Disrupted axonal fiber connectivity in schizophrenia
Open accessAbstract
Background Schizophrenia is believed to result from abnormal functional integration of neural processes thought to arise from aberrant brain connectivity. However, evidence for anatomical dysconnectivity has been equivocal, and few studies have examined axonal fiber connectivity in schizophrenia at the level of whole-brain networks.Methods Cortico-cortical anatomical connectivity at the scale of axonal fiber bundles was modeled as a network. Eighty-two network nodes demarcated functionally specific cortical regions. Sixty-four direction diffusion tensor-imaging coupled with whole-brain tractography was performed to map the architecture via which network nodes were interconnected in each of 74 patients with schizophrenia and 32 age- and gender-matched control subjects. Testing was performed to identify pairs of nodes between which connectivity was impaired in the patient group. The connectional architecture of patients was tested for changes in five network attributes: nodal degree, small-worldness, efficiency, path length, and clustering.Results Impaired connectivity in the patient group was found to involve a distributed network of nodes comprising medial frontal, parietal/occipital, and the left temporal lobe. Although small-world attributes were conserved in schizophrenia, the cortex was interconnected more sparsely and up to 20% less efficiently in patients. Intellectual performance was found to be associated with brain efficiency in control subjects but not in patients.Conclusions This study presents evidence of widespread dysconnectivity in white-matter connectional architecture in a large sample of patients with schizophrenia. When considered from the perspective of recent evidence for impaired synaptic plasticity, this study points to a multifaceted pathophysiology in schizophrenia encompassing axonal as well as putative synaptic mechanisms.
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The network-based analyses depends on the fiber tractography algorithm that is used.
“It is important to note that the network-based analyses depends on the fiber tractography algorithm that is used (Zalesky et al., 2011).”
From Acceptance and Commitment Therapy and white matter plasticity in individuals with subclinical depression and psychotic experiences: A Randomised Controlled Trial (2023) · cites this paper as Zalesky et al., 2011
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Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Complex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820 · see citing works
Self-citationComplex network measures of brain connectivity: Uses and interpretations
Rubinov, M., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.003 · Cited by 11,522 · see citing works
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256 · see citing works
Efficient behavior of small-world networks
Latora, V., & Marchiori, M. (2001) · Physical Review Letters · doi:10.1103/physrevlett.87.198701 · Cited by 5,119 · see citing works
Manual for the Wechsler Adult Intelligence Scale.
Wechsler, D. (1955) · Psychological Corp. eBooks · Cited by 4,941 · see citing works
Thresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923 · see citing works
Mapping the structural core of human cerebral cortex
Hagmann, P., Cammoun, L., Gigandet, X., Meuli, R., Honey, C. J., Wedeen, V. J., & Sporns, O. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060159 · Cited by 4,173 · see citing works
Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging
Mori, S., Crain, B. J., Chacko, V. P., & van Zijl, P. C. M. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199902)45:2 · Cited by 3,479 · see citing works
Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?
Behrens, T. E. J., Berg, H. J., Jbabdi, S., Rushworth, M. F. S., & Woolrich, M. W. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.018 · Cited by 3,471 · see citing works
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371 · see citing works
Predicting human resting-state functional connectivity from structural connectivity
Honey, C. J., Sporns, O., Cammoun, L., Gigandet, X., Thiran, J. P., Meuli, R., & Hagmann, P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811168106 · Cited by 3,307 · see citing works
Characterization and propagation of uncertainty in diffusion-weighted MR imaging
Behrens, T. E. J., Woolrich, M. W., Jenkinson, M., Johansen‐Berg, H., Nunes, R. G., Clare, S., Matthews, P. M., Brady, J. M., & Smith, S. M. (2003) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10609 · Cited by 3,038 · see citing works
Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., Andrews-Hanna, J. R., Sperling, R. A., & Johnson, K. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5062-08.2009 · Cited by 2,862 · see citing works
Neurocognitive deficit in schizophrenia: A quantitative review of the evidence.
