The DOI matches its Crossref record; 385 of the 387 references it cites were found in a registry or an index.
Synaptic vesicle recycling: steps and principles
Open accessAbstract
Synaptic vesicle recycling is one of the best-studied cellular pathways. Many of the proteins involved are known, and their interactions are becoming increasingly clear. However, as for many other pathways, it is still difficult to understand synaptic vesicle recycling as a whole. While it is generally possible to point out how synaptic reactions take place, it is not always easy to understand what triggers or controls them. Also, it is often difficult to understand how the availability of the reaction partners is controlled: how the reaction partners manage to find each other in the right place, at the right time. I present here an overview of synaptic vesicle recycling, discussing the mechanisms that trigger different reactions, and those that ensure the availability of reaction partners. A central argument is that synaptic vesicles bind soluble cofactor proteins, with low affinity, and thus control their availability in the synapse, forming a buffer for cofactor proteins. The availability of cofactor proteins, in turn, regulates the different synaptic reactions. Similar mechanisms, in which one of the reaction partners buffers another, may apply to many other processes, from the biogenesis to the degradation of the synaptic vesicle.
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“The precise mechanisms that govern the number of vesicles undergoing exo- or endocytosis, ensuring efficient resource allocation and preventing membrane imbalances, are still subjects of active investigation [23].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [23]
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757 · cited 1×
“Just as in the ER, the proteins diffuse to proteolipid patches, and may form partially stable protein/lipid assemblies (as described for the plasma membrane (Simons & Ikonen, 1997)).”
Rab GTPases as coordinators of vesicle traffic
Stenmark, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2728 · Cited by 3,413
Rab proteins as membrane organizers
Zerial, M., & McBride, H. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052055 · Cited by 3,381
Phosphoinositides in cell regulation and membrane dynamics
Di Paolo, G., & De Camilli, P. (2006) · Nature · doi:10.1038/nature05185 · Cited by 2,790
SNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
Miesenböck, G., Angelis, D. A. D., & Rothman, J. E. (1998) · Nature · doi:10.1038/28190 · Cited by 2,569
Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491
Wilschut, J. (1990) · Cited by 2,407
Molecular anatomy of a trafficking organelle
Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.10.030 · Cited by 2,373
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
McMahon, H. T., & Boucrot, E. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3151 · Cited by 2,223
Research works printed but not linked: 2
- Plato (1997) Phaedrus. Transl. by Alexander Nehamas and Paul Woodruff. In Complete Works, Cooper J, Hutchinson D (ed.), pp 507–556. Indianapolis: Hackett Publishing Co
- Virchow R (1862) Die Cellularpathologie, in Ihrer Begründung auf Physiologische und Patologische Gewebelehre. Berlin: Hirschwald, pp 1–25
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Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins
Wilhelm, B. G., Mandad, S., Truckenbrodt, S., Kröhnert, K., Schäfer, C., Rammner, B., Koo, S. J., Claßen, G. A., Krauss, M., Haucke, V., et al. (2014) · Science · doi:10.1126/science.1252884 · Cited by 770
Self-citationDissipative self-assembly of vesicular nanoreactors
Maiti, S., Fortunati, I., Ferrante, C., Scrimin, P., & Prins, L. J. (2016) · Nature Chemistry · doi:10.1038/nchem.2511 · Cited by 487
Rab GTPases and Membrane Trafficking in Neurodegeneration
Kiral, F. R., Kohrs, F. E., Jin, E. J., & Hiesinger, P. R. (2018) · Current Biology · doi:10.1016/j.cub.2018.02.010 · Cited by 249
Membrane Lipids in Presynaptic Function and Disease
Lauwers, E., Goodchild, R. E., & Verstreken, P. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.033 · Cited by 236
Molecular Mechanisms of Presynaptic Membrane Retrieval and Synaptic Vesicle Reformation
Kononenko, N. L., & Haucke, V. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.016 · Cited by 220
Metadata
- Authors
- Rizzoli, S. O.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Rizzoli, Silvio O
- ORCID
- Rizzoli, Silvio O
- Venue
- The EMBO Journal
- Published
- 2014-03-04
- Volume
- 33
- Issue
- 8
- Pages
- 788-822
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC4194108
- OpenAlex
- W2011652925
- Cited by
- 317
- References
- 387
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 28 · 2023: 20 · 2022: 21 · 2021: 23 · 2020: 24 · 2019: 34 · 2018: 28 · 2017: 34 · 2016: 25 · 2015: 18 · 2014: 10
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The EMBO Journal (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- GRO (submittedVersion, cc-by)
- Funders
- European Research Council (FP7)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- synaptic vesicle recycling, synaptic vesicle exocytosis, protein availability, synaptic vesicle biogenesis, synaptic vesicle fusion, protein-protein interaction
- MeSH terms
- Animals, Endocytosis, Exocytosis, Humans, Nerve Tissue Proteins, Neurons, Synaptic Vesicles, Metabolic Networks and Pathways
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