The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Epidermal stem cell diversity and quiescence
Open accessAbstract
Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted number of differentiated lineages. However, in response to injury or genetic manipulation the different pools of stem cells demonstrate multi-lineage differentiation ability. While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis. NFATc1 maintains quiescence in the HF, while Lrig1 exerts the same function in the junctional zone. The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.
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Cites
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Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Defining the Epithelial Stem Cell Niche in Skin
Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031
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Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270
WNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088
Strain-Dependent Epithelial Defects in Mice Lacking the EGF Receptor
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Lgr5 marks cycling, yet long-lived, hair follicle stem cells
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A single type of progenitor cell maintains normal epidermis
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Cited by
Epithelialization in Wound Healing: A Comprehensive Review
Pastar, I., Stojadinovic, O., Yin, N. C., Ramirez, H., Nusbaum, A. G., Sawaya, A., Patel, S. B., Khalid, L., Isseroff, R. R., & Tomic-Canic, M. (2014) · Advances in Wound Care · doi:10.1089/wound.2013.0473 · Cited by 1,531
Modulating the stem cell niche for tissue regeneration
Lane, S. W., Williams, D. A., & Watt, F. M. (2014) · Nature Biotechnology · doi:10.1038/nbt.2978 · Cited by 615
Self-citationPhilippeos, C., Telerman, S. B., Oulès, B., Pisco, A. O., Shaw, T. J., Elgueta, R., Lombardi, G., Driskell, R. R., Soldin, M., Lynch, M. D., et al. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.01.016 · Cited by 454
Self-citationHair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis
Matsumura, H., Mohri, Y., Binh, N. T., Morinaga, H., Fukuda, M., Ito, M., Kurata, S., Hoeijmakers, J., & Nishimura, E. K. (2016) · Science · doi:10.1126/science.aad4395 · Cited by 416
Cell-Extracellular Matrix Interactions in Normal and Diseased Skin
Watt, F. M., & Fujiwara, H. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005124 · Cited by 384
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Metadata
- Authors
- Watt, F. M., & Jensen, K. B.
- Venue
- EMBO Molecular Medicine
- Published
- 2009-08
- Volume
- 1
- Issue
- 5
- Pages
- 260-267
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- OpenAlex
- W2116358704
- Cited by
- 188
- References
- 16
- FWCI
- 19.04
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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