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Synaptic vesicle recycling: steps and principles
Open accessAbstract
Synaptic vesicle recycling is one of the best-studied cellular pathways. Many of the proteins involved are known, and their interactions are becoming increasingly clear. However, as for many other pathways, it is still difficult to understand synaptic vesicle recycling as a whole. While it is generally possible to point out how synaptic reactions take place, it is not always easy to understand what triggers or controls them. Also, it is often difficult to understand how the availability of the reaction partners is controlled: how the reaction partners manage to find each other in the right place, at the right time. I present here an overview of synaptic vesicle recycling, discussing the mechanisms that trigger different reactions, and those that ensure the availability of reaction partners. A central argument is that synaptic vesicles bind soluble cofactor proteins, with low affinity, and thus control their availability in the synapse, forming a buffer for cofactor proteins. The availability of cofactor proteins, in turn, regulates the different synaptic reactions. Similar mechanisms, in which one of the reaction partners buffers another, may apply to many other processes, from the biogenesis to the degradation of the synaptic vesicle.
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“The precise mechanisms that govern the number of vesicles undergoing exo- or endocytosis, ensuring efficient resource allocation and preventing membrane imbalances, are still subjects of active investigation [23].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [23]
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Metadata
- Authors
- Rizzoli, S. O.
- Affiliations
- Universitätsmedizin Göttingen (DE)
- Corresponding author
- Rizzoli, Silvio O
- ORCID
- Rizzoli, Silvio O
- Venue
- The EMBO Journal
- Published
- 2014-03-04
- Volume
- 33
- Issue
- 8
- Pages
- 788-822
- ISSN
- 0261-4189 (ISSN-L)
- 1460-2075
- PMC
- PMC4194108
- OpenAlex
- W2011652925
- Cited by
- 317
- References
- 387
- Citations by year
- 2026: 22 · 2025: 29 · 2024: 28 · 2023: 20 · 2022: 21 · 2021: 23 · 2020: 24 · 2019: 34 · 2018: 28 · 2017: 34 · 2016: 25 · 2015: 18 · 2014: 10
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The EMBO Journal (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- GRO (submittedVersion, cc-by)
- Funders
- European Research Council (FP7)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Keywords
- synaptic vesicle recycling, synaptic vesicle exocytosis, protein availability, synaptic vesicle biogenesis, synaptic vesicle fusion, protein-protein interaction
- MeSH terms
- Animals, Endocytosis, Exocytosis, Humans, Nerve Tissue Proteins, Neurons, Synaptic Vesicles, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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