Heinrichs, R. W., & Zakzanis, K. K. (1998) · Neuropsychology · doi:10.1037/0894-4105.12.3.426 · Cited by 2,798 · see citing works
Neurocognitive deficit in schizophrenia: A quantitative review of the evidence.
Heinrichs, R. W., & Zakzanis, K. K. (1998) · Neuropsychology · doi:10.1037//0894-4105.12.3.426 · Cited by 2,791 · see citing works
Network-based statistic: identifying differences in brain networks
Zalesky, A., Fornito, A., & Bullmore, E. T. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.041 · Cited by 2,750 · see citing works
Self-citationDiffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664 · see citing works
Efficiency and Cost of Economical Brain Functional Networks
Achard, S., & Bullmore, E. (2007) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0030017 · Cited by 2,553 · see citing works
Self-citationA review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346 · see citing works
Tracking neuronal fiber pathways in the living human brain
Conturo, T. E., Lori, N. F., Cull, T. S., Akbudak, E., Snyder, A. Z., Shimony, J. S., McKinstry, R. C., Burton, H., & Raichle, M. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.18.10422 · Cited by 1,774 · see citing works
Virtual in vivo interactive dissection of white matter fasciculi in the human brain
Catani, M., Howard, R. J., Pajevic, S., & Jones, D. K. (2002) · NeuroImage · doi:10.1006/nimg.2002.1136 · Cited by 1,637 · see citing works
Basser, P. J. (1995) · NMR in Biomedicine · doi:10.1002/nbm.1940080707 · Cited by 1,526 · see citing works
Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?
Feinberg, I. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90038-3 · Cited by 1,395 · see citing works
(1995) · PubMed · Cited by 1,320 · see citing works
Hierarchical Organization of Human Cortical Networks in Health and Schizophrenia
Bassett, D. S., Bullmore, E. T., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer‐Lindenberg, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1929-08.2008 · Cited by 1,203 · see citing works
Self-citationHakak, Y., Walker, J. R., Li, C., Wong, W. H., Davis, K. L., Buxbaum, J. D., Haroutunian, V., & Fienberg, A. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081071198 · Cited by 1,192 · see citing works
Andreasen, N. C., Paradiso, S., & OʼLeary, D. S. (1998) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033321 · Cited by 1,176 · see citing works
Whole-brain anatomical networks: does the choice of nodes matter?
Zalesky, A., Fornito, A., Harding, I. H., Cocchi, L., Yücel, M., Pantelis, C., & Bullmore, E. T. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.027 · Cited by 1,169 · see citing works
Self-citationDysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring
Stephan, K. E., Friston, K. J., & Frith, C. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn176 · Cited by 1,134 · see citing works
Aberrant “Default Mode” Functional Connectivity in Schizophrenia
Garrity, A. G., Pearlson, G. D., McKiernan, K., Lloyd, D., Kiehl, K. A., & Calhoun, V. D. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.450 · Cited by 1,114 · see citing works
Gong, G., He, Y., Concha, L., Lebel, C., Gross, D. W., Evans, A. C., & Beaulieu, C. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn102 · Cited by 1,112 · see citing works
Efficiency of Functional Brain Networks and Intellectual Performance
van den Heuvel, M. P., Stam, C. J., Kahn, R. S., & Hulshoff Pol, H. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1443-09.2009 · Cited by 1,078 · see citing works
A theory of the effects of fibre size in medullated nerve
Rushton, W. A. H. (1951) · The Journal of Physiology · doi:10.1113/jphysiol.1951.sp004655 · Cited by 1,075 · see citing works
Disrupted small-world networks in schizophrenia
