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Critical review: Grand challenges in assessing the adverse effects of contaminants of emerging concern on aquatic food webs

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Nilsen, Elena, Smalling, Kelly L., Ahrens, Lutz, Gros, Meritxell, Miglioranza, Karina S.B., Picó, Yolanda, Schoenfuss, Heiko L.·2018·Environmental Toxicology and Chemistry

DOI 10.1002/etc.4290

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Abstract

Much progress has been made in the past few decades in understanding the sources, transport, fate, and biological effects of contaminants of emerging concern (CECs) in aquatic ecosystems. Despite these advancements, significant obstacles still prevent comprehensive assessments of the environmental risks associated with the presence of CECs. Many of these obstacles center around the extrapolation of effects of single chemicals observed in the laboratory or effects found in individual organisms or species in the field to impacts of multiple stressors on aquatic food webs. In the present review, we identify 5 challenges that must be addressed to promote studies of CECs from singular exposure events to multispecies aquatic food web interactions. There needs to be: 1) more detailed information on the complexity of mixtures of CECs in the aquatic environment, 2) a greater understanding of the sublethal effects of CECs on a wide range of aquatic organisms, 3) an ascertaining of the biological consequences of variable duration CEC exposures within and across generations in aquatic species, 4) a linkage of multiple stressors with CEC exposure in aquatic systems, and 5) a documenting of the trophic consequences of CEC exposure across aquatic food webs. We examine the current literature to show how these challenges can be addressed to fill knowledge gaps. Environ Toxicol Chem 2019;38:46–60. © 2018 SETAC

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Adding Value to Ecological Risk Assessment with Population Modeling
Forbes, V. E., Calow, P., Grimm, V., Hayashi, T. I., Jager, T., Katholm, A. K., Palmqvist, A., Pastorok, R., Salvito, D., Sibly, R. M., et al. (2011) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807039.2011.552391 · Cited by 108
The toxicity of chemical pollutants in dynamic natural systems: The challenge of integrating environmental factors and biological complexity
Fischer, B. B., Pomati, F., & Eggen, R. I. L. (2013) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.01.066 · Cited by 107
Human and ecological risk assessment of a crop protection chemical: a case study with the azole fungicide epoxiconazole
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Toxicity of naproxen sodium and its mixture with tramadol hydrochloride on fish early life stages
Sehonová, P., Plhalová, L., Blahová, J., Doubková, V., Prokeš, M., Tichý, F., Fiorino, E., Faggio, C., & Svobodová, Z. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.08.151 · Cited by 103
Behavioral and genomic impacts of a wastewater effluent on the fathead minnow
García‐Reyero, N., Lavelle, C. M., Escalon, B. L., Martinović‐Weigelt, D., Kroll, K. J., Sorensen, P. W., & Denslow, N. D. (2010) · Aquatic Toxicology · doi:10.1016/j.aquatox.2010.08.014 · Cited by 99
Reproductive health indicators of fishes from Pennsylvania watersheds: association with chemicals of emerging concern
Blazer, V. S., Iwanowicz, D. D., Walsh, H. L., Sperry, A. J., Iwanowicz, L. R., Alvarez, D. A., Brightbill, R. A., Smith, G. D., Foreman, W. T., & Manning, R. L. (2014) · Environmental Monitoring and Assessment · doi:10.1007/s10661-014-3868-5 · Cited by 99
