·Comprehensive Physiology

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Abstract

The hypothalamic-pituitary-adrenal (HPA) axis regulates circulating levels of glucocorticoid hormones, and is the major neuroendocrine system in mammals that provides a rapid response and defense against stress. Under basal (i.e., unstressed) conditions, glucocorticoids are released with a pronounced circadian rhythm, characterized by peak levels of glucocorticoids during the active phase, that is daytime in humans and nighttime in nocturnal animals such as mice and rats. When studied in more detail, it becomes clear that the circadian rhythm of the HPA axis is characterized by a pulsatile release of glucocorticoids from the adrenal gland that results in rapid ultradian oscillations of hormone levels both in the blood and within target tissues, including the brain. In this review, we discuss the regulation of these circadian and ultradian HPA rhythms, how these rhythms change in health and disease, and how they affect the physiology and behavior of the organism.

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The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
Physiology and neurobiology of stress and adaptation: central role of the brain
McEwen, B. S. (2007) · Physiological Reviews · doi:10.1152/physrev.00041.2006 · Cited by 5,429 · cited 1×
“In addition, glucocorticoids exert anti-inﬂammatory and immunosuppressive actions and can affect mood and cognitive function (35, 49, 128).”
Coordination of circadian timing in mammals
Reppert, S. M., & Weaver, D. R. (2002) · Nature · doi:10.1038/nature00965 · Cited by 4,379
Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965
Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin
Vale, W., Spiess, J., RIVIER, C. L., & Rivier, J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198205000-00013 · Cited by 3,904
Neural regulation of endocrine and autonomic stress responses
Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318
Physiological functions of glucocorticoids in stress and their relation to pharmacological actions
MUNCK, A., GUYRE, P. M., & HOLBROOK, N. J. (1984) · Endocrine Reviews · doi:10.1210/edrv-5-1-25 · Cited by 3,083
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614
Brain corticosteroid receptor balance in health and disease
de Kloet, E. R. (1998) · Endocrine Reviews · doi:10.1210/er.19.3.269 · Cited by 2,614
Two receptor systems for corticosterone in rat brain: Microdistribution and differential occupation
REUL, J. M. H. M., & KLOET, E. R. D. (1985) · Endocrinology · doi:10.1210/endo-117-6-2505 · Cited by 2,580

Show all 219 references

Research works printed but not linked: 6

10.1210/en.130.5.2571 · DOI
10.1210/en.130.3.1394 · DOI
10.1210/en.130.5.2991 · DOI · Paper page
10.1210/me.8.10.1298 · DOI
10.1210/en.133.5.1941 · DOI
10.1210/en.139.10.4044 · DOI · Paper page

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Authors: Spiga, F., Walker, J. J., Terry, J. R., & Lightman, S. L.
Affiliations: University of Bristol (GB)
University of Exeter (GB)
ORCID: Spiga, Francesca
Walker, Jamie J.
Terry, John R.
Lightman, Stafford L.
Venue: Comprehensive Physiology
Publisher: Wiley
Published: 2014-08-07
Volume: 4
Issue: 3
Pages: 1273-1298
ISSN: 2040-4603 (ISSN-L)
DOI: 10.1002/cphy.c140003
OpenAlex: W2110243057
Cited by: 267
References: 219
Citations by year: 2026: 6 · 2025: 10 · 2024: 29 · 2023: 24 · 2022: 29 · 2021: 23 · 2020: 23 · 2019: 34 · 2018: 26 · 2017: 18 · 2016: 27 · 2015: 15 · 2014: 3
Type: other
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Comprehensive physiology (publishedVersion)
PubMed (publishedVersion)
University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Bristol Research (University of Bristol) (submittedVersion)
Funders: Wellcome Trust
Medical Research Council (MR/J008893/1, MR/J013811/1)
Biotechnology and Biological Sciences Research Council
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: hypothalamic-pituitary-adrenal axis, circadian rhythm, ultradian oscillations, glucocorticoids, stress response, neuroendocrine regulation, circadian phase shift
MeSH terms: Animals, Circadian Rhythm, Glucocorticoids, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Physiological

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