Liu, Y., Liang, M., Zhou, Y., Yong He, A., Hao, Y., Song, M., Yu, C., Liu, H., Liu, Z., & Jiang, T. (2008) · Brain · doi:10.1093/brain/awn018 · Cited by 1,020 · see citing works
He, Y., Chen, Z., & Evans, A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0141-08.2008 · Cited by 965 · see citing works
Friston, K. J. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00140-0 · Cited by 882 · see citing works
Synaptic plasticity and dysconnection in schizophrenia
Stephan, K. E., Baldeweg, T., & Friston, K. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.005 · Cited by 841 · see citing works
Mapping Human Whole-Brain Structural Networks with Diffusion MRI
Hagmann, P., Kurant, M., Gigandet, X., Thiran, P., Wedeen, V. J., Meuli, R., & Thiran, J.-P. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000597 · Cited by 788 · see citing works
Meta-analysis of diffusion tensor imaging studies in schizophrenia
Ellison-Wright, I., & Bullmore, E. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.021 · Cited by 715 · see citing works
Self-citationSporns, O. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.2.127 · Cited by 712 · see citing works
Schizophrenia as a Disorder of Developmentally Reduced Synaptic Connectivity
McGlashan, T. H. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.7.637 · Cited by 655 · see citing works
Glahn, D. C., Laird, A. R., Ellison-Wright, I., Thelen, S. M., Robinson, J. L., Lancaster, J. L., Bullmore, E. T., & Fox, P. T. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.031 · Cited by 627 · see citing works
Self-citationAge- and Gender-Related Differences in the Cortical Anatomical Network
Gong, G., Rosa‐Neto, P., Carbonell, F., Chen, Z. J., Yong He, A., & Evans, A. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2308-09.2009 · Cited by 625 · see citing works
Ellison-Wright, I., Glahn, D. C., Laird, A. R., Thelen, S. M., & Bullmore, E. T. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07101562 · Cited by 619 · see citing works
Self-citationBrain Anatomical Network and Intelligence
Li, Y., Liu, Y., Li, J., Qin, W., Li, K., Yu, C., & Jiang, T. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000395 · Cited by 597 · see citing works
Bluhm, R. L., Miller, J., Lanius, R. A., Osuch, E. A., Boksman, K., Neufeld, R. W. J., Théberge, J., Schaefer, B., & Williamson, P. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm052 · Cited by 568 · see citing works
Evidence for Abnormal Cortical Functional Connectivity During Working Memory in Schizophrenia
Meyer‐Lindenberg, A., Poline, J., Kohn, P. D., Holt, J. L., Egan, M. F., Weinberger, D. R., & Berman, K. F. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1809 · Cited by 507 · see citing works
Studying the human brain anatomical network via diffusion-weighted MRI and graph theory
Iturria-Medina, Y., Sotero, R. C., Canales-Rodríguez, E. J., Alemán-Gómez, Y., & Melie-García, L. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.060 · Cited by 506 · see citing works
Skudlarski, P., Jagannathan, K., Anderson, K., Stevens, M. C. G., Calhoun, V. D., Skudlarska, B. A., & Pearlson, G. D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.035 · Cited by 467 · see citing works
Small‐world properties of nonlinear brain activity in schizophrenia
Rubinov, M., Knock, S. A., Stam, C. J., Micheloyannis, S., Harris, A. W. F., Williams, L. M., & Breakspear, M. J. (2007) · Human Brain Mapping · doi:10.1002/hbm.20517 · Cited by 458 · see citing works
Yong He, A., Dagher, A., Chen, Z., Charil, A., Zijdenbos, A. P., Worsley, K. J., & Evans, A. C. (2009) · Brain · doi:10.1093/brain/awp089 · Cited by 454 · see citing works
Measuring brain connectivity: Diffusion tensor imaging validates resting state temporal correlations