Chronic toxicity of an environmentally relevant mixture of pharmaceuticals to three aquatic organisms (alga, daphnid, and fish)
Watanabe, H., Tamura, I., Abe, R., Takanobu, H., Nakamura, A., Suzuki, T., Hirose, A., Nishimura, T., & Tatarazako, N. (2015) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3285 · Cited by 97
Effects of the antidepressant venlafaxine on fish brain serotonin and predation behavior
Bisesi, J. H., Bridges, W. C., & Klaine, S. J. (2014) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.12.033 · Cited by 96
Evidence of Detrimental Effects of Environmental Contaminants on Growth and Reproductive Physiology of White Sturgeon in Impounded Areas of the Columbia River
Feist, G. W., Webb, M. A. H., Gundersen, D. T., Foster, E. P., Schreck, C. B., Maule, A. G., & Fitzpatrick, M. S. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8072 · Cited by 94
An environmental oestrogen disrupts fish population dynamics through direct and transgenerational effects on survival and fecundity
Schwindt, A. R., Winkelman, D. L., Keteles, K., Murphy, M. B., & Vajda, A. M. (2014) · Journal of Applied Ecology · doi:10.1111/1365-2664.12237 · Cited by 92
Pesticides, aquatic food webs, and the conservation of Pacific salmon
Macneale, K. H., Kiffney, P. M., & Scholz, N. L. (2010) · Frontiers in Ecology and the Environment · doi:10.1890/090142 · Cited by 91
Comparing biological effects and potencies of estrone and 17β-estradiol in mature fathead minnows, Pimephales promelas
Dammann, A. A., Shappell, N. W., Bartell, S. E., & Schoenfuss, H. L. (2011) · Aquatic Toxicology · doi:10.1016/j.aquatox.2011.08.011 · Cited by 88
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1H NMR-based metabolomics of Daphnia magna responses after sub-lethal exposure to triclosan, carbamazepine and ibuprofen
Kovacevic, V., Simpson, A. J., & Simpson, M. J. (2016) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2016.01.004 · Cited by 86
Interspecies differences in biochemical, histopathological, and population responses in four wild fish species exposed to ethynylestradiol added to a whole lakeThis paper is part of the series “Forty Years of Aquatic Research at the Experimental Lakes Area”.
Palace, V. P., Evans, R. E., Wautier, K. G., Mills, K. H., Blanchfield, P. J., Park, B. J., Baron, C. L., & Kidd, K. A. (2009) · Canadian Journal of Fisheries and Aquatic Sciences · doi:10.1139/f09-125 · Cited by 83
Anti-anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects
Huerta, B., Margiotta‐Casaluci, L., Rodríguez‐Mozaz, S., Scholze, M., Winter, M. J., Barceló, ‪., & Sumpter, J. P. (2016) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3448 · Cited by 82
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McCallum, E. S., Krutzelmann, E., Brodin, T., Fick, J. B., Sundelin, A., & Balshine, S. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.06.073 · Cited by 82
A WEIGHT-OF-EVIDENCE APPROACH FOR NORTHERN RIVER RISK ASSESSMENT: INTEGRATING THE EFFECTS OF MULTIPLE STRESSORS
Lowell, R. B., Culp, J. M., & Dubé, M. G. (2000) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620190452 · Cited by 81
Review of emerging contaminants in aquatic biota from Latin America: 2002–2016
Llorca, M., Farré, M., Eljarrat, E., Díaz‐Cruz, M. S., Rodríguez‐Mozaz, S., Wunderlin, D. A., & Barceló, ‪. (2016) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3626 · Cited by 81
Environmental relevant levels of a benzodiazepine (oxazepam) alters important behavioral traits in a common planktivorous fish, ( Rutilus rutilus )
Brodin, T., Nordling, J., Lagesson, A., Klaminder, J., Hellström, G., Christensen, B. T., & Fick, J. B. (2017) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2017.1352214 · Cited by 81
