Postweaning isolation affects responses to incentive contrast in adulthood
Open accessAbstract
Adolescence is a time involving a series of changes in the use of appetitive reinforcers like food, as well as neuroendocrine changes like those taking place in the mesolimbic dopamine function. Social isolation from postnatal day 21 to 36 in rats leads to behavioral and neurophysiological alterations such as increased consumption of appetitive reinforcers. The work is focused on studying how exposure to chronic stress induced by social isolation during adolescence can have a long-lasting effect on responses to reinforcement shifts in adulthood. Two experiments were performed in rats in order to analyze the effect of adolescent isolation on the responses to unanticipated shifts in reinforcement during adulthood, in reinforcement devaluation (32-4% of sucrose solution), increase (4-32% of sucrose solution), and extinction (32-0% of sucrose solution) procedures. Adolescent isolation intensified the intake response resulting from a reinforcement increase (i.e., greater positive contrast), but had no effect on the response to reinforcement devaluation and omission. The implications of this procedure are discussed, along with the underlying behavioral and neurochemical mechanisms.
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Social isolation increases indices of approach motivation, including enhanced responding for increasing sucrose concentrations and greater conditioned responses to sucrose-related stimuli.
“Increased indices of approach motivation are also found following social isolation, with evidence of enhanced responding for increasing concentrations of sucrose (Cuenya et al., 2015; Hall et al., 1997), as well as greater conditioned responses to sucrose-related stimuli (Jones et al., 1990).”
From The effects of early life stress on reward processing (2018) · cites this paper as Cuenya et al., 2015
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The effects of early life stress on reward processing
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“Increased indices of approach motivation are also found following social isolation, with evidence of enhanced responding for increasing concentrations of sucrose (Cuenya et al., 2015; Hall et al., 1997), as well as greater conditioned responses to sucrose-related stimuli (Jones et al.”
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Post-weaning social isolation increases reward-seeking behavior in mice
Noback, M. N., Husaini, Z. A., van Kralingen, T., Afzal, A., Ye, L., Barrow, J. C., & Carr, G. V. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115437
- Authors
- Cuenya, L., Mustaca, A., & Kamenetzky, G.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Cuenya, Lucas
- Venue
- Developmental Psychobiology
- Publisher
- Wiley
- Published
- 2015-01-21
- Volume
- 57
- Issue
- 2
- Pages
- 177-188
- ISSN
- 0012-1630 (ISSN-L)
- 1098-2302
- OpenAlex
- W2107131664
- Cited by
- 9
- References
- 51
- Citations by year
- 2026: 1 · 2021: 2 · 2018: 2 · 2017: 2 · 2016: 2
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Developmental Psychobiology (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad Abierta Interamericana
- Universidad de Buenos Aires (20020130300017BA)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- adolescent social isolation, extinction, sucrose intake, chronic stress, mesolimbic dopamine system
- MeSH terms
- Age Factors, Animals, Appetitive Behavior, Conditioning, Classical, Male, Reinforcement, Psychology, Social Isolation, Stress, Psychological, Weaning, Rats, Wistar, Maze Learning, Rats
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