Skudlarski, P., Jagannathan, K., Calhoun, V. D., Hampson, M., Skudlarska, B. A., & Pearlson, G. D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.063 · Cited by 450 · see citing works
Kubicki, M., Westin, C.-F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., & Shenton, M. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00419-0 · Cited by 376 · see citing works
Self-citationAltered Functional and Anatomical Connectivity in Schizophrenia
Camchong, J., MacDonald, A. W., Bell, C., Mueller, B. A., & Lim, K. O. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp131 · Cited by 364 · see citing works
Fornito, A., Yücel, M., Patti, J., Wood, S. J., & Pantelis, C. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2008.12.011 · Cited by 359 · see citing works
Self-citationDiffusion Tensor Imaging in Schizophrenia
Kanaan, R., Kim, J.-S., Kaufmann, W. E., Pearlson, G. D., Barker, G. J., & McGuire, P. K. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.05.015 · Cited by 332 · see citing works
The diagnostic interview for psychoses (DIP): development, reliability and applications
Castle, D. J., Jablensky, A. V., McGrath, J. J., Carr, V. J., Morgan, V. A., Waterreus, A. J., Valuri, G. M., Stain, H. J., McGuffin, P., & FARMER, A. E. (2005) · Psychological Medicine · doi:10.1017/s0033291705005969 · Cited by 323 · see citing works
Progression of cerebral white matter lesions: 6-year results of the Austrian Stroke Prevention Study
Schmidt, R., Enzinger, C., Ropele, S., Schmidt, H., & Fazekas, F. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13616-1 · Cited by 306 · see citing works
Aberrant “Default Mode” Functional Connectivity in Schizophrenia
Garrity, A. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.3.450 · Cited by 290 · see citing works
Bullmore, E. T., Frangou, S., & Murray, R. M. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00114-x · Cited by 265 · see citing works
Self-citationAbnormal Cingulate Modulation of Fronto-Temporal Connectivity in Schizophrenia
Fletcher, P. C., McKenna, P., Friston, K. J., Frith, C., & Dolan, R. J. (1999) · NeuroImage · doi:10.1006/nimg.1998.0411 · Cited by 261 · see citing works
Fornito, A., Yucel, M., Dean, B., Wood, S. J., & Pantelis, C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn025 · Cited by 259 · see citing works
Self-citationA Bayesian framework for global tractography
Jbabdi, S., Woolrich, M. W., Andersson, J., & Behrens, T. E. J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.04.039 · Cited by 251 · see citing works
Snitz, B. E., MacDonald, A. W., Cohen, J. D., Cho, R. Y., Becker, T. M., & Carter, C. S. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.12.2322 · Cited by 248 · see citing works
MRI study of white matter diffusion anisotropy in schizophrenia
Ardekani, B. A., Nierenberg, J. J., Hoptman, M. J., Javitt, D. C., & Lim, K. O. (2003) · Neuroreport · doi:10.1097/00001756-200311140-00004 · Cited by 244 · see citing works
Genetic Control of Cortical Regionalization and Connectivity
Rubenstein, J. L. R. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.6.524 · Cited by 224 · see citing works
A connectionist approach to the prefrontal cortex
Weinberger, D. R. (1993) · Journal of Neuropsychiatry · doi:10.1176/jnp.5.3.241 · Cited by 214 · see citing works
Wen, W., Sachdev, P. S., Li, J. J., Chen, X., & Anstey, K. J. (2009) · Human Brain Mapping · doi:10.1002/hbm.20586 · Cited by 210 · see citing works
Diffusion tensor magnetic resonance imaging tractography in cognitive disorders
Catani, M. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000247610.44106.3f · Cited by 202 · see citing works
Disturbed Structural Connectivity in Schizophrenia Primary Factor in Pathology or Epiphenomenon?
