Cited by 317Cellular transport and secretionNeuroscience and Neuropharmacology ResearchExtracellular vesicles in disease

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Synaptic vesicle recycling: steps and principles

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Rizzoli, Silvio O·2014·The EMBO Journal

DOI 10.1002/embj.201386357PMC PMC4194108

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Abstract

Synaptic vesicle recycling is one of the best-studied cellular pathways. Many of the proteins involved are known, and their interactions are becoming increasingly clear. However, as for many other pathways, it is still difficult to understand synaptic vesicle recycling as a whole. While it is generally possible to point out how synaptic reactions take place, it is not always easy to understand what triggers or controls them. Also, it is often difficult to understand how the availability of the reaction partners is controlled: how the reaction partners manage to find each other in the right place, at the right time. I present here an overview of synaptic vesicle recycling, discussing the mechanisms that trigger different reactions, and those that ensure the availability of reaction partners. A central argument is that synaptic vesicles bind soluble cofactor proteins, with low affinity, and thus control their availability in the synapse, forming a buffer for cofactor proteins. The availability of cofactor proteins, in turn, regulates the different synaptic reactions. Similar mechanisms, in which one of the reaction partners buffers another, may apply to many other processes, from the biogenesis to the degradation of the synaptic vesicle.

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Authors: Rizzoli, S. O.
Affiliations: Universitätsmedizin Göttingen (DE)
Corresponding author: Rizzoli, Silvio O
ORCID: Rizzoli, Silvio O
Venue: The EMBO Journal
Publisher: Springer Science and Business Media LLC
Published: 2014-03-04
Volume: 33
Issue: 8
Pages: 788-822
ISSN: 0261-4189 (ISSN-L)
1460-2075
DOI: 10.1002/embj.201386357
PMC: PMC4194108
OpenAlex: W2011652925
Cited by: 317
References: 387
Citations by year: 2026: 22 · 2025: 29 · 2024: 28 · 2023: 20 · 2022: 21 · 2021: 23 · 2020: 24 · 2019: 34 · 2018: 28 · 2017: 34 · 2016: 25 · 2015: 18 · 2014: 10
FWCI: 2.91
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
creativecommons.org/licenses/by/4.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: The EMBO Journal (publishedVersion, other-oa)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
GRO (submittedVersion, cc-by)
Funders: European Research Council (FP7)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Keywords: synaptic vesicle recycling, synaptic vesicle exocytosis, protein availability, synaptic vesicle biogenesis, synaptic vesicle fusion, protein-protein interaction
MeSH terms: Animals, Endocytosis, Exocytosis, Humans, Nerve Tissue Proteins, Neurons, Synaptic Vesicles, Metabolic Networks and Pathways

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Synaptic vesicle recycling: steps and principles

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