Altered cerebellar-cerebral functional connectivity in geriatric depression
Open accessAbstract
Although volumetric and activation changes in the cerebellum have frequently been reported in studies on major depression, its role in the neural mechanism of depression remains unclear. To understand how the cerebellum may relate to affective and cognitive dysfunction in depression, we investigated the resting-state functional connectivity between cerebellar regions and the cerebral cortex in samples of patients with geriatric depression (n = 11) and healthy controls (n = 18). Seed-based connectivity analyses were conducted using seeds from cerebellum regions previously identified as being involved in the executive, default-mode, affective-limbic, and motor networks. The results revealed that, compared with controls, individuals with depression show reduced functional connectivity between several cerebellum seed regions, specifically those in the executive and affective-limbic networks with the ventromedial prefrontal cortex (vmPFC) and increased functional connectivity between the motor-related cerebellum seed regions with the putamen and motor cortex. We further investigated whether the altered functional connectivity in depressed patients was associated with cognitive function and severity of depression. A positive correlation was found between the Crus II-vmPFC connectivity and performance on the Hopkins Verbal Learning Test-Revised delayed memory recall. Additionally, the vermis-posterior cinglate cortex (PCC) connectivity was positively correlated with depression severity. Our results suggest that cerebellum-vmPFC coupling may be related to cognitive function whereas cerebellum-PCC coupling may be related to emotion processing in geriatric depression.
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PCC-cerebellum connectivity is altered in patients with depression, which could represent heightened rumination during resting state.
“Alalade et al. (2011) showed that PCC-cerebellum connectivity (in a subregion of the cerebellum that was different from the significantly activated region of the cerebellum in the current study) is altered in patients with depression, and suggested that this could represent heightened rumination during resting state.”
From Oxytocin effects on complex brain networks are moderated by experiences of maternal love withdrawal (2013) · cites this paper as Alalade et al., 2011
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- Authors
- Alalade, E., Denny, K., Potter, G., Steffens, D., & Wang, L.
- Affiliations
- Morehouse School of Medicine (US)
- Duke University (US)
- Duke Medical Center (US)
- Corresponding author
- Wang, Lihong
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-05-26
- Volume
- 6
- Issue
- 5
- Pages
- e20035
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3102667
- OpenAlex
- W2132741811
- Cited by
- 149
- References
- 59
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 8 · 2023: 9 · 2022: 13 · 2021: 17 · 2020: 7 · 2019: 9 · 2018: 10 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 14 · 2013: 9 · 2012: 11
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute on Aging (K23AG028982)
- National Institute of Mental Health (MH087741, MH60451, K24MH070027, MH70027, R25MH071544, K23MH087741, P50MH060451)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- geriatric depression, cerebellum, resting-state functional connectivity, ventromedial prefrontal cortex, posterior cingulate cortex, executive network, motor network, depression severity, emotional processing, cognitive function
- MeSH terms
- Aged, Aging, Cerebellum, Cognition, Demography, Depression, Female, Geriatrics, Gyrus Cinguli, Health, Humans, Male, Middle Aged, Nerve Net, Neuropsychological Tests, Case-Control Studies, Cerebrum
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