Konrad, A., & Winterer, G. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm034 · Cited by 197 · see citing works
Cheung, V., Cheung, C. C. G., McAlonan, G. M., Deng, Y. M., Wong, J. G., Yip, L., Tai, K. S., Khong, P. L., Sham, P. C., & Chua, S. E. (2007) · Psychological Medicine · doi:10.1017/s0033291707001808 · Cited by 197 · see citing works
FUNCTIONAL CONNECTIVITY IN SCHIZOPHRENIA
van den Heuvel, M. P., Mandl, R. C. W., Scheeuwe, T., Kahn, W., Kahn, R. S., & Pol, H. E. H. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2010.02.894 · Cited by 190 · see citing works
Tract-based morphometry for white matter group analysis
O'Donnell, L. J., Westin, C.-F., & Golby, A. J. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.023 · Cited by 186 · see citing works
Self-citationAbnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study
Sun, Z., Wang, F., Cui, L., Breeze, J. L., Du, X., Wang, X., Cong, Z., Zhang, H., Li, B., Hong, N., et al. (2003) · Neuroreport · doi:10.1097/00001756-200310060-00015 · Cited by 171 · see citing works
Formal characterization and extension of the linearized diffusion tensor model
Salvador, R. M., Peña, A., Menon, D. K., Carpenter, T. A., Pickard, J. D., & Bullmore, E. T. (2004) · Human Brain Mapping · doi:10.1002/hbm.20076 · Cited by 171 · see citing works
Self-citationNeuropathological abnormalities in schizophrenia: evidence from magnetization transfer imaging
Foong, J. (2001) · Brain · doi:10.1093/brain/124.5.882 · Cited by 168 · see citing works
Wang, F., Sun, Z., Cui, L., Du, X., Wang, X., Zhang, H., Cong, Z., Hong, N., & Zhang, D. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.3.573 · Cited by 165 · see citing works
Tract-specific anisotropy measurements in diffusion tensor imaging
Kanaan, R., Shergill, S. S., Barker, G. J., Catani, M., Ng, V., Howard, R. J., McGuire, P. K., & Jones, D. K. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.11.002 · Cited by 163 · see citing works
Evidence for white matter abnormalities in schizophrenia
Kubicki, M. R., McCarley, R. W., & Shenton, M. E. (2005) · Current Opinion in Psychiatry · doi:10.1097/00001504-200503000-00004 · Cited by 160 · see citing works
Neurobiological Investigations in Cingulate Cortex of Schizophrenic Brain
Benes, F. M. (1993) · Schizophrenia Bulletin · doi:10.1093/schbul/19.3.537 · Cited by 158 · see citing works
A DTI-Derived Measure of Cortico-Cortical Connectivity
Zalesky, A., & Fornito, A. (2009) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2008.2012113 · Cited by 141 · see citing works
Self-citationDysfunctional neural plasticity in patients with schizophrenia
Daskalakis, Z. J., Christensen, B. K., Fitzgerald, P. B., & Chen, R. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.378 · Cited by 130 · see citing works
Is the Concept of Frontal–Subcortical Dementia Relevant to Schizophrenia?
Pantelis, C., Barnes, T. R. E., & Nelson, H. E. (1992) · The British Journal of Psychiatry · doi:10.1192/bjp.160.4.442 · Cited by 129 · see citing works
Self-citationSurface‐based morphometry of the anterior cingulate cortex in first episode schizophrenia
Fornito, A., Yücel, M., Wood, S. J., Adamson, C. L., Velakoulis, D., Saling, M. M., McGorry, P. D., & Pantelis, C. (2007) · Human Brain Mapping · doi:10.1002/hbm.20412 · Cited by 123 · see citing works
Self-citationFunctional and effective frontotemporal connectivity and genetic risk for schizophrenia
Winterer, G., Coppola, R., Egan, M. F., Goldberg, T. E., & Weinberger, D. R. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00532-8 · Cited by 116 · see citing works
Dysfunctional connectivity in schizophrenia.