Global warming and environmental contaminants in aquatic organisms: The need of the etho-toxicology approach
Manciocco, A., Calamandrei, G., & Alleva, E. (2014) · Chemosphere · doi:10.1016/j.chemosphere.2013.12.072 · Cited by 80
Waterborne citalopram has anxiolytic effects and increases locomotor activity in the three-spine stickleback ( Gasterosteus aculeatus )
Kellner, M., Porseryd, T., Hallgren, S., Porsch-Hällström, I., Hansen, S. H., & Olsén, K. H. (2016) · Aquatic Toxicology · doi:10.1016/j.aquatox.2015.12.026 · Cited by 79
Dietary Bioaccumulation of Perfluorophosphonates and Perfluorophosphinates in Juvenile Rainbow Trout: Evidence of Metabolism of Perfluorophosphinates
Lee, H., De Silva, A. O., & Mabury, S. A. (2012) · Environmental Science & Technology · doi:10.1021/es204533m · Cited by 78
Rainbow trout (Oncorhynchus mykiss) pro-oxidant and genotoxic responses following acute and chronic exposure to the antibiotic oxytetracycline
Rodrigues, S., Antunes, S. C., Correia, A. T., & Nunes, B. (2016) · Ecotoxicology · doi:10.1007/s10646-016-1746-3 · Cited by 78
Influence of pH-dependent aquatic toxicity of ionizable pharmaceuticals on risk assessments over environmental pH ranges
Boström, M. L., & Berglund, O. (2014) · Water Research · doi:10.1016/j.watres.2014.08.040 · Cited by 77
Assessing the risks of pesticides to threatened and endangered species using population modeling: A critical review and recommendations for future work
Forbes, V. E., Galić, N., Schmolke, A., Vavra, J. M., Pastorok, R., & Thorbek, P. (2016) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3440 · Cited by 76
Transcriptomic, cellular and life-history responses of Daphnia magna chronically exposed to benzotriazoles: Endocrine-disrupting potential and molting effects
Giraudo, M., Douville, M., Cottin, G., & Houde, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171763 · Cited by 76
Environmental contaminant mixtures at ambient concentrations invoke a metabolic stress response in goldfish not predicted from exposure to individual compounds alone.
Jordan, J., Zare, A., Jackson, L., Habibi, H., & Weljie, A. (2012) · Journal of Proteome Research · doi:10.1021/pr200840b · Cited by 74
Estimating the future decline of wild coho salmon populations resulting from early spawner die-offs in urbanizing watersheds of the Pacific Northwest, USA
Spromberg, J. A., & Scholz, N. L. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.219 · Cited by 73
The functional and physiological status of Gammarus fossarum (Crustacea; Amphipoda) exposed to secondary treated wastewater
Bundschuh, M., Zubrod, J. P., & Schulz, R. (2010) · Environmental Pollution · doi:10.1016/j.envpol.2010.08.030 · Cited by 70
Complex mixtures, complex responses: Assessing pharmaceutical mixtures using field and laboratory approaches
Schoenfuss, H. L., Furlong, E. T., Phillips, P. J., Scott, T., Kolpin, D. W., Ćetković-Cvrlje, M., Lesteberg, K. E., & Rearick, D. C. (2015) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3147 · Cited by 68
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Genotoxic effects in fish induced by pharmacological agents present in the sewage of some Italian water‐treatment plants
Rocco, L., Frenzilli, G., Zito, G., Archimandritis, A., Peluso, C., & Stingo, V. (2010) · Environmental Toxicology · doi:10.1002/tox.20607 · Cited by 67
Landscape Ecotoxicology of Coho Salmon Spawner Mortality in Urban Streams
Feist, B. E., Buhle, E. R., Arnold, P., Davis, J. W., & Scholz, N. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023424 · Cited by 65
