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Cited by 450Autism Spectrum Disorder ResearchAdvanced Neuroimaging Techniques and ApplicationsGenetics and Neurodevelopmental Disorders

Diffusion tensor imaging in autism spectrum disorder: a review

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Travers, Brittany G., Adluru, Nagesh, Ennis, Chad, Tromp, Do P. M., Destiche, Dan, Doran, Sam, Bigler, Erin D., Lange, Nicholas +2 more·2012·Autism Research
DOI 10.1002/aur.1243PMC PMC3474893
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Abstract

White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder ( ASD ). From the 48 studies we reviewed, persons with ASD tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with ASD . Clinical implications and future research directions are discussed. Autism Res 2012, 5: 289–313. © 2012 International Society for Autism Research, Wiley Periodicals, Inc.

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  • Reduced FA in the dorsal cingulum is a frequent feature of ASD.

    “reduced FA in the dorsal cingulum is also a frequent feature of ASD (Rane et al., 2015; Shukla et al., 2011; Travers et al., 2012; but see Aoki et al., 2013; Table 2).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Travers et al., 2012

    The “Group Differences in the Cingulum Bundle” section reports that multiple studies found decreased FA and/or increased MD in the anterior cingulum in ASD, and cautiously suggests that decreased cingulum FA may be common. The review supports a recurring cingulum finding, but it does not specifically establish reduced FA in the dorsal cingulum as a frequent feature. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • In ASD, there is a recurrent pattern of reduced FA and increased diffusivity, consistent with altered development.

    “Overall, there is a recurrent pattern of reduced FA and increased diffusivity, consistent with altered development (Ameis and Catani, 2015; Rane et al., 2015; Travers et al., 2012).”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Travers et al., 2012

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Cited by

Sorted by citations

Authors
Travers, B. G., Adluru, N., Ennis, C., Tromp, D. P. M., Destiche, D., Doran, S., Bigler, E. D., Lange, N., Lainhart, J. E., & Alexander, A. L.
Affiliations
  • University of Wisconsin–Madison (US)
  • Brigham Young University (US)
  • Harvard University (US)
  • University of Utah (US)
Corresponding author
Travers, Brittany G.
ORCID
Venue
Autism Research
Publisher
Wiley
Published
2012-07-11
Volume
5
Issue
5
Pages
289-313
ISSN
  • 1939-3792 (ISSN-L)
  • 1939-3806
DOI
10.1002/aur.1243
PMC
PMC3474893
OpenAlex
W2135438065
Cited by
450
References
19
Citations by year
2026: 34 · 2025: 33 · 2024: 20 · 2023: 24 · 2022: 23 · 2021: 27 · 2020: 27 · 2019: 40 · 2018: 29 · 2017: 39 · 2016: 32 · 2015: 44 · 2014: 41 · 2013: 33 · 2012: 4
FWCI
3.09
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Autism Research (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (R01MH080826, P50-MH84051, P50MH069315, P50MH084051, R01MH084795)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32 HD 07489, P30HD003352, T32HD007489)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
autism spectrum disorder, diffusion tensor imaging, white matter integrity, fractional anisotropy, mean diffusivity, radial diffusivity, corpus callosum, cingulum, temporal lobe, laterality
MeSH terms
Adolescent, Brain, Child, Child Development Disorders, Pervasive, Humans, Functional Laterality, Nerve Fibers, Myelinated, Anisotropy, Diffusion Tensor Imaging

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