Friston, K. J. (2002) · Europe PMC (PubMed Central) · Cited by 114 · see citing works
White matter microstructure in schizophrenia: effects of disorder, duration and medication
Kanaan, R., Barker, G. J., Brammer, M. J., Giampietro, V., Shergill, S. S., Woolley, J., Picchioni, M., Toulopoulou, T., & McGuire, P. K. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.054320 · Cited by 109 · see citing works
Gasparotti, R., Valsecchi, P., Carletti, F., Galluzzo, A., Liserre, R., Cesana, B. M., & Sacchetti, E. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.11.015 · Cited by 108 · see citing works
Kubicki, M. R., Styner, M. A., Sylvain Bouix, A., Gerig, G., Markant, D. B., SMITH, K., Kikinis, R., McCarley, R. W., & Shenton, M. E. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.08.027 · Cited by 108 · see citing works
Seal, M. L., Yücel, M., Fornito, A., Wood, S. J., Harrison, B. J., Walterfang, M., Pell, G. S., & Pantelis, C. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.12.489 · Cited by 105 · see citing works
Self-citationWalterfang, M., WOOD, A. G., Reutens, D. C., Wood, S. J., Chen, J., Velakoulis, D., McGorry, P. D., & Pantelis, C. (2008) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.107.041251 · Cited by 87 · see citing works
Self-citationThalamo‐frontal white matter alterations in chronic schizophrenia
Oh, J. S., Kubicki, M. R., Rosenberger, G., Sylvain Bouix, A., Levitt, J. J., McCarley, R. W., Westin, C., & Shenton, M. E. (2009) · Human Brain Mapping · doi:10.1002/hbm.20809 · Cited by 84 · see citing works
Self-citationPark, C.-H., Kim, S. Y., Kim, Y., & Kim, K. (2008) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2008.06.048 · Cited by 77 · see citing works
Corpus callosum shape alterations in individuals prior to the onset of psychosis
Walterfang, M., Yung, A. R., WOOD, A. G., Reutens, D. C., Phillips, L., Wood, S. J., Chen, J., Velakoulis, D., McGorry, P. D., & Pantelis, C. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.042 · Cited by 76 · see citing works
Self-citationDT-MRI Fiber Tracking: A Shortest Paths Approach
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Self-citationUranova, N. A., Casanova, M. F., DeVaughn, N. M., Orlovskaya, D. D., & Denisov, D. V. (1996) · Schizophrenia Research · doi:10.1016/0920-9964(96)00059-x · Cited by 56 · see citing works
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Hoffman, R. E., Buchsbaum, M. S., Escobar, M. D., Makuch, R., Nuechterlein, K. H., & Guich, S. (1991) · Journal of Neuropsychiatry · doi:10.1176/jnp.3.2.169 · Cited by 56 · see citing works
Basser (2000) · doi:10.1002/1522-2594(200010)44:4
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Hong, S.-B., Zalesky, A., Fornito, A., Park, S., Yang, Y.-H., Park, M.-H., Song, I.-C., Sohn, C.-H., Shin, M.-S., Kim, B.-N., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.12.013 · Cited by 99 · see citing works
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Ehrlich, S., Lord, A. R., Geisler, D., Borchardt, V., Boehm, I., Seidel, M., Ritschel, F., Schulze, A., King, J. A., Weidner, K., et al. (2015) · Human Brain Mapping · doi:10.1002/hbm.22736 · Cited by 65 · see citing works
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“The current study applied deterministic tractography (Zalesky et al., 2011).”
- Authors
- Zalesky, A., Fornito, A., Seal, M. L., Cocchi, L., Westin, C.-F., Bullmore, E. T., Egan, G. F., & Pantelis, C.
- Affiliations
- The University of Melbourne (AU)
- Brigham and Women's Hospital (US)
- University of Cambridge (GB)
- Corresponding author
- Zalesky, Andrew
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 69
- Issue
- 1
- Pages
- 80-89
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC4881385
- OpenAlex
- W2053533857
- Cited by
- 439
- References
- 99
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 13 · 2023: 14 · 2022: 16 · 2021: 23 · 2020: 23 · 2019: 38 · 2018: 32 · 2017: 28 · 2016: 40 · 2015: 44 · 2014: 44 · 2013: 45 · 2012: 33
- FWCI
- 22.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Australian Schizophrenia Research Bank
- National Health and Medical Research Council
- Pratt Foundation
- Ramsay Health Care
- Viertel Charitable Foundation
- Schizophrenia Research Institute
- Human Brain Project
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of Mental Health
- Australian Research Council (DP0986320)
- NHMRC (454797, 628386)
- Ronald Phillip Griffith Fellowship
- Swiss Academy of Medical Science
- Swiss National Science Foundation (PASMP3 129357/1)
- National Institutes of Health (R01MH074794)
- Neuroimage Analysis Center (P41RR013218)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- schizophrenia, corticocortical connections, white matter, brain network efficiency, small-worldness, network topology, diffusion tensor imaging, tractography, cognitive performance, synaptic plasticity
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Male, Nerve Fibers, Myelinated, Nerve Net, Neural Pathways, Schizophrenia, Neural Networks, Computer, Diffusion Tensor Imaging
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