Influence of simulated climate change and eutrophication on three‐spined stickleback populations: a large scale mesocosm experiment
Moran, R. E., Harvey, I. F., Moss, B., Feuchtmayr, H., Hatton, K., Heyes, T., & Atkinson, D. (2009) · Freshwater Biology · doi:10.1111/j.1365-2427.2009.02276.x · Cited by 65
From Classical Toxicology to Tox21: Some Critical Conceptual and Technological Advances in the Molecular Understanding of the Toxic Response Beginning From the Last Quarter of the 20th Century
Choudhuri, S., Patton, G. W., Chanderbhan, R. F., Mattia, A., & Klaassen, C. D. (2017) · Toxicological Sciences · doi:10.1093/toxsci/kfx186 · Cited by 60
Interactive effects of selected pharmaceutical mixtures on bioaccumulation and biochemical status in crucian carp (Carassius auratus)
Ding, J., Lu, G., & Li, Y. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.01.017 · Cited by 57
The influence of global climate change on the scientific foundations and applications of Environmental Toxicology and Chemistry: Introduction to a SETAC international workshop
Stahl, R. G., Hooper, M. J., Balbus, J. M., Clements, W. H., Fritz, A., Gouin, T., Helm, R. C., Hickey, C. W., Landis, W. G., & Moe, S. J. (2012) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2037 · Cited by 56
Hidden drivers of low-dose pharmaceutical pollutant mixtures revealed by the novel GSA-QHTS screening method
Rodea‐Palomares, I., González-Pleiter, M., Gonzalo, S., Rosal, R., Leganés, F., Sabater, S., Casellas, M., Muñoz‐Carpena, R., & Fernández‐Piñas, F. (2016) · Science Advances · doi:10.1126/sciadv.1601272 · Cited by 55
Transcriptional and cellular effects of benzotriazole UV stabilizers UV-234 and UV-328 in the freshwater invertebrates Chlamydomonas reinhardtii and Daphnia magna
Giraudo, M., Cottin, G., Esperanza, M., Gagnon, P., Silva, A. O. D., & Houde, M. (2017) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3908 · Cited by 53
Synthetic estrogen directly affects fish biomass and may indirectly disrupt aquatic food webs
Hallgren, P., Nicolle, A., Hansson, L., Brönmark, C., Nikoleris, L., Hyder, M., & Persson, A. (2014) · Environmental Toxicology and Chemistry · doi:10.1002/etc.2528 · Cited by 52
Evaluation of DNA damage and physiological responses in Nile tilapia, Oreochromis niloticus (Linnaeus, 1758) exposed to sub-lethal diclofenac (DCF)
Pandey, P. K., Ajima, M. N. O., Kumar, K., Poojary, N., & Kumar, S. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.03.007 · Cited by 50
Contaminants of legacy and emerging concern in largescale suckers (Catostomus macrocheilus) and the foodweb in the lower Columbia River, Oregon and Washington, USA
Nilsen, E. B., Zaugg, S. D., Alvarez, D. A., Morace, J. L., Waite, I. R., Counihan, T. D., Hardiman, J. M., Torres, L., Patiño, R., Mesa, M. G., et al. (2014) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2013.04.012 · Cited by 49
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Toxicity of emerging antifouling biocides to non-target freshwater organisms from three trophic levels
Oliveira, I., Groh, K. J., Schönenberger, R., Barroso, C. M., Thomas, K. V., & Suter, M. J. ‐. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.07.019 · Cited by 49
Eco-epidemiology of aquatic ecosystems: Separating chemicals from multiple stressors
Posthuma, L., Dyer, S. D., de Zwart, D., Kapo, K. E., Holmes, C. M., & Burton, G. A. (2016) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2016.06.242 · Cited by 48
ADAPTATION TO FLUORANTHENE EXPOSURE IN A LABORATORY POPULATION OF FATHEAD MINNOWS
Diamond, S. A., Oris, J. T., & Guttman, S. I. (1995) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620140816 · Cited by 47
Toxicity of individual pharmaceuticals and their mixtures to Aliivibrio fischeri: Experimental results for single compounds and considerations of their mechanisms of action and potential acute effects on aquatic organisms
Nica, V. D., Villa, S., & Finizio, A. (2016) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3568 · Cited by 47
Exposure to cocaine and its main metabolites altered the protein profile of zebrafish embryos
Parolini, M., Bini, L., Magni, S., Rizzo, A., Ghilardi, A., Landi, C., Armini, A., Giacco, L. D., & Binelli, A. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.09.097 · Cited by 46
Environmentally relevant chemical mixtures of concern in waters of United States tributaries to the Great Lakes
Elliott, S. M., Brigham, M. E., Kiesling, R. L., Schoenfuss, H. L., & Jorgenson, Z. G. (2018) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.4041 · Cited by 44
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Evolved pesticide tolerance in amphibians: Predicting mechanisms based on pesticide novelty and mode of action
Hua, J., Jones, D. K., Mattes, B. M., Cothran, R. D., Relyea, R. A., & Hoverman, J. T. (2015) · Environmental Pollution · doi:10.1016/j.envpol.2015.06.030 · Cited by 42
Metabolomic responses in caged clams, Ruditapes decussatus, exposed to agricultural and urban inputs in a Mediterranean coastal lagoon (Mar Menor, SE Spain)
Campillo, J. A., Sevilla, A., Albentosa, M., Bernal, C., Lozano, A. B., Cánovas, M., & León, V. M. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.03.136 · Cited by 42
A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures
Rodd, A. L., Messier, N. J., Vaslet, C. A., & Kane, A. B. (2017) · Aquatic Toxicology · doi:10.1016/j.aquatox.2017.02.018 · Cited by 42
Uptake and Disposition of Select Pharmaceuticals by Bluegill Exposed at Constant Concentrations in a Flow-Through Aquatic Exposure System
Zhao, J., Furlong, E. T., Schoenfuss, H. L., Kolpin, D. W., Bird, K., Feifarek, D. J., Schwab, E. A., & Ying, G. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b00604 · Cited by 41
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Populational divergence in the impact of three nitrogenous compounds and their combination on larvae of the frog Pelophylax perezi (Seoane, 1885)
Egea‐Serrano, A., Tejedo, M., & Torralva, M. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2009.05.017 · Cited by 40
Histopathological and proteomic responses in male Chinese rare minnow (Gobiocypris rarus) indicate hepatotoxicity following benzotriazole exposure
Liang, X., Zha, J., Martyniuk, C. J., Wang, Z., & Zhao, J. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.06.013 · Cited by 40
Biotic interactions modify multiple‐stressor effects on juvenile brown trout in an experimental stream food web
Bruder, A., Salis, R. K., Jones, P. E., & Matthaei, C. D. (2017) · Global Change Biology · doi:10.1111/gcb.13696 · Cited by 38
Multigenerational exposure of the estuarine sheepshead minnow (Cyprinodon variegatus) to 17β-estradiol. I. Organism-level effects over three generations
Cripe, G. M., Hemmer, B. L., Goodman, L. R., Fournie, J. W., Raimondo, S., Vennari, J., Danner, R. L., Smith, K., Manfredonia, B. R., Kulaw, D. H., et al. (2009) · Environmental Toxicology and Chemistry · doi:10.1897/08-542.1 · Cited by 37
Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease
Kopras, E. J., Potluri, V., Bermúdez, M.-L., Williams, K., Belcher, S. M., & Kasper, S. (2013) · Endocrine Related Cancer · doi:10.1530/erc-13-0360 · Cited by 37
The antidepressant venlafaxine may act as a neurodevelopmental toxicant in cuttlefish ( Sepia officinalis )
Bidel, F., Poi, C. D., Budzinski, H., Pardon, P. R., Callewaert, W., Arini, A., Basu, N., Dickel, L., Bellanger, C., & Jozet‐Alves, C. (2016) · NeuroToxicology · doi:10.1016/j.neuro.2016.05.023 · Cited by 37
Individual and combined effects of fine sediment and glyphosate herbicide on invertebrate drift and insect emergence: a stream mesocosm experiment
Magbanua, F. S., Townsend, C. R., Hageman, K. J., Piggott, J. J., & Matthaei, C. D. (2015) · Freshwater Science · doi:10.1086/684363 · Cited by 36
Biomarkers and Effects
Hampel, M., Blasco, J., & Díaz, M. L. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803371-5.00005-9 · Cited by 36
Challenges in assigning endocrine-specific modes of action: Recommendations for researchers and regulators
Mihaich, E. M., Schäfers, C., Dreier, D. A., Hecker, M., Ortego, L. S., Kawashima, Y., Dang, Z.-C., & Solomon, K. R. (2016) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.1883 · Cited by 36
Tributyltin: Advancing the Science on Assessing Endocrine Disruption with an Unconventional Endocrine-Disrupting Compound
Lagadic, L., Katsiadaki, I. G., Biever, R. C., Guiney, P. D., Karouna‐Renier, N. K., Schwarz, T. I., & Meador, J. P. (2017) · Reviews of Environmental Contamination and Toxicology · doi:10.1007/398_2017_8 · Cited by 36
Simulated climate change conditions unveil the toxic potential of the fungicide pyrimethanil on the midge Chironomus riparius: a multigeneration experiment
Müller, R., Seeland, A., Jagodzinski, L. S., Diogo, J. B., Nowak, C., & Oehlmann, J. (2011) · Ecology and Evolution · doi:10.1002/ece3.71 · Cited by 34
Exposure of three generations of the estuarine sheepshead minnow (Cyprinodon variegatus) to the androgen, 17β-trenbolone: Effects on survival, development, and reproduction
Cripe, G. M., Hemmer, B. L., Raimondo, S., Goodman, L. R., & Kulaw, D. H. (2010) · Environmental Toxicology and Chemistry · doi:10.1002/etc.261 · Cited by 33
Contrasting effects of nitrogenous pollution on fitness and swimming performance of Iberian waterfrog, Pelophylax perezi (Seoane, 1885), larvae in mesocosms and field enclosures
Egea‐Serrano, A., & Tejedo, M. (2013) · Aquatic Toxicology · doi:10.1016/j.aquatox.2013.11.003 · Cited by 32
Evaluation of the influence of surfactants in the bioaccumulation kinetics of sulfamethoxazole and oxazepam in benthic invertebrates
García-Galán, M. J., Sordet, M., Buleté, A., Garric, J., & Vulliet, E. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.03.085 · Cited by 32
Diurnal activity patterns as a sensitive behavioural outcome in fish: effect of short‐term exposure to treated sewage and a sub‐lethal PPCP mixture
Melvin, S. D., Buck, D. R., & Fabbro, L. D. (2016) · Journal of Applied Toxicology · doi:10.1002/jat.3284 · Cited by 27
Uncertainties in biological responses that influence hazard and risk approaches to the regulation of endocrine active substances
Parrott, J. L., Bjerregaard, P., Brugger, K. E., Gray, L. E., Iguchi, T., Kadlec, S. M., Weltje, L., & Wheeler, J. R. (2016) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.1866 · Cited by 27
Effects of chronic pollution and water flow intermittency on stream biofilms biodegradation capacity
Rožman, M., Acuña, V., & Petrović, M. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.10.019 · Cited by 27
Genotoxicity of gemfibrozil in the gilthead seabream (Sparus aurata)
Barreto, Â., Luis, L. G., Soares, A. M. V. M., Paíga, P., Santos, L. H. M. L. M., Delerue-Matos, C. M., Hylland, K., Loureiro, S., & Oliveira, M. (2017) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2017.05.011 · Cited by 26
How Can Omic Science be Improved?
Simons, K. (2018) · PROTEOMICS · doi:10.1002/pmic.201800039 · Cited by 24
Omega-3 and alpha-tocopherol provide more protection against contaminants in novel feeds for Atlantic salmon ( Salmo salar L.) than omega-6 and gamma tocopherol
Søfteland, L., Berntssen, M. H. G., Kirwan, J., Størseth, T. R., Viant, M. R., Torstensen, B. E., Waagbø, R., & Olsvik, P. A. (2016) · Toxicology Reports · doi:10.1016/j.toxrep.2016.01.008 · Cited by 22
Shotgun Proteomics Analysis Discards Alkali Labile Phosphate as a Reliable Method To Assess Vitellogenin Levels in Mytilus galloprovincialis
Sánchez‐Marín, P., Fernández-González, L. E., Mantilla, L., Diz, Á. P., & Beiras, R. (2017) · Environmental Science & Technology · doi:10.1021/acs.est.7b01734 · Cited by 21
Potential estrogenic effects of wastewaters on gene expression in Pimephales promelas and fish assemblages in streams of southeastern New York
Baldigo, B. P., George, S. D., Phillips, P. J. J., Hemming, J. D. C., Denslow, N. D., & Kroll, K. J. (2015) · Environmental Toxicology and Chemistry · doi:10.1002/etc.3120 · Cited by 19
Ecological Implications of Steady State and Nonsteady State Bioaccumulation Models
McLeod, A. M., PATERSON, G. L. J., Drouillard, K. G., & Haffner, G. D. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b03169 · Cited by 19
In ovo inhibition of steroid metabolism by bisphenol-A as a potential mechanism of endocrine disruption
Clairardin, S. G., Paitz, R. T., & Bowden, R. M. (2013) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2013.1773 · Cited by 17
Reductions in fish-community contamination following lowhead dam removal linked more to shifts in food-web structure than sediment pollution
Davis, R. P., Sullivan, S. M. P., & Stefanik, K. C. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.07.096 · Cited by 15
Concentration of Metabolites from Low-density Planktonic Communities for Environmental Metabolomics using Nuclear Magnetic Resonance Spectroscopy
Everroad, R. C., Yoshida, S., Tsuboi, Y., Date, Y., Kikuchi, J., & Moriya, S. (2012) · Journal of Visualized Experiments · doi:10.3791/3163-v · Cited by 14
Fathead Minnow and Bluegill Sunfish Life‐Stage Responses to 17β‐Estradiol Exposure in Outdoor Mesocosms
Elliott, S. M., Kiesling, R. L., Jorgenson, Z. G., Rearick, D. C., Schoenfuss, H. L., Fredricks, K. T., & Gaikowski, M. P. (2014) · JAWRA Journal of the American Water Resources Association · doi:10.1111/jawr.12169 · Cited by 14
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Ontogenetic dietary shifts and bioaccumulation of diphenhydramine in Mugil cephalus from an urban estuary
Haddad, S. P., Du‌, B., Scott, W. C., Saari, G. N., Breed, C. S., Kelly, M., Broach, L., Chambliss, C. K., & Brooks, B. W. (2017) · Marine Environmental Research · doi:10.1016/j.marenvres.2017.03.006 · Cited by 12
Estimating the effects of 17α-ethinylestradiol on stochastic population growth rate of fathead minnows: a population synthesis of empirically derived vital rates
Schwindt, A. R., & Winkelman, D. L. (2016) · Ecotoxicology · doi:10.1007/s10646-016-1688-9 · Cited by 7

Microalgae in aquatic environs: A sustainable approach for remediation of heavy metals and emerging contaminants
Singh, D. V., Bhat, R. A., Upadhyay, A. K., Singh, R., & Singh, D. (2021) · Environmental Technology & Innovation · doi:10.1016/j.eti.2020.101340 · Cited by 128
Transcriptome signatures of wastewater effluent exposure in larval zebrafish vary with seasonal mixture composition in an effluent-dominated stream
Meade, E. B., Iwanowicz, L. R., Neureuther, N., LeFevre, G. H., Kolpin, D. W., Zhi, H., Meppelink, S. M., Lane, R. F., Schmoldt, A., Mohaimani, A., et al. (2023) · Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159069 · Cited by 12
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See all 257

Authors: Nilsen, E., Smalling, K. L., Ahrens, L., Gros, M., Miglioranza, K. S. B., Picó, Y., & Schoenfuss, H. L.
Venue: Environmental Toxicology and Chemistry
Publisher: Oxford University Press (OUP)
Published: 2018-10-08
Volume: 38
Issue: 1
Pages: 46-60
ISSN: 0730-7268 (ISSN-L)
1552-8618
DOI: 10.1002/etc.4290
OpenAlex: W2906718898
Cited by: 257
References: 168
FWCI: 8.96
Type: journal article
Language: en
Open access: hybrid

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.

Critical review: Grand challenges in assessing the adverse effects of contaminants of emerging concern on aquatic food webs

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